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62 条记录 (耗时 0.032 秒)

    L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
    21.
    发明授权
    L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides 失效
    掺入聚合物结构中的L-核苷用于寡核苷酸的稳定化

    公开(公告)号：US5808040A

    公开(公告)日：1998-09-15

    申请号：US682623

    申请日：1997-01-24

    申请人： Chung K. Chu ,  Yung-Chi Cheng ,  Balakrishna S. Pai ,  Gang-Qing Yao

    发明人： Chung K. Chu ,  Yung-Chi Cheng ,  Balakrishna S. Pai ,  Gang-Qing Yao

    IPC分类号： C07H19/04 ,  C07H1/00 ,  C07H21/04

    CPC分类号： C07H19/04

    摘要： A method for stabilizing an oligonucleotide by including a .beta.-L-2'-deoxy-2'-fluoro-arabinofuranosyl nucleoside at the 5'-terminus, the 3'-terminus, or in the interior of the oligonucleotide. The oligonucleotide can be used in the modulation of gene expression through a process wherein a synthetic oligonucleotide is hybridized to a complementary nucleic acid sequence to inhibit transcription or replication of DNA or to inhibit translation or processing of RNA.

    摘要翻译： PCT No.PCT / US95 / 01253 Sec。 371日期1997年1月24日 102（e）日期1997年1月24日PCT 1995年1月30日PCT PCT。 公开号WO95 / 20595 日期1995年8月3日一种通过在寡核苷酸的5'端，3'端或内部包含β-2'-2'-脱氧-2'-氟 - 阿拉伯呋喃糖基核苷来稳定寡核苷酸的方法 。 寡核苷酸可以通过其中合成的寡核苷酸与互补核酸序列杂交以抑制DNA的转录或复制或抑制RNA的翻译或加工的方法用于调节基因表达。

    Process of preparing 2-azido-2-deoxyarabinofuranosyl halides
    23.
    发明授权
    Process of preparing 2-azido-2-deoxyarabinofuranosyl halides 失效
    2-叠氮基-2-脱氧阿拉伯呋喃糖基卤化物的制备方法

    公开(公告)号：US4321366A

    公开(公告)日：1982-03-23

    申请号：US156202

    申请日：1980-06-03

    申请人： Miroslav V. Bobek ,  Alexander Bloch ,  Yung-Chi Cheng

    发明人： Miroslav V. Bobek ,  Alexander Bloch ,  Yung-Chi Cheng

    IPC分类号： C07H9/04 ,  C07H11/00 ,  C07H19/06 ,  C07H19/16 ,  C07H5/02 ,  C07H5/04

    CPC分类号： C07H9/04 ,  C07H11/00 ,  C07H19/06 ,  C07H19/16

    摘要： Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido,2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2'-azido group to a 2'-amino group and, if desired, alkylation or the like to convert the 2'-amino group to a 2'-hydrocarbylamino group.

    摘要翻译： 通过嘧啶，嘌呤或1,3-恶嗪碱的缩合制备具有抗肿瘤，抗病毒和抗微生物特性的具有2'-叠氮基，2'-氨基或2'-烃基氨基取代基的新型阿拉伯呋喃糖基核苷和核苷酸 与酰化的2-叠氮基-2-脱氧阿拉伯呋喃糖基卤化物反应，然后适当地解封和催化氢化，将2'-叠氮基转化为2'-氨基，如果需要，将烷基化等转化成2 '氨基组成2'-烃基氨基。

    CASE FOR COMMUNICATION SIGNAL ACCESS APPARATUS
    24.
    发明申请
    CASE FOR COMMUNICATION SIGNAL ACCESS APPARATUS 审中-公开
    用于通信信号接入设备的情况

    公开(公告)号：US20110147246A1

    公开(公告)日：2011-06-23

    申请号：US12683469

    申请日：2010-01-07

    申请人： Yung-Chi Cheng ,  Ching-Feng Hsieh

    发明人： Yung-Chi Cheng ,  Ching-Feng Hsieh

    IPC分类号： B65D43/14 ,  B65D85/00

    CPC分类号： H05K5/061

    摘要： A case for communication signal access apparatus comprises a box, a cover, and a hinge portion. The opening surrounding the box is configured with a first leaning part, and the opening surrounding the box is configured with a second leaning part, and the edge surrounding the second leaning part is configured with side dike. The hinge portion is configured on the inner surface on one side of the box and on the inner surface on one side of the cover. When the cover is closed and sealed with the box, the side dike seals the seam from the closing of the first leaning part with the second leaning part. Thus, the case for communication signal access apparatus according to the present invention employs the side dike to separate water or dust from introducing into the case through the seam between the first leaning part and the second leaning part.

    摘要翻译： 用于通信信号存取装置的壳体包括盒，盖和铰链部。 围绕箱体的开口配置有第一倾斜部分，围绕箱体的开口构造有第二倾斜部分，并且围绕第二倾斜部分的边缘构造有侧堤。 铰链部分配置在箱的一侧的内表面和盖的一侧的内表面上。 当盖子被封闭并用箱密封时，侧堤将第一倾斜部分与第二倾斜部分的关闭密封在一起。 因此，根据本发明的通信信号存取装置的情况采用侧堤将水或灰尘从第一倾斜部分和第二倾斜部分之间的接缝分开引入壳体。

    ELECTRICAL PROTECTION
    26.
    发明申请
    ELECTRICAL PROTECTION 有权
    电气保护

    公开(公告)号：US20110097912A1

    公开(公告)日：2011-04-28

    申请号：US12620099

    申请日：2009-11-17

    申请人： Yung-Chi Cheng ,  Ching-Feng Hsieh

    发明人： Yung-Chi Cheng ,  Ching-Feng Hsieh

    IPC分类号： H01R13/44

    CPC分类号： H01R13/447

    摘要： An electrical protection for mounting on a wire connector housing, wherein the wire connector housing comprises a fixed hole and a plurality of wire-lock apertures exposed on a top surface of the wire connector housing, and the electrical protection comprise an insulating body and an insulating protrusion located at bottom surface of the insulating body. The insulating body is used to cover the wire-lock apertures at the top surface of the wire connector housing, and the insulating protrusion is designed and constructed to fit into the fixed hole of the wire connector housing. The wire-lock apertures of the wire connector housing are all covered and insulated to prevent electrical shock from the electrical leakage through the exposed apertures.

    摘要翻译： 一种用于安装在电线连接器壳体上的电气保护，其中所述电线连接器壳体包括固定孔和暴露在所述电线连接器壳体的顶表面上的多个线锁孔，并且所述电保护包括绝缘体和绝缘体 突起位于绝缘体的底面。 绝缘体用于覆盖电线连接器壳体顶表面处的线锁孔，并且绝缘突起被设计和构造成装配到电线连接器壳体的固定孔中。 电线连接器外壳的线锁孔全部被覆盖和绝缘，以防止通过暴露孔的漏电引起的电击。

    Novel Antiviral Helioxanthin Analogs
    28.
    发明申请
    Novel Antiviral Helioxanthin Analogs 有权
    新型抗病毒Helioxanthin类似物

    公开(公告)号：US20080167353A1

    公开(公告)日：2008-07-10

    申请号：US11579284

    申请日：2005-05-02

    申请人： Hosup Yeo ,  David J. Austin ,  Ling Li ,  Yung-Chi Cheng

    发明人： Hosup Yeo ,  David J. Austin ,  Ling Li ,  Yung-Chi Cheng

    IPC分类号： C07D285/02 ,  A61K31/335

    CPC分类号： A61K31/365 ,  A61K31/36 ,  A61K31/517 ,  C07D405/04 ,  C07D407/04 ,  C07D491/04 ,  C07D493/04

    摘要： The present invention relates to novel antiviral helioxanthin analogs. These compounds may particularly be used alone or in combination with other drugs for the treatment of the following: hepadnaviruses, flaviviruses, herpesviruses and human immunodeficiency virus. In addition, compounds according to the present invention can be used to prevent or reduce the likelihood of the occurrence of tumors secondary to virus infection as well as other infections or disease states that are secondary to the virus infection.

    摘要翻译： 本发明涉及新的抗病毒螺甲黄素类似物。 这些化合物可以单独使用或与其他药物组合使用，用于治疗以下物质：肝素病毒，黄病毒，疱疹病毒和人类免疫缺陷病毒。 此外，根据本发明的化合物可用于预防或减少继发于病毒感染的肿瘤以及其它感染或继发于病毒感染的疾病状态的可能性。

    Novel nucleosides and related processes, pharmaceutical compositions and methods
    29.
    发明申请
    Novel nucleosides and related processes, pharmaceutical compositions and methods 审中-公开
    新型核苷和相关方法，药物组合物和方法

    公开(公告)号：US20050239726A1

    公开(公告)日：2005-10-27

    申请号：US11171181

    申请日：2005-06-30

    申请人： Alan Sartorelli ,  Yung-Chi Cheng ,  Mao-Chin Liu

    发明人： Alan Sartorelli ,  Yung-Chi Cheng ,  Mao-Chin Liu

    IPC分类号： A61K31/7052 ,  A61K31/7056 ,  C07H19/22

    CPC分类号： C07H19/22

    摘要： The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

    摘要翻译： 本发明提供新的核苷和相关方法，药物组合物和方法。 新型核苷可用于各种抗病毒，抗肿瘤和抗菌应用。 本发明的优选实施方案包括3-脱氮腺苷的新的2个卤素取代的3个卤素取代的和2'，3'-卤素取代的类似物，以及3-脱氮鸟苷的新的3个卤素取代的类似物。 本发明的化合物包括4-氨基-6-氟-1-（β-D-呋喃核糖基）咪唑并[4,5-c]吡啶和6-氨基-7-溴-1,5-二氢-1- β-吡唑糖基咪唑并[4,5-c]吡啶-4-酮在体外具有很强的抗病毒和抗癌活性。 该化合物也可用于伴随病毒感染如AIDS的细菌感染的治疗。