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公开(公告)号：US07629386B2
公开(公告)日：2009-12-08
申请号：US10926514
申请日：2004-08-26
CPC分类号： C11D3/48 , A61L12/141 , A61L12/142 , A61L12/143 , A61L12/145 , C11D1/722 , C11D3/0078 , C11D3/30 , C11D3/323 , C11D3/3703 , C11D3/3723 , C11D3/3726
摘要： The use of compositions containing one or more antimicrobial agents with one or more trialkanolamine alkoxylate buffers to disinfect and/or preserve medical devices is described. Solutions containing one or more antimicrobial agents with one or more trialkanolamine alkoxylate buffers and methods of making and using the same are also described.
摘要翻译： 描述了使用含有一种或多种抗微生物剂与一种或多种三烷醇胺烷氧基化物缓冲剂来消毒和/或保存医疗装置的组合物。 还描述了含有一种或多种抗微生物剂与一种或多种三烷醇胺烷氧基化物缓冲液的方法及其制备和使用方法。
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公开(公告)号：US07582704B2
公开(公告)日：2009-09-01
申请号：US11173703
申请日：2005-07-01
IPC分类号： C08F114/18
CPC分类号： C08F214/18 , C08F216/125 , C08G77/385 , G02B1/043 , C08L27/12
摘要： Biomedical devices formed from a polymerization product of a monomeric mixture comprising one or more monomers comprising at least two trifluorovinyl groups are provided. Also provided are biomedical devices formed from a network of a polymer comprising one or more perfluorocyclobutane rings in the polymer backbone wherein the network is formed by crosslinks in the polymer.
摘要翻译： 提供由包含一种或多种包含至少两个三氟乙烯基的单体的单体混合物的聚合产物形成的生物医学装置。 还提供了由在聚合物主链中包含一个或多个全氟环丁烷环的聚合物网络形成的生物医学装置，其中网络由聚合物中的交联形成。
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公开(公告)号：US20090192263A1
公开(公告)日：2009-07-30
申请号：US12421056
申请日：2009-04-09
CPC分类号： C08G65/337
摘要： The present invention provides prepolymers based on poly(alkyl ethers) having terminal trifluorovinyl aromatic containing groups and polymers produced from such prepolymers. The prepolymers and polymers are useful as biomedical devices such as contact lenses or intraocular lenses.
摘要翻译： 本发明提供基于具有末端三氟乙烯基芳族化合物的聚（烷基醚）和由这些预聚物制备的聚合物的预聚物。 预聚物和聚合物可用作生物医学装置如隐形眼镜或人工晶状体。
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公开(公告)号：US20090142292A1
公开(公告)日：2009-06-04
申请号：US12266646
申请日：2008-11-07
IPC分类号： A61K31/74 , A61K31/715 , A61P27/02 , A61K31/79 , A61K31/785 , A61K31/765
CPC分类号： G02B1/043 , A61K9/0051
摘要： A method for the mitigation of symptoms of dry eye is disclosed. The method involves at least (a) incorporating one or more non-functionalized polymers having one or more hydrophilic moieties into an ophthalmic device that is a polymerization product of a comonomer mixture comprising: (i) a major amount of a non-silicone-containing hydrophilic monomer; and (ii) an end terminal functionalized surfactant; and (b) inserting the ophthalmic device in the eye of a patient.
摘要翻译： 公开了一种减轻干眼症状的方法。 该方法至少包括（a）将一种或多种具有一个或多个亲水部分的非官能化聚合物掺入到作为共聚单体混合物的聚合产物的眼科装置中，所述共聚单体混合物包含：（i）主要量的非含硅氧烷 亲水单体; 和（ii）末端官能化表面活性剂; 和（b）将眼科装置插入患者的眼睛。
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25.发明授权High refractive-index siloxy-containing monomers and polymers, and ophthalmic devices comprising such polymers 有权含高折射率甲硅烷氧基的单体和聚合物，以及包含这种聚合物的眼科装置公开(公告)号：US07423108B2
公开(公告)日：2008-09-09
申请号：US11305606
申请日：2005-12-16
IPC分类号： C08G77/12
CPC分类号： C08G77/50 , G02B1/043 , C08L51/085 , C08L83/14
摘要： Siloxy-containing monomers, macromonomers, or polymers have at least a siloxy-containing side group that comprises a refractive-index increasing substituent. Polymeric compositions comprising such siloxy-containing monomers, macromonomers, or polymers are advantageously used for making ophthalmic devices, such as intraocular lenses, contact lenses, corneal rings, corneal inlays, and keratoprostheses.
摘要翻译： 含硅氧基的单体，大分子单体或聚合物具有至少含有甲硅烷氧基的侧基，其包含折射率增加取代基。 包含这种含甲硅烷氧基的单体，大分子单体或聚合物的聚合物组合物有利地用于制造眼科装置，例如眼内透镜，隐形眼镜，角膜环，角膜嵌体和角膜假体。
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公开(公告)号：US20080142038A1
公开(公告)日：2008-06-19
申请号：US11924336
申请日：2007-10-25
IPC分类号： B08B7/00
摘要： A method for improving the wettability of a medical device is provided, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a siloxy-containing monomer, (b) subjecting a surface of the medical device to a surface treatment, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.
摘要翻译： 提供一种改善医疗装置的润湿性的方法，所述方法包括以下步骤：（a）提供由包含亲水性单体和含甲硅烷氧基的单体的单体混合物形成的医疗装置，（b）使 医疗装置进行表面处理，以及（c）使处理过的医疗装置的表面与包含含羧酸的聚合物或共聚物的润湿剂溶液接触，以在经处理的表面上形成含羧酸的聚合物或共聚物层 医疗装置。
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公开(公告)号：US20080000201A1
公开(公告)日：2008-01-03
申请号：US11480053
申请日：2006-06-30
申请人： Derek Schorzman , Jay Kunzler , Joseph C. Salamone
发明人： Derek Schorzman , Jay Kunzler , Joseph C. Salamone
CPC分类号： C07F7/0838
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain carboxylic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerized carboxylic hydrophilic siloxanyl monomers.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地说，本发明涉及能够聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些羧酸单体。 聚合物组合物包含聚合的羧酸亲水硅氧烷基单体。
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公开(公告)号：US20070161810A1
公开(公告)日：2007-07-12
申请号：US11611512
申请日：2006-12-15
IPC分类号： C07F7/10
CPC分类号： C07F7/0838 , C08G77/388
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymeric compositions comprise polymerized cationic hydrophilic siloxanyl monomers prepared by the process disclosed herein.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子单体。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含通过本文公开的方法制备的聚合的阳离子亲水硅氧烷基单体。
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公开(公告)号：US07132494B2
公开(公告)日：2006-11-07
申请号：US10848305
申请日：2004-05-18
IPC分类号： C08G77/00
CPC分类号： C07F7/081 , Y10S623/905 , Y10S623/907
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.
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公开(公告)号：US06989430B2
公开(公告)日：2006-01-24
申请号：US10692391
申请日：2003-10-23
申请人： Joseph C. Salamone , Jay F. Kunzler
发明人： Joseph C. Salamone , Jay F. Kunzler
IPC分类号： C08G77/04
CPC分类号： C08G77/38 , A61L27/18 , A61L2430/16 , C07F7/0838 , C08F283/12 , C08F290/068 , G02B1/043 , Y10S623/905 , C08L51/085 , C08L83/04
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.
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