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公开(公告)号：US20240361243A1
公开(公告)日：2024-10-31
申请号：US18626595
申请日：2024-04-04
Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.
Inventor： Craig Prater
IPC: G01N21/64
CPC classification number: G01N21/6456 , G01N21/6486 , G01N2201/062 , G01N2201/0636
Abstract: Methods and systems described herein detect autofluorescence of a sample. These methods and systems obviate the need for addition of fluorophores to samples to create IR absorption
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公开(公告)号：US20240044782A1
公开(公告)日：2024-02-08
申请号：US18452023
申请日：2023-08-18
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater , David Grigg , Derek Decker
CPC classification number: G01N21/35 , G02B21/002 , G01J3/45
Abstract: Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to enhance the signal strength indicating the photothermal effect on a sample.
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23.发明授权公开(公告)号：US11885745B2
公开(公告)日：2024-01-30
申请号：US17872418
申请日：2022-07-25
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater
IPC: G01N21/64 , G01N21/359 , G01J3/02 , G01N21/3563 , G01N21/35
CPC classification number: G01N21/645 , G01J3/0227 , G01N21/359 , G01N21/3563 , G01N21/6428 , G01N21/6456 , G01N2021/3595 , G01N2021/6439 , G01N2021/6471
Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.
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公开(公告)号：US20240011830A1
公开(公告)日：2024-01-11
申请号：US18311748
申请日：2023-05-03
Applicant: Photothermal Spectroscopy Corp
Inventor： Derek Decker , Craig Prater
CPC classification number: G01J3/0297 , G01J3/0216 , G01J3/0229 , G01J3/108 , G01J2003/102
Abstract: Apparatuses and methods for microscopic analysis of a sample using spatial light manipulation to increase signal to noise ratio are described herein.
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公开(公告)号：US11774354B2
公开(公告)日：2023-10-03
申请号：US17955131
申请日：2022-09-28
Applicant: Photothermal Spectroscopy Corp
Inventor： Craig Prater , David Grigg , Derek Decker
CPC classification number: G01N21/35 , G01J3/45 , G02B21/002
Abstract: Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to enhance the signal strength indicating the photothermal effect on a sample.
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Patent Agency Ranking
公开(公告)号：US20230251190A1
公开(公告)日：2023-08-10
申请号：US18003131
申请日：2021-06-25
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig PRATER
IPC: G01N21/359 , G01J3/42 , A61B1/00
CPC classification number: G01N21/359 , G01J3/42 , A61B1/00167 , G01N2021/3595
Abstract: Improvements in spectroscopy are disclosed herein that rely on the interaction of both an infrared beam and a probe beam with a sample. These beams are used in a pump-probe arrangement, with a fiber optic probe collecting the beams of infrared and probe radiation from the infrared source and delivering it to the sample. At least a portion of the beam of infrared radiation and the beam of probe radiation overlap one another on the sample. The fiber also collects probe radiation that has interacted with the sample. A detector can use this collected signal to indicate an intensity of the collected probe radiation, and an analyzer can generate a signal indicative of infrared absorption of the sample adjacent the fiber.
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公开(公告)号：US20230236118A1
公开(公告)日：2023-07-27
申请号：US17955131
申请日：2022-09-28
Applicant: Photothermal Spectroscopy Corp
Inventor： Craig Prater , David Grigg , Derek Decker
CPC classification number: G01N21/35 , G02B21/002 , G01J3/45
Abstract: Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to enhance the signal strength indicating the photothermal effect on a sample.
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公开(公告)号：US20230131208A1
公开(公告)日：2023-04-27
申请号：US17955122
申请日：2022-09-28
Applicant: Photothermal Spectroscopy Corp.
Inventor： Derek Decker , Craig Prater
Abstract: Apparatuses and methods for microscopic analysis of a sample using spatial light manipulation to increase signal to noise ratio are described herein.
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29.发明申请公开(公告)号：US20220357275A1
公开(公告)日：2022-11-10
申请号：US17872418
申请日：2022-07-25
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater
IPC: G01N21/64 , G01N21/359 , G01J3/02
Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.
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30.发明申请公开(公告)号：US20220018773A1
公开(公告)日：2022-01-20
申请号：US17381021
申请日：2021-07-20
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater
IPC: G01N21/64 , G01N21/359 , G01J3/02
Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.
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