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公开(公告)号：USRE45911E1
公开(公告)日：2016-03-01
申请号：US13228889
申请日：2011-09-09
CPC分类号： H01B1/20 , A61K8/02 , A61K8/044 , A61K8/19 , A61K8/25 , A61K8/27 , A61K8/29 , A61K2800/413 , A61K2800/52 , A61Q3/02 , B82Y5/00 , B82Y30/00 , Y10S977/926
摘要： Embodiments of the present invention provide polymer matrix nanocomposites reinforced with nano-scale materials such as nanoparticles and carbon nanotubes and methods of fabricating. The nanomaterials are provided within relatively low weight fractions, for example in the range of approximately 0.01 to about 0.4% by weight and distributed within the matrix by a magnetic mixing procedure to provide substantially uniform reinforcement of the nanocomposites. Advantageously, these nanocomposites provide significantly enhanced tensile strength, strain to failure, and fracture toughness over corresponding neat matrices.
摘要翻译： 本发明的实施方案提供用纳米尺度材料如纳米颗粒和碳纳米管增强的聚合物基质纳米复合材料及其制造方法。 纳米材料以相对低的重量分数提供，例如在约0.01至约0.4重量％的范围内，并通过磁力混合程序分布在基体内，以提供纳米复合材料的基本均匀的增强。 有利地，这些纳米复合材料在相应的纯基体上提供显着增强的拉伸强度，破坏应变和断裂韧性。
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22.发明授权Treatment regimen for N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors 有权N-MYC，c-MYC和L-MYC扩增和过表达肿瘤的治疗方案公开(公告)号：US09072778B2
公开(公告)日：2015-07-07
申请号：US12158661
申请日：2006-12-20
申请人： Andre S. Bachmann
发明人： Andre S. Bachmann
IPC分类号： A61K31/198 , A61K31/365 , A61K31/203 , A61K45/06 , A61K31/167
CPC分类号： A61K45/06 , A61K31/167 , A61K31/198 , A61K31/203 , A61K31/365 , A61K2300/00
摘要： The present invention relates to methods and compositions for treating diseases. More specifically, the present invention relates to the administration of multiple drugs as part of a treatment of disease. Specific embodiments of the invention relate to a treatment regimen for neuroblastomas and other N-MYC, c-MYC, and L-MYC amplified and overexpressed tumors, comprising administering multiple therapeutic compounds like DFMO, SAM486A, a verinoid and a cytotoxic drug and placing the patient on a low polyamine diet and/or providing the patient with a polyamine limiting dietary supplement.
摘要翻译： 本发明涉及治疗疾病的方法和组合物。 更具体地，本发明涉及作为疾病治疗的一部分的多种药物的给药。 本发明的具体实施方案涉及用于神经母细胞瘤和其它N-MYC，c-MYC和L-MYC扩增和过表达肿瘤的治疗方案，包括施用多种治疗性化合物，如DFMO，SAM486A，verinoid和细胞毒性药物， 患者在低多胺饮食和/或为患者提供多胺限制性膳食补充剂。
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公开(公告)号：US08945876B2
公开(公告)日：2015-02-03
申请号：US13683869
申请日：2012-11-21
申请人： University Of Hawaii
发明人： Wei Wen Su , Bei Zhang
CPC分类号： C12P21/00 , C12N15/8201
摘要： Embodiments herein include methods and constructs that can be used to co-express two or more polypeptides of interest from a single polynucleotide encoding a precursor polypeptide. Within this precursor polypeptide can reside at least one autonomous processing unit, which can mediate release of flanking polypeptides of interest in cis. The processing unit can include an N-terminal autocatalytic cleavage domain and a C-terminal cleavage domain. Some embodiments include constructs and methods for co-expressing polypeptides without N- or C-terminal overhangs, in any cellular or extracellular location, and/or in stoichiometric ratios.
摘要翻译： 本文的实施方案包括可以用于共同表达来自编码前体多肽的单个多核苷酸的两种或更多种目的多肽的方法和构建体。 在该前体多肽中可以存在至少一个自主加工单元，其可以介导顺式释出感兴趣的侧翼多肽。 处理单元可以包括N-末端自催化切割结构域和C末端切割结构域。 一些实施方案包括用于在任何细胞或细胞外位置和/或化学计量比下共同表达多肽而不具有N-或C-末端突出端的构建体和方法。
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公开(公告)号：US08632780B2
公开(公告)日：2014-01-21
申请号：US11579235
申请日：2005-04-29
CPC分类号： C07K14/472 , A61K38/00 , C07K14/463 , C07K2319/00
摘要： A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which results in a human C3 protein with CVF functions, but with substantially reduced immunogenicity. Advantageously, the C3 protein can be manipulated to contain at least one of the following CVF functions: increased stability of the C3 convertase and increased resistance to the actions of factors H and/or I. A large number of hybrid C3 proteins containing substitutions in the C-terminal portion of the alpha chain of C3 are presented and tested for the above functions. Methods of treatment of diseases such as reperfusion injury, autoimmune diseases, and other diseases of increased complement activation are presented as well as methods of increasing the effectiveness of gene therapeutics and other therapeutics.
摘要翻译： 公开了修饰的人补体C3蛋白（C3），其包含部分人C3蛋白的取代与眼镜蛇毒因子蛋白（CVF）的相应部分，其导致具有CVF功能的人C3蛋白，但基本上 免疫原性降低。 有利地，可以操作C3蛋白以包含以下CVF功能中的至少一种：增加C3转化酶的稳定性和增加对因子H和/或I的作用的抗性。大量含有取代的杂合C3蛋白 呈现C3的α链的C末端部分并进行上述功能的测试。 提出了治疗诸如再灌注损伤，自身免疫疾病和其他增加补体活化的疾病的方法以及增加基因治疗剂和其它治疗剂的有效性的方法。
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公开(公告)号：US20130216811A1
公开(公告)日：2013-08-22
申请号：US13520878
申请日：2011-01-06
IPC分类号： B32B37/16
CPC分类号： B32B37/16 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B32/17 , C01B2202/34 , C04B35/117 , C04B35/565 , C04B35/803 , C04B35/806 , C04B35/83 , C04B2235/5288 , H01M8/0234 , H01M8/0241 , H01M2008/1095 , Y10T156/10 , Y10T428/249921 , Y10T442/30
摘要： Provided are nanostructure-containing nanotape materials. The materials may be incorporated at the interface between two other structures to provide strength and toughness at the interface. The materials may also be applied to a standalone structure to provide strength and toughness. Also provided are related methods of fabricating the nanotape materials, as well as gas diffusion membranes and fuel cells that include nanostructured materials.
摘要翻译： 提供纳米结构的纳米材料。 材料可以结合在两个其它结构之间的界面处以在界面处提供强度和韧性。 这些材料也可以应用于独立结构以提供强度和韧性。 还提供了制造纳米尺寸材料的相关方法，以及包括纳米结构材料的气体扩散膜和燃料电池。
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公开(公告)号：US08420494B1
公开(公告)日：2013-04-16
申请号：US12807188
申请日：2010-08-30
IPC分类号： H01L21/331 , H01L21/70
CPC分类号： G01N27/4145 , H01L29/7393
摘要： A new class of electronic devices suitable for Si IC incorporation and of diverse utility are described. The devices are useful for many sensing applications as well as for special circuit applications. Sensing applications include chemical and biochemical sensing, photo detection (UV, visible, IR and FIR), magnetic field sensing, electric field sensing, and force sensing. The devices are MEMs compatible. Sensor sensitivity is voltage and current tunable over a wide range. The devices further constitute a new and useful class of IC reference voltage devices. Selective non linear features are also achievable in support of non-linear device applications. These unique devices may be considered as distributed merged bipolar and FET structures. The new distributed channel bipolar devices (DCBDs) have a channel of a selected shape formed in a surface of a substrate by doping or by influencing of a coating. In the device structure, the channel acts as an NPN or PNO BJT collector or emitter.
摘要翻译： 描述了适用于Si IC并入和多种效用的新类型的电子器件。 这些器件对于许多传感应用以及特殊的电路应用是有用的。 感测应用包括化学和生物化学感测，光电检测（UV，可见光，IR和FIR），磁场感测，电场感测和力感测。 这些设备与MEM兼容。 传感器灵敏度是电压和电流可调范围广泛。 这些器件还构成了一种新的有用的IC参考电压器件。 选择性非线性特征也可以实现，以支持非线性器件应用。 这些独特的器件可以被认为是分布式合并的双极和FET结构。 新的分布式通道双极器件（DCBD）具有通过掺杂或通过影响涂层形成在衬底的表面中的选定形状的沟道。 在器件结构中，通道用作NPN或PNO BJT集电极或发射极。
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公开(公告)号：US20120231029A1
公开(公告)日：2012-09-13
申请号：US13510923
申请日：2010-11-18
IPC分类号： A61K39/002 , A61P37/04 , A61P33/06 , C07K14/445 , C12P21/02
CPC分类号： A61K39/015 , A61K2039/55566 , C07K14/445 , C07K2319/00 , C12N2799/026 , Y02A50/412
摘要： Recombinant subunit proteins derived from the MSP-1 C-terminal region of the parasite Plasmodium falciparum are described that have enhanced immunogenic properties. Selected regions of p33 have been combined with p19 to enhance the immunogenic potential of the p19 core region. As the constructs represent discontinuous segments fused to create unique proteins, the recombinant proteins expressed are not found in nature. The enhanced immunogenic potential of the disclosed recombinant proteins provided for strong, consistent and specific antibody responses. The disclosed recombinant subunit proteins are vaccine candidates for protection against infection with malaria.
摘要翻译： 描述了从寄生虫恶性疟原虫的MSP-1 C末端区域衍生的重组亚基蛋白，其具有增强的免疫原性。 p33的选择区已经与p19结合，以增强p19核心区的免疫原性潜力。 由于构建体表示融合以产生独特蛋白质的不连续区段，所以表达的重组蛋白在自然界中并不发现。 所公开的重组蛋白的增强的免疫原性潜力提供强的，一致的和特异性的抗体应答。 所公开的重组亚基蛋白是用于防止疟疾感染的疫苗候选物。
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28.发明申请公开(公告)号：US20100267070A1
公开(公告)日：2010-10-21
申请号：US12742921
申请日：2008-11-14
申请人： Andre S. Bachmann , Robert Dudler , Michael Groll
发明人： Andre S. Bachmann , Robert Dudler , Michael Groll
CPC分类号： C07D245/02 , A61K31/395 , Y02A50/411
摘要： The invention disclosed herein generally relates to methods and compositions for inhibiting proteasome activity comprising a syrbactin compound have the structure of Formula (I) or (II).
摘要翻译： 本文公开的发明一般涉及用于抑制蛋白酶体活性的方法和组合物，其包含具有式（I）或（II）结构的syrbactin化合物。
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29.发明授权公开(公告)号：US07741128B2
公开(公告)日：2010-06-22
申请号：US11440215
申请日：2006-05-23
申请人： Wei Wen Su
发明人： Wei Wen Su
IPC分类号： G01N33/566 , G01N33/563 , G01N33/00
CPC分类号： G01N33/542 , G01N33/58
摘要： The present invention relates to methods and compositions to detect analytes in a sample using antibody molecules that are transformed into nanoscale “self-signaling” biosensors. It relates in particular to those methods and compositions that provide for single-step detection of target analytes without the need for labor-intensive steps necessary in conventional assays.
摘要翻译： 本发明涉及使用转化成纳米级“自我信号”生物传感器的抗体分子检测样品中分析物的方法和组合物。 它特别涉及提供目标分析物的单步检测而不需要在常规测定中所需的劳动密集型步骤的那些方法和组合物。
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30.发明申请METABOLICALLY ENGINEERED ORGANISMS FOR THE PRODUCTION OF HYDROGEN AND HYDROGENASE 审中-公开用于生产氢和氢的代表性工程有机体公开(公告)号：US20100041121A1
公开(公告)日：2010-02-18
申请号：US12160764
申请日：2007-02-01
申请人： Guangyi Wang
发明人： Guangyi Wang
CPC分类号： C12N9/0067 , H01M8/16 , Y02E60/527
摘要： The present application relates to the use of metabolically-engineered microbial cells for the production of hydrogen and hydrogenase enzymes. The microbial cells are strains of E. coli which are genetically engineered to optimize the cell for production of hydrogen or active hydrogenase. The strains of E. coli are transformed with at least one expression vector directed towards the biosynthesis of a hydrogenase enzyme. Methods of hydrogen production, fuel-cell systems and recombinant fuel-cell catalysts are also provided.
摘要翻译： 本申请涉及代谢工程化的微生物细胞用于生产氢和氢化酶的用途。 微生物细胞是大肠杆菌菌株，其被遗传工程化以优化用于产生氢或活性氢化酶的细胞。 用至少一种用于氢化酶生物合成的表达载体转化大肠杆菌菌株。 还提供氢气生产方法，燃料电池系统和重组燃料电池催化剂。
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