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21.发明申请公开(公告)号：US20170190792A1
公开(公告)日：2017-07-06
申请号：US15365104
申请日：2016-11-30
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K9/0019 , A61K9/19 , A61K38/53 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01009 , G01N33/5011 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/10
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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22.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases 有权与精氨酸-trna合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09593322B2
公开(公告)日：2017-03-14
申请号：US14593620
申请日：2015-01-09
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： A61K39/3955 , A61K9/19 , A61K38/00 , A61K38/53 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2319/00 , C12N9/1085 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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23.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetasis 有权与甲硫氨酰-tRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09422538B2
公开(公告)日：2016-08-23
申请号：US14619713
申请日：2015-02-11
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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24.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF LEUCYL-tRNA SYNTHETASES 有权与LEUCYL-tRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20160010075A1
公开(公告)日：2016-01-14
申请号：US14688822
申请日：2015-04-16
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , A61K2039/505 , C07K16/40 , C12Q1/527 , C12Y601/01 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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25.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF GLUTAMINYL-TRNA SYNTHETASES 有权与谷氨酰胺-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150361412A1
公开(公告)日：2015-12-17
申请号：US14689900
申请日：2015-04-17
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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26.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ALANYL TRNA SYNTHETASES 有权与ALANYL TRNA合成蛋白质蛋白相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150290305A1
公开(公告)日：2015-10-15
申请号：US14620817
申请日：2015-02-12
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： A61K38/53 , C07K14/00 , C12N9/00 , A61K35/12 , G01N33/573
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C12N5/0602 , C12N9/18 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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27.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ASPARTYL-TRNA SYNTHETASES 有权与ASPARTYL-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150252349A1
公开(公告)日：2015-09-10
申请号：US14598717
申请日：2015-01-16
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , A61K38/00 , A61K38/53 , C07K2317/24 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US11078299B2
公开(公告)日：2021-08-03
申请号：US16842195
申请日：2020-04-07
发明人： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
IPC分类号： C07K16/40 , C12Q1/6886 , G01N33/573 , C12N9/00 , C12N15/113 , C12Q1/6876 , A61K38/00
摘要： Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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公开(公告)号：US10941214B2
公开(公告)日：2021-03-09
申请号：US16688374
申请日：2019-11-19
发明人： Jie Zhou , Ching-Fun Lau , Zhiwen Xu , Wing-Sze Lo , Kristi Helen Piehl , Leslie Ann Greene
IPC分类号： C07K16/40 , C12Q1/6886 , G01N33/573 , C12N9/00 , C12N15/113 , C12Q1/6876 , A61K38/00
摘要： Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
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公开(公告)号：US10196629B2
公开(公告)日：2019-02-05
申请号：US15700751
申请日：2017-09-11
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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