公开(公告)号：US09481677B2

公开(公告)日：2016-11-01

申请号：US14355549

申请日：2012-10-30

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Shifeng Liu ,  Thilo Focken ,  Navjot Chahal ,  Zaihui Zhang ,  Renata Marcella Oballa ,  Julia Fonarev

IPC: C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D417/14 ,  C07D403/12

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00

Abstract: This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract translation: 本发明涉及用于治疗和/或预防钠通道介导的疾病或病症例如疼痛的联芳基醚磺酰胺或其药学上可接受的盐，溶剂合物或前药。

公开(公告)号：US20140256736A1

公开(公告)日：2014-09-11

申请号：US14355549

申请日：2012-10-30

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Shifeng Liu ,  Thilo Focken ,  Navjot Chahal ,  Zaihui Zhang ,  Renata Marcella Oballa ,  Julia Fonarev

IPC: C07D487/04 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00

Abstract: This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Abstract translation: 本发明涉及用于治疗和/或预防钠通道介导的疾病或病症如疼痛的联芳基醚磺酰胺或其药学上可接受的盐，溶剂合物或前药。

公开(公告)号：US09365578B2

公开(公告)日：2016-06-14

申请号：US14355549

申请日：2012-10-30

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Shifeng Liu ,  Thilo Focken ,  Navjot Chahal ,  Zaihui Zhang ,  Renata Marcella Oballa ,  Julia Fonarev

IPC: C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D417/14 ,  C07D403/12

Abstract: This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

公开(公告)号：US20140296245A1

公开(公告)日：2014-10-02

申请号：US14355552

申请日：2012-10-30

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Shaoyi Sun ,  Alla Yurevna Zenova ,  Mikhail Chafeev ,  Qi Jia ,  Zaihui Zhang ,  Renata Marcella Oballa

IPC: C07D417/12 ,  C07D285/08 ,  C07D257/06 ,  C07D277/52 ,  C07D261/14 ,  C07D239/42 ,  C07D285/135

CPC classification number: C07D239/42 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/08 ,  C07D285/135 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.

Abstract translation: 本发明涉及苯磺酰胺化合物，作为立体异构体，对映异构体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗钠通道介导的疾病或病症，例如疼痛。

公开(公告)号：US20140024583A1

公开(公告)日：2014-01-23

申请号：US13942404

申请日：2013-07-15

Applicant: Novartis AG ,  Xenon Pharmaceuticals Inc.

Inventor： Natalie Dales ,  Julia Fonarev ,  Jianmin Fu ,  Duanjie Hou ,  Rajender Kamboj ,  Vishnumurthy Kodumuru ,  Natalia Pokrovskaia ,  Vandna Raina ,  Shaoyi Sun ,  Zaihui Zhang

IPC: C07D409/04 ,  A61K31/444 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/497 ,  C07F7/08 ,  C07D417/14 ,  A61K31/4436

CPC classification number: A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07F7/0834

Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract translation: 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。

公开(公告)号：US09630929B2

公开(公告)日：2017-04-25

申请号：US14355552

申请日：2012-10-30

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Shaoyi Sun ,  Alla Yurevna Zenova ,  Mikhail Chafeev ,  Qi Jia ,  Zaihui Zhang ,  Renata Marcella Oballa

IPC: C07D417/12 ,  C07D239/42 ,  C07D285/08 ,  C07D401/12 ,  C07D413/12 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135

CPC classification number: C07D239/42 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/08 ,  C07D285/135 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.