公开(公告)号：US20210009617A1

公开(公告)日：2021-01-14

申请号：US17032267

申请日：2020-09-25

申请人： Massachusetts Institute of Technology

发明人： Mircea Dinca ,  Dennis Sheberla ,  Lei Sun ,  Casey R. Wade ,  Michael Glenn Campbell

IPC分类号： C07F15/04 ,  B01J20/22 ,  C07F15/06 ,  C07F1/00 ,  C07F1/08 ,  H01G11/30

摘要： Compositions and methods comprising metal organic frameworks (MOFs) and related uses are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core.

公开(公告)号：US10774095B2

公开(公告)日：2020-09-15

申请号：US14963897

申请日：2015-12-09

申请人： The King Abdulaziz City for Science and Technology

发明人： Nezar Hassan Khdary ,  Abdulaziz Almalik

IPC分类号： C07F1/08

摘要： The invention provides metal-ascorbic acid crystals and a method for synthesizing the metal-ascorbic acid crystals. The metal in the metal-ascorbic acid crystals is one of copper (Cu), gold (Au) and silver (Ag). The method for synthesizing the metal-ascorbic acid crystals includes sonicating a solution of ascorbic acid and a solvent in dark to obtain a clear solution, wherein the solvent is one of dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). A metal salt is added to the clear solution, wherein the metal salt is one of copper (II) sulfate pentahydrate (CuSO4.5H2O), gold (III)-chloride (AuCl3), and silver sulfate (Ag2SO4). The clear solution is sonicated after adding the metal salt to obtain a reaction mixture. Thereafter, the reaction mixture is heated in dark. The reaction mixture is treated to facilitate solvent extraction of the metal-ascorbic acid. Finally, the metal-ascorbic acid is crystallized.

公开(公告)号：US20200270275A1

公开(公告)日：2020-08-27

申请号：US16803845

申请日：2020-02-27

申请人： The University of North Carolina at Greensboro

发明人： Daniel J. C. HERR ,  Hemali Rathnayake ,  Kristen Dellinger

IPC分类号： C07F1/08 ,  C09D5/24 ,  H05K1/09 ,  H01B1/22

摘要： The devices and methods described herein push forward the resolution limits of directed self-assembly (DSA) technology for advanced device applications. Specifically described herein, are compositions of bioinspired DSA materials and methods using these bioinspired DSA materials to form sub-7 nm line-space patterns and to achieve functional nanoscopic structures, e.g., conducting nanowires on a substrate.

公开(公告)号：US10737239B2

公开(公告)日：2020-08-11

申请号：US15779314

申请日：2016-11-23

申请人： BASF SE

发明人： Julia Burckhart ,  Stefan Marx ,  Lena Arnold ,  Claus Hofmann ,  Ulrich Müller

IPC分类号： C07F1/08 ,  B01J20/22 ,  B01J20/30 ,  B01J20/28 ,  C07F3/06 ,  C07F5/06

摘要： The invention relates to a process for the preparation of metal-organic frameworks (MOFs) in form of a homogenous powder, and a process wherein the metal-organic framework is molded into shaped bodies.

公开(公告)号：US20200230245A1

公开(公告)日：2020-07-23

申请号：US16222500

申请日：2018-12-17

申请人： AUBURN UNIVERSITY

发明人： FENG LI ,  WU CHEN ,  PENGYU CHEN

IPC分类号： A61K47/52 ,  C07F1/08 ,  A61K31/337 ,  A61K31/704 ,  A61K49/18 ,  A61K31/325 ,  A61K47/69

摘要： The present disclosure provides method of making a nanoparticle complex wherein the nanoparticle complex comprises a ligand and a metal cation. The disclosure also provides nanoparticle complexes, methods of treating a disease in a patient utilizing the nanoparticle complexes, methods of identifying a disease in a patient utilizing the nanoparticle complexes, and kits involving the nanoparticle complexes.

公开(公告)号：US10596193B2

公开(公告)日：2020-03-24

申请号：US15706467

申请日：2017-09-15

申请人： C LAB PHARMA INTERNATIONAL, S.A.

发明人： Charles Louis Albartus Barker ,  William A. Boulanger

IPC分类号： A61K33/34 ,  A61K31/555 ,  C07F1/08

摘要： The present invention is directed to a pharmaceutical and/or dietary supplement composition comprising an effective amount of a copper (I) complex with glycine, pyruvate, or succinic acid and methods of treating mitochondrial, neuromuscular, and other diseases. Also provided are pharmaceutical treatment regimes and kits comprising a copper (I) complex with glycine, pyruvate, or succinate.

公开(公告)号：US20200079796A1

公开(公告)日：2020-03-12

申请号：US16537806

申请日：2019-08-12

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA

发明人： Seyed Fatemeh Seyedpour ,  Ahmad Rahimpour ,  Milad Rabbani Esfahani

IPC分类号： C07F1/00 ,  C07F1/08 ,  C07F3/06 ,  C07F15/06 ,  C07F15/04 ,  C07F13/00 ,  C07F3/00 ,  B01J31/22 ,  B01D39/16 ,  B01D53/02 ,  C02F1/28

摘要： Disclosed herein are methods of making nanostructured metal-organic frameworks. The methods include contacting a homogenized ligand solution with a homogenized aqueous metal salt solution at room temperature to form a mixture; and agitating the mixture for an amount of time to thereby form the nanostructured metal-organic framework at room temperature; wherein the homogenized ligand solution comprises a ligand dispersed substantially homogenously in a solvent selected from the group consisting of water, ethanol, isopropanol, n-propanol, lactic acid, and combinations thereof; and wherein the homogenized aqueous metal salt solution comprises a metal salt dispersed substantially homogenously in an aqueous solvent. Also disclosed herein are nanostructured metal-organic frameworks made by the methods described herein. Also disclosed herein are articles of manufacture comprising nanostructured metal-organic frameworks made by the methods described herein, such as filters, respirators, gas masks, human protection devices, catalysts, and catalyst supports.

公开(公告)号：US10556873B2

公开(公告)日：2020-02-11

申请号：US14834516

申请日：2015-08-25

申请人： Hyun-Soon Chong

发明人： Hyun-Soon Chong

IPC分类号： C07D255/02 ,  C07F9/94 ,  C07K16/40 ,  C07D413/12 ,  C07J43/00 ,  C07F1/08 ,  A61K49/10 ,  C07F5/00

摘要： Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacycicododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.

公开(公告)号：US10463901B2

公开(公告)日：2019-11-05

申请号：US15661232

申请日：2017-07-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES

发明人： Claude Grison ,  Jose Escarre

IPC分类号： A62D3/35 ,  B01J23/06 ,  B01J23/72 ,  B01J23/755 ,  C07C29/62 ,  C07C2/86 ,  C07C17/16 ,  C07C41/30 ,  C07C45/00 ,  C07C67/02 ,  C07C67/347 ,  C07C209/32 ,  C07D239/22 ,  C07F1/08 ,  A62D101/04

摘要： A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

公开(公告)号：US20190298734A1

公开(公告)日：2019-10-03

申请号：US16433030

申请日：2019-06-06

申请人： THE UNIVERSITY OF MELBOURNE

发明人： Paul Donnelly ,  James Hilton ,  Peter Crouch

IPC分类号： A61K31/555 ,  A61K31/145 ,  A61K31/28 ,  C07F3/06 ,  A61K31/315 ,  C07F1/08 ,  A61K31/30

摘要： The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.