公开(公告)号：US20130301893A1

公开(公告)日：2013-11-14

申请号：US13821572

申请日：2011-09-05

申请人： Thomas Netsch ,  Daniel Bystrov

发明人： Thomas Netsch ,  Daniel Bystrov

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  A61N5/103 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30096

摘要： A contouring module (22, 24) iteratively adjusts contours delineating a radiation target region and risk regions in a planning image. An intensity modulation optimization module (30) generates a radiation therapy plan conforming with dosage or dosage constraints (26) for the radiation target region and the risk regions delineated by the contours. A differential analysis module (40) is configured to invoke the intensity modulation optimization module (30) to estimate partial derivatives of an output of the intensity modulation optimization respective to the contours. The contouring module (22, 24) is configured to invoke the differential analysis module (40) after each iterative contour adjustment to estimate the partial derivatives respective to the contour segments and to render the contour segments on a display of the planning image with the contour segments coded based on the estimated partial derivatives to indicate impact of the contour segments on the intensity modulation optimization.

摘要翻译： 轮廓模块（22,24）迭代地调整描绘辐射目标区域的轮廓并且在规划图像中风险区域。 强度调制优化模块（30）产生符合用于辐射目标区域的剂量或剂量约束（26）和由轮廓描绘的风险区域的放射治疗计划。 差分分析模块（40）被配置为调用强度调制优化模块（30）以估计相应于轮廓的强度调制优化的输出的偏导数。 轮廓模块（22,24）被配置为在每次迭代轮廓调整之后调用差分分析模块（40）以估计相应于轮廓段的偏导数，并且使轮廓段在具有轮廓的规划图像的显示器上呈现 基于估计的偏导数编码的段，以指示轮廓段对强度调制优化的影响。

公开(公告)号：US08326086B2

公开(公告)日：2012-12-04

申请号：US10596321

申请日：2004-12-10

申请人： Ingwer Carlsen ,  Thomas Netsch ,  Astrid Franz

发明人： Ingwer Carlsen ,  Thomas Netsch ,  Astrid Franz

IPC分类号： G06K9/32 ,  G06K9/00

CPC分类号： G06T3/0068

摘要： Image registration very often used to be a tedious task which had to be performed manually. According to an exemplary embodiment of the present invention, a non-rigid image registration by an iterative refinement process based on a combination of landmarks with similarity values is proposed. Advantageously, a very fast and robust method maybe provided.

摘要翻译： 图像注册常常是一个繁琐的任务，必须手动执行。 根据本发明的示例性实施例，提出了通过基于具有相似值的地标的组合的迭代细化处理的非刚性图像配准。 有利地，可以提供非常快速和鲁棒的方法。

公开(公告)号：US20090232369A1

公开(公告)日：2009-09-17

申请号：US11721171

申请日：2005-12-16

申请人： Julien Senegas ,  Cristian Lorenz ,  Thomas Netsch ,  Heiner Gunnar Konrad Lund ,  Alexander Stork

发明人： Julien Senegas ,  Cristian Lorenz ,  Thomas Netsch ,  Heiner Gunnar Konrad Lund ,  Alexander Stork

IPC分类号： G06K9/00 ,  G06T15/00

CPC分类号： G06T7/0012 ,  G06F19/00 ,  G06T15/04 ,  G06T2207/10076 ,  G06T2207/30048 ,  G06T2210/41

摘要： The system 10 comprises an input 2 for accessing the suitable input data. The core of the system 10 is formed by a processor 4 which is arranged to operate the components of the system 10, it being the input 2, a computing unit 5, a working memory 6. The computing unit 5 preferably comprises a suitable number of executable subroutines 5a, 5b, 5c, 5d, 5e, and 5f to enable a constructing of a geometric model of the movable body based on the results of the segmentation step, finding a spatial correspondence between the first and second image dataset, mapping the texture image dataset on geometric model, fusing the geometric model and the mapped texture image dataset. The apparatus 10 according to the invention further comprises a coder 7 arranged to code the determined region of interest in accordance to a pre-selected criterion. The criterion may be selectable from a list of valid criteria, stored in a file 7a. Preferably, the coder 7, the computing unit 5 and the processor 4 are operable by a computer program 3, preferably stored in memory 8. An output 9 is used for outputting the results of the processing, like fused image data representing the textured, preferably animated geometric model of the movable body. The invention further relates to a method for integration of medical diagnostic information and a geometric model of a movable body and to a computer program.

摘要翻译： 系统10包括用于访问合适的输入数据的输入2。 系统10的核心由处理器4形成，处理器4被设置为操作系统10的组件，它是输入2，计算单元5，工作存储器6.计算单元5优选地包括适当数量的 可执行子程序5a，5b，5c，5d，5e和5f，以使得能够基于分割步骤的结果构建可移动体的几何模型，找到第一和第二图像数据集之间的空间对应关系， 几何模型的图像数据集，融合几何模型和映射纹理图像数据集。 根据本发明的装置10还包括编码器7，编码器7被布置成根据预先选择的标准对所确定的感兴趣区域进行编码。 标准可以从存储在文件7a中的有效标准的列表中选择。 优选地，编码器7，计算单元5和处理器4可由计算机程序3操作，优选地存储在存储器8中。输出9用于输出处理结果，如表示纹理的融合图像数据，优选地 动画的动画几何模型。 本发明还涉及用于将医疗诊断信息和可移动体的几何模型和计算机程序集成的方法。

公开(公告)号：US20080310760A1

公开(公告)日：2008-12-18

申请号：US12092991

申请日：2006-11-03

申请人： Ingwer-Curt Carlsen ,  Thomas Netsch ,  Daniel Bystrov

发明人： Ingwer-Curt Carlsen ,  Thomas Netsch ,  Daniel Bystrov

IPC分类号： G06K9/32

CPC分类号： G06T3/0081 ,  G06T7/35 ,  G06T7/38 ,  G06T2207/30004

摘要： The invention relates to a method for volumetric registration of a floating image with a reference image. At step 2′ a floating image and a reference image are accessed. At step 4 and at step 6 a transformation function T and a similarity function (S) are accessed. The method according to the invention uses a-priori knowledge, notably a restricted parameter set, which is accessed at step 3. Preferably, the restricted parameter set is obtained by performing a suitable volumetric registration of a set of training images. The training set preferably comprises a sequence of floating images and reference images for each clinical application. Likewise, the training set may be composed of images of a patient group representing a certain group of disease, age, gender, race, etc. The invention further relates to a system and a computer program for enabling volumetric registration.

摘要翻译： 本发明涉及一种浮动图像与参考图像的体积配准的方法。 在步骤2'中，访问浮动图像和参考图像。 在步骤4和步骤6，访问变换函数T和相似度函数（S）。 根据本发明的方法使用在步骤3访问的先验知识，特别是限制参数集合。优选地，通过执行一组训练图像的合适的体积登记来获得受限参数集。 训练集优选地包括用于每个临床应用的浮动图像和参考图像的序列。 类似地，训练集可以由代表某一组疾病，年龄，性别，种族等的患者群体的图像组成。本发明还涉及用于启用体积登记的系统和计算机程序。

公开(公告)号：US07440535B2

公开(公告)日：2008-10-21

申请号：US11568115

申请日：2005-03-31

申请人： Thomas Netsch ,  Georg Rose ,  Hermann Schomberg

发明人： Thomas Netsch ,  Georg Rose ,  Hermann Schomberg

IPC分类号： G01N23/00

CPC分类号： G06T11/005 ,  A61B6/027 ,  G06T2211/432 ,  Y10S378/901

摘要： A 3D image of a region of an object is computed from truncated cone beam projection data acquired with an x-ray device and a prior CT image representing a larger region of the object. The truncated projection data are extrapolated to derive pseudoprojection data associated with projection directions outside the detector, and an intermediate CT image is reconstructed based on the truncated projection data completed with the pseudoprojection data. The prior CT image is then registered with the intermediate CT image. Forward projection data associated with projection directions outside the detector are computed from the truncated projection data and the registered prior CT image. The 3D image is finally reconstructed based on the truncated projection data completed with the forward projection data.

摘要翻译： 使用由X射线装置获得的截头圆锥束投影数据和表示对象的较大区域的先前CT图像计算物体区域的3D图像。 外推截断的投影数据以导出与检测器外部的投影方向相关联的伪投影数据，并且基于用伪投影数据完成的截断的投影数据来重建中间CT图像。 然后将先前的CT图像与中间CT图像对准。 从截断的投影数据和注册的先前CT图像计算与检测器外部的投影方向相关联的前向投影数据。 基于用前向投影数据完成的截断的投影数据，最终重建3D图像。

公开(公告)号：US20080029448A1

公开(公告)日：2008-02-07

申请号：US11580074

申请日：2006-10-13

申请人： Richard Duncum ,  Thomas Netsch ,  Albert O'Bryant ,  Brian Pahl ,  Mark Schroder

发明人： Richard Duncum ,  Thomas Netsch ,  Albert O'Bryant ,  Brian Pahl ,  Mark Schroder

IPC分类号： B01D35/06

CPC分类号： B03C1/288

摘要： A liquid collection system for liquid coolant from a series of a plurality of machine tools with magnets for arresting and holding magnetic objects, such as broken bits from the milling machines or inadvertently dropped hand tools, entrained in the liquid coolant before they can damage liquid coolant recirculation pumps, with adjustable supports for adjusting the height of a coolant liquid collecting trough, and with a system of seals for sealing the collecting trough to support rails for the machine tools.

摘要翻译： 一种用于液体冷却剂的液体收集系统，其具有用于阻止和保持磁性物体的磁体的多个机床的液体冷却剂，例如来自铣床的破碎的钻头或无意中掉落的手动工具，在液体冷却剂可能损坏液体冷却剂之前夹带在液体冷却剂中 再循环泵，具有用于调节冷却剂液体收集槽的高度的可调节支撑件，以及用于将收集槽密封以用于机床的支撑轨道的密封系统。

公开(公告)号：US07062078B2

公开(公告)日：2006-06-13

申请号：US10003051

申请日：2001-11-02

申请人： Juergen Weese ,  Thomas Netsch

发明人： Juergen Weese ,  Thomas Netsch

IPC分类号： G06K9/00 ,  G06K9/32

CPC分类号： G06T3/0075 ,  G06T7/30

摘要： The invention relates to a method for the registration of a series of at least three temporally successively acquired images (I1–In) of an object. Individual images (I2–In) to be registered are transformed into registered images (I2′-In′) using an individual mapping rule (T2–Tn). A similarity measure (M) is used to determine a mapping rule (T2–Tn), where to achieve a higher registration accuracy, a common similarity measure (M) of all images (I1′-In′) in order to determine the mapping rules (T2–Tn) for all images is implemented. The invention also relates to a corresponding registration device.

摘要翻译： 本发明涉及一种用于登记一系列至少三个时间上连续获取的图像（I-1 -I）的方法。 将被登记的单独图像（I 2 2 -I N n N）被转换成已登记的图像（I < SUB>'），使用单独的映射规则（T> 2 -T ）。 使用相似性度量（M）来确定映射规则（T 2 -T n n N），其中为了获得更高的注册精度，公共相似性度量（M） 为了确定映射规则（T 2> -T N n＆lt; n＆gt;），所有图像（I <1> / SUB>）。 本发明还涉及相应的配准装置。

公开(公告)号：US07684604B2

公开(公告)日：2010-03-23

申请号：US11568121

申请日：2005-03-30

申请人： Daniel Bystrov ,  Thomas Netsch

发明人： Daniel Bystrov ,  Thomas Netsch

IPC分类号： G06K9/00 ,  A61B6/00

CPC分类号： A61B5/055 ,  A61B5/0037 ,  G01R33/54

摘要： A diagnostic imaging system includes a magnetic resonance imaging scanner (10) for imaging an organ of interest, a reformatting processor (70) for constructing reformatted images corresponding to a scout image in different coordinate systems, and a graphical user interface (62) for displaying acquired images and reformatted images to an associated user. An imaging processor (60) causes the scanner (10) to acquire a base sparse scout image of an organ of interest in a standard coordinate system, causes the reformatting processor (70) to generate one or more reformatted images from the sparse scout image in coordinate systems other than the standard coordinate system, determines a diagnostic imaging coordinate system aligned with the organ of interest using the base sparse scout image and the one or more reformatted images, and causes the scanner (10) to acquire one or more diagnostic images of the organ of interest in the diagnostic imaging coordinate system.

摘要翻译： 诊断成像系统包括用于对感兴趣的器官成像的磁共振成像扫描器（10），用于构造与不同坐标系中的侦察图像相对应的重新格式化的图像的重新格式化处理器（70），以及用于显示的图形用户界面 获取的图像和重新格式化的图像到相关联的用户。 成像处理器（60）使得扫描器（10）获取标准坐标系中感兴趣的器官的基本稀疏侦察图像，使得重新格式化处理器（70）从稀疏侦察图像生成一个或多个重新格式化的图像 除了标准坐标系之外的坐标系统，使用基本稀疏侦察图像和一个或多个重新格式化的图像来确定与感兴趣的器官对准的诊断成像坐标系，并且使扫描仪（10）获取一个或多个诊断图像 在诊断成像坐标系中感兴趣的器官。

公开(公告)号：US20090154783A1

公开(公告)日：2009-06-18

申请号：US11568121

申请日：2005-03-30

申请人： Daniel Bystrov ,  Thomas Netsch

发明人： Daniel Bystrov ,  Thomas Netsch

IPC分类号： G06T7/00 ,  G06F3/048 ,  G01R33/54

CPC分类号： A61B5/055 ,  A61B5/0037 ,  G01R33/54

摘要： A diagnostic imaging system includes a magnetic resonance imaging scanner (10) for imaging an organ of interest, a reformatting processor (70) for constructing reformatted images corresponding to a scout image in different coordinate systems, and a graphical user interface (62) for displaying acquired images and reformatted images to an associated user An imaging processor (60) causes the scanner (10) to acquire a base sparse scout image of an organ of interest in a standard coordinate system, causes the reformatting processor (70) to generate one or more reformatted images from the sparse scout image in coordinate systems other than the standard coordinate system, determines a diagnostic imaging coordinate system aligned with the organ of interest using the base sparse scout image and the one or more reformatted images, and causes the scanner (10) to acquire one or more diagnostic images of the organ of interest in the diagnostic imaging coordinate system.

摘要翻译： 诊断成像系统包括用于对感兴趣的器官成像的磁共振成像扫描器（10），用于构造与不同坐标系中的侦察图像相对应的重新格式化的图像的重新格式化处理器（70），以及用于显示的图形用户界面 获取的图像和重新格式化的图像到相关联的用户成像处理器（60）使得扫描仪（10）获取标准坐标系中感兴趣的器官的基本稀疏侦察图像，使重新格式化处理器（70）产生一个或 使用除了标准坐标系以外的坐标系中的稀疏侦察图像的更多的重新格式化图像，使用基本稀疏侦察图像和一个或多个重新格式化的图像来确定与感兴趣的器官对准的诊断成像坐标系，并且使扫描器 ）以获取诊断成像坐标系中的感兴趣器官的一个或多个诊断图像。

公开(公告)号：US20080205724A1

公开(公告)日：2008-08-28

申请号：US11911216

申请日：2006-04-11

申请人： Christian Adrian Cocosco ,  Wiro Joep Niessen ,  Thomas Netsch

发明人： Christian Adrian Cocosco ,  Wiro Joep Niessen ,  Thomas Netsch

IPC分类号： G06K9/00

CPC分类号： G06K9/342 ,  G06K2009/366 ,  G06K2209/05 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/10072 ,  G06T2207/20092 ,  G06T2207/20132 ,  G06T2207/30048

摘要： The method 1 according to the invention is preferably practiced in real time and directly after a suitable acquisition 3 of the multi-dimensional dataset, which is accessed at step 5 and the images constituting the multi-dimensional dataset are classified at step 8. Preferably, for reducing an amount of data to be processed at step 6 the image data is subjected to a restrictive region of interest determination. At step 9 the classified cardiac images are subjected to a an image thinning operator so that the resulting images comprise a plurality of connected image components which are further analyzed at step 14. After the thinning step 9 a labeling step 11 is performed, where different connected components in the multi-dimensional dataset are accordingly labeled. This step is preferably followed by a region growing step 13, which is constrained by binary threshold used at step 8b. For each connected image component a factor F is computed at step 14. The anatomic structure is segmented at step 16 by selecting the connected image component with factor F meeting a pre-determined criterion. After this, the segmented anatomic structure is stored in a suitable format at step 18. The invention further relates to an apparatus, a working station, a viewing station and a computer program.

摘要翻译： 根据本发明的方法1优选地实时地并且直接在多维数据集的合适的获取3之后实施，该多维数据集在步骤5被访问，并且构成多维数据集的图像在步骤8被分类。 优选地，为了减少在步骤6处理的数据量，图像数据经受限制性关注区域确定。 在步骤9，对分类的心脏图像进行图像稀疏算子，使得所得到的图像包括在步骤14进一步分析的多个连接图像分量。 在变薄步骤9之后，执行标记步骤11，其中相应地标记多维数据集中不同的连接分量。 该步骤优选地是区域生长步骤13，其由在步骤8b使用的二进制阈值约束。 对于每个连接的图像分量，在步骤14计算因子F. 通过选择具有满足预定标准的因子F的连接图像分量，在步骤16分割解剖结构。 之后，分段的解剖结构以适当的格式存储在步骤18。 本发明还涉及一种装置，工作站，观察站和计算机程序。