公开(公告)号：US20230181779A1

公开(公告)日：2023-06-15

申请号：US17569392

申请日：2022-01-05

Applicant: STERIFRE MEDICAL, INC.

Inventor： Czeslaw Golkowski ,  Rick Shea ,  Jonathan W. Greene ,  Mark Golkowski ,  Anya Golkowski ,  Tom Steffie

IPC: A61L2/14 ,  A61L2/00 ,  A61L2/20 ,  A61L2/24

CPC classification number: A61L2/14 ,  A61L2/0094 ,  A61L2/208 ,  A61L2/24 ,  A61L2/007 ,  A61L2/26

Abstract: A sterilization, disinfection, sanitization, or decontamination system having a chamber defining a region, and a generator for creating a free radical effluent with reactive oxygen, nitrogen, and other species and/or a vaporizer. A closed loop circulating system without a free-radical destroyer is provided for supplying the mixture of free radicals from the generator mixed with the hydrogen peroxide solution in the form of the effluent to the chamber. The system is used in sterilizing, disinfecting, sanitizing, or decontaminating items in the chamber or room and, with a wound chamber, in treating wounds on a body. The wound chamber may be designed to maintain separation from wounds being treated. Various embodiments can control moisture to reduce or avoid unwanted condensation. Some embodiments can be incorporated into an appliance having a closed space, such as a washing machine. Some embodiments may include a residual coating device that deposits a bactericidal coating on sterilized items.

公开(公告)号：US09919066B2

公开(公告)日：2018-03-20

申请号：US14762235

申请日：2014-01-08

Applicant: LifeCell Corporation

Inventor： Gary Monteiro ,  Martin J. Byrne ,  Rick T. Owens

IPC: A61L2/00 ,  A01N25/00 ,  A01N37/16

CPC classification number: A61L2/0011 ,  A01N25/00 ,  A01N37/16 ,  A61L2/007 ,  A61L2/0088

Abstract: The present disclosure provides methods for reducing bioburden on a tissue product, as well as the tissue products produced according to the disclosed methods. In particular, the disclosure relates to methods of electroporating tissue in the presence of one or more bactericides in order to reduce bioburden. The methods allow for reduced exposure to electrical energy and/or bactericide while reducing bioburden.

公开(公告)号：US20180015189A1

公开(公告)日：2018-01-18

申请号：US15718831

申请日：2017-09-28

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Andreas Castan ,  Colin R. Tuohey

IPC: A61L2/00 ,  C12N5/00 ,  C12N13/00

CPC classification number: A61L2/0017 ,  A61L2/0023 ,  A61L2/0035 ,  A61L2/007 ,  C12N5/0018 ,  C12N13/00 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2523/00

Abstract: The invention discloses a method for virus clearance of a cell culture medium, comprising the steps of: i) providing a bulk medium portion, comprising amino acids and glucose, and a first additive portion, comprising vitamins in aqueous solution; ii) subjecting the bulk medium portion to a high temperature short time treatment (HTST); iii) passing the first additive portion through a virus retentive filter or an ultrafilter; and iv) after steps ii) and iii), mixing the bulk medium portion with the first additive portion to obtain a cell culture medium.

公开(公告)号：US09403960B2

公开(公告)日：2016-08-02

申请号：US14808220

申请日：2015-07-24

Applicant: Arkema Inc.

Inventor： Saeid Zerafati

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C08K3/22 ,  C08J7/12 ,  C08K5/00 ,  A61L2/00 ,  A61L2/08

CPC classification number: C08K3/22 ,  A61L2/0035 ,  A61L2/0041 ,  A61L2/007 ,  A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  C08J7/123 ,  C08J2300/102 ,  C08J2327/16 ,  C08K5/0058 ,  C08K2003/2296 ,  C08L27/16

Abstract: The invention relates to fluoropolymer articles that have been irradiated with at least 5 Kilo Gray of radiation, where the resulting articles have low levels of leachable or extractable fluoride ion. The low fluoride ion migration from the irradiated article is due to the presence of low levels of metallic salts or oxides in the fluoropolymer composition. The invention is especially useful for fluoropolymer articles in which the fluoropolymer layer contacts a biological or pharmaceutical fluid, and that are subjected to sterilization by irradiation.

Abstract translation: 本发明涉及已经用至少5千克雷的辐射照射的氟聚合物制品，其中所得制品具有低水平的可浸出或可萃取的氟离子。 来自照射制品的低氟离子迁移是由于氟聚合物组合物中存在低水平的金属盐或氧化物。 本发明特别适用于其中含氟聚合物层接触生物或药物流体并且通过照射进行灭菌的含氟聚合物制品。

公开(公告)号：US09150318B1

公开(公告)日：2015-10-06

申请号：US12650902

申请日：2009-12-31

Applicant: Wendell Sun ,  Jerome Connor ,  Qing-Qing Qiu ,  Rick Owens

Inventor： Wendell Sun ,  Jerome Connor ,  Qing-Qing Qiu ,  Rick Owens

IPC: B65B55/02 ,  A61L2/00 ,  B65B55/08 ,  B65B55/16 ,  B65B55/22

CPC classification number: B65B55/02 ,  A61L2/0029 ,  A61L2/0035 ,  A61L2/007 ,  A61L2430/40 ,  B65B31/02 ,  B65B55/08 ,  B65B55/16 ,  B65B55/22

Abstract: The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.

Abstract translation: 本公开提供了用于制备，灭菌和保存组织的各种方法和组合物。 本公开还具有通过该方法制备的无细胞组织基质。

公开(公告)号：US09023273B2

公开(公告)日：2015-05-05

申请号：US12858065

申请日：2010-08-17

Applicant: Benjamin Kibalo

Inventor： Benjamin Kibalo

IPC: A61L2/00 ,  C12N5/00 ,  A61K35/36

CPC classification number: A61L2/0011 ,  A61K35/36 ,  A61L2/0035 ,  A61L2/0041 ,  A61L2/007 ,  A61L2/0088

Abstract: Methods for processing tissue are provided. In some embodiments, the methods comprise methods for decellularizing tissue samples by applying high hydrostatic pressure to the tissues samples. In some embodiments, the methods comprise methods for thawing tissue samples and/or reducing the bioburden in a sample by applying high hydrostatic pressure to the tissue samples.

Abstract translation: 提供了处理组织的方法。 在一些实施方案中，所述方法包括通过对组织样品施加高静水压力来使组织样品脱细胞化的方法。 在一些实施方案中，所述方法包括通过对组织样品施加高静水压力来解冻组织样品和/或减少样品中的生物负载的方法。

公开(公告)号：US08653319B2

公开(公告)日：2014-02-18

申请号：US12989150

申请日：2009-04-23

Applicant: Drew Powell Amery ,  Matthew F. Myntti

Inventor： Drew Powell Amery ,  Matthew F. Myntti

IPC: A61F13/00 ,  A61L2/00 ,  A61K9/00

CPC classification number: A61K31/722 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0046 ,  A61K9/0085 ,  A61K9/06 ,  A61K31/045 ,  A61K31/717 ,  A61K31/718 ,  A61K47/36 ,  A61K47/38 ,  A61L2/007 ,  A61L2/081 ,  A61L2/087 ,  A61L27/20 ,  A61L27/26 ,  A61L27/52 ,  A61L27/56 ,  A61L2300/404 ,  A61L2400/06 ,  C08B15/005 ,  C08B37/003 ,  C08B37/0042 ,  C08G2210/00 ,  C08J3/124 ,  C08L1/286 ,  C08L5/08 ,  C08L1/26 ,  C08L2666/26

Abstract: A hydratable gel-forming polymer may be sterilized by chilling the polymer below ambient temperature and sterilizing the chilled polymer using ionizing radiation (e.g., E-Beam radiation). Doing so may reduce the degradation in physical properties caused by ionizing radiation sterilization of the polymer while at ambient temperature, and may preserve or retain desired hydration or gel-forming characteristics.

Abstract translation: 可水合的凝胶形成聚合物可以通过将聚合物冷却至低于环境温度并且使用电离辐射（例如，E-Beam辐射）对冷冻的聚合物进行灭菌来灭菌。 这样做可以降低聚合物在环境温度下电离辐射灭菌引起的物理性能的降解，并且可以保持或保持所需的水合或凝胶形成特性。

公开(公告)号：US20080080998A1

公开(公告)日：2008-04-03

申请号：US11826513

申请日：2007-07-16

Applicant: Wilson Burgess ,  William Drohan ,  Martin MacPhee ,  David Mann

Inventor： Wilson Burgess ,  William Drohan ,  Martin MacPhee ,  David Mann

IPC: A61L2/08 ,  A61L2/00

CPC classification number: A61L2/0047 ,  A01N1/02 ,  A01N1/0294 ,  A61K35/12 ,  A61L2/0011 ,  A61L2/0035 ,  A61L2/0041 ,  A61L2/0052 ,  A61L2/0058 ,  A61L2/0064 ,  A61L2/007 ,  A61L2/0082 ,  A61L2/0088 ,  C12M37/00

Abstract: Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.

Abstract translation: 公开了用于灭菌组织以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶原，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用照射对一个或多个组织进行消毒。

公开(公告)号：US20050106608A1

公开(公告)日：2005-05-19

申请号：US10969034

申请日：2004-10-20

Applicant: Jangbir Sangha ,  James Schumm ,  John Fox ,  Robert Bever

Inventor： Jangbir Sangha ,  James Schumm ,  John Fox ,  Robert Bever

IPC: A61B10/00 ,  A61B10/02 ,  A61L2/00 ,  A61L2/08 ,  A61L2/20 ,  B01L3/00 ,  C12Q1/68 ,  C12Q1/6806 ,  G01N1/00 ,  G01N1/02 ,  C12M1/34

CPC classification number: A61L2/007 ,  A61B10/00 ,  A61B10/0051 ,  A61B10/0064 ,  A61B10/0096 ,  A61B10/02 ,  A61L2/0011 ,  A61L2/0035 ,  A61L2/0094 ,  A61L2/206 ,  B01L3/5055 ,  B01L3/508 ,  B01L2200/141 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0825 ,  B01L2300/0887 ,  C12Q1/6806 ,  G01N2001/007 ,  G01N2001/028 ,  Y10T436/143333 ,  C12Q2527/125

Abstract: A device for collection of DNA-containing materials is provided and a method of preventing DNA specimen contamination is provided which prevents extraneous DNA found in DNA evidence collection kits from interfering with DNA specimen analysis, further a device an method is provided for collecting the DNA-containing material of a subject from the subject's skin.

Abstract translation: 提供了用于收集含DNA材料的装置，并且提供了一种防止DNA样本污染的方法，其防止DNA证据收集试剂盒中发现的外来DNA干扰DNA标本分析，此外，提供了一种用于收集DNA- 从受试者的皮肤含有受试者的材料。

公开(公告)号：US20040101436A1

公开(公告)日：2004-05-27

申请号：US10694733

申请日：2003-10-29

Applicant: Clearant, Inc.

Inventor： Martin J. MacPhee ,  Randall S. Kent ,  Edward A. Horton ,  Dawson Beall

IPC: A61L002/08 ,  A01N001/02

CPC classification number: A61L2/0035 ,  A61L2/0041 ,  A61L2/0047 ,  A61L2/0052 ,  A61L2/0058 ,  A61L2/007 ,  A61L2202/22

Abstract: Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.

Abstract translation: 公开了用于灭菌生物制品以降低活性生物污染物（例如病毒，细菌，酵母，霉菌，支原体和寄生虫）的水平的方法。