公开(公告)号：US20250003865A1

公开(公告)日：2025-01-02

申请号：US18886739

申请日：2024-09-16

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater ,  Kevin Kjoller ,  Roshan Shetty

IPC: G01N21/17 ,  G01J3/28 ,  G01J3/427 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

公开(公告)号：US20230236112A1

公开(公告)日：2023-07-27

申请号：US18162385

申请日：2023-01-31

Applicant: Photothermal Spectroscopy Corp

Inventor： Craig Prater ,  Kevin Kjoller ,  Roshan Shetty

IPC: G01N21/17 ,  G01J3/28 ,  G01J3/427 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/171 ,  G01J3/2823 ,  G01J3/427 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/1714

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

公开(公告)号：US20230063843A1

公开(公告)日：2023-03-02

申请号：US17796822

申请日：2021-02-01

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater ,  Derek Decker ,  David Grigg

IPC: G01J3/10 ,  G01J3/447 ,  G01J3/02 ,  G01J3/453 ,  G01J3/28

Abstract: A system for infrared analysis over a wide field area of a sample is disclosed herein that relies on interference of non-diffractively separated beams of light containing image data corresponding to the sample, as well as a photothermal effect on the sample.

公开(公告)号：US10969405B2

公开(公告)日：2021-04-06

申请号：US15826147

申请日：2017-11-29

Applicant: Photothermal Spectroscopy Corp.

Inventor： Roshan Shetty ,  Kevin Kjoller ,  Craig Prater

IPC: G01N21/17 ,  G01N21/31 ,  G01N21/65 ,  G01Q30/02 ,  G01N21/3563

Abstract: Methods and apparatus for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including atomic force microscopy, infrared spectroscopy, confocal microscopy, Raman spectroscopy and mass spectrometry. For infrared spectroscopy, a sample is illuminated with infrared light and the resulting sample distortion is read out with either a focused UV/visible light beam and/or AFM tip. Using the AFM tip or the UV/visible light beam it is possible to measure the IR absorption characteristics of a sample with spatial resolution ranging from around 1 μm or less to the nanometer scale. The combination of both techniques provides a rapid and large area survey scan with the UV/visible light and a high resolution measurement with the AFM tip. The methods and apparatus also include the ability to analyze light reflected/scattered from the sample via a Raman spectrometer for complementary analysis by Raman spectroscopy. Using a UV/vis source or IR source at higher intensity it is possible to thermally desorb material from a sample for analysis by mass spectrometry. The AFM tip can also be heated to desorb material for mass spec analysis at even higher spatial resolution.

公开(公告)号：US20190120753A1

公开(公告)日：2019-04-25

申请号：US16155089

申请日：2018-10-09

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater ,  Kevin Kjoller ,  Roshan Shetty

IPC: G01N21/35 ,  G01N21/65 ,  G01N21/59 ,  G01N21/552 ,  G01N23/20091 ,  G01N23/207 ,  H01J49/26 ,  H01J37/26

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

公开(公告)号：US12140475B2

公开(公告)日：2024-11-12

申请号：US18311748

申请日：2023-05-03

Applicant: Photothermal Spectroscopy Corp.

Inventor： Derek Decker ,  Craig Prater

IPC: G01J3/02 ,  G01J3/10

Abstract: Apparatuses and methods for microscopic analysis of a sample using spatial light manipulation to increase signal to noise ratio are described herein.

公开(公告)号：US20240280477A1

公开(公告)日：2024-08-22

申请号：US18171161

申请日：2023-02-17

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater ,  Kevin Kjoller

IPC: G01N21/35 ,  G06T5/50 ,  G06V10/141 ,  H04N23/20

CPC classification number: G01N21/35 ,  G06T5/50 ,  G06V10/141 ,  H04N23/20 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/20221

Abstract: Methods described herein provide improvements on composite infrared absorption imaging. Scanning patterns described herein reduce erroneous measurements caused by thermal drift, as well as optical interference that occurs between light scattering from the top surface of the sample and light scattering from an underlying substrate.

公开(公告)号：US12066328B2

公开(公告)日：2024-08-20

申请号：US17955122

申请日：2022-09-28

Applicant: Photothermal Spectroscopy Corp.

Inventor： Derek Decker ,  Craig Prater

IPC: G01J3/02 ,  G01J3/10

CPC classification number: G01J3/0297 ,  G01J3/0216 ,  G01J3/0229 ,  G01J3/108 ,  G01J2003/102

Abstract: Apparatuses and methods for microscopic analysis of a sample using spatial light manipulation to increase signal to noise ratio are described herein.

公开(公告)号：US20240110872A1

公开(公告)日：2024-04-04

申请号：US18538506

申请日：2023-12-13

Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.

Inventor： Craig Prater

IPC: G01N21/64 ,  G01J3/02 ,  G01N21/3563 ,  G01N21/359

CPC classification number: G01N21/645 ,  G01J3/0227 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2021/3595 ,  G01N2021/6471

Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.

公开(公告)号：US20220065772A1

公开(公告)日：2022-03-03

申请号：US17316453

申请日：2021-05-10

Applicant: Photothermal Spectroscopy Corp.

Inventor： Craig Prater ,  Kevin Kjoller ,  Roshan Shetty

IPC: G01N21/17 ,  G01J3/28 ,  G01J3/427 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.