公开(公告)号：US07838855B2

公开(公告)日：2010-11-23

申请号：US12141603

申请日：2008-06-18

申请人： Yusuke Fujii ,  Hisataka Fujimaki ,  Kazuo Hiramoto

发明人： Yusuke Fujii ,  Hisataka Fujimaki ,  Kazuo Hiramoto

IPC分类号： A61N5/00 ,  H05H13/04 ,  G21K5/10

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  G21K5/04

摘要： A charged particle irradiation system that positions the beam at a target position to avoid irradiation of normal tissue includes an acceleration system 6 for extracting a charged particle beam, scanning magnets 24 and 25, and charged particle beam position monitors 26 and 27. On the basis of signals received from the charged particle beam position monitors 26 and 27, the control unit 70 calculates a beam position at a target position and then controls the scanning magnets 24 and 25 so that the charged particle beam is moved to a desired irradiation position at the target position. The control unit 70 corrects the value of an excitation current applied to each of the scanning magnets 24 and 25 on a specified cycle basis on the basis of information about the position and the angle of the charged particle beam.

摘要翻译： 将光束定位在目标位置以避免正常组织照射的带电粒子照射系统包括用于提取带电粒子束的加速系统6，扫描磁体24和25以及带电粒子束位置监视器26和27.在此基础上 从充电的粒子束位置监视器26和27接收的信号，控制单元70计算目标位置处的光束位置，然后控制扫描磁体24和25，使得带电粒子束移动到所需的照射位置 目标位置。 控制单元70基于关于带电粒子束的位置和角度的信息，在指定的周期基础上校正施加到每个扫描磁体24和25的激励电流的值。

公开(公告)号：US07709818B2

公开(公告)日：2010-05-04

申请号：US11239073

申请日：2005-09-30

申请人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

发明人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1079 ,  A61N2005/1074 ,  A61N2005/1087

摘要： To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes: a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.

摘要翻译： 为了确保照射精度和安全性，即使使用采用不同的照射方式的照射装置，在此公开了一种带电粒子束照射被照射靶的带电粒子束照射装置，包括：带电粒子束发生器，用于产生带电粒子 梁; 被动散射照射装置和扫描照射装置，用于向照射目标照射带电粒子束; 用于将从带电粒子束发生器提取的带电粒子束传送到两个照射装置中的一个的光束传输系统; 以及根据所选择的照射装置采用的照射方法修改带电粒子束发生器的工作参数的中央控制器。

公开(公告)号：US20090039256A1

公开(公告)日：2009-02-12

申请号：US12141603

申请日：2008-06-18

申请人： Yusuke FUJII ,  Hisataka Fujimaki ,  Kazuo Hiramoto

发明人： Yusuke FUJII ,  Hisataka Fujimaki ,  Kazuo Hiramoto

IPC分类号： G01N23/00

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  G21K5/04

摘要： A charged particle irradiation system that positions the beam at a target position to avoid irradiation of normal tissue includes an acceleration system 6 for extracting a charged particle beam, scanning magnets 24 and 25, and charged particle beam position monitors 26 and 27. On the basis of signals received from the charged particle beam position monitors 26 and 27, the control unit 70 calculates a beam position at a target position and then controls the scanning magnets 24 and 25 so that the charged particle beam is moved to a desired irradiation position at the target position. The control unit 70 corrects the value of an excitation current applied to each of the scanning magnets 24 and 25 on a specified cycle basis on the basis of information about the position and the angle of the charged particle beam.

摘要翻译： 将光束定位在目标位置以避免正常组织照射的带电粒子照射系统包括用于提取带电粒子束的加速系统6，扫描磁体24和25以及带电粒子束位置监视器26和27.在此基础上 从充电的粒子束位置监视器26和27接收的信号，控制单元70计算目标位置处的光束位置，然后控制扫描磁体24和25，使得带电粒子束移动到所需的照射位置 目标位置。 控制单元70基于关于带电粒子束的位置和角度的信息，在指定的周期基础上校正施加到每个扫描磁体24和25的激励电流的值。

公开(公告)号：US07405407B2

公开(公告)日：2008-07-29

申请号：US11704372

申请日：2007-02-09

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Yoshihiko Nagamine ,  Alfred Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Yoshihiko Nagamine ,  Alfred Smith ,  Wayne Newhauser

IPC分类号： H01L25/00 ,  A61N5/01 ,  A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/1069 ,  A61N2005/1061 ,  A61N2005/1087

摘要： A therapy system using an ion beam, which can shorten the time required for positioning a couch (patient). The therapy system using the ion beam comprises a rotating gantry provided with an ion beam delivery unit including an X-ray tube. An X-ray detecting device having a plurality of X-ray detectors can be moved in the direction of a rotation axis of the rotating gantry. A couch on which a patient is lying is moved until a tumor substantially reaches an extension of an ion beam path in the irradiating unit. The X-ray tube is positioned on the ion beam path and the X-ray detecting device is positioned on the extension of the ion beam path. With rotation of the rotating gantry, both the X-ray tube emitting an X-ray and the X-ray detecting device revolve around the patient. The X-ray is emitted to the patient and detected by the X-ray detectors after penetrating the patient. Tomographic information of the patient is formed based on signals outputted from the X-ray detectors. Information for positioning the couch is generated by using the tomographic information.

摘要翻译： 使用离子束的治疗系统，其可以缩短定位沙发（患者）所需的时间。 使用离子束的治疗系统包括设置有包括X射线管的离子束输送单元的旋转台架。 具有多个X射线检测器的X射线检测装置能够沿旋转机架的旋转轴线的方向移动。 将患者躺在其上的沙发移动直到肿瘤基本上到达照射单元中的离子束路径的延伸。 X射线管位于离子束路径上，X射线检测装置位于离子束路径的延伸部上。 通过旋转机架的旋转，发射X射线的X射线管和X射线检测装置都围绕患者转动。 X射线发射到患者身上，并在穿透患者后由X射线检测器进行检测。 基于从X射线检测器输出的信号形成病人的层析信息。 通过使用层析信息生成用于定位沙发的信息。

公开(公告)号：US20070252093A1

公开(公告)日：2007-11-01

申请号：US11414204

申请日：2006-05-01

申请人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred Smith ,  Kazuo Hiramoto

发明人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred Smith ,  Kazuo Hiramoto

IPC分类号： G21K1/10 ,  A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10 ,  G21K5/04

摘要： The invention is intended to confirm whether the SOBP (spread-out Bragg peak) width is a desired value in real time during beam irradiation, and to improve safety in treatment. Ion beam delivery equipment comprises a beam generator including a synchrotron, an RMW (range modulation wheel) device for forming an SOBP width of an ion beam extracted from the beam generator, a beam delivery nozzle including a reference dose monitor and a main dose monitor which are installed respectively upstream and downstream of the RMW device in the direction of travel of the ion beam, and an SOBP width computing unit for computing the SOBP width of the ion beam, which is formed by the RMW device, based on values detected by both the reference dose monitor and the main dose monitor.

摘要翻译： 本发明旨在确认在光束照射期间SOBP（展​​开布拉格峰）宽度是否是实时的期望值，并且提高了处理中的安全性。 离子束输送设备包括一个光束发生器，它包括同步加速器，用于形成从光束发生器提取的离子束的SOBP宽度的RMW（范围调制轮）装置，包括参考剂量监测器和主剂量监测器 分别安装在RMW装置的上游和下游沿着离子束行进的方向;以及SOBP宽度计算单元，用于根据由两个检测到的值计算由RMW装置形成的离子束的SOBP宽度 参考剂量监测仪和主剂量监测仪。

公开(公告)号：US20070215819A1

公开(公告)日：2007-09-20

申请号：US11704372

申请日：2007-02-09

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Yoshihiko Nagamine ,  Alfred Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Yoshihiko Nagamine ,  Alfred Smith ,  Wayne Newhauser

IPC分类号： A61N5/01

CPC分类号： A61N5/1049 ,  A61N5/1069 ,  A61N2005/1061 ,  A61N2005/1087

摘要： A therapy system using an ion beam, which can shorten the time required for positioning a couch (patient). The therapy system using the ion beam comprises a rotating gantry provided with an ion beam delivery unit including an X-ray tube. An X-ray detecting device having a plurality of X-ray detectors can be moved in the direction of a rotation axis of the rotating gantry. A couch on which a patient is lying is moved until a tumor substantially reaches an extension of an ion beam path in the irradiating unit. The X-ray tube is positioned on the ion beam path and the X-ray detecting device is positioned on the extension of the ion beam path. With rotation of the rotating gantry, both the X-ray tube emitting an X-ray and the X-ray detecting device revolve around the patient. The X-ray is emitted to the patient and detected by the X-ray detectors after penetrating the patient. Tomographic information of the patient is formed based on signals outputted from the X-ray detectors. Information for positioning the couch is generated by using the tomographic information.

公开(公告)号：US20060065855A1

公开(公告)日：2006-03-30

申请号：US11206150

申请日：2005-08-18

申请人： Shunji Kakiuchi ,  Akiko Kakiuchi ,  Kikuo Umegaki ,  Kazuo Hiramoto

发明人： Shunji Kakiuchi ,  Akiko Kakiuchi ,  Kikuo Umegaki ,  Kazuo Hiramoto

IPC分类号： G21K5/10

CPC分类号： H05H7/04 ,  G21K5/04

摘要： A particle beam irradiation system which can increase an availability factor. An ion beam extracted from one proton beam linac is bent at 90 degrees by a switching magnet and is introduced to RI production equipment through a beam line. In the RI production equipment, a RI is produced using the introduced ion beam. An ion beam extracted from the other proton beam linac is bent at 90 degrees by the switching magnet and is introduced to a synchrotron through a beam line. The ion beam extracted from the synchrotron is irradiated to a patient from irradiation equipment. If one proton beam linac comes into an abnormal state, the one proton beam linac is stopped in operation and checked. During the check, the ion beam extracted from the other proton beam linac is selectively introduced to the RI production equipment and the synchrotron by the switching magnet.

摘要翻译： 可以增加可用性因素的粒子束照射系统。 从一个质子束线性加速器提取的离子束通过切换磁体以90度弯曲，并通过射束线被引入RI生产设备。 在RI生产设备中，使用引入的离子束产生RI。 从另一质子束直线加速器提取的离子束通过切换磁体以90度弯曲，并通过射束线被引入同步加速器。 从同步加速器提取的离子束从照射设备照射到患者身上。 如果一个质子束线性加速器处于异常状态，则一个质子束线性加速器停止运行并进行检查。 在检查期间，从其他质子束线性加速器提取的离子束通过切换磁体选择性地引入RI生产设备和同步加速器。

公开(公告)号：US06774383B2

公开(公告)日：2004-08-10

申请号：US10395144

申请日：2003-03-25

申请人： Tetsuro Norimine ,  Masumi Umezawa ,  Kazuo Hiramoto

发明人： Tetsuro Norimine ,  Masumi Umezawa ,  Kazuo Hiramoto

IPC分类号： H05H1304

CPC分类号： A61N5/1048 ,  A61N5/1065 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04 ,  H05H7/04

摘要： A particle therapy system is provided which can simply and quickly correct a beam orbit. In a particle therapy system provided with an irradiation facility comprising a first beam transport system for receiving a beam and transporting the beam to the patient side, and an irradiation nozzle for forming an irradiation field of the beam, the particle therapy system comprises first beam position monitors for detecting a position upstream of the irradiation nozzle at which the beam passes, second beam position monitors for detecting a position downstream of the irradiation nozzle at which the charged-particle beam passes, and first and second steering magnets. Correction bending amounts for causing the beam to be coincident with a predetermined orbit after the correction are determined in accordance with detected results from the first and second beam position monitors, and first and second steering magnets are excited under control so that the determined correction bending amounts are obtained.

公开(公告)号：US06265837B1

公开(公告)日：2001-07-24

申请号：US09265557

申请日：1999-03-09

申请人： Hiroshi Akiyama ,  Kazuo Hiramoto ,  Koji Matsuda

发明人： Hiroshi Akiyama ,  Kazuo Hiramoto ,  Koji Matsuda

IPC分类号： H05H1304

CPC分类号： A61N5/1043 ,  A61N5/1045 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K5/04

摘要： A charged-particle beam irradiation method and system are disclosed in which while a charged-particle beam ejected from an accelerator is scanned by an electromagnet, each layer resulting from the division of an affected part into a plurality of layers in the direction of progression of the charged-particle beam is irradiated with the charged-particle beam. The intensity of a charged-particle beam for irradiation of a first layer is made lower than the intensity of a charged-particle beam for irradiation of a second layer existing at a position deeper than the first layer in the beam progressing direction. A scanning speed in the first layer is changed between a portion of the first layer subjected to irradiation at the time of irradiation of the second layer and a portion of the first layer subjected to no irradiation at the time of irradiation of the second layer.

摘要翻译： 公开了一种带电粒子束照射方法和系统，其中当从加速器喷射的带电粒子束被电磁体扫描时，由将受影响部分分解为沿着 用带电粒子束照射带电粒子束。 使用于照射第一层的带电粒子束的强度低于存在于比第一层在光束前进方向更深的位置处的第二层的照射的带电粒子束的强度。 第一层的扫描速度在照射第二层时照射的第一层的一部分与在第二层的照射时不进行照射的第一层的一部分之间变化。

公开(公告)号：US5783914A

公开(公告)日：1998-07-21

申请号：US931840

申请日：1997-09-17

申请人： Kazuo Hiramoto ,  Junichi Hirota ,  Masahiro Tadokoro ,  Hiroaki Sakurabata

发明人： Kazuo Hiramoto ,  Junichi Hirota ,  Masahiro Tadokoro ,  Hiroaki Sakurabata

IPC分类号： H05H13/04 ,  A61N5/10 ,  H05H7/10 ,  H05H11/00

CPC分类号： H05H7/10 ,  A61N2005/1087

摘要： The present invention provides apparatus for acceleration of a charged particle beam which includes energy means for altering the energy of a circulating beam circulating in the apparatus and means for extracting output beams from the apparatus. Control means are arranged to be operable to alter the energy of the circulating beam using the energy means so as to be able to extract output beams of at least two energies from the apparatus using the means for extracting. Thus there is provided an accelerator, and an extraction method therefor, which is capable of extracting a small diameter beam having a varying energy level. This facilitates improved medical irradiation treatment using the beam.

摘要翻译： 本发明提供了一种用于加速带电粒子束的装置，其包括用于改变在装置中循环的循环波束的能量的能量装置和用于从装置中提取输出光束的装置。 控制装置被布置成可操作以使用能量装置改变循环波束的能量，以便能够使用提取装置从装置中提取至少两个能量的输出光束。 因此，提供了能够提取具有变化的能级的小直径光束的加速器及其提取方法。 这有利于使用束的改进的医疗照射处理。