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公开(公告)号：US09714251B2
公开(公告)日：2017-07-25
申请号：US15038818
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Daniel Christopher Brookings , Julien Alistair Brown , Victoria Elizabeth Jackson , John Robert Porter , Joanna Rachel Quincey
IPC: C07D487/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D401/04 , C07D401/12 , C07D401/14 , A61K31/53 , A61P19/02
CPC classification number: C07D487/04 , A61K31/53 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14
Abstract: A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20170158688A1
公开(公告)日：2017-06-08
申请号：US15039199
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Victoria Elizabeth Jackson , John Robert Porter
IPC: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377
Abstract: A series of substituted 1H imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20160297818A1
公开(公告)日：2016-10-13
申请号：US15100697
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D473/00 , A61K31/5377
CPC classification number: C07D473/00 , A61K31/5377 , C07D473/32
Abstract: A series of substituted purine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Abstract translation: 因此，作为人类TNFα活性的有效调节剂的一系列取代的嘌呤衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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24.发明申请公开(公告)号：US20160289228A1
公开(公告)日：2016-10-06
申请号：US15038239
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Sabine Defays , Jag Paul Heer , Victoria Elizabeth Jackson , James Andrew Johnson , Boris Kroeplien , John Robert Porter
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/4184 , A61K31/437 , A61K2300/00
Abstract: A series of substituted 5,6,7,8-tetrahydroimidazo[1,2-α]pyridine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Abstract translation: 因此，作为人TNFα活性的有效调节剂的一系列取代的5,6,7,8-四氢咪唑并[1,2-α]吡啶衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫和 炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20150191482A1
公开(公告)日：2015-07-09
申请号：US14414299
申请日：2013-07-05
Applicant: UCB Biopharma SPRL
Inventor： Jonathan Mark Bentley , Daniel Christopher Brookings , Julien Alistair Brown , Thomas Paul Cain , Laura Jane Gleave , Alexander Heifetz , Victoria Elizabeth Jackson , Craig Johnstone , Deborah Leigh , James Madden , John Robert Porter , Matthew Duncan Selby , Zhaoning Zhu
IPC: C07D491/107 , A61K31/5377 , C07D451/02 , A61K31/506 , C07D487/04 , C07D471/08 , A61K31/5513 , A61K31/4985
CPC classification number: C07D491/107 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/5513 , C07D451/02 , C07D471/08 , C07D487/04
Abstract: A series of imidazo[1,2-α]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorder; and oncological disorders.
Abstract translation: 因此，作为人TNFα活性的有效调节剂的一系列咪唑并[1,2-α]吡嗪衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病 和肿瘤疾病。
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Patent Agency Ranking
![Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity](/abs-image/US/2019/05/14/US10287299B2/abs.jpg.150x150.jpg)
公开(公告)号：US10287299B2
公开(公告)日：2019-05-14
申请号：US15580059
申请日：2016-06-07
Applicant: UCB Biopharma SPRL
Inventor： Gareth Neil Brace , Prafulkumar Tulshibhai Chovatia , Gregory Foulkes , James Andrew Johnson , Severine Danielle Jones , Boris Kroeplien , Fabien Claude Lecomte , Pui Leng Loke , Martin Alexander Lowe , Ajay Mandal , Timothy John Norman , Christopher Francis Palmer , Yolanda Pérez-Fuertes , John Robert Porter , Donald Smyth , Giancarlo Trani , Muhammed Uddin , Zhaoning Zhu
IPC: A61K31/5365 , C07D265/36 , C07D498/04 , C07D401/06 , C07D413/06 , A61P27/02 , A61P3/00 , A61P9/00 , A61P23/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61K31/423 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/473 , A61K31/538 , A61K31/5383 , A61K31/55 , C07D413/12 , C07D413/14 , C07D471/04 , C07D519/00
Abstract: A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09932334B2
公开(公告)日：2018-04-03
申请号：US15039194
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/5377 , A61K31/444
CPC classification number: C07D471/04 , A61K31/444 , A61K31/5377
Abstract: A series of substituted 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine derivatives, being potent treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09890154B2
公开(公告)日：2018-02-13
申请号：US15038555
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Victoria Elizabeth Jackson , Boris Kroeplien , John Robert Porter
IPC: C07D471/04 , A61K31/437 , A61K31/444
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444
Abstract: A series of substituted 3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09834553B2
公开(公告)日：2017-12-05
申请号：US15101203
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: A61K31/44 , C07D515/02 , C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437
Abstract: A series of substituted 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20170129883A1
公开(公告)日：2017-05-11
申请号：US15039194
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/5377 , A61K31/444
CPC classification number: C07D471/04 , A61K31/444 , A61K31/5377
Abstract: A series of substituted 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine derivatives, being potent treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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