公开(公告)号：US09535141B2

公开(公告)日：2017-01-03

申请号：US13939599

申请日：2013-07-11

Applicant: Aspect Imaging Ltd.

Inventor： Uri Rapoport

IPC: G01V3/00 ,  G01R33/28

CPC classification number: G01R33/288 ,  G01R33/30

Abstract: A magnetic shielding mechanism for preventing penetration of metallic objects through an aperture, towards the open bore of an magnetic resonance imaging device, where the magnetic field is maximized. The magnetic resonance imaging device produces a fringing magnetic field that decreases with increasing distance (L) from the aperture. The mechanism includes at least one magnet with a magnetic field. The mechanism is affixed at a distance from the aperture of magnetic resonance imaging device.

Abstract translation: 一种磁屏蔽机构，用于防止金属物体穿过孔朝向磁场最大化的磁共振成像装置的开孔渗透。 磁共振成像装置产生随距距离（L）的增加而减小的边缘磁场。 该机构包括至少一个具有磁场的磁体。 该机构与磁共振成像装置的孔径相距一定距离。

公开(公告)号：US09482643B2

公开(公告)日：2016-11-01

申请号：US14090298

申请日：2013-11-26

Applicant: Aspect Imaging Ltd.

Inventor： Uri Rapoport ,  Camila Cavallotti ,  Simonetta Geninatti Crich

IPC: G01R33/12 ,  G01N27/74 ,  A61B5/05

CPC classification number: G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

Abstract: A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.

Abstract translation: 一种检测目标生化分子种类或与主要成分为水的样品中与生化分子种类的发生相关的至少一种性质的方法。 该方法包括：获得主要成分为水的样品; 提供功能性顺磁性颗粒（FPP），其包括顺磁性核和被配置成与靶生物化学分子物质相互作用的部分，或与共同报告靶生物化学分子种类的性质的分子相结合; 将FPP与样品接触; 将样品暴露于施加的磁场; 测量样品的核松弛性质的变化; 并将该变化与样品中生化分子物质的存在相关联，或与样品中生化分子物质的发生相关的至少一种性质相关联。

公开(公告)号：US20160166353A1

公开(公告)日：2016-06-16

申请号：US15041274

申请日：2016-02-11

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT ,  Aryeh BATT

IPC: A61B90/30 ,  A61B90/00 ,  A61B90/20

CPC classification number: A61B90/30 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0084 ,  A61B6/508 ,  A61B6/5247 ,  A61B8/5261 ,  A61B90/20 ,  A61B90/361 ,  A61B2090/306 ,  A61B2090/373 ,  A61B2090/3762 ,  A61B2090/378

Abstract: The present invention provides an imaging system having an imaging device for imaging at least a portion of an animal; said imaging device selected from a group consisting of X-ray computed tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), fluorescence and phosphorescence microscopy (FPM) and any combination thereof; consisting of CT, computer-assisted tomography; IR, rendered images comprising infrared light spectroscopy; PET, positron emission tomography; fluorescence and phosphorescence microscopy, a Raman spectroscopic imaging system, ultrasound and any combination thereof.

Abstract translation: 本发明提供了一种成像系统，其具有用于对动物的至少一部分进行成像的成像装置; 所述成像装置选自由X射线计算机断层摄影（CT），正电子发射断层摄影（PET），单光子发射计算机断层摄影（SPECT），荧光和磷光显微镜（FPM）及其任何组合组成的组中; 由CT，计算机辅助断层摄影组成; IR，包括红外光谱的渲染图像; PET，正电子发射断层扫描; 荧光和磷光显微镜，拉曼光谱成像系统，超声波及其任何组合。

公开(公告)号：US20160089055A1

公开(公告)日：2016-03-31

申请号：US14892209

申请日：2014-05-21

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: A61B5/055 ,  G01R33/28 ,  G01R33/34 ,  A61G11/00 ,  G01R33/30

CPC classification number: A61B5/0555 ,  A61B2017/00911 ,  A61B2503/045 ,  A61F7/00 ,  A61G11/00 ,  A61G11/002 ,  A61G11/005 ,  A61G13/02 ,  A61G13/104 ,  A61M2202/0208 ,  G01R33/288 ,  G01R33/30 ,  G01R33/34 ,  G01R33/3806

Abstract: A maneuverable RF coil assembly, useful for being maneuvered at both positions: (i) over at least a portion of a neonate immobilized within a cradle at time of MR imaging; and (ii) below or aside the cradle when it is not required for imaging. The maneuverable RF coil assembly comprises at least one RF coil and maneuvering mechanism. The maneuvering mechanism comprises both: (i) a linear reciprocating mechanism for approaching or otherwise drawing away at least one coil to and from the neonate; and (ii) tilting mechanism for placing at least one coil away from the neonate.

Abstract translation: 一种可操作的RF线圈组件，可用于在两个位置操纵：（i）在MR成像时固定在支架内的至少一部分新生儿; 和（ii）在不需要成像时在底座或旁边的摇篮。 机动RF线圈组件包括至少一个RF线圈和操纵机构。 操纵机构包括：（i）线性往复机构，用于接近或以其他方式将至少一个线圈从新生儿中抽出; 和（ii）用于将至少一个线圈放置于新生儿的倾斜机构。

公开(公告)号：US20160061925A1

公开(公告)日：2016-03-03

申请号：US14840003

申请日：2015-08-30

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: G01R33/58 ,  G01R33/48 ,  G01R33/50

CPC classification number: G01R33/58 ,  G01R33/50

Abstract: A method for automatic determination of optimal Magnetic Resonance Imaging (MRI) acquisition parameters for imaging in an MRI instrument a sample containing two types of tissue, tissue A and tissue B, wherein said method comprises: determining T1A, T2A, T1B, T2B, ρA, and ρB, where ρ represents the density of NMR-active nuclei being probed; setting initial values of TR and TE; determining the signal intensities SA and SB from the equation S=ρE1E2, where E1=1−e−TR/T1 and E2=e−TE/T2; calculating the contrast-to-noise ratio for tissue A in the presence of tissue B (CNRAB) from the equation CNR AB = P  ( S A - S B ) T R , where P is a proportionality constant; and, determining optimal values of TR and TE that yield a maximum value of CNRAB(TR,TE). In other embodiments of the invention, the method includes optimization of additional acquisition parameters. An MRI system in which the method is implemented so that acquisition parameters can be optimized without any intervention by the system operator is also disclosed.

Abstract translation: 一种用于自动确定最佳磁共振成像（MRI）获取参数的方法，用于在MRI仪器中成像含有两种类型的组织，组织A和组织B的样品，其中所述方法包括：确定T1A，T2A，T1B，T2B，＆rgr ; A和＆rgr; B，其中＆rgr; 表示被探测的核磁共振活性核的密度; 设定TR和TE的初始值; 从等式S =＆rgr; E1E2确定信号强度SA和SB，其中E1 = 1-e-TR / T1和E2 = e-TE / T2; 在组织B（CNRAB）的存在下，从方程式CNR AB = P（S A-S B）T R计算组织A的对比度信噪比，其中P是比例常数; 并且确定产生CNRAB（TR，TE）的最大值的TR和TE的最佳值。 在本发明的其它实施例中，该方法包括优化额外的采集参数。 还公开了一种MRI系统，其中实施该方法使得获取参数可以在没有系统操作者的任何干预的情况下被优化。

公开(公告)号：US09272107B2

公开(公告)日：2016-03-01

申请号：US14537266

申请日：2014-11-10

Applicant: ASPECT IMAGING LTD.

Inventor： Uri Rapoport

IPC: A61M16/01 ,  A61D7/04 ,  A01K1/03 ,  A01K1/00

CPC classification number: A61M16/01 ,  A01K1/00 ,  A01K1/03 ,  A61D7/04 ,  A61M2250/00

Abstract: The present invention provides a chamber having at least one operator hand access port; the port comprising a port aperture located within the chamber wall; and at least two flexible non-resilient lightweight sealing gas-tight flaps(SFs), disposed the same plane of the port aperture in an overlapping manner, entirely enclosing the port aperture; each of the SFs is defined by a port aperture edge and chamber edges; the chamber edges are anchored to the chamber wall along more than half of the perimeter of the flap, at a distance from the center of the port greater than the radius of the port and beyond its perimeter; the port aperture edge of each flap is stretched across an entire chord of the port aperture; stretched port apertures edges define an interior access zone, disposed the same plane of the port aperture, characterized solely by the port aperture edges.

Abstract translation: 本发明提供一种具有至少一个操作者手入口的腔室; 所述端口包括位于所述室壁内的端口孔; 和至少两个柔性非弹性的轻质密封气密翼片（SF），其以重叠的方式设置在端口孔的同一平面上，完全包围端口孔; 每个SF由端口孔边缘和腔室边缘限定; 腔室边缘沿着瓣的周边的一半以上锚定到腔室壁，距离端口的中心一定距离大于端口的半径并超出其周边; 每个翼片的孔口边缘在端口孔的整个弦上被拉伸; 拉伸端口孔边缘限定内部进入区域，其设置在端口孔的相同平面上，其特征仅在于孔口边缘。

公开(公告)号：US20150147746A1

公开(公告)日：2015-05-28

申请号：US14090298

申请日：2013-11-26

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT ,  Camilla CAVALLOTTI ,  Simonetta GENINATTI CRICH

IPC: G01N27/74

CPC classification number: G01N27/745 ,  A61B5/05 ,  G01N24/088 ,  G01R33/1269 ,  G01R33/1276 ,  G01R33/281

Abstract: A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.

Abstract translation: 一种检测目标生化分子种类或与主要成分为水的样品中与生化分子种类的发生相关的至少一种性质的方法。 该方法包括：获得主要成分为水的样品; 提供功能性顺磁性颗粒（FPP），其包括顺磁性核和被配置成与靶生物化学分子物质相互作用的部分，或与共同报告靶生物化学分子种类的性质的分子相结合; 将FPP与样品接触; 将样品暴露于施加的磁场; 测量样品的核松弛性质的变化; 并将该变化与样品中生化分子物质的存在相关联，或与样品中生化分子物质的发生相关的至少一种性质相关联。

公开(公告)号：US20150123657A1

公开(公告)日：2015-05-07

申请号：US14070695

申请日：2013-11-04

Applicant: ASPECT IMAGING LTD.

Inventor： Uri RAPOPORT

IPC: G01R33/54

CPC classification number: G01R33/543

Abstract: A method of operating a magnetic resonance imaging (MRI) device for habituating a patient and/or user to acoustic-noise of the device's operation. The method includes: listing a required set of the pulse-sequences (RSPS) for the patient, modifying the RSPS to a new set of sequences (NSPS) further comprising at least one demo-sequence, and operating, by means of generating the pulse-sequences, according to the NSPS. The demo-sequence is a redundant sequence, used solely for acoustic-sound habituation, while the originally listed RSPS are used for medical readings, thereby habituating the patient and/or user to the acoustic-noise of the operation.

Abstract translation: 一种操作磁共振成像（MRI）装置的方法，用于将患者和/或使用者习惯于装置操作的声学噪声。 该方法包括：列出用于患者的所需脉冲序列集合（RSPS），将RSPS修改为还包括至少一个演示序列的新的序列集（NSPS），并且通过产生脉冲 根据NSPS。 演示序列是冗余序列，仅用于声音习惯，而原始列出的RSPS用于医疗读数，从而使患者和/或用户习惯于操作的声学噪声。

公开(公告)号：US08844470B2

公开(公告)日：2014-09-30

申请号：US13241350

申请日：2011-09-23

Applicant: Uri Rapoport ,  Itzchak Rabinovitz

Inventor： Uri Rapoport ,  Itzchak Rabinovitz

IPC: A01K1/03 ,  A01K1/06 ,  A61D3/00

CPC classification number: A01K1/0613 ,  A61D3/00

Abstract: An animal handling system (AMS), useful for positioning an immobilized animal in a predefined configuration, including: a proximal portion, held outside a medical device, comprises at least one inner shaft, and at least one outer shaft, the at least one outer shaft telescopically maneuverable along the at least one inner shaft to provide a telescopic mechanism of variable (proximal-) length, the proximal portion; and a distal portion comprising a configurable encapsulatable life support system (ELSS), the ELSS is rotatable and/or linearly reciprocatable along the main longitudinal axis of the shafts by means of the maneuverable telescopic mechanism of the proximal portion. The proximal portion further comprising indicia indicating the linear displacement and rotation of the ELSS of the distal portion, such that the ELSS is accurately and reversibly configured within the medical device to optimized animal analyses.

Abstract translation: 一种用于将固定化动物定位在预定构型中的动物处理系统（AMS），包括：保持在医疗装置外部的近端部分，包括至少一个内部轴和至少一个外部轴，所述至少一个外部轴 所述轴可沿着所述至少一个内轴可伸缩地操纵以提供可变（近端）长度的伸缩机构，所述近端部分; 以及包括可配置的可密封的寿命支持系统（ELSS）的远端部分，所述ELSS通过所述近端部分的可操纵的伸缩机构沿着所述轴的主纵向轴线可旋转和/或可直线地往复运动。 近端部分还包括指示远侧部分的ELSS的线性位移和旋转的标记，使得ELSS在医疗装置内精确和可逆地构造以优化动物分析。

公开(公告)号：US08807084B2

公开(公告)日：2014-08-19

申请号：US13241367

申请日：2011-09-23

Applicant: Uri Rapoport ,  Itzchak Rabinovitz

Inventor： Uri Rapoport ,  Itzchak Rabinovitz

IPC: G01R33/30

CPC classification number: A61B5/0555 ,  A01K29/005 ,  G01R33/30

Abstract: An animal handling system for use in a magnetic resonance device (MRD) device, including: a first elongated enclosure having a proximal end, a distal open end and a first geometry, and a second elongated enclosure having a proximal end, a distal open end and a second geometry. The first geometry comprises a first cross-sectional area that is larger than a second cross-sectional area of the second geometry. The first elongated enclosure is inserted into a first input port of the MRD device and the second elongated enclosure is inserted in a second input port of the MRD device diametrically opposite to first input port. When the first elongated enclosure and the second elongated enclosure are inserted into the respective input ports, the second elongated enclosure slides into the first elongated enclosure through the open distal end of the first elongated enclosure.

Abstract translation: 一种用于磁共振装置（MRD）装置的动物处理系统，包括：具有近端，远端开口端和第一几何形状的第一细长外壳，以及具有近端，远端开口端 和第二个几何。 第一几何形状包括大于第二几何形状的第二横截面积的第一横截面面积。 第一细长外壳被插入到MRD装置的第一输入端口中，并且第二细长外壳插入在与第一输入端口径向相对的MRD装置的第二输入端口中。 当第一细长外壳和第二细长外壳插入相应的输入端口时，第二细长外壳通过第一细长外壳的开口远端滑入第一细长外壳。