公开(公告)号：US20190231956A1

公开(公告)日：2019-08-01

申请号：US16381354

申请日：2019-04-11

申请人： NxStage Medical, Inc.

发明人： Jeffrey H. BURBANK ,  Dennis M. TREU ,  Daniel J. RUBERY, JR. ,  Scott W. NEWELL ,  James M. BRUGGER ,  William J. SCHNELL ,  William K. WEIGEL ,  Steven A. WHITE ,  Mark T. WYETH ,  Jerome JAMES ,  David DESOUZA ,  Joseph E. TURK, JR. ,  Garrett CASEY

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/14 ,  A61M1/36

CPC分类号： A61M1/1605 ,  A61M1/14 ,  A61M1/1613 ,  A61M1/1615 ,  A61M1/1647 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3448 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3635 ,  A61M2205/058 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3365 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/702

摘要： The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

公开(公告)号：US20180353672A1

公开(公告)日：2018-12-13

申请号：US15781425

申请日：2016-12-02

申请人： QIDNI LABS, INC.

发明人： Morteza AHMADI

IPC分类号： A61M1/34 ,  A61M1/16 ,  A61M37/00

CPC分类号： A61M1/3482 ,  A61M1/1678 ,  A61M1/341 ,  A61M1/3437 ,  A61M1/3609 ,  A61M37/00 ,  A61M2205/3334 ,  A61M2205/505 ,  A61M2205/705 ,  A61M2205/7554 ,  A61M2209/088 ,  A61M2230/20

摘要： Various types of a medical device are described which is used as an implantable renal replacement therapy (an implantable artificial kidney). This device removes toxins and excess water from blood of patients with kidney failure or end stage renal disease. Additionally, other configurations of the device can be used as an external (extracorporeal) device.

公开(公告)号：US10052423B2

公开(公告)日：2018-08-21

申请号：US14342025

申请日：2012-08-23

申请人： Dominique Pouchoulin

发明人： Dominique Pouchoulin

IPC分类号： A61M1/16 ,  G01F1/00 ,  G06F19/00 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/1613 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3607 ,  A61M1/3609 ,  A61M2202/0413 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/75 ,  G01F1/00 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

摘要： An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (Dset).

公开(公告)号：US09968725B2

公开(公告)日：2018-05-15

申请号：US15044194

申请日：2016-02-16

申请人： Fresenius Medical Care Holdings, Inc.

发明人： Barry Neil Fulkerson ,  Martin Hering ,  Frank Isackson

IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M1/16

CPC分类号： A61M1/3643 ,  A61M1/16 ,  A61M1/1696 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3672 ,  A61M2205/128 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/3372 ,  Y10T137/0491

摘要： The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.

公开(公告)号：US09925321B2

公开(公告)日：2018-03-27

申请号：US14654066

申请日：2013-12-16

申请人： GAMBRO LUNDIA AB

发明人： Alessandro Surace ,  Paolo Rovatti

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/1613 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1605 ,  A61M1/1611 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/36 ,  A61M1/3607 ,  A61M2205/3303 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2230/20 ,  A61M2230/65

摘要： It is disclosed an apparatus for extracorporeal blood treatment (1) having a control unit (15) connected to an ultrafiltration device (20) and to a fluid preparation section (30) of fresh dialysis liquid. The control unit (15) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV %mes(t); UFmes(t), WLmes(t); Cbmes(t)); the control unit (15) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

公开(公告)号：US09744284B2

公开(公告)日：2017-08-29

申请号：US14980935

申请日：2015-12-28

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Gino Cicchello ,  Christian Bernard ,  Robert W. Childers ,  Anthony Simiele

IPC分类号： A61M1/28 ,  A61M1/16 ,  A61M1/30 ,  A61M1/34

CPC分类号： A61M1/282 ,  A61M1/1039 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1611 ,  A61M1/1639 ,  A61M1/168 ,  A61M1/1682 ,  A61M1/1686 ,  A61M1/1688 ,  A61M1/169 ,  A61M1/1694 ,  A61M1/1696 ,  A61M1/28 ,  A61M1/284 ,  A61M1/288 ,  A61M1/30 ,  A61M1/34 ,  A61M1/3417 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3437 ,  A61M1/3444 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2210/1017

摘要： A method for a hybrid blood and peritoneal dialysis (“PD”) machine comprising: (i) determining whether a previous treatment left a last fill of dialysate in a patient's peritoneum; (ii) if a next treatment is a PD treatment, and if the previous treatment did not leave the last fill of dialysate, causing a PD treatment in which a first cycle is a fill cycle to be initiated; (iii) if the next treatment is a PD treatment, and if the previous treatment did leave the last fill of dialysate, causing a PD treatment in which a first cycle is a last fill drain cycle to be initiated; and (iv) if the next treatment is a blood treatment and if the previous treatment did leave the last fill of dialysate, causing a blood treatment including a last fill drain cycle to be initiated.

公开(公告)号：US20170065760A1

公开(公告)日：2017-03-09

申请号：US15353883

申请日：2016-11-17

申请人： GAMBRO LUNDIA AB

发明人： Mauro Suffritti ,  Michela Carpani

IPC分类号： A61M1/34 ,  B01D61/32 ,  B01D61/22

CPC分类号： A61M1/341 ,  A61M1/1603 ,  A61M1/1615 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3639 ,  A61M2205/3331 ,  A61M2205/502 ,  A61M2205/52 ,  B01D61/22 ,  B01D61/32 ,  B01D2311/14

摘要： An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9; 9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (δTMP1), determine a value of a control parameter (φ1) corresponding to the first increase, compare the value of the control parameter (φ1) with a reference value (φref) and, if the value of the control parameter is greater than the reference value, command the regulating device (20) by setting a second increase (δTMP2) which is greater than the first increase (δTMP1).

摘要翻译： 一种用于体外血液处理的装置，包括具有通过半透膜（5）彼此分离的第一室（3）和第二室（4）的处理单元（2），连接在入口 与第一腔室（3）和血液回流管线（7）连接在出口与第一腔室; 更换流体的输液管线（9; 9a，9b）和连接在第二室的出口处的排液管线（10）。 跨膜压力的调节装置（20）在至少一条线路上有效，并且控制单元（15）被配置为：通过设定第一增加（δTMP1）来指示调节装置（20），确定 对应于第一增加的控制参数（φ1），将控制参数（φ1）的值与参考值（φref）进行比较，并且如果控制参数的值大于参考值，则命令调节装置 20）通过设定大于第一增加（δTMP1）的第二增加（δTMP2）。

公开(公告)号：US20160296688A1

公开(公告)日：2016-10-13

申请号：US15184492

申请日：2016-06-16

申请人： Fenwal, Inc.

发明人： Daniel R. Boggs ,  Kyungyoon Min ,  Lan T. Nguyen ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/34 ,  A61M1/38 ,  A61M1/36

CPC分类号： A61M1/3455 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3496 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2205/3334 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/207 ,  G06F19/00

摘要： Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

摘要翻译： 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。

公开(公告)号：US20160106904A1

公开(公告)日：2016-04-21

申请号：US14980935

申请日：2015-12-28

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Gino Cicchello ,  Christian Bernard ,  Robert W. Childers ,  Anthony Simiele

IPC分类号： A61M1/28 ,  A61M1/16

CPC分类号： A61M1/282 ,  A61M1/1039 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1611 ,  A61M1/1639 ,  A61M1/168 ,  A61M1/1682 ,  A61M1/1686 ,  A61M1/1688 ,  A61M1/169 ,  A61M1/1694 ,  A61M1/1696 ,  A61M1/28 ,  A61M1/284 ,  A61M1/288 ,  A61M1/30 ,  A61M1/34 ,  A61M1/3417 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3437 ,  A61M1/3444 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2210/1017

摘要： A method for a hybrid blood and peritoneal dialysis (“PD”) machine comprising: (i) determining whether a previous treatment left a last fill of dialysate in a patient's peritoneum; (ii) if a next treatment is a PD treatment, and if the previous treatment did not leave the last fill of dialysate, causing a PD treatment in which a first cycle is a fill cycle to be initiated; (iii) if the next treatment is a PD treatment, and if the previous treatment did leave the last fill of dialysate, causing a PD treatment in which a first cycle is a last fill drain cycle to be initiated; and (iv) if the next treatment is a blood treatment and if the previous treatment did leave the last fill of dialysate, causing a blood treatment including a last fill drain cycle to be initiated.

摘要翻译： 一种混合血液和腹膜透析（“PD”）机器的方法，包括：（i）确定先前的治疗是否留在患者腹膜中最后一次填充透析液; （ii）如果接下来的治疗是PD治疗，并且如果先前的治疗没有留下透析液的最后一次填充，则进行第一周期是填充周期的PD治疗开始; （iii）如果下一次治疗是PD治疗，并且如果先前的治疗确实离开了最后一次充满透析液，则进行首次循环是最后一次填充排水循环的PD治疗; 和（iv）如果接下来的治疗是血液处理，并且如果先前的治疗确实离开了最后一次充满透析液，则开始进行包括最后一次填充排水循环的血液处理。

公开(公告)号：US20160106901A1

公开(公告)日：2016-04-21

申请号：US14976773

申请日：2015-12-21

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Thomas Kelly ,  Robert W. Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Musalem El Sayyid ,  Shahid Din

IPC分类号： A61M1/16 ,  A61M1/34

CPC分类号： A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

摘要： A renal failure therapy machine includes a blood cleaning filter, a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter, a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance.

摘要翻译： 肾衰竭治疗机包括血液清洁过滤器，被配置为从血液清洁过滤器再生使用的治疗流体的吸附剂装置，被配置为将再生的治疗流体从吸附装置泵回到血液净化过滤器的治疗液泵， 与血液净化过滤器，治疗流体泵和吸附剂装置流体连通的限流器，流量限制器构造成使由治疗流体泵从吸附装置泵送到血液净化过滤器的再生治疗液被加压，使得第一 再生治疗液的量进行对流清除，第二量的再生治疗液进行扩散间隙。