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公开(公告)号：US09932342B2
公开(公告)日：2018-04-03
申请号：US15100690
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
发明人： Mezher Hussein Ali , Daniel Christopher Brookings , Julien Alistair Brown , Victoria Elizabeth Jackson , Boris Kroeplien , John Robert Porter
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： A series of substituted imidazo[1,2-a]pyrimidine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09902720B2
公开(公告)日：2018-02-27
申请号：US15038766
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
摘要： A series of substituted pyrazolo[1,5-a]pyridine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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3.发明申请公开(公告)号：US20160297837A1
公开(公告)日：2016-10-13
申请号：US15100825
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
发明人： Rikki Peter Alexander , Jonathan Mark Bentley , Gareth Neil Brace , Daniel Christopher Brookings , Praful Tulshi Chovatia , Hervé Jean Claude Deboves , Craig Johnstone , Elizabeth Pearl Jones , Boris Kroeplien , Fabien Claude Lecomte , James Madden , Craig Miller , John Robert Porter , Matthew Duncan Selby , Michael Alan Shaw , Darshan Gunvant Vaidya , Ian Andrew Yule
IPC分类号： C07D519/00 , A61K31/4709 , A61K31/4355 , A61K31/538 , A61K31/5383 , C07D471/04
CPC分类号： C07D519/00 , A61K31/4355 , A61K31/4709 , A61K31/538 , A61K31/5383 , C07D471/04
摘要： A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 一系列取代的苯并咪唑，咪唑并[1,2-a]吡啶和吡唑并[1,5-a]吡啶衍生物及其类似物是人类TNFα活性的有效调节剂，因此在治疗和/或预防中有益 各种人类疾病，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20150152065A1
公开(公告)日：2015-06-04
申请号：US14406848
申请日：2013-06-11
申请人： UCB Biopharma SPRL
发明人： Daniel Christopher Brookings , Mark Daniel Calmiano , Ellen Olivia Gallimore , Helen Tracey Horsley , Martin Clive Hutchings , James Andrew Johnson , Boris Kroeplien , Fabien Claude Lecomte , Martin Alexander Lowe , Timothy John Norman , John Robert Porter , Joanna Rachel Quincey , James Thomas Reuberson , Matthew Duncan Selby , Michael Alan Shaw , Zhaoning Zhu , Anne Marie Foley
IPC分类号： C07D235/12 , C07D401/04 , A61K31/4439 , A61K31/454 , C07D405/06 , A61K31/4192 , C07D403/04 , A61K31/4709 , A61K31/4725 , A61K31/444 , C07D401/14 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D491/107 , A61K31/506 , A61K31/4184
CPC分类号： C07D235/12 , A61K31/4184 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/06 , C07D491/107
摘要： A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人TNFα活性的有效调节剂的一系列苯并咪唑衍生物有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20200022988A1
公开(公告)日：2020-01-23
申请号：US16487988
申请日：2018-03-14
申请人： UCB Biopharma SPRL , Sanofi
发明人： Julien Alistair Brown , Daniel Christopher Brookings , Jag Paul Heer , James Andrew Johnson , Zhaoning Zhu
IPC分类号： A61K31/55 , C07D471/22
摘要： A series of substituted fused pentacyclic imidazopyridine and imidazopyridazine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09868749B2
公开(公告)日：2018-01-16
申请号：US15100825
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
发明人： Rikki Peter Alexander , Jonathan Mark Bentley , Gareth Neil Brace , Daniel Christopher Brookings , Prafulkumar Tulshibhai Chovatia , Hervé Jean Claude Deboves , Craig Johnstone , Elizabeth Pearl Jones , Boris Kroeplien , Fabien Claude Lecomte , James Madden , Craig Miller , John Robert Porter , Matthew Duncan Selby , Michael Alan Shaw , Darshan Gunvant Vaidya , Ian Andrew Yule
IPC分类号： C07D519/00 , C07D471/04 , A61K31/4355 , A61K31/4709 , A61K31/538 , A61K31/5383
CPC分类号： C07D519/00 , A61K31/4355 , A61K31/4709 , A61K31/538 , A61K31/5383 , C07D471/04
摘要： A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09850240B2
公开(公告)日：2017-12-26
申请号：US15101044
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
IPC分类号： C07D471/04 , A61K31/506 , A61K31/437 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
摘要： A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20170305932A1
公开(公告)日：2017-10-26
申请号：US15513357
申请日：2015-10-02
申请人： UCB Biopharma SPRL , Sanofi
发明人： Teresa De Haro Garcia , Michael Deligny , Jag Paul Heer , Joanna Rachel Quincey , Mengyang Xuan , Zhaoning Zhu , Daniel Christopher Brookings , Mark Daniel Calmiano , Yves Evrard , Martin Clive Hutchings , James Andrew Johnson , Sophie Jadot , Jean Keyaerts , Malcolm Mac Coss , Matthew Duncan Selby , Michael Alan Shaw , Dominique Louis Leon Swinnen , Laurent Schio , Yann Foricher , Bruno Filoche-Romme
IPC分类号： C07D519/00 , C07D495/18 , C07D487/18 , C07D491/18 , C07F7/18 , C07D513/18
CPC分类号： C07D519/00 , A61K31/4184 , A61K31/506 , A61K31/55 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/08 , C07D491/18 , C07D493/18 , C07D495/08 , C07D495/18 , C07D513/18 , C07F7/1804
摘要： A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
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公开(公告)号：US20160304512A1
公开(公告)日：2016-10-20
申请号：US15101044
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
IPC分类号： C07D471/04 , A61K31/506 , A61K31/437 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
摘要： A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人类TNF活性的有效调节剂的一系列取代的[1,2,4]三唑并[4,3-a]吡啶衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫和炎症 疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20160297827A1
公开(公告)日：2016-10-13
申请号：US15100690
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
发明人： Mezher Hussein Ali , Daniel Christopher Brookings , Julien Alistair Brown , Victoria Elizabeth Jackson , Boris Kroeplien , John Robert Porter
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： A series of substituted imidazo[1,2-a]pyrimidine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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