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公开(公告)号：US20220307767A1
公开(公告)日：2022-09-29
申请号：US17703404
申请日：2022-03-24
申请人： Torsten Pächnatz
发明人： Torsten Pächnatz
摘要： A freeze drying plant for drying products containing liquid has a vacuum chamber configured to receive the products. A reception device has at least one reception plate onto which the products can be applied. A cooling system has a fluid circuit configured to cool and/or to heat the products by a cooling fluid conducted in the fluid circuit. The reception plate has at least one closed fluid space that is connected to the fluid circuit and that cooling fluid flows through. At least one sound generator introduces ultrasound into the products during a drying phase, with the sound generator disposed in the fluid space and being able to be flowed around by cooling fluid.
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公开(公告)号：US20220155010A1
公开(公告)日：2022-05-19
申请号：US17588929
申请日：2022-01-31
发明人： Andrew Strongrich , Alina Alexeenko
摘要： A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
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公开(公告)号：US20220062180A1
公开(公告)日：2022-03-03
申请号：US17359394
申请日：2021-06-25
摘要： System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.
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公开(公告)号：US20220031621A1
公开(公告)日：2022-02-03
申请号：US17410395
申请日：2021-08-24
摘要： The present invention relates to a process for lyophilising a product (3), comprising the steps of providing a bulk product (3) loading system in the form of a bag (1), the bag (1) having an interior and an exterior defined by a flexible wall, the bag (1) further comprising a filling port (5) providing access to the interior of the bag (1), filling a product (3) having a first moisture content into the interior of the bag (1) via the filling port (5), and exposing the product (3) in the interior of the bag (1) to a lyophilisation cycle such that the moisture content of the product (3) is reduced from the first moisture content to a second, lower, moisture content.
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公开(公告)号：US11236943B2
公开(公告)日：2022-02-01
申请号：US15299803
申请日：2016-10-21
发明人： Martin Christ
摘要： A freeze-drying apparatus (1) includes an arrangement of individual product platforms (19) that are supported vertically in a frame (20) in a drying chamber, in which each platform is able to be moved to a shift level, in which lateral guides (20, 21) designed to support a carriage (15) are arranged with a fixed height position, and which cooperate with the guides (16, 18) of a loading and unloading device (49). All product platforms (19) in the drying chamber can be loaded by repeating this operation cyclically. The freeze-drying apparatus (1) comprises an electrical drive unit powered by a battery (44).
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公开(公告)号：US11236942B2
公开(公告)日：2022-02-01
申请号：US14345913
申请日：2012-11-03
发明人： Martin Christ
摘要： A freeze-drying apparatus (1) includes an arrangement of individual product platforms (19) that are supported vertically in a frame (20) in a drying chamber, in which each platform is able to be moved to a shift level, in which lateral guides (20, 21) designed to support a carriage (15) are arranged with a fixed height position, and which cooperate with the guides (16, 18) of a loading and unloading device. All product platforms (19) in the drying chamber can be loaded by repeating this operation cyclically. In order to unload the drying chamber, the arrangement of the product platforms (19) are moved to such a position above the shift level in which the carriage (15) can be moved as far as its rear limit position inside the drying chamber, travelling underneath each loaded product platform (19).
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公开(公告)号：US20220024965A1
公开(公告)日：2022-01-27
申请号：US17186920
申请日：2021-02-26
IPC分类号： C07H21/04 , A61K9/19 , A61K31/7084 , F26B5/06 , C07H19/173
摘要： The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.
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公开(公告)号：US20210310734A1
公开(公告)日：2021-10-07
申请号：US17345779
申请日：2021-06-11
发明人： Byron J. KNIGHT
摘要： A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.
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公开(公告)号：US11105555B2
公开(公告)日：2021-08-31
申请号：US16499482
申请日：2018-04-02
发明人： Chie Matsumoto , Takao Yoshikawa , Takuya Shishido , Yuji Toyota , Sachiko Sakamoto , Yoshimitsu Shimomura , Mitsuhiko Hori
摘要： The present invention aims to provide a method and an apparatus for producing a lyophilized body, each of which can achieve energy saving, low cost, and a reduction in processing time and can provide a lyophilized body less damaged by a freezing process and a drying process. The present invention relates to a method for lyophilizing a substance using an electromagnetic wave, and the lyophilization method includes freezing the substance under irradiation of at least an electromagnetic wave and reduced-pressure drying the frozen substance under irradiation of at least an electromagnetic wave.
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公开(公告)号：US11084908B1
公开(公告)日：2021-08-10
申请号：US17271342
申请日：2019-08-07
发明人： Peter Niepoth , Verena Melk , Andrea Engel
摘要： A process prepares a polymer powder, with a D50 particle size from 40 to 200 μm and a Hausner factor of 1.25 or less, by freeze drying and subsequent loosening up of an aqueous polymer dispersion containing 15 to 50% by weight of a polymer. The polymer is polymerized from 10 to 30% by weight of methyl methacrylate, 50 to 70% by weight of methyl acrylate, and 5 to 15% by weight of methacrylic acid.
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