公开(公告)号：US20110169997A1

公开(公告)日：2011-07-14

申请号：US13119336

申请日：2009-11-11

Applicant: Akihiko Nagano ,  Ichiro Onuki ,  Makoto Takamiya ,  Makoto Oikawa ,  Yoshitaka Hashimoto ,  Fumihiro Kajimura ,  Yasuo Suda

Inventor： Akihiko Nagano ,  Ichiro Onuki ,  Makoto Takamiya ,  Makoto Oikawa ,  Yoshitaka Hashimoto ,  Fumihiro Kajimura ,  Yasuo Suda

IPC: H04N5/225

CPC classification number: H01L27/14627 ,  G02B3/0056 ,  G02B5/003 ,  G02B5/005 ,  G02B5/201 ,  G02B7/346 ,  H01L27/14623 ,  H04N5/23212 ,  H04N5/3696 ,  H04N9/045

Abstract: An image sensor that output a signal for detecting a focus state of a photographing lens. The image sensor includes a microlens; a light-receiving pixel; a first focus state detection pixel pair for outputting a focus state detection signal, in which aperture areas of the first focus state detection pixel pair are small in comparison to the light-receiving pixel; and a second focus state detection pixel pair for outputting a focus state detection signal, in which aperture areas of the second focus state detection pixel pair are small in comparison to the light-receiving pixel, wherein the second focus state detection pixel pair is arranged at a position that is shifted by a predetermined amount relative to each aperture position, with respect to the microlens of the first focus state detection pixel pair.

Abstract translation: 输出用于检测拍摄镜头的聚焦状态的信号的图像传感器。 图像传感器包括微透镜; 光接收像素; 第一焦点状态检测像素对，用于输出聚焦状态检测信号，其中第一焦点状态检测像素对的开口面积与光接收像素相比较小; 以及第二焦点状态检测像素对，用于输出焦点状态检测信号，其中第二聚焦状态检测像素对的开口面积与光接收像素相比较小，其中第二聚焦状态检测像素对布置在 相对于第一聚焦状态检测像素对的微透镜相对于每个孔径位置偏移预定量的位置。

公开(公告)号：US20110117602A1

公开(公告)日：2011-05-19

申请号：US12743739

申请日：2008-11-18

Applicant: Yuji Ito ,  Masanori Baba ,  Naomichi Arima ,  Yasuo Suda ,  Toshihiro Nakashima ,  Masaharu Torikai

Inventor： Yuji Ito ,  Masanori Baba ,  Naomichi Arima ,  Yasuo Suda ,  Toshihiro Nakashima ,  Masaharu Torikai

IPC: C07K16/30 ,  C07H21/04 ,  C12N15/63 ,  C12P21/00

CPC classification number: C07K16/005 ,  C07K16/2833 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  G01N33/57484

Abstract: A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases.

Abstract translation: 提供了与多种肿瘤细胞系（包括ATL细胞）具有特异性反应性并具有安全性和治疗功效以及所述抗体片段的人类抗体。 可以识别HLA-DR和bgr的人抗体和所述抗体的片段; 获得在肿瘤细胞表面表达的链​​。 特别地，发现所述抗体的scFv（双抗体）的二聚体可能在表达HLA-DR和bgr的细胞中诱导有效的凋亡; 链。 根据本发明获得的抗体和所述抗体的片段可用于检测试剂，诊断剂和用于保护或治疗包括ATL和/或病毒感染性疾病的癌症的药物。

公开(公告)号：US07838549B2

公开(公告)日：2010-11-23

申请号：US10588612

申请日：2005-02-04

Applicant: Yasuo Suda ,  Akio Arano ,  Shoichi Kusumoto ,  Michael Sobel ,  Masahiro Wakao

Inventor： Yasuo Suda ,  Akio Arano ,  Shoichi Kusumoto ,  Michael Sobel ,  Masahiro Wakao

IPC: A61K31/385 ,  C07D409/14

CPC classification number: C07H15/04 ,  C07D339/04 ,  G01N33/54353

Abstract: The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

Abstract translation: 本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。 连接体化合物为下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含三个以上的烃 衍生链，其中所述烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。 配体缀合物包括其中引入糖分子的连接体化合物。

公开(公告)号：US20080316353A1

公开(公告)日：2008-12-25

申请号：US12188385

申请日：2008-08-08

Applicant: Yasuo Suda

Inventor： Yasuo Suda

IPC: H04N5/232

CPC classification number: G03B13/36 ,  G03B19/12 ,  H04N5/2253 ,  H04N5/23212

Abstract: An image taking apparatus which can perform a focusing operation quickly is described. The image taking apparatus comprises a light splitting unit which splits a light flux from the image-taking lens into a plurality of light fluxes, a view finder optical system for observing an object image formed by the light flux from the image-taking lens, an image pickup element which photoelectrically converts the object image to an electric signal and a focus detection unit for detecting the focusing state of the image-taking lens according to a phase difference detection system. Here, the light splitting unit changes between a first state in which the light flux is directed to the view finder optical system and the focus detection unit and a second state in which the light flux is directed to the image pickup element and the focus detection unit.

Abstract translation: 描述能够快速进行聚焦操作的摄像装置。 图像摄取装置包括将来自摄像镜头的光束分解成多个光束的分光单元，用于观察由摄像镜头的光束形成的被摄体图像的取景器光学系统， 将物体图像光电转换成电信号的摄像元件和用于根据相位差检测系统检测摄像镜头的聚焦状态的焦点检测单元。 这里，分光单元在光束被引导到取景器光学系统和焦点检测单元的第一状态和光束被引导到图像拾取元件的第二状态和焦点检测单元之间变化 。

公开(公告)号：US07414664B2

公开(公告)日：2008-08-19

申请号：US10770437

申请日：2004-02-04

Applicant: Yasuo Suda

Inventor： Yasuo Suda

IPC: H04N5/225 ,  G03B7/099 ,  G03B19/12 ,  G03B13/00 ,  G02B7/28

CPC classification number: G03B13/36 ,  G03B19/12 ,  H04N5/2253 ,  H04N5/23212

Abstract: An image taking apparatus performs a focusing operation quickly and includes a light splitting unit which splits a light flux from an image-taking lens into a plurality of light fluxes, a view finder optical system observing an object image formed by the light flux from the lens, an image pickup element which photoelectrically converts the object image to an electrical signal and a focus detector detecting the focusing state of the lens according to a phase difference detector. Here, the light splitting unit changes between a first state for directing the light flux to the view finder optical system and the focus detector, a second state for directing the light flux to the image pickup element and the focus detector, and a third state in which the light flux is directed only to the image pickup element.

Abstract translation: 摄像装置快速进行聚焦操作，并且包括将来自摄像镜头的光束分解成多个光束的分光单元，观察由来自透镜的光束形成的物体图像的取景器光学系统 ，将对象图像光电转换成电信号的图像拾取元件和根据相位差检测器检测透镜的聚焦状态的聚焦检测器。 这里，分光单元在用于将光束引导到取景器光学系统和焦点检测器的第一状态之间改变，用于将光束引导到图像拾取元件和焦点检测器的第二状态，以及第三状态 光通量仅被引导到图像拾取元件。

公开(公告)号：US06893941B2

公开(公告)日：2005-05-17

申请号：US10630680

申请日：2003-07-31

Applicant: Yasuo Suda

Inventor： Yasuo Suda

IPC: H01L27/146 ,  H01L31/0203 ,  H01L31/0216 ,  H01L31/0232 ,  H01L21/30

CPC classification number: H01L27/14685 ,  H01L27/14618 ,  H01L27/14625 ,  H01L27/14627 ,  H01L31/0203 ,  H01L31/02164 ,  H01L31/02325 ,  H01L31/02327 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2924/00014

Abstract: A semiconductor device formed by cutting a first substrate and a second substrate bonded together by a spacer, wherein: the spacer is disposed at an end of the first substrate after cutting; the second substrate is a semiconductor wafer formed with a light reception element or elements; and the first substrate has an optical element or an optical element set for converging light on the light reception element or elements. A method of manufacturing such a semiconductor device. A semiconductor device manufacture method includes: a step of detecting a warp of a semiconductor substrate; a step of holding the semiconductor substrate on a base under a condition that the warp is removed; a step of bonding an opposing substrate to the semiconductor substrate; and a step of cutting the opposing substrate, wherein the opposing substrate bonded to the semiconductor substrate is set with a size corresponding to the warp of the semiconductor substrate or with a gap to an adjacent opposing substrate.

Abstract translation: 一种半导体器件，其通过切割通过间隔物结合在一起的第一基板和第二基板而形成，其中：所述间隔件设置在所述第一基板的切割后的端部; 第二基板是形成有光接收元件的半导体晶片; 并且第一基板具有用于在光接收元件上会聚光的光学元件或光学元件组。 一种制造这种半导体器件的方法。 半导体器件制造方法包括：检测半导体衬底的翘曲的步骤; 在去除翘曲的条件下将半导体衬底保持在基底上的步骤; 将相对基板接合到半导体基板的步骤; 以及切割对置基板的步骤，其中，将与半导体基板结合的对置基板的尺寸设定为与半导体基板的翘曲相对应的尺寸或与相邻的相对基板的间隙。

公开(公告)号：US06882368B1

公开(公告)日：2005-04-19

申请号：US09604743

申请日：2000-06-28

Applicant: Yasuo Suda

Inventor： Yasuo Suda

IPC: H04N9/04 ,  H04N5/225

CPC classification number: H04N9/045 ,  H04N5/3415

Abstract: An image pickup apparatus is provided having first and second image pickup portions for receiving at least first and second distinct wavelength components of object light, respectively, and first and second optical systems for guiding the first and second wavelength components to the first and second image pickup portions, respectively, via different optical paths. The first and second optical systems are formed to have respective shapes so that the focal length of the first optical system with regard to the first wavelength component is equal to the focal length of the second optical system with regard to the second wavelength component. When a virtual object distance, as defined as set forth herein, an interval between optical axes of the first and second optical systems is set such that a change in an interval between object images of the first and second wavelength components received by the first and second image pickup portions, respectively, between when an object exists at the virtual object distance and when it exists at infinity is smaller than a pixel pitch of the image pickup portions multiplied by two.

Abstract translation: 一种图像拾取装置，具有分别用于分别接收物体光的至少第一和第二不同波长分量的第一和第二图像拾取部分，以及用于将第一和第二波长分量引导到第一和第二图像拾取器的第一和第二光学系统 分别经由不同的光路。 第一和第二光学系统形成为具有各自的形状，使得第一光学系统相对于第一波长分量的焦距等于第二光学系统相对于第二波长分量的焦距。 当如本文所述定义的虚拟对象距离被设置为第一和第二光学系统的光轴之间的间隔，使得由第一和第二光学系统接收的第一和第二波长分量的对象图像之间的间隔的变化 分别在物体存在于虚拟对象距离处和当其存在于无限远处时的图像拾取部分小于图像拾取部分的像素间距乘以2。

公开(公告)号：US5678097A

公开(公告)日：1997-10-14

申请号：US151779

申请日：1993-11-15

Applicant: Yasuo Suda

Inventor： Yasuo Suda

IPC: G03B13/36 ,  G02B7/34 ,  G03B3/00 ,  G03B13/18

CPC classification number: G02B7/346

Abstract: A focus detecting device having a light distribution forming device for forming the light intensity distribution whose relative position varies in accordance with the focus adjustment of an object lens from the light flux passing through the object lens, a sensing device for receiving the light intensity distribution and outputting a signal representing the state of focus adjustment of the object lens based on the relative position in the light intensity distribution, and having a plurality of sensing elements, and a light diffusing device disposed in or near a predetermined imaging plane of the object lens, and having the degree of light diffusion determined so that the light intensity distribution can be moved relatively in accordance with the adjustment of the object lens.

Abstract translation: 一种聚焦检测装置，具有用于形成相对位置根据物镜的焦点调节而变化的光强度分布的光分布形成装置，该光束分布形成装置具有：通过物镜的光束;受光装置， 基于所述光强分布中的相对位置输出表示所述物镜的焦点调整状态的信号，并具有多个感测元件，以及设置在所述物镜的预定成像面内或附近的光漫射装置， 并且具有确定光扩散度使得可以根据物镜的调节相对地移动光强度分布。

公开(公告)号：US5598248A

公开(公告)日：1997-01-28

申请号：US194642

申请日：1994-02-10

Applicant: Akihiko Nagano ,  Yasuo Suda ,  Kazuki Konishi

Inventor： Akihiko Nagano ,  Yasuo Suda ,  Kazuki Konishi

IPC: A61B3/113 ,  A61B3/14 ,  G02B7/28 ,  G03B13/02 ,  G03B13/18

CPC classification number: G03B13/02 ,  G03B2213/025

Abstract: An optical apparatus detects a visual point of an observer, and reduces the visual axis detection error due to anatomical differences between people, such as the difference in the size of the eye. The apparatus sequentially displays a plurality of marks in a finder, and can calculate a precise visual point position on the basis of errors between the calculated visual point position and the marks when the observer sequentially watches these marks.

Abstract translation: 光学装置检测观察者的视点，并且由于人之间的解剖学差异（诸如眼睛尺寸的差异）而减小视轴检测误差。 设备依次在取景器中显示多个标记，并且当观察者顺序地观看这些标记时，可以基于计算出的视点位置和标记之间的误差来计算精确的视点位置。

公开(公告)号：US5508759A

公开(公告)日：1996-04-16

申请号：US364503

申请日：1994-12-27

Applicant: Kazuki Konishi ,  Yasuo Suda ,  Akihiko Nagano

Inventor： Kazuki Konishi ,  Yasuo Suda ,  Akihiko Nagano

IPC: A61B3/113 ,  A61B3/10

CPC classification number: A61B3/113

Abstract: An apparatus for detecting the visual axis of an observer in accordance with light reflected by a photo-sensor by illuminating an eye of the observer includes a controller means for controlling the accumulation time of the photo-sensor or a quantity of light emitted by a light projector so that the reflected light is sufficient to permit the detection of the visual axis.

Abstract translation: 用于通过照射观察者的眼睛来检测由光传感器反射的光的观察者的视轴的装置包括：控制装置，用于控制光传感器的累积时间或由光发射的光量 使得反射光足以允许检测视轴。