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32 条记录 (耗时 0.03 秒)

    Dosing schedule for a novel anticancer agent
    24.
    发明申请
    Dosing schedule for a novel anticancer agent 审中-公开
    一种新型抗癌剂的给药方案

    公开(公告)号：US20050119288A1

    公开(公告)日：2005-06-02

    申请号：US10919831

    申请日：2004-08-17

    申请人： Samit Bhattacharya ,  Richard Connell ,  Jitesh Jani ,  James Moyer ,  Dennis Noe ,  Stefanus Steyn

    发明人： Samit Bhattacharya ,  Richard Connell ,  Jitesh Jani ,  James Moyer ,  Dennis Noe ,  Stefanus Steyn

    IPC分类号： A61K31/00 ,  A61K31/506 ,  A61K31/517 ,  A61P35/00

    CPC分类号： A61K31/00 ,  A61K31/506 ,  A61K31/517 ,  A61K2300/00

    摘要： The invention is directed to methods for the a method for treating overexpression of the erbB2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbB2 receptor and then, after an interval of less than 24 hours, administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbB2 receptor. The invention is also directed to a slow daily infusion of the erbB2 inhibitor. The overexpression of the erbB2 receptor can result in abnormal cell growth and lead to cancer. By the methods of the invention, the efficacy and safety of the inhibitors is increased. The invention is also directed to kits for facilitating the dose administration method of the invention.

    摘要翻译： 本发明涉及用于治疗需要治疗的哺乳动物中erbB2的过度表达的方法，其通过向哺乳动物施用治疗有效量的第一种erbB2受体抑制剂，然后在间隔小于24 小时，向哺乳动物施用1至6个治疗有效量的相同或不同的erbB2受体抑制剂。 本发明还涉及缓慢的每日输注erbB2抑制剂。 erbB2受体的过度表达可导致细胞生长异常并导致癌症。 通过本发明的方法，抑制剂的功效和安全性增加。 本发明还涉及用于促进本发明的剂量给药方法的试剂盒。

    Implement frame tube joint with weldable connector
    26.
    发明申请
    Implement frame tube joint with weldable connector 有权
    用可焊接连接器实现框架管接头

    公开(公告)号：US20070246235A1

    公开(公告)日：2007-10-25

    申请号：US11409295

    申请日：2006-04-21

    申请人： Richard Connell ,  Shawn Becker ,  Garrett Goins ,  Jarrod Ruckle ,  Mark Barker

    发明人： Richard Connell ,  Shawn Becker ,  Garrett Goins ,  Jarrod Ruckle ,  Mark Barker

    IPC分类号： A01B15/14 ,  A01B23/04 ,  A01D13/00 ,  B25G3/00

    CPC分类号： A01B51/00 ,  B23K31/02 ,  B23K2101/06 ,  Y10T403/39 ,  Y10T403/7001 ,  Y10T403/7188 ,  Y10T403/7194

    摘要： A tube over tube joint for an implement frame includes a self-fixturing weldable connector positioned between upper and lower tubes. Standard fillet welds connect the tubes to the connector. A unitary casting can be used made from material selected to optimize load transfer between the top and bottom tubes to improve the fatigue life of the joint. The casting is self-fixturing so the top tubes can be located by simply placing in the casting on the lower tubes. A tube end connector provides fixturing and weld surfaces for butt joints in planar frames. Outwardly extended weld edges on the connector increase resistance to parallelogramming.

    摘要翻译： 用于工具框架的管接头管包括定位在上管和下管之间的自固定可焊接连接件。 标准角焊缝将管连接到连接器。 可以使用从所选材料制成的单一铸件来优化顶管和底管之间的载荷传递，以提高接头的疲劳寿命。 铸件是自固定的，因此顶管可以通过简单地将铸件放置在下管上来定位。 管端连接器为平面框架中的对接接头提供夹具和焊接表面。 连接器上的向外延伸的焊接边缘增加了对平行四边形的阻力。

    Control system
    27.
    发明申请
    Control system 失效
    控制系统

    公开(公告)号：US20050134430A1

    公开(公告)日：2005-06-23

    申请号：US10743995

    申请日：2003-12-22

    申请人： James French ,  William White ,  Michael Brading ,  Rizwan Ahmad ,  Richard Connell

    发明人： James French ,  William White ,  Michael Brading ,  Rizwan Ahmad ,  Richard Connell

    IPC分类号： G01R22/06 ,  H02J13/00 ,  H04M11/02 ,  H04Q1/30

    CPC分类号： H04M11/022 ,  G01R22/063 ,  H02J13/0013 ,  Y02B90/2607 ,  Y04S40/12

    摘要： In a system for remotely controlling the supply of electric power to customer premises, each customer premises is fitted with a power-switching arrangement coupled to a paging receiver (5-1, 5-2, 5-3). A utility company supplying the electric power can input requests to a server (1), optionally via a terminal (2) or a network link (3). A software application running on the server generates a control instruction in response to a request and sends it to a paging service (4) for transmission over a paging network. When a paging message is received at one of said customer-premises paging receivers, if the control instruction is appropriately addressed the power-switching arrangement will put it into effect, for example to connect or reconnect the customer premises power supply.

    摘要翻译： 在用于远程控制向客户驻地供电的系统中，每个客户驻地配备有耦合到寻呼接收机（5-1,5-2-5-3）的功率切换装置。 提供电力的公用事业公司可以可选地通过终端（2）或网络链路（3）向服务器（1）输入请求。 在服务器上运行的软件应用程序响应于请求生成控制指令，并将其发送到寻呼服务（4），以通过寻呼网络传输。 当在所述客户驻地寻呼接收机之一处接收到寻呼消息时，如果控制指令被适当寻址，则电源切换装置将使其生效，例如连接或重新连接客户驻地供电。

    Harrow tine angle adjustment
    29.
    发明申请
    Harrow tine angle adjustment 有权
    耙角调整

    公开(公告)号：US20070284125A1

    公开(公告)日：2007-12-13

    申请号：US11365194

    申请日：2006-03-01

    申请人： David Payne ,  Richard Connell ,  Shawn Becker ,  Garrett Goins

    发明人： David Payne ,  Richard Connell ,  Shawn Becker ,  Garrett Goins

    IPC分类号： E02F3/76

    CPC分类号： A01B71/02 ,  A01B23/043

    摘要： A simplified spike tooth harrow includes an apertured bracket pivotally connected to the fore-and-aft connecting strap extending between the tine bars. The bracket adjustably supports a tine bar from the strap. A pin selectively secured in one of the apertures contacts the strap to set the working angle of the tines on the bar when the harrow is operated in the field. A chain or link connected to the bracket at a location offset from the bracket pivot suspends the harrow from an upper drawbar assembly which is movable vertically between field-working and transport positions. When the drawbar assembly is raised to the transport position so the harrow is out of ground contact, the bracket pivots so the pin is offset from the strap and can be easily and quickly removed from the aperture and reinserted in a different aperture to change the tine angle.

    摘要翻译： 简化的穗齿耙包括一个可枢转地连接到在杆之间延伸的前后连接带的有孔托架。 支架可调节地支撑带子上的齿条。 选择性地固定在其中一个孔中的销钉接触带子，以在耙子在现场操作时将叉子的工作角度设置在杆上。 在与支架枢轴偏置的位置处连接到支架的链条或链节将耙从上部牵引杆组件悬挂，该上牵引杆组件可在现场作业和运输位置之间垂直移动。 当牵引杆组件升高到运输位置时，耙子脱离地面接触，支架枢转，使销钉从带子上偏移，并且可以容易地并且快速地从孔中移出并重新插入不同的孔径以改变齿 角度。

    Rockshaft liner with thrust surface
    30.
    发明申请
    Rockshaft liner with thrust surface 有权
    带推力面的岩心衬套

    公开(公告)号：US20070201780A1

    公开(公告)日：2007-08-30

    申请号：US11361376

    申请日：2006-02-24

    申请人： Richard Connell ,  Shawn Becker ,  Garrett Goins

    发明人： Richard Connell ,  Shawn Becker ,  Garrett Goins

    IPC分类号： F16C17/00

    CPC分类号： F16C35/02 ,  A01B63/16 ,  A01B63/24 ,  A01B71/04 ,  F16C17/022 ,  F16C33/08 ,  F16C33/20 ,  F16C2208/78 ,  F16C2226/50

    摘要： A bearing block assembly includes a liner having a two piece ring of low friction material extending around the rockshaft and held in place by a bearing block. The rockshaft includes a radially projecting member interacting with the bearing block assembly to maintain the axial position of the rockshaft. The bearing liner includes a flange extending beyond the bearing block to contact the projecting member. The flange is seated in a groove at the side of the bearing block and lowers the coeffiecient of friction at the rockshaft/thrust surface interface.

    摘要翻译： 一种轴承座组件包括一个具有两片低摩擦材料环的衬套，所述两片环围绕所述岩石轴延伸并由轴承座保持就位。 岩心包括与轴承座组件相互作用的径向突出的构件，以保持轴的轴向位置。 轴承衬套包括延伸超过轴承座的凸缘以接触突出构件。 凸缘位于轴承座侧面的凹槽中，降低了轴/推力面界面处的摩擦系数。