公开(公告)号：US07917215B2

公开(公告)日：2011-03-29

申请号：US12276070

申请日：2008-11-21

申请人： Yi Zhang ,  Yinghong Yu ,  Aaron McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos A. Ricci ,  Scott A. Meyer

发明人： Yi Zhang ,  Yinghong Yu ,  Aaron McCabe ,  Jiang Ding ,  Jeffrey E. Stahmann ,  Carlos A. Ricci ,  Scott A. Meyer

IPC分类号： A61N1/00

CPC分类号： A61N1/3712 ,  A61N1/3627 ,  A61N1/365 ,  G06F19/00

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。 设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。 使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。 在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

公开(公告)号：US07890159B2

公开(公告)日：2011-02-15

申请号：US10955397

申请日：2004-09-30

申请人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

发明人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

IPC分类号： A61B5/0428 ,  A61B5/0452

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

公开(公告)号：US20110144511A1

公开(公告)日：2011-06-16

申请号：US13027612

申请日：2011-02-15

申请人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

发明人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

IPC分类号： A61B5/0402

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

公开(公告)号：US20060253164A1

公开(公告)日：2006-11-09

申请号：US11124972

申请日：2005-05-09

申请人： Yi Zhang ,  Jiang Ding ,  Aaron McCabe ,  Scott Meyer

发明人： Yi Zhang ,  Jiang Ding ,  Aaron McCabe ,  Scott Meyer

IPC分类号： A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/365

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

公开(公告)号：US20070043395A1

公开(公告)日：2007-02-22

申请号：US11208923

申请日：2005-08-22

申请人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

发明人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

IPC分类号： A61N1/39

CPC分类号： A61N1/3943

摘要： A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

摘要翻译： 在第一内部胸部位置输送非去纤颤和非诱导性能量。 在心脏的目标区域中或附近的第二内部胸部位置检测到第一个产生的电信号。 使用非去纤颤和非原纤维诱发能量，首先得到的电信号和目标电场强度来估计第一除颤阈值。 除颤阈值表示当在第一内部胸部位置递送时在心脏的目标区域中产生满足或超过目标电场强度的电场强度的能量。

公开(公告)号：US08696589B2

公开(公告)日：2014-04-15

申请号：US12847698

申请日：2010-07-30

申请人： Jonathan T. Kwok ,  Marina Brockway ,  Kent Lee ,  Quan Ni ,  Yachuan Pu ,  Jeffrey E. Stahmann ,  Yi Zhang ,  Jesse W. Hartley

发明人： Jonathan T. Kwok ,  Marina Brockway ,  Kent Lee ,  Quan Ni ,  Yachuan Pu ,  Jeffrey E. Stahmann ,  Yi Zhang ,  Jesse W. Hartley

IPC分类号： A61B5/08

CPC分类号： A61B5/091 ,  A61B5/0031 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/113 ,  A61B5/4818 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36535

摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.

摘要翻译： 基于无序呼吸指数提供心力衰竭状态评估。 感测患者呼吸并产生呼吸信号。 基于呼吸信号检测到无序呼吸事件。 基于无序呼吸发作确定无序呼吸指数。 无序呼吸指数趋向并用于评估心力衰竭状态。 无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

公开(公告)号：US07922669B2

公开(公告)日：2011-04-12

申请号：US11148107

申请日：2005-06-08

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US20090287106A1

公开(公告)日：2009-11-19

申请号：US12510962

申请日：2009-07-28

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US20080139951A1

公开(公告)日：2008-06-12

申请号：US11608578

申请日：2006-12-08

申请人： Abhilash Patangay ,  Marina Brockway ,  Jeffrey E. Stahmann ,  Yi Zhang ,  Gerrard M. Carlson

发明人： Abhilash Patangay ,  Marina Brockway ,  Jeffrey E. Stahmann ,  Yi Zhang ,  Gerrard M. Carlson

IPC分类号： A61B5/026 ,  A61F2/82

CPC分类号： A61B5/411 ,  A61B5/0031 ,  A61B5/02007 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/0402 ,  A61B5/076 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61F2/02 ,  A61F2/91 ,  A61F2250/0002

摘要： A system for detecting stenosis in a patient. The system includes an implantable sensing unit having a turbulence sensor and a communication device for transmitting a signal from the turbulence sensor. The system also includes a cardiac sensor for generating a signal corresponding to cardiac activity and a processing device configured to receive signals from the sensing unit and from the cardiac sensor. The processing device is configured to determine a time window corresponding to cardiac activity, to determine a turbulence level from the turbulence signal within the time window, and to detect the presence of stenosis from the turbulence level.

摘要翻译： 一种用于检测患者狭窄的系统。 该系统包括具有湍流传感器的可植入感测单元和用于从湍流传感器发送信号的通信装置。 该系统还包括用于产生对应于心​​脏活动的信号的心脏传感器和被配置为从感测单元和心脏传感器接收信号的处理装置。 处理装置被配置为确定对应于心脏活动的时间窗口，以确定在时间窗口内的湍流信号的湍流水平，并且从湍流水平检测狭窄的存在。

公开(公告)号：US20060282000A1

公开(公告)日：2006-12-14

申请号：US11148107

申请日：2005-06-08

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。