公开(公告)号：US06863821B2

公开(公告)日：2005-03-08

申请号：US10066311

申请日：2002-02-02

Applicant: Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

Inventor： Julie Moriarty ,  Rohit Vishnoi ,  Gretchen Kunas

IPC: A61M1/16 ,  A61M1/26 ,  B01D61/18 ,  B01D61/28 ,  B01D63/16 ,  B01D65/08 ,  B01D61/00 ,  B01D21/26 ,  B01D61/24

CPC classification number: B01D63/16 ,  A61M1/16 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/145 ,  B01D61/18 ,  B01D61/28 ,  B01D63/06 ,  B01D65/08 ,  B01D2321/2033 ,  B01D2321/2041 ,  B01D2321/205

Abstract: Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

公开(公告)号：US06706008B2

公开(公告)日：2004-03-16

申请号：US09800133

申请日：2001-03-06

Applicant: Rohit Vishnoi ,  Richard I. Brown ,  Kyungyoon Min ,  Tom Westberg

Inventor： Rohit Vishnoi ,  Richard I. Brown ,  Kyungyoon Min ,  Tom Westberg

IPC: A61M3700

CPC classification number: A61M1/3693 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/342 ,  A61M1/3441 ,  A61M1/3672 ,  A61M1/3675 ,  A61M1/3679 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/3696 ,  A61M2205/12

Abstract: Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.

Abstract translation: 公开了用于从血液中取出选定化合物的自动化系统和方法。 系统和方法利用安装在可重复使用的硬件部件或模块上的一次性流体回路。 系统从供体或患者抽出血液，将血液分离成两个或更多个组分，并进一步将分离的组分与溶剂组合，以从血液组分中除去化合物。

公开(公告)号：US06348156B1

公开(公告)日：2002-02-19

申请号：US09390492

申请日：1999-09-03

Applicant: Rohit Vishnoi ,  Tom Westberg ,  Matthew R. Muller ,  Kelly B Smith ,  Michel L. F. Joie ,  Mark R Vandlik

Inventor： Rohit Vishnoi ,  Tom Westberg ,  Matthew R. Muller ,  Kelly B Smith ,  Michel L. F. Joie ,  Mark R Vandlik

IPC: B01D2126

CPC classification number: B01D21/34 ,  A61M1/0236 ,  A61M1/3496 ,  A61M1/3646 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0429 ,  A61M2205/125 ,  A61M2205/128 ,  A61M2205/331 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/302 ,  B01D2221/08 ,  B01D2221/10

Abstract: Blood processing systems and methods employ two sensors, one to detect a condition of plasma exiting a separation device and another sensor to detect a condition of a cellular component exiting the separation device. The first sensor detects, e.g., contamination of the plasma due to presence of unwanted cellular components. The second sensor detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors.

Abstract translation: 血液处理系统和方法采用两个传感器，一个用于检测离开分离装置的等离子体的状态，另一个传感器用于检测离开分离装置的细胞组分的状况。 第一传感器检测例如由于存在不想要的细胞组分而导致的等离子体的污染。 第二传感器例如由于存在等离子体而检测细胞成分的稀释。 至少部分地基于由一个或两个传感器检测到的条件进行血液处理参数。