公开(公告)号：US20210093874A1

公开(公告)日：2021-04-01

申请号：US16955362

申请日：2018-12-21

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： ERIC IRWIN ,  ANDREW HINDMARSH ,  JOHN BENNETT

IPC: A61N1/375 ,  A61B17/3209 ,  A61N1/378

Abstract: An implantation system and methods of inserting an implant are disclosed. The method includes the step of making an incision in an abdominal wall with an instrument positioned within an abdominal cavity. The method further includes the steps of forming a pocket between a first surface of the abdominal wall and a second surface of the abdominal wall, such that the incision defines an opening into the pocket, inserting an implant through the opening and into the pocket, and closing the opening such that the implant is captured within the pocket.

公开(公告)号：US20210093853A1

公开(公告)日：2021-04-01

申请号：US15733239

申请日：2018-12-14

Applicant: Galvani Bioelectronics Limited

Inventor： Benjamin YAFFE ,  Kenneth Douglas RYS

IPC: A61N1/05

Abstract: An implant insertion system and methods of use of the implant insertion system are disclosed. The implant insertion system includes an implant and an instrument configured to deliver the implant to a biological structure and assist in deploying the implant to the biological structure. The instrument includes a retention member the secures the implant to the instrument and retains the implant in a first configuration. The retention member is movable to decouple the implant from the instrument. The implant is configured to transition from the first configuration to a second configuration, such that in the second configuration the implant is secured to the biological structure.

公开(公告)号：US10960209B2

公开(公告)日：2021-03-30

申请号：US16320288

申请日：2017-07-25

Applicant: Galvani Bioelectronics Limited ,  Case Western Reserve University

Inventor： Arun Sridhar ,  Corey Smith ,  Kyle Wolf ,  Georgy Zarkua ,  Shyue-An Chan

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.

公开(公告)号：US20210085977A1

公开(公告)日：2021-03-25

申请号：US16955345

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： DANIEL JOHN CHEW ,  MATTEO DONEGA ,  ISHA GUPTA

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：US10603486B2

公开(公告)日：2020-03-31

申请号：US16309182

申请日：2017-06-12

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Dwight Sherod Walker ,  Daniel John Chew

IPC: B29C43/18 ,  A61N1/05 ,  A61B5/04 ,  A61B5/00

Abstract: Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.

公开(公告)号：US20190015675A1

公开(公告)日：2019-01-17

申请号：US16080143

申请日：2017-02-27

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Alessandra GIAROLA ,  Arun SRIDHAR ,  Nicolas WISNIACKI

IPC: A61N2/00 ,  A61N5/06 ,  A61N7/00 ,  A61F7/00 ,  A61H7/00

Abstract: The present disclosure provides an apparatus or system and methods for treating xerostomia or Sjögren's Syndrome in a subject.

公开(公告)号：US12296171B2

公开(公告)日：2025-05-13

申请号：US17872319

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.

公开(公告)号：US12296162B2

公开(公告)日：2025-05-13

申请号：US17595169

申请日：2020-05-07

Applicant: GALVANI BIOELECTRONICS LIMITED ,  Cindy Au

Inventor： Cindy Au

IPC: A61N1/05 ,  B29C45/14 ,  B29C45/16 ,  B29K83/00 ,  B29L31/00

Abstract: A method for use in making an electrode assembly (20) comprises the steps of applying an electrode (24) on a first layer of material (22); laser welding a lead (23) to the electrode; applying an adhesive backfill (26) over the electrode and the lead; and applying a second layer of material (28) over the adhesive backfill and a portion of the first layer to prevent a leakage path between the electrode and the second layer.

公开(公告)号：US20250082937A1

公开(公告)日：2025-03-13

申请号：US18791161

申请日：2024-07-31

Applicant: Galvani Bioelectronics Limited ,  Case Western Reserve University

Inventor： Alessandra Giarola ,  Yee-Hsee Hsieh ,  Stephen J. Lewis ,  Arun Sridhar

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/08 ,  A61N1/00 ,  A61N1/05 ,  A61N1/18

Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.

公开(公告)号：US12083340B2

公开(公告)日：2024-09-10

申请号：US18141045

申请日：2023-04-28

Applicant: Galvani Bioelectronics Limited

Inventor： Daniel John Chew ,  Matteo Donega ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/20 ,  A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/205 ,  A61N1/36135 ,  A61N1/3616 ,  A61N1/36171

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.