公开(公告)号：US08163787B2

公开(公告)日：2012-04-24

申请号：US13006004

申请日：2011-01-13

申请人： Richard Clark ,  Fumiyoshi Matsuura ,  Kazunobu Kira ,  Shinsuke Hirota ,  Hiroshi Azuma ,  Tadashi Nagakura ,  Tatsuo Horizoe ,  Kimiyo Tabata ,  Kazutomi Kusano ,  Takao Omae ,  Atsushi Inoue

发明人： Richard Clark ,  Fumiyoshi Matsuura ,  Kazunobu Kira ,  Shinsuke Hirota ,  Hiroshi Azuma ,  Tadashi Nagakura ,  Tatsuo Horizoe ,  Kimiyo Tabata ,  Kazutomi Kusano ,  Takao Omae ,  Atsushi Inoue

IPC分类号： A61K31/41 ,  A61K31/415 ,  C07D233/00 ,  C07D249/00

CPC分类号： C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04

摘要： A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen.

摘要翻译： 由下列通式（1）表示的化合物或其盐或前述的水合物：其中R1a，R1b，R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R3代表任选取代的C6-10芳基等; Z1和Z2各自独立地表示氢。

公开(公告)号：US07928228B2

公开(公告)日：2011-04-19

申请号：US12748806

申请日：2010-03-29

申请人： Richard Clark ,  Fumiyoshi Matsuura ,  Kazunobu Kira ,  Shinsuke Hirota ,  Hiroshi Azuma ,  Tadashi Nagakura ,  Tatsuo Horizoe ,  Kimiyo Tabata ,  Kazutomi Kusano ,  Takao Omae ,  Atsushi Inoue

发明人： Richard Clark ,  Fumiyoshi Matsuura ,  Kazunobu Kira ,  Shinsuke Hirota ,  Hiroshi Azuma ,  Tadashi Nagakura ,  Tatsuo Horizoe ,  Kimiyo Tabata ,  Kazutomi Kusano ,  Takao Omae ,  Atsushi Inoue

IPC分类号： C07D207/00 ,  C07D233/00 ,  C07D249/00 ,  C07D257/04

CPC分类号： C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04

摘要： A Compound represented by the following general formula (1): wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen or salts thereof or hydrates of the foregoing.

摘要翻译： 由以下通式（1）表示的化合物：其中R1a，R1b，R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R 3表示任选取代的C 6-10芳基等; 并且Z 1和Z 2各自独立地表示氢或其盐或前述的水合物。

公开(公告)号：US07524847B2

公开(公告)日：2009-04-28

申请号：US10537227

申请日：2003-12-02

申请人： Kazunobu Kira ,  Richard Clark ,  Seiji Yoshikawa ,  Taisuke Uehara

发明人： Kazunobu Kira ,  Richard Clark ,  Seiji Yoshikawa ,  Taisuke Uehara

IPC分类号： C07D473/40 ,  C07D473/34 ,  C07D473/18 ,  A61K31/52 ,  A61K31/522 ,  C07D471/04 ,  A61P3/10 ,  A61P3/06 ,  A61P3/04

CPC分类号： C07D473/18 ,  C07D471/04 ,  C07D473/16 ,  C07D473/24 ,  C07D473/32 ,  C07D473/40

摘要： The objective of this invention is to provide novel compounds that show excellent DPPIV-inhibiting activity. The present invention provides compounds represented by the general formula (I), salts thereof, or hydrates thereof, [wherein, T1 stands for a monocyclic or bicyclic 4 to 12-membered heterocycle having 1 or 2 nitrogen atoms in the ring, which may have substituents; in formula (I), the following formula represents a double bond or a single bond; X3 denotes an oxygen atom or a sulfur atom; X1 denotes a C2-6 alkyl group which may have substituents; Z1 denotes a nitrogen atom or the formula —CR3=; Z2 and Z3 each independently denote a nitrogen atom, the formula —CR1=, a carbonyl group, or the formula —NR2—; R1, R2, R3, and X2 each independently denote a C1-6 alkyl group which may have substituents, and such].

摘要翻译： 本发明的目的是提供显示优异DPPIV抑制活性的新型化合物。 本发明提供由通式（I）表示的化合物，其盐或其水合物[其中，T1表示环中具有1或2个氮原子的单环或双环4至12元杂环，其可具有 取代基; 在式（I）中，下式表示双键或单键; X3表示氧原子或硫原子; X1表示可具有取代基的C 2-6烷基; Z1表示氮原子或式-CR3 =; Z2和Z3各自独立地表示氮原子，式-CR1 =，羰基或式-NR2-; R 1，R 2，R 3和X 2各自独立地表示可以具有取代基的C 1-6烷基等。

公开(公告)号：US20080104883A1

公开(公告)日：2008-05-08

申请号：US11874782

申请日：2007-10-18

申请人： Claire Ansell ,  Richard Clark ,  Robert Wardle

发明人： Claire Ansell ,  Richard Clark ,  Robert Wardle

IPC分类号： C10L1/10

CPC分类号： C10L1/1616 ,  C10L1/04 ,  C10L1/08 ,  C10L1/14 ,  C10L1/1608 ,  C10L1/2437 ,  C10L10/00

摘要： In a fuel composition containing a static dissipator additive, a Fischer-Tropsch derived fuel component is blended for the purpose of increasing the electrical conductivity of the composition and/or for reducing the concentration of the static dissipator additive in the composition. The fuel composition is preferably an automotive diesel fuel composition.

摘要翻译： 在含有静电消散剂添加剂的燃料组合物中，为了提高组合物的导电性和/或降低组合物中的静电消散剂添加剂的浓度，共混费 - 托衍生的燃料组分。 燃料组合物优选为汽车柴油燃料组合物。

公开(公告)号：US20080048579A1

公开(公告)日：2008-02-28

申请号：US11881758

申请日：2007-07-27

申请人： David Vernondier ,  Richard Clark

发明人： David Vernondier ,  Richard Clark

IPC分类号： H05B41/24

CPC分类号： H05B39/00 ,  H05B33/0803 ,  H05B33/0815 ,  Y02B20/346

摘要： A light fitting is provided with a first connector piece arranged to support a light and provide power thereto, an input connected to a power source and arranged to provide power permanently to an output comprising a primary coil, and a transmitter operable to transmit a switch signal. A light is provided comprising a sealed light housing, a light source, a back-up battery, a controller and a second connector piece having a secondary coil and a receiver. The receiver receives the switch signal and the controller controls power delivery to the light source in response to the switch signal received by the receiver thereby to turn the light on and off. The light fitting and the light are arranged to present the primary coil and the secondary coil for inductive coupling therebetween and to present the transmitter and the receiver for wireless communication therebetween.

摘要翻译： 灯具设置有第一连接器片，其布置成支撑光并向其提供电力;输入端连接到电源并被布置成永久地向包括初级线圈的输出提供电力;以及发射器，其可操作以传送开关信号 。 提供了包括密封的灯壳体，光源，备用电池，控制器和具有次级线圈和接收器的第二连接器件的灯。 接收器接收开关信号，并且控制器响应于由接收器接收到的开关信号控制向光源的功率传递，从而打开和关闭灯。 灯具和灯被布置成呈现初级线圈和次级线圈，用于在它们之间感应耦合，并且呈现发射器和接收器之间的无线通信。

公开(公告)号：US07253178B2

公开(公告)日：2007-08-07

申请号：US10469173

申请日：2002-03-27

申请人： Hitoshi Harada ,  Masanobu Shinoda ,  Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

发明人： Hitoshi Harada ,  Masanobu Shinoda ,  Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

IPC分类号： A61K31/435 ,  A61K31/44 ,  C07D211/72 ,  C07D211/70

CPC分类号： C07D213/64 ,  C07D213/79

摘要： The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

摘要翻译： 本发明提供了可用作胰岛素敏化剂的新型羧酸衍生物，其盐或其水合物，以及包含该衍生物作为有效成分的药物。 更具体地，它提供由式（I）表示的羧酸化合物，其盐或它们的水合物。 在该式中，Ar表示可以具有至少一个取代基的6至14元芳环基团; R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 8彼此相同或不同，并且各自表示氢原子，卤素原子， 羟基，C 1-6烷基或C 1-6烷氧基; X表示氧原子或亚甲基; Y表示由式（II）或（III）表示的基团：（其中Z表示由式（IV）表示的基团：（其中R 9，R 10， >，R 11和R 12彼此相同或不同，并且各自表示氢原子，卤素原子，羟基，C 1 -C 12烷基， 1-6烷基或C 1-6烷氧基））; m为0或1; n为0或1。

公开(公告)号：US20070055627A1

公开(公告)日：2007-03-08

申请号：US11514207

申请日：2006-09-01

申请人： Serge Rivest ,  Michael King ,  Richard Clark

发明人： Serge Rivest ,  Michael King ,  Richard Clark

IPC分类号： G06Q40/00

CPC分类号： G06Q40/06 ,  G06Q20/10 ,  G06Q20/102 ,  G06Q30/08 ,  G06Q40/00 ,  G06Q40/02 ,  G06Q40/025

摘要： A system and method of preparing a transfer document for a client to transfer financial services using a first account to use a second account, the method comprising the steps of: (i) preparing a transfer document to effect transfer of the financial services, each transfer document identifying at least the service to be transferred, the client, the second account, the desired date for the transfer and providing authorization from the client; and (ii) including on said transfer document of a replica of an account document, with choice of said account document determined according to the financial service being transferred and the second account.

摘要翻译： 一种为客户准备转移文件以使用第一帐户转移金融服务以使用第二帐户的系统和方法，所述方法包括以下步骤：（i）准备转移文件以实现金融服务的转移，每次转移 至少识别要转让的服务的文件，客户端，第二帐户，转移的期望日期以及从客户端提供授权; 和（ii）在所述转让文件上包括帐户文件的副本，根据所转移的金融服务确定的所述帐户文件的选择和第二帐户。

公开(公告)号：US20070053743A1

公开(公告)日：2007-03-08

申请号：US10558138

申请日：2003-07-18

申请人： Richard Clark ,  Timothy Coyle

发明人： Richard Clark ,  Timothy Coyle

IPC分类号： E01F9/00

CPC分类号： E01F9/629

摘要： A load assembly for a self-uprighting delineator which moves from a first upright position to a second yielded or deflected position upon impact and returns to the upright position after impact. The assembly has upper and lower cell elements that have cooperating and complimentary alignment members in the form of notches and ridges. When the assembly is twisted, the alignment members cause the upper and lower cells to properly align the spring loaded cables passing through cable passages in the elements.

摘要翻译： 用于自立式划线器的装载组件，其在冲击时从第一直立位置移动到第二屈曲或偏转位置，并在冲击后返回到直立位置。 该组件具有上下单元元件，其具有凹口和凸脊形式的配合和互补对准构件。 当组件扭曲时，对准构件使得上部和下部电池适当地对准穿过元件中的电缆通道的弹簧加载的电缆。

公开(公告)号：US20070024460A1

公开(公告)日：2007-02-01

申请号：US11460752

申请日：2006-07-28

申请人： Richard Clark

发明人： Richard Clark

IPC分类号： G08B21/00

CPC分类号： H02H3/24 ,  H01B7/32

摘要： An electrical apparatus has an indicator for indicating a voltage drop across an electrical system. The electrical apparatus includes a core, a sense lead, and an indicator. The core transmits electrical current from a source to a load. The sense lead electrically connects to the core for sensing a voltage drop between a source end and a sink end of the core. The indicator is operably connected to the sense lead and provides an indication when the voltage drop exceeds a predetermined limit.

摘要翻译： 电气设备具有用于指示跨越电气系统的电压降的指示器。 电气设备包括核心，感测引线和指示器。 核心将电流从源传输到负载。 感测引线电连接到磁芯，用于感测芯体的源极端部和漏极端部之间的电压降。 指示器可操作地连接到感测引线，并且当电压降超过预定极限时提供指示。

公开(公告)号：US20060293602A1

公开(公告)日：2006-12-28

申请号：US10553286

申请日：2004-04-08

申请人： Richard Clark

发明人： Richard Clark

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61M21/00 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2230/06 ,  A61M2230/005

摘要： A short sleep/nap management apparatus and method are disclosed. The apparatus has sensor means (35) to detect one or more physiological parameters associated with a transition in sleep stages (13-19) from wakefulness (13), processing means (37, 39, 33) to process the parameters to determine when the transition is reached and start the timer to run for a predetermined period, and alarm means (47) to actuate at the end of said predetermined period to awaken the user.

摘要翻译： 公开了一种短睡眠/睡眠管理装置和方法。 该装置具有传感器装置（35），用于检测与从觉醒（13），处理装置（37,39,33）的睡眠阶段（13-19）的转变相关联的一个或多个生理参数，以处理参数以确定何时 达到转换并启动定时器运行预定时间，并且在所述预定时段结束时启动报警装置（47）以唤醒用户。