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    &ohgr;-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
    21.
    发明授权
    &ohgr;-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient 失效
    ω-取代的苯基 - 前列腺素E衍生物和含有与活性成分相同的药物

    公开(公告)号：US06586468B1

    公开(公告)日：2003-07-01

    申请号：US09787087

    申请日：2001-06-11

    申请人： Toru Maruyama ,  Shuichi Ohuchida

    发明人： Toru Maruyama ,  Shuichi Ohuchida

    IPC分类号： A61K31215

    CPC分类号： A61K31/5575 ,  C07C405/00

    摘要： A &ohgr;-substituted phenyl-prostaglandin of formula (I), a process for the preparation thereof, a mediciament comprising it as active ingredient (all symbols have the same meaning as described in the specification). The compounds of the formula (I) bind strongly in PGE2 receptor (especially subtype EP4) and therefore are useful for the prophylaxis and/or treatment of immune diseases (autoimmune diseases (amyotrophic lateral sclerosis (ALS) etc.), post-transplantation graft rejection, etc.), asthma, abnormal bone formation, neurocyte death, pulmopathy, hepatopathy, etc. They are also related to sleeping disorders and platelet coagulations, and therefore they are also applicable to these diseases.

    摘要翻译： 式（I）的ω-取代的苯基 - 前列腺素，其制备方法，包含其作为活性成分的药物（所有符号具有与说明书中所述相同的含义）。式（I）化合物结合 PGE2受体（特别是EP4亚型），因此可用于预防和/或治疗免疫疾病（自身免疫性疾病（肌萎缩性侧索硬化（ALS）等）），移植后移植排斥反应等），哮喘，异常 骨形成，神经细胞死亡，肺病，肝病等。它们也与睡眠障碍和血小板凝血有关，因此也适用于这些疾病。

    Polishing device
    22.
    发明授权
    Polishing device 有权
    抛光装置

    公开(公告)号：US06293858B1

    公开(公告)日：2001-09-25

    申请号：US09445220

    申请日：1999-12-06

    申请人： Norio Kimura ,  Toru Maruyama ,  Shunichiro Kojima ,  Seiji Katsuoka ,  Shin Ohwada

    发明人： Norio Kimura ,  Toru Maruyama ,  Shunichiro Kojima ,  Seiji Katsuoka ,  Shin Ohwada

    IPC分类号： B24B500

    CPC分类号： B24B37/32 ,  B24B49/16

    摘要： A polishing apparatus for polishing a workpiece such as a semiconductor wafer to a flat mirror finish includes a turntable with a polishing cloth mounted on an upper surface thereof and a top ring for polishing a semiconductor wafer to a flat mirror finish by placing the semiconductor wafer between the turntable and the top ring and pressing the semiconductor wafer under a certain pressing force. A presser ring is vertically movably provided around the top ring. A pressing device presses the presser ring against the polishing cloth under a variable pressing force, and the presser ring is supported by the top ring through a bearing.

    摘要翻译： 用于将诸如半导体晶片的工件抛光到平面镜面抛光的抛光装置包括具有安装在其上表面上的抛光布的转台和用于通过将半导体晶片放置在 转台和顶环，并在一定的压力下按压半导体晶片。 压环围绕顶环垂直移动。 按压装置以可变的按压力将压脚压在抛光布上，并且压环通过轴承被顶环支撑。

    Bicyclic compound and use thereof for medical purposes
    23.
    发明授权
    Bicyclic compound and use thereof for medical purposes 有权
    双环化合物及其用于医疗用途

    公开(公告)号：US09150537B2

    公开(公告)日：2015-10-06

    申请号：US13982052

    申请日：2012-01-26

    申请人： Toru Maruyama ,  Tohru Kambe ,  Shinsaku Yamane ,  Satoshi Nakayama

    发明人： Toru Maruyama ,  Tohru Kambe ,  Shinsaku Yamane ,  Satoshi Nakayama

    IPC分类号： C07D335/04 ,  C07F7/18

    CPC分类号： C07D335/04 ,  C07F7/1804

    摘要： Provided is a compound which has strong intraocular pressure lowering action and has no side effect on eyes such as ocular stimulating property, humor protein rise etc.Since a compound represented by the formula (I): (wherein definition of each group is as described in the specification), or a salt thereof, a solvate thereof, or a prodrug thereof has strong intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

    摘要翻译： 本发明提供一种具有强烈的眼内降低作用，对眼睛无刺激性，幽默蛋白质上升等副作用的化合物。由式（I）表示的化合物：（其中，各组的定义如 说明书）或其盐，其溶剂合物或其前药具有强烈的眼内压降低活性，并且对眼睛没有副作用，例如眼刺激性（充血，角膜混浊等），房水蛋白 上升等，安全性高，可以作为预防和/或治疗青光眼等的优异剂。

    Medicinal composition for inhalation
    26.
    发明授权
    Medicinal composition for inhalation 失效
    吸入药物成分

    公开(公告)号：US07858650B2

    公开(公告)日：2010-12-28

    申请号：US11665966

    申请日：2005-10-21

    申请人： Shigeki Yamamoto ,  Tsutomu Shiroya ,  Michiaki Kadode ,  Toru Maruyama ,  Kousuke Tani ,  Toshihiko Nagase

    发明人： Shigeki Yamamoto ,  Tsutomu Shiroya ,  Michiaki Kadode ,  Toru Maruyama ,  Kousuke Tani ,  Toshihiko Nagase

    IPC分类号： A61K31/427 ,  C07D277/36

    CPC分类号： A61K31/427 ,  A61K31/00 ,  A61K45/06 ,  C07D417/12

    摘要： A medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist topically exhibits a prolonged bronchodilating and antiinflammatory effects. Namely, the medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist is useful as a safe preventive and/or a remedy for respiratory diseases (for example, asthma, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, adult respiratory distress syndrome, cystic fibrosis, pulmonary hypertension or the like) without causing any systemic effect such as lowering blood pressure. Thus, a safe and useful remedy for respiratory diseases is provided.

    摘要翻译： 含有EP2激动剂的连续释放型前药的用于吸入的药物组合物局部显示出延长的支气管扩张和抗炎作用。 即，含有EP2激动剂的连续释放型前药的吸入药物组合物可用作呼吸系统疾病的安全预防和/或补救措施（例如，哮喘，肺损伤，肺纤维化，肺气肿，支气管炎，慢性 阻塞性肺疾病，成人呼吸窘迫综合征，囊性纤维化，肺动脉高压等），而不引起诸如降低血压的全身作用。 因此，提供了一种安全有效的呼吸系统疾病补救措施。

    OIL SEPARATOR AND COMPRESSOR FOR REGENERATIVE REFRIGERATOR
    27.
    发明申请
    OIL SEPARATOR AND COMPRESSOR FOR REGENERATIVE REFRIGERATOR 审中-公开
    用于再生式制冷机的油分离器和压缩机

    公开(公告)号：US20100269538A1

    公开(公告)日：2010-10-28

    申请号：US12706113

    申请日：2010-02-16

    申请人： TSUTOMU SUZUKI ,  Toru Maruyama

    发明人： TSUTOMU SUZUKI ,  Toru Maruyama

    IPC分类号： F25B43/02 ,  B01D35/02

    CPC分类号： B01D46/0031 ,  B01D46/2403 ,  B01D2265/06

    摘要： An oil separator, includes a first cylindrical-shaped punching plate having a plurality of first piercing holes; a second cylindrical-shaped punching plate having a plurality of second piercing holes, the second cylindrical-shaped punching plate being situated inside the first cylindrical-shaped punching plate; a filter member received between the first cylindrical-shaped punching plate and the second cylindrical-shaped punching plate, the filter member being configured to eliminate oil contained in a coolant gas; a filter element where the coolant gas moves from the second cylindrical-shaped punching plate to the first cylindrical-shaped punching plate; and a part configured to control leaking oil leaking from the first piercing holes of the first cylindrical-shaped punching plate so that the leaking oil flows on a surface of the first cylindrical-shaped punching plate excluding positions of the first piercing holes.

    摘要翻译： 油分离器包括具有多个第一穿孔的第一圆柱形冲压板; 具有多个第二穿孔的第二圆柱形冲孔板，所述第二圆柱形冲孔板位于所述第一圆柱形冲压板的内部; 所述过滤构件容纳在所述第一圆筒形冲压板和所述第二圆柱形冲压板之间，所述过滤构件用于消除冷却剂气体中所含的油; 过滤元件，其中所述冷却剂气体从所述第二圆柱形冲压板移动到所述第一圆柱形冲压板; 以及被配置为控制从第一圆柱形冲孔板的第一穿孔泄漏的漏油的部分，使得泄漏的油在除了第一穿孔的位置之外的第一圆柱形冲压板的表面上流动。

    8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient
    28.
    发明授权
    8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient 失效
    8-氮杂的前列腺素衍生物化合物和包含该化合物作为活性成分的试剂

    公开(公告)号：US07683094B2

    公开(公告)日：2010-03-23

    申请号：US12139260

    申请日：2008-06-13

    申请人： Kousuke Tani ,  Kaoru Kobayashi ,  Toru Maruyama ,  Tohru Kambe ,  Mikio Ogawa ,  Tsutomu Shiroya

    发明人： Kousuke Tani ,  Kaoru Kobayashi ,  Toru Maruyama ,  Tohru Kambe ,  Mikio Ogawa ,  Tsutomu Shiroya

    IPC分类号： A61K31/40 ,  C07D207/00

    CPC分类号： C07D413/06 ,  C07D207/26 ,  C07D263/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

    摘要： An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.

    摘要翻译： 由式（I）（其中所有符号具有与说明书中所述相同的含义）表示的8-氮杂前列腺素，其药学上可接受的盐或其环糊精包合物。 由于式（I）表示的化合物强烈地与PGE受体中的EP2亚型结合，因此可用于免疫疾病，过敏性疾病，神经元细胞死亡，痛经，早产，流产，秃发，视网膜神经病变等的预防和/或治疗 青光眼，勃起功能障碍，关节炎，肺损伤，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺病，肝损伤，急性肝炎，肝硬化，休克，肾炎，肾衰竭，循环系统疾病，全身性炎症反应综合征，败血症， 血细胞增多综合征，巨噬细胞活化综合征，静止病，川崎病，烧伤，全身肉芽肿，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭或骨骼疾病等。

    8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
    29.
    发明授权
    8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient 失效
    8-氮杂的前列腺素衍生物化合物和含有这些化合物作为活性成分的药物

    公开(公告)号：US07402605B2

    公开(公告)日：2008-07-22

    申请号：US10506536

    申请日：2003-03-04

    申请人： Kousuke Tani ,  Kaoru Kobayashi ,  Toru Maruyama ,  Tohru Kambe ,  Mikio Ogawa ,  Tsutomu Shiroya

    发明人： Kousuke Tani ,  Kaoru Kobayashi ,  Toru Maruyama ,  Tohru Kambe ,  Mikio Ogawa ,  Tsutomu Shiroya

    IPC分类号： A61K31/40 ,  C07D207/00

    CPC分类号： C07D413/06 ,  C07D207/26 ,  C07D263/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

    摘要： An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.

    摘要翻译： 由式（I）（其中所有符号具有与说明书中所述相同的含义）表示的8-氮杂前列腺素，其药学上可接受的盐或其环糊精包合物。 由于式（I）表示的化合物强烈地与PGE受体中的EP2亚型结合，因此可用于免疫疾病，过敏性疾病，神经元细胞死亡，痛经，早产，流产，秃发，视网膜神经病变等的预防和/或治疗 青光眼，勃起功能障碍，关节炎，肺损伤，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺病，肝损伤，急性肝炎，肝硬化，休克，肾炎，肾衰竭，循环系统疾病，全身炎症反应综合征，败血症， 血细胞增多综合征，巨噬细胞活化综合征，静止病，川崎病，烧伤，全身肉芽肿，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭或骨骼疾病等。

    Vehicle window glass
    30.
    发明申请
    Vehicle window glass 审中-公开
    车窗玻璃

    公开(公告)号：US20070248796A1

    公开(公告)日：2007-10-25

    申请号：US11784386

    申请日：2007-04-06

    申请人： Toyoyuki Teranishi ,  Yasukazu Kanatani ,  Yoshimitsu Matsushita ,  Toru Maruyama

    发明人： Toyoyuki Teranishi ,  Yasukazu Kanatani ,  Yoshimitsu Matsushita ,  Toru Maruyama

    IPC分类号： B32B23/02 ,  B32B17/06

    CPC分类号： B60J1/17 ,  Y10T428/24777

    摘要： A vehicle window glass that can reduce the load on the opening and closing mechanism when the window glass to which frozen water or snow is adhering is changed from a closed state to an open state. The vehicle window glass openably and closably is sandwiched between weather strips comprising lip portions installed in a window portion of the vehicle and has a water-repellent coating formed on at least on one principal surface of the window glass. The water-repellent coating is formed at least in a first contact portion at which an outer principal surface of the window glass and the lip portion placed outside the vehicle contact each other while the window glass is closed.

    摘要翻译： 一种车窗玻璃，当冷冻水或雪粘附的窗玻璃从闭合状态变为打开状态时，能够减轻打开和关闭机构的负荷。 可开启和关闭的车窗玻璃被夹在包括安装在车辆的窗口部分中的唇部的防风条之间，并且具有形成在窗玻璃的至少一个主表面上的防水涂层。 所述防水涂层至少形成在所述窗玻璃的外表面和位于所述车辆外部的所述唇部的所述第一接触部分在所述窗玻璃关闭的状态下彼此接触。