公开(公告)号：US20150216665A1

公开(公告)日：2015-08-06

申请号：US14543234

申请日：2014-11-17

申请人： Theodore Malinin

发明人： Theodore Malinin

IPC分类号： A61F2/28

CPC分类号： A61B17/8085 ,  A61B2017/00526 ,  A61L31/005 ,  A61L31/146 ,  A61L2430/02 ,  Y10T83/0405

摘要： A flexible, bendable organic decalcified or partially decalcified bone, cortical or cancellous, adapted for use in augmentation or repair of animal skeletal structures comprising a continuous plate or sheet of natural bone, as well as dermis is described. The thickness, flexibility and tensile strength of the construct is such as to allow it to be shaped and contoured without damage to it. The composition is ultimately remodeled by the body, thus obviating the need for additional surgical intervention. The clinical indications for the use of the invented construct are many, but are particularly prominent in dentistry, oral and maxillofacial surgery and implantology. It is particularly useful in the maxillary sinus augmentation. A unique new method, different from previously described methods for the preparation of the disclosed constructs, is described.

摘要翻译： 描述适用于增强或修复包括天然骨的连续板或片的动物骨骼结构以及真皮的柔性的，可弯曲的有机脱钙或部分脱钙的骨，皮层或松质骨。 构造物的厚度，柔韧性和拉伸强度使得其可以成形和成型而不损坏其。 组合物最终被身体重塑，从而避免了额外的手术干预的需要。 使用本发明构造物的临床适应症很多，但在牙科，口腔和颌面外科学和种植学中尤为突出。 它在上颌窦扩大中特别有用。 描述了与用于制备所公开的构建体的先前描述的方法不同的独特的新方法。

公开(公告)号：US20070093896A1

公开(公告)日：2007-04-26

申请号：US11259749

申请日：2005-10-26

申请人： Theodore Malinin

发明人： Theodore Malinin

IPC分类号： A61F2/28 ,  A61B17/90

CPC分类号： A61B17/1615 ,  A61B17/06166 ,  A61B17/1604 ,  A61B17/1675 ,  A61B17/282 ,  A61B2017/2837 ,  A61B2017/922 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2/4601 ,  A61F2/4618 ,  A61F2/4644 ,  A61F2002/2839 ,  A61F2002/30113 ,  A61F2002/30153 ,  A61F2002/30156 ,  A61F2002/3021 ,  A61F2002/30233 ,  A61F2002/30273 ,  A61F2002/30275 ,  A61F2002/30299 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30971 ,  A61F2002/4649 ,  A61F2002/4681 ,  A61F2230/0006 ,  A61F2230/0019 ,  A61F2230/0023 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0086 ,  A61F2230/0089 ,  A61F2230/0093

摘要： Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilnear. At the recipient site of the host bone, a cutout is formed corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.

摘要翻译： 提供了用于制备和移植骨软骨同种异体移植物栓塞到宿主骨以修复关节软骨缺损的程序和工具。 从供体骨中除去具有附着于其上的软骨板和松质骨组织的同种异体移植骨栓。 同种异体移植栓通过去除或切除松质骨组织进一步成形，以形成从软骨板延伸的松质骨。 形成的松质骨可以具有任何合适的形状，包括圆柱形，锥形和圆形。 在宿主骨的受体位置处，形成相应于同种异体移植栓的形状的切口。 将同种异体移植物塞插入切口中，使得松质骨保留在宿主骨中，并且软骨板与宿主骨的髁表面对准。 本发明的方面也可适用于制备和移植骨软骨自体移植栓塞。

公开(公告)号：US20060074466A1

公开(公告)日：2006-04-06

申请号：US10958207

申请日：2004-10-04

申请人： Theodore Malinin

发明人： Theodore Malinin

IPC分类号： A61N5/06

CPC分类号： A61L2/0035 ,  A61F2/28 ,  A61F2002/2835 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61L2/0041 ,  A61L2/007 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3691 ,  A61N5/10

摘要： An implantable bone-containing composition and a method for making same are disclosed. The compositions includes sterilized bone, which has been exposed to a dose of radiation in excess of about 45 kGy in the absence of radio-protective agents. The sterilized bone has higher osteogenic capacity than bone sterilized at the conventional dose of between 15 kGy and 35 kGy, approaching or surpassing the osteogenic capacity of the bone prior to irradiation.

摘要翻译： 公开了一种可植入骨组合物及其制备方法。 组合物包括灭菌骨，其在不存在放射性保护剂的情况下暴露于超过约45kGy的辐射剂量。 灭菌的骨的成骨能力比在15kGy和35kGy之间的常规剂量下消毒的骨更高，接近或超过照射前骨的成骨能力。