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21.发明申请公开(公告)号：US20150291623A1
公开(公告)日：2015-10-15
申请号：US14542367
申请日：2014-11-14
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: C07D513/20 , C07D519/00 , C07D491/22 , C07D491/20 , C07D498/20
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US20220348570A1
公开(公告)日：2022-11-03
申请号：US17183401
申请日：2021-02-24
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Qi Jia , Verner Alexander Lofstrand , Shaoyi Sun , Steven Sigmund Wesolowski , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D417/14 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US11299490B2
公开(公告)日：2022-04-12
申请号：US16940696
申请日：2020-07-28
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , James Philip Johnson, Jr. , Alla Yurevna Zenova
IPC: C07D451/06 , C07D403/12 , C07D213/76 , C07D237/20 , C07D239/69 , C07D413/12 , C07D417/12 , C07D261/16 , C07D493/10 , C07D277/52 , C07D285/08 , C07D401/12 , C07D417/14
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
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公开(公告)号：US20140296245A1
公开(公告)日：2014-10-02
申请号：US14355552
申请日：2012-10-30
Applicant: XENON PHARMACEUTICALS INC.
Inventor： Shaoyi Sun , Alla Yurevna Zenova , Mikhail Chafeev , Qi Jia , Zaihui Zhang , Renata Marcella Oballa
IPC: C07D417/12 , C07D285/08 , C07D257/06 , C07D277/52 , C07D261/14 , C07D239/42 , C07D285/135
CPC classification number: C07D239/42 , C07D211/22 , C07D257/06 , C07D261/14 , C07D277/52 , C07D285/08 , C07D285/135 , C07D401/12 , C07D413/12 , C07D417/12
Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及苯磺酰胺化合物，作为立体异构体，对映异构体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US20240101531A1
公开(公告)日：2024-03-28
申请号：US18330100
申请日：2023-06-06
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Paul Scott Charifson , Christoph Martin Dehnhardt , Julien A. Delbrouck , Thilo Focken , Wei Gong , Shawn Johnstone , Xiangyu Li , Jia Yi Mo , Juliette Sabbatani , Hong Wang , Steven Sigmund Wesolowski , Alla Yurevna Zenova , Wei Zhang
IPC: C07D401/12 , C07D401/14 , C07D405/14 , C07D495/04 , C07D513/04 , C07D471/04 , C07D491/048 , C07D491/107 , C07D498/04 , C07D413/14 , C07D487/04 , C07D417/14 , C07D409/14 , C07B59/00 , A61P25/08
CPC classification number: C07D401/12 , C07D401/14 , C07D405/14 , C07D495/04 , C07D513/04 , C07D471/04 , C07D491/048 , C07D491/107 , C07D498/04 , C07D413/14 , C07D487/04 , C07D417/14 , C07D409/14 , C07B59/002 , A61P25/08 , C07B2200/05
Abstract: The present disclosure is directed to compounds of Formula (1):
wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.-
Patent Agency Ranking
公开(公告)号：US20210171537A1
公开(公告)日：2021-06-10
申请号：US16805895
申请日：2020-03-02
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D493/10 , C07D237/20 , C07D213/76 , C07D239/69 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D417/14 , C07D451/06
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US20190382398A1
公开(公告)日：2019-12-19
申请号：US16440459
申请日：2019-06-13
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Kristen Nicole Burford , Thilo Focken , Verner Alexander Lofstrand , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D417/12 , C07D277/52 , C07D413/12 , A61P25/08
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US20180162868A1
公开(公告)日：2018-06-14
申请号：US15600612
申请日：2017-05-19
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D277/52 , C07D417/12 , C07D213/76 , C07D285/08 , C07D401/12 , C07D403/12 , C07D275/03 , C07D239/69 , C07D261/16 , C07D413/12 , C07D263/50 , C07D487/10
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US09458178B2
公开(公告)日：2016-10-04
申请号：US14542367
申请日：2014-11-14
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: C07D513/20 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D519/00
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US08916580B2
公开(公告)日：2014-12-23
申请号：US13787558
申请日：2013-03-06
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: A61K31/44 , C07D491/107 , C07D491/10 , C07D491/22 , C07D491/20 , C07D498/20 , C07D495/20 , C07D513/20
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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