公开(公告)号：US20080221430A1

公开(公告)日：2008-09-11

申请号：US12030893

申请日：2008-02-14

申请人： Hisaaki OCHI ,  Yo Taniguchi ,  Yoshihisa Soutome ,  Yoshitaka Bito

发明人： Hisaaki OCHI ,  Yo Taniguchi ,  Yoshihisa Soutome ,  Yoshitaka Bito

IPC分类号： A61B5/055

CPC分类号： G01R33/5601 ,  G01R33/54 ,  G01R33/5616 ,  G01R33/5617

摘要： A magnetic resonance imaging (MRI) apparatus for high-speed and high-accuracy detection of cell positions labeled with magnetic nanoparticles. A transmitter coil is controlled to generate amplitude-modulated burst RF pulses as excitation RF pulses whose amplitude is modulated by a function that repeatedly inverts the polarity of multiple high-frequency magnetic field sub-pulses separated time-wise and changes the amplitude at each polarity inversion, moreover the time interval of the amplitude-modulated burst RF pulse is set to effectively 1/(2×a first frequency), and the transmitter coil controlled so the carrier frequency of the amplitude-modulated burst RF pulse is set to a second frequency shifted substantially from the first frequency of the magnetic resonance frequency of the proton at the magnetic field strength in the MRI apparatus. The first frequency is here determined based on magnetic nanoparticle information loaded from the magnetic nanoparticle information storage unit and the magnetic resonance frequency of the proton in the static magnetic field. The MRI apparatus can in this way detect the position of cells labeled with magnetic nanoparticles, with high-speed and high accuracy.

摘要翻译： 一种磁共振成像（MRI）装置，用于高速和高精度检测用磁性纳米颗粒标记的细胞位置。 发射器线圈被控制以产生幅度调制的突发RF脉冲作为激励RF脉冲，其幅度通过重复地反转时间间隔分离的多个高频磁场子脉冲的极性并改变每个极性的振幅的函数来调制 此外，调幅脉冲串RF脉冲的时间间隔被有效地设置为1 /（2×a第一频率），并且被控制的发射机线圈被调制的调幅脉冲串RF脉冲的载波频率设置为第二频移 基本上从MRI装置中的磁场强度的质子的磁共振频率的第一频率开始。 这里基于从磁性纳米颗粒信息存储单元加载的磁性纳米颗粒信息和静态磁场中质子的磁共振频率来确定第一频率。 MRI装置可以以这种方式以高速和高精度检测用磁性纳米颗粒标记的细胞的位置。

公开(公告)号：US07723987B2

公开(公告)日：2010-05-25

申请号：US12071896

申请日：2008-02-27

申请人： Yoshitaka Bito ,  Yo Taniguchi ,  Toru Shirai ,  Shinji Kurokawa

发明人： Yoshitaka Bito ,  Yo Taniguchi ,  Toru Shirai ,  Shinji Kurokawa

IPC分类号： G01V3/00

CPC分类号： G01R33/4833 ,  G01R33/4835 ,  G01R33/561

摘要： A magnetic resonance measurement technique is provided which shortens the measurement time while suppressing artifacts caused by body movement of a measuring object and enables high-speed imaging. An excitation pulse which excites a plurality of slice planes and an excitation pulse which excites slice planes perpendicular to the slice planes are applied and a plurality of substantially parallel linear crossing areas are simultaneously measured. Spatial information of a linear direction of the crossing areas is acquired by modulating a magnetic resonance signal from the crossing areas by a gradient magnetic field. A spatial information of a direction perpendicular to the linear direction is acquired by changing the position of the plane and an image is reconstructed.

摘要翻译： 提供一种磁共振测量技术，其可以在抑制由测量对象的身体移动引起的伪像的同时缩短测量时间并且能够进行高速成像。 激励激发多个切片平面的激励脉冲和激发与切片平面垂直的切片平面的激励脉冲，同时测量多个基本上平行的线性交叉区域。 交叉区域的线性方向的空间信息是通过梯度磁场调制来自交叉区域的磁共振信号而得到的。 通过改变平面的位置并且重建图像来获取垂直于线性方向的方向的空间信息。

公开(公告)号：US5808467A

公开(公告)日：1998-09-15

申请号：US653315

申请日：1996-05-24

申请人： Hisaaki Ochi ,  Yo Taniguchi ,  Kenichi Okajima ,  Yoshitaka Bito ,  Etsuji Yamamoto

发明人： Hisaaki Ochi ,  Yo Taniguchi ,  Kenichi Okajima ,  Yoshitaka Bito ,  Etsuji Yamamoto

IPC分类号： G01R33/3415 ,  G01V3/00

CPC分类号： G01R33/3415

摘要： In the inspection system using nuclear magnetic resonance comprising magnetic field generators such as a static magnetic field, a gradient magnetic field, and an RF magnetic field, an RF probe for detecting an NMR signal from a subject, and a calculator for operating a detected signal by the RF probe, a RF probe for detection comprises a plurality of coils arranged in the predetermined direction and includes a plurality of switching elements and the inspection system selects two or more coils from the plurality of coils for each measurement of NMR signals, turns the switching elements connected to the selected coils ON, turns the switching elements connected to coils other than the selected coils OFF, changes a combination of two or more coils for each measurement of NMR signals, and changes the sensitivity distribution of the RF probe in the predetermined direction according to the Wavelet basis function for each measurement of NMR signals.

摘要翻译： 在使用包括诸如静磁场，梯度磁场和RF磁场的磁场发生器的核磁共振的检查系统中，用于检测来自被检体的NMR信号的RF探针和用于操作检测信号的计算器 通过RF探头，用于检测的RF探针包括沿预定方向布置的多个线圈，并且包括多个开关元件，并且检查系统从每个测量NMR信号中选择来自多个线圈的两个或更多个线圈， 连接到所选择的线圈的开关元件接通，将与所选线圈以外的线圈相连的开关元件断开，对每个NMR信号的测量改变两个或更多个线圈的组合，并将RF探针的灵敏度分布改变为预定的 根据每个NMR信号测量的小波基函数的方向。

公开(公告)号：US09389289B2

公开(公告)日：2016-07-12

申请号：US13881739

申请日：2011-10-26

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

IPC分类号： G01R33/36 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48 ,  G01R33/485 ,  G01R33/561

CPC分类号： G01R33/3621 ,  A61B5/055 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5611

摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.

摘要翻译： 在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。 例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。 在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈​​接收不少于待分离物质的数量的数量的磁共振信号 。 使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。 然后，执行用于将移动的图像返回到原始位置的校正。 此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

公开(公告)号：US20100097062A1

公开(公告)日：2010-04-22

申请号：US12519197

申请日：2007-06-29

申请人： Toru Shirai ,  Yoshitaka Bito ,  Yo Taniguchi ,  Satoshi Hirata

发明人： Toru Shirai ,  Yoshitaka Bito ,  Yo Taniguchi ,  Satoshi Hirata

IPC分类号： G01V3/14

CPC分类号： G01R33/485 ,  G01R33/483 ,  G01R33/5602 ,  G01R33/5607

摘要： A method for obtaining the most appropriate amplitude of signal suppression pulse, which suppresses unnecessary signals from the substance not subjected to measurement, highly accurately, swiftly and stably, and an MRI apparatus that enables the optimization are provided.A pulse amplitude adjusting means equipped in the MRI apparatus acquires signals while changing the amplitude of signal suppression pulse and calculates signal absolute values and phase values, and computes reference signals, which are polarized signal absolute values, based on the changes in signal phase values. This reference signals are subjected to polynomial fitting. A value which makes this fitting curve is 0 or closes to 0 is set as the optimal pulse amplitude.

摘要翻译： 提供了一种用于获得信号抑制脉冲的最适当振幅的方法，其能够高度准确，快速且稳定地抑制不被测量的物质的不必要的信号，并且提供能够进行优化的MRI装置。 装备在MRI装置中的脉冲幅度调整装置在改变信号抑制脉冲的振幅的同时获取信号，并且计算信号绝对值和相位值，并且基于信号相位值的变化来计算作为极化信号绝对值的参考信号。 该参考信号经过多项式拟合。 使该拟合曲线为0或接近0的值被设定为最佳脉冲幅度。

公开(公告)号：US20090085563A1

公开(公告)日：2009-04-02

申请号：US12071896

申请日：2008-02-27

申请人： Yoshitaka Bito ,  Yo Taniguchi ,  Toru Shirai ,  Shinji Kurokawa

发明人： Yoshitaka Bito ,  Yo Taniguchi ,  Toru Shirai ,  Shinji Kurokawa

IPC分类号： G01R33/32

CPC分类号： G01R33/4833 ,  G01R33/4835 ,  G01R33/561

摘要： A magnetic resonance measurement technique is provided which shortens the measurement time while suppressing artifacts caused by body movement of a measuring object and enables high-speed imaging. An excitation pulse which excites a plurality of slice planes and an excitation pulse which excites slice planes perpendicular to the slice planes are applied and a plurality of substantially parallel linear crossing areas are simultaneously measured. Spatial information of a linear direction of the crossing areas is acquired by modulating a magnetic resonance signal from the crossing areas by a gradient magnetic field. A spatial information of a direction perpendicular to the linear direction is acquired by changing the position of the plane and an image is reconstructed.

摘要翻译： 提供一种磁共振测量技术，其可以在抑制由测量对象的身体移动引起的伪像的同时缩短测量时间并且能够进行高速成像。 激励激发多个切片平面的激励脉冲和激发与切片平面垂直的切片平面的激励脉冲，同时测量多个基本上平行的线性交叉区域。 交叉区域的线性方向的空间信息是通过梯度磁场调制来自交叉区域的磁共振信号而得到的。 通过改变平面的位置并且重建图像来获取垂直于线性方向的方向的空间信息。

公开(公告)号：US20140292334A1

公开(公告)日：2014-10-02

申请号：US14241515

申请日：2012-07-27

申请人： Yukio Kaneko ,  Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hideta Habara ,  Yosuke Otake

发明人： Yukio Kaneko ,  Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hideta Habara ,  Yosuke Otake

IPC分类号： G01R33/565

CPC分类号： G01R33/5659 ,  A61B5/055 ,  G01R33/246 ,  G01R33/4835 ,  G01R33/5612

摘要： With minimizing extension of imaging time, the B1 non-uniformity reducing effect of RF shimming is maximized for an imaging section of an arbitrary axis direction and an arbitrary position. B1 distributions are measured for only several sections of one predetermined direction, and a radio frequency magnetic field condition that maximizes the B1 non-uniformity reducing effect for an imaging section of an arbitrary direction and an arbitrary position is calculated from the B1 distribution data. For example, after B1 distributions of only several sections of the AX direction are measured, the optimal radio frequency magnetic field condition for an imaging section of an arbitrary position for the AX direction is obtained by interpolation with optimal radio frequency magnetic field conditions calculated from B1 distributions of two sections near the imaging section, and the optimal radio frequency magnetic field condition for an imaging section of an arbitrary position for the SAG or COR direction is obtained by using only B1 values of a crossing region with the imaging section extracted from the B1 distributions.

摘要翻译： 随着成像时间的延长最小化，对于任意轴方向和任意位置的成像部分，RF匀场的B1均匀性减小效果最大化。 B1分布仅测量一个预定方向的几个部分，并且从B1分布数据计算使任意方向和任意位置的成像部分的B1不均匀性减小效果最大化的射频磁场条件。 例如，在AX方向的仅仅几个部分的B1分布被测量之后，通过利用从B1计算出的最佳射频磁场条件进行插值来获得用于AX方向的任意位置的成像部分的最佳射频磁场条件 通过仅使用从B1提取的成像部分的交叉区域的B1值获得用于SAG或COR方向的任意位置的成像部分的最佳射频磁场条件， 分布。

公开(公告)号：US20130069652A1

公开(公告)日：2013-03-21

申请号：US13522928

申请日：2011-01-25

申请人： Yosuke Otake ,  Yoshihisa Soutome ,  Yukio Kaneko ,  Yoshitaka Bito ,  Hisaaki Ochi ,  Koji Hirata

发明人： Yosuke Otake ,  Yoshihisa Soutome ,  Yukio Kaneko ,  Yoshitaka Bito ,  Hisaaki Ochi ,  Koji Hirata

IPC分类号： G01R33/34

CPC分类号： G01R33/3664 ,  G01R33/34053 ,  G01R33/34076 ,  G01R33/3415

摘要： There is a provided a technology of receiving a magnetic resonance signal highly sensitively and with a uniform sensitivity distribution in an RF coil of an MRI device which is an RF coil including a switch circuit of switching a circuit configuration. The RF coil of the MRI device of the present invention includes a switch circuit of switching a circuit configuration. Also, the switch circuit switches the circuit configuration by being driven by a control signal received by wireless. For that purpose, the switch circuit includes an antenna of receiving the control signal and a conversion circuit of converting an alternating current voltage received into a direct current voltage.

摘要翻译： 提供了一种技术，其高灵敏度地接收磁共振信号，并且在作为包括切换电路配置的开关电路的RF线圈的MRI装置的RF线圈中具有均匀的灵敏度分布。 本发明的MRI装置的RF线圈包括切换电路结构的开关电路。 此外，开关电路通过由无线接收的控制信号驱动来切换电路配置。 为此，开关电路包括接收控制信号的天线和将所接收的交流电压转换成直流电压的转换电路。

公开(公告)号：US09726744B2

公开(公告)日：2017-08-08

申请号：US14241515

申请日：2012-07-27

申请人： Yukio Kaneko ,  Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hideta Habara ,  Yosuke Otake

发明人： Yukio Kaneko ,  Yoshihisa Soutome ,  Yoshitaka Bito ,  Hiroyuki Takeuchi ,  Tetsuhiko Takahashi ,  Hideta Habara ,  Yosuke Otake

IPC分类号： G01R33/565 ,  G01R33/24 ,  A61B5/055 ,  G01R33/483 ,  G01R33/561

CPC分类号： G01R33/5659 ,  A61B5/055 ,  G01R33/246 ,  G01R33/4835 ,  G01R33/5612

摘要： Systems and methods for magnetic resonance imaging, including adjusting spatial distribution of a rotating magnetic field. By minimizing imaging time, the B1 nonuniformity reducing effect of RF shimming is maximized for an imaging section of an arbitrary axis direction and an arbitrary position. B1 distributions are measured for only several sections of one predetermined direction, and a radio frequency magnetic field condition that maximizes the B1 non-uniformity reducing effect for an imaging section of an arbitrary direction and an arbitrary position is calculated from the B1 distribution data.

公开(公告)号：US08198894B2

公开(公告)日：2012-06-12

申请号：US12417852

申请日：2009-04-03

申请人： Yukio Kaneko ,  Hideta Habara ,  Yoshihisa Soutome ,  Yosuke Otake ,  Yoshitaka Bito

发明人： Yukio Kaneko ,  Hideta Habara ,  Yoshihisa Soutome ,  Yosuke Otake ,  Yoshitaka Bito

IPC分类号： G01V3/00

CPC分类号： G01R33/34046 ,  G01R33/34053 ,  G01R33/34076 ,  G01R33/341 ,  G01R33/3635

摘要： An RF coil for MR Imaging that can change a resonance frequency easily and instantaneously in response to a nuclide to be imaged without exchange and adjustment and that also causes only small lowering of sensitivity. The RF coil has a sub coil for changing a resonance frequency of the transmitting/receiving RF coil for transmitting and receiving an MR signal between itself and a nuclide that is an object to be imaged. The sub coil is equipped with a switch, and at the time of switching-on, shifts the resonance frequency of the RF coil by changing an inductance value of the RF coil in a noncontact manner using inductance coupling.

摘要翻译： 用于MR成像的RF线圈，其能够响应于待成像的核素而容易且瞬时地改变谐振频率而不进行交换和调整，并且也仅导致灵敏度的小的降低。 RF线圈具有用于改变发射/接收RF线圈的谐振频率的子线圈，用于在其与作为要成像的对象的核素之间发送和接收MR信号。 子线圈配备有开关，并且在接通时通过使用电感耦合以非接触方式改变RF线圈的电感值来移动RF线圈的谐振频率。