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公开(公告)号:US08568626B2
公开(公告)日:2013-10-29
申请号:US12252406
申请日:2008-10-16
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: B29D11/00
CPC分类号: G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionoperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.
摘要翻译: 提供了制备硅酮水凝胶隐形眼镜的方法。 在一个实施方案中,预聚物混合物在具有小于约10000ppm氧气的气氛中在透镜模具中聚合以形成适于延长磨损的硅氧烷水凝胶隐形眼镜,其特征在于连续磨损一段时间后产生小于10%的角膜溶胀 包括正常睡眠期为7天。 在一个实施方案中,预聚物混合物包含至少一种含有亲水基团的含氧物质,其中所述至少一种含氧物质是含硅氧烷的大分子单体或至少一种离子交换材料和交联剂。 在某些实施方案中,预聚物混合物的聚合可以在具有小于约1000ppm氧气的气氛中进行。
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公开(公告)号:US20090039535A1
公开(公告)日:2009-02-12
申请号:US12252406
申请日:2008-10-16
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: B29D11/00
CPC分类号: G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.
摘要翻译: 提供了制备硅酮水凝胶隐形眼镜的方法。 在一个实施方案中,预聚物混合物在具有小于约ppm氧气的气氛中在透镜模具中聚合以形成适于延长磨损的硅氧烷水凝胶隐形眼镜,其特征在于在连续磨损一段时间后产生小于10%的角膜溶胀 包括正常睡眠期的7天。 在一个实施方案中,预聚物混合物包含至少一种含有亲水基团的含氧物质,其中所述至少一种含氧物质是含硅氧烷的大分子单体或单体,至少一种离子精子材料和交联剂。 在某些实施方案中,预聚物混合物的聚合可以在具有小于约1000ppm氧气的气氛中进行。
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公开(公告)号:US20060004165A1
公开(公告)日:2006-01-05
申请号:US11148104
申请日:2005-06-08
申请人: John Phelan , Michael Quinn , Angelika Domschke
发明人: John Phelan , Michael Quinn , Angelika Domschke
IPC分类号: C08F130/08 , G02C7/04
CPC分类号: C08F290/068 , C08F230/08 , G02B1/043 , C08L51/085
摘要: The present invention provides silicone hydrogel materials which can be lathed at room temperature and has a high oxygen permeability and a water content of from about 18% to 55% by weight. In addition, the invention provides contact lenses comprising a silicone hydrogel material of the invention.
摘要翻译: 本发明提供了可在室温下车床并具有高透氧性和约18-55重量%的含水量的硅酮水凝胶材料。 此外,本发明提供了包含本发明的硅氧烷水凝胶材料的隐形眼镜。
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公开(公告)号:US08415404B2
公开(公告)日:2013-04-09
申请号:US12794333
申请日:2010-06-04
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: G02B1/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译: 一种适用于眼睛延长磨损期至少一天的眼科镜片,没有临床显着量的角膜肿胀,并且没有实质的佩戴者不适。 在一个实施方案中,眼用透镜是至少一种氧精,至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中,透镜的拉伸模量小于约3.0MPa,而在另一个实施方案中,拉伸模量为约0.5至约1.5MPa。
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公开(公告)号:US20100238398A1
公开(公告)日:2010-09-23
申请号:US12794333
申请日:2010-06-04
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号: G02C7/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译: 一种适用于眼睛延长磨损期至少一天的眼科镜片,没有临床显着量的角膜肿胀,并且没有实质的佩戴者不适。 在一个实施方案中,眼用透镜是至少一种氧精,至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中,透镜的拉伸模量小于约3.0MPa,而在另一个实施方案中,拉伸模量为约0.5至约1.5MPa。
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公开(公告)号:US20070105974A1
公开(公告)日:2007-05-10
申请号:US11618800
申请日:2006-12-30
申请人: Paul Nicolson , Richard Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Griesser , Arthur Ho , Jens Hopken , Bronwyn Laycock , Qin Liu , Dieter Lohmann , Gordon Meijs , Eric Papaspiliotopoulos , Judy Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Terry , Jurgen Vogt , Lynn Winterton
发明人: Paul Nicolson , Richard Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Griesser , Arthur Ho , Jens Hopken , Bronwyn Laycock , Qin Liu , Dieter Lohmann , Gordon Meijs , Eric Papaspiliotopoulos , Judy Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Terry , Jurgen Vogt , Lynn Winterton
IPC分类号: G02B1/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译: 一种适用于眼睛延长磨损期至少一天的眼科镜片,没有临床显着量的角膜肿胀,并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡,离子或水渗透性足以提供良好的眼内运动,使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜,其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。
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公开(公告)号:US20070105973A1
公开(公告)日:2007-05-10
申请号:US11618798
申请日:2006-12-30
申请人: Paul Nicolson , Richard Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Griesser , Arthur Ho , Jens Hopken , Bronwyn Laycock , Qin Liu , Dieter Lohmann , Gordon Meijs , Eric Papaspiliotopoulos , Judy Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Terry , Jurgen Vogt , Lynn Winterton
发明人: Paul Nicolson , Richard Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Griesser , Arthur Ho , Jens Hopken , Bronwyn Laycock , Qin Liu , Dieter Lohmann , Gordon Meijs , Eric Papaspiliotopoulos , Judy Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Terry , Jurgen Vogt , Lynn Winterton
IPC分类号: G02B1/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
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公开(公告)号:US20070002470A1
公开(公告)日:2007-01-04
申请号:US10564323
申请日:2004-06-16
申请人: Angelika Domschke , Xiaodong Hu , Jian Zhou
发明人: Angelika Domschke , Xiaodong Hu , Jian Zhou
IPC分类号: G02B7/02
CPC分类号: A61B5/14532 , A61B5/1455 , A61B5/411 , B29C35/0894 , B29C2035/0827 , B29D11/00134 , B29D11/0074 , B29L2011/0041 , G01N21/75 , G01N21/77 , G01N2021/773 , G01N2021/7773 , G01N2021/7779 , G03H1/0005 , G03H1/0248 , G03H2001/0033 , G03H2001/0044 , G03H2001/0264 , G03H2001/0415 , G03H2260/12 , G03H2270/55
摘要: This invention is generally related to a biocompatible sensor for detecting/measuring an analyte of interest in a body fluid and a method for making the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of a reflection hologram therein or thereon, wherein the reflection hologram is produced in a crosslinkable and/or polymerizable fluid material. The polymer matrix contains a molecular sensing moiety which interacts or reacts with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram.
摘要翻译: 本发明通常涉及用于检测/测量体液中感兴趣的分析物的生物相容性传感器和用于制造生物相容性传感器的方法。 本发明的生物相容性传感器包括基本上由其中或其上的反射全息图组成,其中反射全息图在可交联和/或可聚合流体材料中产生。 聚合物基质包含与感兴趣的分析物相互作用或反应的分子感测部分,以提供指示反射全息图的一个或多个光学性质变化的光学信号。
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公开(公告)号:US5922249A
公开(公告)日:1999-07-13
申请号:US944940
申请日:1997-10-02
IPC分类号: A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , G02B1/04 , B29D11/00
CPC分类号: B05D1/62 , A61L27/26 , A61L27/34 , B29C39/42 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , B29C71/00 , B29L2011/0041 , Y10S425/808
摘要: A method of making an ophthalmic lens including the steps of: preparing a polymerizable composition comprising excessive oxygen content; contacting the polymerizable composition with a gas that is inert or substantially inert to the polymerizable composition, and deoxygenating or partially deoxygenating the polymerizable composition; conveying all or part of the polymerizable composition to an ophthalmic lens mold; polymerizing all or part of the polymerizable composition and obtaining a polymeric ophthalmic lens, and the lens produced by such process.
摘要翻译: 一种制造眼用透镜的方法,包括以下步骤:制备包含过量氧含量的可聚合组合物; 使可聚合组合物与可聚合组合物呈惰性或基本上惰性的气体接触,并使可聚合组合物脱氧或部分脱氧; 将全部或部分可聚合组合物输送到眼用透镜模具; 聚合全部或部分可聚合组合物并获得聚合物眼科镜片,以及通过这种方法制备的镜片。
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公开(公告)号:US20090046242A1
公开(公告)日:2009-02-19
申请号:US12252397
申请日:2008-10-16
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: G02C7/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译: 一种适用于眼睛延长磨损期至少一天的眼科镜片,没有临床显着量的角膜肿胀,并且没有实质的佩戴者不适。 在一个实施方案中,眼用透镜是至少一种氧精,至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中,透镜的拉伸模量小于约3.0MPa,而在另一个实施方案中,拉伸模量为约0.5至约1.5MPa。
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