公开(公告)号：US20060077341A1

公开(公告)日：2006-04-13

申请号：US11226604

申请日：2005-09-14

申请人： Barry Atkins ,  Norbert Doerr ,  Alfred Fischer ,  Michael Quinn ,  Roland Schmieder ,  Robert Tucker

发明人： Barry Atkins ,  Norbert Doerr ,  Alfred Fischer ,  Michael Quinn ,  Roland Schmieder ,  Robert Tucker

IPC分类号： G02C7/04

CPC分类号： B29D11/00865 ,  B29D11/00903 ,  D06P5/003 ,  D06P5/007 ,  D06P5/2005 ,  G02B1/043

摘要： The invention provides a method for producing colored contact lenses with high quality color images. The method of the invention comprises the steps of (a) providing a water based ink in at least one cliche wherein a pattern to be printed on the contact lens has been created; (b) transferring the water based ink from the cliché to at least a surface of at least a contact lens forming mold by means of at least a transfer pad; (c) at least partially curing the ink transferred on the mold to form a colored film; (d) dispensing a hydrogel lens-forming material into a lens-forming cavity of the mold; and (e) curing the lens-forming material within the lens-forming cavity to form the contact lens, whereby the colored film detaches from the molding surface and becomes integral with the body of the contact lens; characterized in that the relative air humidity in the immediate vicinities of the transfer pad/s is kept higher than 50% at standard temperature and pressure conditions during ink transfer.

摘要翻译： 本发明提供一种生产具有高质量彩色图像的彩色隐形眼镜的方法。 本发明的方法包括以下步骤：（a）在至少一个刻薄中提供水性油墨，其中已经形成要被印刷在隐形眼镜上的图案; （b）借助于至少一个转印垫将水基油墨从陈年代转移到至少一个隐形眼镜成型模的表面; （c）至少部分地固化在模具上转印的油墨以形成着色膜; （d）将水凝胶透镜形成材料分配到模具的透镜形成腔中; 和（e）固化透镜形成腔内的透镜形成材料以形成隐形眼镜，由此着色膜从模制表面脱离并与隐形眼镜的主体成一体; 其特征在于，在墨水转印期间，在标准温度和压力条件下，传送垫的紧邻附近的相对空气湿度保持高于50％。

公开(公告)号：US20060043214A1

公开(公告)日：2006-03-02

申请号：US11219144

申请日：2005-09-01

申请人： Aaron Macan ,  Michael Quinn

发明人： Aaron Macan ,  Michael Quinn

IPC分类号： B05B3/02

CPC分类号： B05B3/049 ,  B05B1/1654 ,  B05B1/18 ,  B05B3/04 ,  B05B3/0495 ,  B05B15/654

摘要： An improved shower head having multiple modes of operation. The shower head may include a first turbine and turbine, each disposed within a unique flow channel. The first and second turbines may interrupt water flow through their respective flow channels, thereby providing at least one pulsating water spray emanating from the shower head. The shower head may include a third flow channel having no turbine disposed therein, such that water flowing through the third flow channel is not interrupted and thus emitted from the shower head as a drenching spray.

摘要翻译： 具有多种操作模式的改进的淋浴喷头。 淋浴头可以包括第一涡轮机和涡轮机，每个设置在唯一的流动通道内。 第一和第二涡轮机可以中断通过它们各自的流动通道的水流，从而提供从喷淋头发出的至少一个脉动喷水。 喷淋头可以包括没有涡轮机设置在其中的第三流动通道，使得流过第三流动通道的水不会被中断，并且因此作为喷淋喷雾从喷淋头排出。

公开(公告)号：US20060005822A1

公开(公告)日：2006-01-12

申请号：US11064693

申请日：2005-02-23

申请人： Michael Quinn ,  Mel Maravilla ,  Kerry Johnson

发明人： Michael Quinn ,  Mel Maravilla ,  Kerry Johnson

IPC分类号： F41B11/00

CPC分类号： F41B11/723

摘要： A pneumatic assembly for a compressed gas gun having a hammer chamber including a hammer conduit, and a hammer with an aperture surrounding at least a portion of the hammer conduit. A compressed gas gun has a breech, a bolt moveable within the breech from a loading position to a firing position, a pneumatic assembly in communication with the breech, the pneumatic assembly comprising a high pressure chamber, and a hammer chamber. A discharge valve is disposed in the pneumatic assembly between the high pressure chamber and hammer chamber. A solenoid valve is provided for selectively supplying compressed gas to the hammer conduit.

摘要翻译： 一种用于压缩气枪的气动组件，其具有包括锤导管的锤室，以及围绕锤导管的至少一部分的具有孔的锤。 压缩气枪具有后膛，在从后挂位置到射击位置的后膛中可移动的螺栓，与后膛连通的气动组件，气动组件包括高压腔和锤室。 排气阀设置在高压室和锤室之间的气动组件中。 提供电磁阀用于选择性地将压缩气体供应到锤导管。

公开(公告)号：US20060004165A1

公开(公告)日：2006-01-05

申请号：US11148104

申请日：2005-06-08

申请人： John Phelan ,  Michael Quinn ,  Angelika Domschke

发明人： John Phelan ,  Michael Quinn ,  Angelika Domschke

IPC分类号： C08F130/08 ,  G02C7/04

CPC分类号： C08F290/068 ,  C08F230/08 ,  G02B1/043 ,  C08L51/085

摘要： The present invention provides silicone hydrogel materials which can be lathed at room temperature and has a high oxygen permeability and a water content of from about 18% to 55% by weight. In addition, the invention provides contact lenses comprising a silicone hydrogel material of the invention.

摘要翻译： 本发明提供了可在室温下车床并具有高透氧性和约18-55重量％的含水量的硅酮水凝胶材料。 此外，本发明提供了包含本发明的硅氧烷水凝胶材料的隐形眼镜。

公开(公告)号：US20050218536A1

公开(公告)日：2005-10-06

申请号：US11093819

申请日：2005-03-30

申请人： Michael Quinn ,  Gregory Carlson ,  Barry Atkins

发明人： Michael Quinn ,  Gregory Carlson ,  Barry Atkins

IPC分类号： B29D11/00 ,  C09D11/00 ,  C09D11/10 ,  G02B1/04 ,  G02C7/04

CPC分类号： G02B1/10 ,  B29C41/003 ,  B29D11/00048 ,  B29D11/00317 ,  B29K2083/005 ,  B29K2105/0014 ,  B29K2105/0032 ,  B29K2105/0061 ,  B29L2009/00 ,  B29L2011/0041 ,  C09D11/107 ,  G02B1/043 ,  C08L83/04

摘要： The present invention provides a method for making colored silicone hydrogel contact lenses. The method of the invention comprises the steps of: (a) applying a color coat to at least a portion of at least one of molding surfaces of a lens mold with an ink, wherein the ink comprises at least one colorant, a binder polymer, an adhesion promoter, and optionally a diluent, wherein the binder polymer is a copolymerization product of a polymerizable mixture including (i) at least one hydrophilic vinylic monomer; (ii) at least one functionalizing vinylic monomer containing at least one functional group selected from the group consisting of hydroxyl group —OH, amino group —NHR (wherein R is hydrogen or C1 to C8 alkyl), carboxylic group —COOH, epoxy group, amide group —CONHR, and combinations thereof; (iii) at least one silicone-containing vinylic monomer or macromer, and (iv) optionally one or more components selected from the group consisting of a polymerization initiator, a chain transfer agent, and a solvent, wherein the mold has a lens-forming cavity between the molding surfaces, wherein the colored coat contains a first surface exposed to the interior of the lens-forming cavity and a second surface in contact with the molding surface; (b) curing the ink printed on the mold; (c) dispensing a silicone hydrogel lens-forming material into the lens-forming cavity of the mold; (d) curing the lens-forming material within the lens-forming cavity to form the contact lens, whereby the colored coat detaches from the molding surface and becomes integral with the body of the contact lens.

摘要翻译： 本发明提供一种制备有色硅酮水凝胶隐形眼镜的方法。 本发明的方法包括以下步骤：（a）将彩色涂层施加到具有油墨的透镜模具的至少一个模制表面的至少一部分上，其中所述油墨包括至少一种着色剂，粘合剂聚合物， 粘合促进剂和任选的稀释剂，其中粘合剂聚合物是可聚合混合物的共聚产物，其包含（i）至少一种亲水性乙烯基单体; （ii）至少一种官能化乙烯基单体，其含有至少一个选自羟基-OH，氨基-NHR（其中R是氢或C 1至C 1至C 1）的官能团， 烷基），羧基-COOH，环氧基，酰胺基-CONHR及其组合; （iii）至少一种含硅酮的乙烯基单体或大分子单体，和（iv）任选的一种或多种选自聚合引发剂，链转移剂和溶剂的组分，其中模具具有透镜形成 模制表面之间的空腔，其中着色涂层包含暴露于透镜形成腔的内部的第一表面和与模制表面接触的第二表面; （b）固化印在模具上的油墨; （c）将硅酮水凝胶透镜形成材料分配到模具的透镜形成腔中; （d）固化透镜形成腔内的透镜形成材料以形成隐形眼镜，由此着色涂层从模制表面脱离并与隐形眼镜的主体成一体。

公开(公告)号：US5146414A

公开(公告)日：1992-09-08

申请号：US510897

申请日：1990-04-18

申请人： Russel McKown ,  Mark Yelderman ,  Michael Quinn

发明人： Russel McKown ,  Mark Yelderman ,  Michael Quinn

IPC分类号： A61B5/028 ,  A61B5/026 ,  A61B5/0275 ,  G01F1/712

CPC分类号： G01F1/712 ,  A61B5/026 ,  A61B5/7257

摘要： Method and apparatus for adapting the volumetric flow rate measurement system taught by Yelderman in U.S. Pat. No. 4,507,974 to clinical environments by reducing the effects of physiological noise. Signal processing techniques are used to characterize the background noise power spectrum of the system under test so that the effect of noise aberrations on the measured data may be eliminated and so that the predominant periodicities of the background noise spectra may be avoided. The invention further cross-correlates the input data of the system with the corresponding ouput data of the system to determine weighting values for each input frequency so that data collected at noisy frequencies is discounted. Low frequency noise or drift is also removed from the output signal by fitting the average of the output data to a quadratic function which is then subtracted from the original output signal, point by point. Finally, the processed data is fit to a lagged normal normal distribution curve in the frequency domain to solve for the parameters necessary to mathematically model the transfer function of the system. Given the input to the system as well as the frequency domain transfer function and noise data of the system, the volumetric flow of the system then may be determined for virtually any input even in very noisy environments without knowledge of the volume of the system.

摘要翻译： 用于适应Yelderman教授的体积流量测量系统的方法和装置， 通过减少生理噪音的影响，临床环境的4,507,974号。 信号处理技术用于表征被测系统的背景噪声功率谱，从而可以消除噪声像差对测量数据的影响，从而可以避免背景噪声谱的主要周期。 本发明还将系统的输入数据与系统的相应输出数据相互关联，以确定每个输入频率的加权值，使得以嘈杂频率收集的数据被打折扣。 低频噪声或漂移也通过将输出数据的平均值拟合为二次函数从输出信号中去除，然后从原始输出信号逐点减去。 最后，处理后的数据适合于频域的滞后正态分布曲线，以解决数学建模系统传递函数所需的参数。 给定系统的输入以及系统的频域传递函数和噪声数据，然后即使在非常嘈杂的环境中也可以确定几乎任何输入的系统的体积流量，而不了解系统的体积。

公开(公告)号：US09656027B2

公开(公告)日：2017-05-23

申请号：US14117846

申请日：2011-05-18

申请人： Michael Quinn

发明人： Michael Quinn

IPC分类号： A61M5/32 ,  A61M5/28 ,  A61M5/46 ,  A61M5/24

CPC分类号： A61M5/3271 ,  A61M5/282 ,  A61M5/283 ,  A61M5/288 ,  A61M5/326 ,  A61M5/3272 ,  A61M5/3287 ,  A61M5/46 ,  A61M2005/2474 ,  A61M2005/3247 ,  A61M2005/3267

摘要： An injection device (100, 200), including a safety shield (104, 204) and a housing (108, 208). The safety shield (104, 204) has a first end and a surface disposed at a second end thereof for contacting a patient's skin, and a shield tab (164, -240) extending therefrom. The housing (108, 208) is slidably disposed with respect to the safety shield (104, 204) and includes a guide groove (172, 252) for engaging the shield tab (164, 240) to guide movement of the housing (108, 208) relative to the safety shield (104, 204). The guide groove (172, 252) has first (184, 256) and second (188, 260) axial portions and a substantially helical portion (192, 264) connecting the first and second axial portions (184,188, 256, 260). The device (100, 200) also includes a medicament container (120, 220) connected with the housing (108, 208) and having a needle (124, 224) affixed thereto in communication with a medicament disposed within the medicament container (120, 220). The medicament container (120, 220) is displaceable relative to the safety shield (104, 204) from an initial position to an injection position, to a withdrawn position.

公开(公告)号：US09417218B2

公开(公告)日：2016-08-16

申请号：US12814387

申请日：2010-06-11

申请人： Gregory E. Rice ,  Michael Quinn

发明人： Gregory E. Rice ,  Mark S. Baker ,  Michael Quinn

IPC分类号： G01N33/543 ,  G01N30/14 ,  C07K1/22 ,  G01N33/68 ,  G01N30/00

CPC分类号： G01N30/14 ,  C07K1/22 ,  G01N33/6854 ,  G01N2030/009 ,  B01D15/3804

摘要： This invention relates to methods of analysis, and in particular to methods for the preliminary fractionation of samples in which low abundance molecules of interest, for example proteins, polysaccharides or fatty acids, are present together with more abundant molecules of little or no interest. In particular, the invention relates to methods of depletion of high abundance proteins from biological samples. Products and kits for use in the method are also disclosed, and form part of the invention. In one aspect, the invention provides a method of depleting a high-abundance molecule from a biological sample, comprising the steps of a) subjecting the sample to affinity depletion using an affinity support with high affinity for a high abundance molecule, and/or b) immunodepletion using an affinity support coupled to an antibody directed against whole or previously fractionated plasma or serum.

公开(公告)号：US20150112274A1

公开(公告)日：2015-04-23

申请号：US14385141

申请日：2012-03-15

申请人： Michael Quinn ,  Richard Cronenberg

发明人： Michael Quinn ,  Richard Cronenberg

IPC分类号： A61M5/315

CPC分类号： A61M5/31501 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/3155 ,  A61M5/31551 ,  A61M5/31558 ,  A61M5/31575 ,  A61M5/31585 ,  A61M5/31593 ,  A61M2205/581 ,  A61M2205/582

摘要： A medication injection pen (11) includes a housing (1) and a dose set knob (2) rotatable with respect to the housing (1). A brake assembly (68) is disposed in the housing (1) and has a ratchet member (43). A driver (21) includes at least one external tooth (57) engaging the ratchet member (43). The engagement between the ratchet member (43) and the at least one external tooth (57) substantially prevents the driver (21) from rotating with respect to the dose set knob (2) during dose setting and dose correcting. The engagement between the ratchet member (43) and the at least one external tooth (57) allows the driver (21) to rotate with the dose set knob (2) during an injection.

摘要翻译： 药物注射笔（11）包括可相对于壳体（1）旋转的壳体（1）和剂量设定旋钮（2）。 制动组件（68）设置在壳体（1）中并且具有棘轮构件（43）。 驱动器（21）包括与棘轮构件（43）接合的至少一个外齿（57）。 在剂量设定和剂量校正期间，棘轮构件（43）和至少一个外齿（57）之间的接合基本上防止驱动器（21）相对于剂量设定旋钮（2）旋转。 棘轮构件（43）和至少一个外齿（57）之间的接合允许驾驶员（21）在注射期间随着剂量设定旋钮（2）旋转。

公开(公告)号：USD676547S1

公开(公告)日：2013-02-19

申请号：US29405936

申请日：2011-11-08

申请人： Michael Quinn ,  Natalie Darlene Macon ,  Francis Lovell ,  Aurèle Hurtis

设计人： Michael Quinn ,  Natalie Darlene Macon ,  Francis Lovell ,  Aurèle Hurtis