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![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-buteramide and crystalline forms thereof](/abs-image/US/2013/03/12/US08394959B2/abs.jpg.150x150.jpg)
21.发明授权Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-buteramide and crystalline forms thereof 有权（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基）-4-（二甲基氨基）-2-丁酰胺的马来酸盐和 其结晶形式公开(公告)号：US08394959B2
公开(公告)日：2013-03-12
申请号：US13441168
申请日：2012-04-06
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/abs-image/US/2012/05/08/US08173814B2/abs.jpg.150x150.jpg)
22.发明授权Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof 有权（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式公开(公告)号：US08173814B2
公开(公告)日：2012-05-08
申请号：US13181375
申请日：2011-07-12
申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D215/44
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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23.发明申请MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF 有权（E）-N-4-（二甲基氨基）-2-丁酮及其结晶形式的色谱柱公开(公告)号：US20110313166A1
公开(公告)日：2011-12-22
申请号：US13181375
申请日：2011-07-12
申请人： Qinghong LU , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
发明人： Qinghong LU , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , A61K31/4709 , C07C51/412 , C07C57/145
摘要： The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
摘要翻译： 本发明涉及（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基 ）-2-丁烯酰胺，制备结晶马来酸盐形式的方法，相关化合物和含有它们的药物组合物。 马来酸盐可用于治疗癌症，特别是受表皮生长因子受体家族激酶影响的癌症。
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24.发明申请METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS 审中-公开羟基取代的芳基磺酰胺化合物的制备方法公开(公告)号：US20090156826A1
公开(公告)日：2009-06-18
申请号：US12332400
申请日：2008-12-11
申请人： Maria Papamichelakis , Jacqueline Francesca Lunetta , Mark Lankau , Luc Richard , Christopher Kendall , Marcelo Cesar Saraiva , Xianghui Wen , Mahmoud Mirmehrabi , Valerie Paquet , Sylvain Daigneault , Puwen Zhang
发明人： Maria Papamichelakis , Jacqueline Francesca Lunetta , Mark Lankau , Luc Richard , Christopher Kendall , Marcelo Cesar Saraiva , Xianghui Wen , Mahmoud Mirmehrabi , Valerie Paquet , Sylvain Daigneault , Puwen Zhang
IPC分类号： C07D417/06
CPC分类号： C07D417/06 , C07D285/14
摘要： The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.
摘要翻译： 本发明涉及制备式I的羟基取代的芳基磺酰胺衍生物或其药学上可接受的盐，立体异构体或互变异构体的方法，其是单胺再摄取抑制剂，其中组成变量如本文所定义。
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25.发明申请CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS PHARMACEUTICALLY ACCEPTABLE SALTS 审中-公开N-（3-（二甲基氨基）丙基）-4-（4-（3-氟-4-甲氧基苯基）嘧啶-2-基氨基）苯甲酰胺作为药物接受性盐的结晶形式和聚合物公开(公告)号：US20080275073A1
公开(公告)日：2008-11-06
申请号：US12105567
申请日：2008-04-18
IPC分类号： A61K31/505 , C07D239/42
CPC分类号： C07D239/42
摘要： The present invention relates to one or more crystalline forms and polymorphs of compounds of formula I: in the form of pharmaceutically acceptable salts. The present invention is directed to crystalline polymorphs and forms of specific anilino-pyrimidine benzenesulfonamide compounds of formula I as pharmaceutically acceptable salts.
摘要翻译： 本发明涉及式I化合物的一种或多种结晶形式和多晶型物：药学上可接受的盐形式。 本发明涉及作为药学上可接受的盐的结晶多晶型物和式I的特定苯胺基 - 嘧啶苯磺酰胺化合物的形式。
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26.发明申请CRYSTALLINE POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS D-GLUCORONATE SALTS 审中-公开N-（3-（二甲基氨基）丙基）-4-（4-（3-氟-4-甲氧基苯基）嘧啶-2-基氨基）苯甲酰胺作D-葡萄糖醛酸盐的结晶聚合物公开(公告)号：US20080262010A1
公开(公告)日：2008-10-23
申请号：US12105520
申请日：2008-04-18
IPC分类号： A61K31/505 , C07D239/42 , A61P35/00
CPC分类号： C07D239/42
摘要： The present invention relates to methods for preparing one or more crystalline polymorphs of a compound of formula I: and structurally related compounds. The present invention is also directed to methods for converting one polymorph to other different polymorphs of formula I and structurally related compounds.
摘要翻译： 本发明涉及制备式I化合物的一种或多种结晶多晶型物的方法：和结构上相关的化合物。 本发明还涉及将一种多晶型物转化为式I的其它不同多晶型物和结构相关化合物的方法。
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27.发明申请CRYSTAL FORM OF 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL 审中-公开2-（3-氟-4-羟基苯基）-7-乙烯基-1,3-苯并恶唑-5-OL的晶体形式公开(公告)号：US20080139633A1
公开(公告)日：2008-06-12
申请号：US11942897
申请日：2007-11-20
IPC分类号： A61K31/423 , C07D263/56 , A61P15/00 , A61P25/00 , A61P9/00 , A61P1/00 , A61P35/00 , A61P19/02
CPC分类号： C07D263/56
摘要： The present invention is directed to a hydrate crystal form (designated as Form F herein) of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.
摘要翻译： 本发明涉及2-（3-氟-4-羟基苯基）-7-乙烯基-1,3-苯并恶唑-5-醇的水合物结晶形式（此处称为F型），可用于 治疗例如与异常水平的雌激素相关的疾病。
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