公开(公告)号：US11747323B2

公开(公告)日：2023-09-05

申请号：US17962163

申请日：2022-10-07

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher Barbee ,  Nathan Beckett ,  Denis Pristinski ,  Derek Schulte ,  Avishai Bartov ,  Jamie Sullivan ,  Dumitru Brinza ,  Abizar Lakdawalla ,  Steven Menchen ,  Gilad Almogy ,  Mark Pratt

IPC: G01N33/49 ,  G01N1/02 ,  G01Q10/04 ,  G01N1/22

CPC classification number: G01N33/492 ,  G01N1/02 ,  G01Q10/04 ,  G01N2001/2291

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

公开(公告)号：US11648554B2

公开(公告)日：2023-05-16

申请号：US16665559

申请日：2019-10-28

Applicant: Ultima Genomics, Inc.

Inventor： Nathan Beckett ,  Nathan Caswell

IPC: B01L3/00 ,  B01L1/02 ,  G01N7/02 ,  G01N33/487

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/502761 ,  G01N7/02 ,  G01N33/487 ,  B01L2300/0877 ,  B01L2300/14 ,  B01L2400/049

Abstract: Provided herein are methods for processing and/or detecting a sample. A method can comprise providing a barrier between a first region and a second region, wherein the first region comprises the sample, wherein the barrier maintains the first region at a first atmosphere that is different than a second atmosphere of the second region, wherein a portion of the barrier comprises a fluid in coherent motion; and using a detector at least partially contained in the first region to detect one or more signals from the sample while the first region is maintained at the first atmosphere that is different than the second atmosphere of the second region. The portion of the barrier comprising fluid may have a pressure lower than the first atmosphere, the second atmosphere, or both.

公开(公告)号：US10830703B1

公开(公告)日：2020-11-10

申请号：US16677067

申请日：2019-11-07

Applicant: Ultima Genomics, Inc.

Inventor： Gilad Almogy ,  Nathan Beckett ,  Nathan Caswell ,  Gene Polovy

IPC: G01N21/65 ,  G02B21/00

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US10512911B1

公开(公告)日：2019-12-24

申请号：US16440026

申请日：2019-06-13

Applicant: Ultima Genomics, Inc.

Inventor： Nathan Beckett ,  Nathan Caswell

IPC: B01L3/00 ,  G01N7/02 ,  G01N33/487

Abstract: Provided herein are methods for processing and/or detecting a sample. A method can comprise providing a barrier between a first region and a second region, wherein the first region comprises the sample, wherein the barrier maintains the first region at a first atmosphere that is different than a second atmosphere of the second region, wherein a portion of the barrier comprises a fluid in coherent motion; and using a detector at least partially contained in the first region to detect one or more signals from the sample while the first region is maintained at the first atmosphere that is different than the second atmosphere of the second region. The portion of the barrier comprising fluid may have a pressure lower than the first atmosphere, the second atmosphere, or both.