公开(公告)号：US11142795B2

公开(公告)日：2021-10-12

申请号：US16491163

申请日：2018-03-15

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Ya-Lang Huang ,  Tsung-Yu Tsai

IPC: G01N33/53 ,  A61K38/21 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N33/566 ,  G01N33/576

Abstract: Disclosed herein is a novel use of C-type lectin 18 (CLEC18) in disease prognosis. According to embodiments of the present disclosure, the mRNA or protein level of CLEC18 may serve as an indicator for diagnosing hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) loss and seroconversion, and/or liver fibrosis.

公开(公告)号：US11097134B2

公开(公告)日：2021-08-24

申请号：US16874019

申请日：2020-05-14

Applicant: Academia Sinica

Inventor： Song-Kun Shyue ,  Szu-Fu Chen ,  Chun-Hu Wu ,  Che-Feng Chang

IPC: A61P25/00 ,  C07K16/28 ,  A61K39/00

Abstract: A method for treating a neurological disorder, symptom or disease that is associated with an increase in the brain levels of caveolin-1 (Cav-1) in a subject in need thereof is disclosed. The method comprises administering to the subject in need thereof a composition comprising: (a) a therapeutically effective amount of an antibody specific against the Cav-1 or an antigen-binding fragment thereof; and (b) a pharmaceutically acceptable carrier. Methods for reducing cerebral inflammation, brain tissue damage, brain neuronal death, and improving behavioral outcomes or functional recovery related to a hemorrhagic stroke in a subject in need thereof are also disclosed.

公开(公告)号：US11097000B2

公开(公告)日：2021-08-24

申请号：US16338501

申请日：2017-10-03

Applicant: NATIONAL TAIWAN UNIVERSITY ,  Academia Sinica

Inventor： Jin-Town Wang ,  Shih-Hsiung Wu ,  Chung-Yi Wu

IPC: A61K39/108 ,  A61K31/04 ,  C08B37/00 ,  A61P31/04 ,  A61K39/00

Abstract: The disclosure provides various immunogens comprising a repeat unit of saccharide of Klebsiella pneumoniae CPS, which has a formula selected from the group consisting of Formulae (I) to (VI) as described herein. Also provided are vaccines including one or more immunogens selected from Formula (I) to (VI) and methods of eliciting an immune response against a Klebsiella pneumoniae and preventing infection of Klebsiella pneumoniae by using an immunogen of the invention.

公开(公告)号：US11096977B2

公开(公告)日：2021-08-24

申请号：US16800178

申请日：2020-02-25

Applicant: Academia Sinica

Inventor： Pei-wen Hsiao ,  Chin-Hsien Tsai ,  Shih-Chuan Hsieh

IPC: A61K36/00 ,  A61K36/28

Abstract: A composition including a standardized Wedelia chinensis extract and a method of treating an androgen-stimulated disorder with such a composition. Also provided are a method for qualifying a standardized preparation of a Wedelia chinensis extract for treating an androgen-stimulated disorder and a method for treating said disorder with a thus qualified preparation.

公开(公告)号：US20210254072A1

公开(公告)日：2021-08-19

申请号：US17049048

申请日：2018-12-21

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Pan-Chyr Yang ,  Wei-Yun Lai ,  Jen-Wei Wang

IPC: C12N15/115 ,  A61K47/60 ,  G01N33/53

Abstract: Nucleic acid aptamers that bind to tumor necrosis factor alpha (TNF). Also provided herein are pharmaceutical compositions comprising such anti-TNF aptamers and methods for the using the same for therapeutic and diagnostic applications, for example, alleviating liver injury and monitoring presence of TNF in vivo or in vitro.

公开(公告)号：US20210214424A1

公开(公告)日：2021-07-15

申请号：US17054994

申请日：2019-05-16

Applicant: CHANG GUNG MEMORIAL HOSPITAL, LINKOU ,  ACADEMIA SINICA

Inventor： Alice YU ,  Han-Chung WU ,  John YU

IPC: C07K16/18 ,  A61K47/68 ,  A61P35/00

Abstract: The present invention provides monoclonal antibodies or the antigen-binding portion thereof, that bind to a feto-embryonic dedifferentiated antigen, such as Leucine-rich Repeat Neuronal Protein 1 (LRRN1), a surface glycoprotein that is expressed abundantly on the surface of human embryonic stem cells prior to differentiation into embryoid bodies. Also disclosed herein are the uses of the novel LRRN1 antibodies.

公开(公告)号：US20210154472A1

公开(公告)日：2021-05-27

申请号：US17105056

申请日：2020-11-25

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  ACADEMIA SINICA

Inventor： Roy SHENHAR ,  Meital RECHES ,  Hsiao-hua YU

IPC: A61N1/32 ,  A61K9/00 ,  B32B27/08 ,  C08G61/12 ,  A61K9/70 ,  B32B27/28

Abstract: Nano-patterned devices for triggered intracellular delivery of active materials are disclosed. The device may comprise a nano-sized polyelectrolyte multilayer (PEM) comprising at least one layer of an electroactive polyelectrolyte polymer, where the PEM is configured to hold or receive an active material to be disposed within the multilayer and to release the active material under an electric field.

公开(公告)号：US20210147796A1

公开(公告)日：2021-05-20

申请号：US16620395

申请日：2018-06-06

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Yu-Tsen LIN

IPC: C12N5/00 ,  C07D307/04 ,  C12N5/0775

Abstract: The present invention relates to a method for removing undifferentiated embryonic stem cells. In particular, the present invention relates to a method for removing undifferentiated embryonic stem cells by using cardiac glycosides (CGs). The present invention also relates to a method for preparing differentiated cells in which undifferentiated embryonic stem cells have been removed and a method for cell therapy by using such differentiated cells.

公开(公告)号：US20210113179A1

公开(公告)日：2021-04-22

申请号：US17073408

申请日：2020-10-19

Applicant: Academia Sinica ,  National Chiao Tung University

Inventor： Chung-Hsuan CHEN ,  Shok-Li NG ,  Yung-Chieh CHAN ,  Peter LAI ,  Michael HSIAO ,  Olga K KOSHELEVA ,  Nelson G. CHEN

IPC: A61B8/08 ,  A61K49/22

Abstract: Disclosed herein is a method of enhancing the accuracy and/or sensitivity of ultrasound imaging in detecting a tumor in a subject. The method comprises administering to the subject an effective amount of a nanoparticle prior to the application of ultrasound to the subject. According to certain embodiments of the present disclosure, the nanoparticle is a magnetic nanoparticle, for example, a gold, silver, or iron oxide nanoparticle. Also disclosed herein are methods of treating a tumor in a subject by detecting the tumor via ultrasound with the aid of a nanoparticle, and then administering to the subject an anti-cancer treatment based on the location of the tumor revealed by the ultrasound image.

公开(公告)号：US10978091B2

公开(公告)日：2021-04-13

申请号：US16205328

申请日：2018-11-30

Applicant: ACADEMIA SINICA

Inventor： Yu Tsao ,  Syu-Siang Wang

IPC: G10L25/69 ,  G06F40/20 ,  G08G1/01 ,  G10L21/02 ,  G10L25/06 ,  G10L15/30 ,  G10L15/22 ,  G10L15/02 ,  G10L25/03

Abstract: A system is provided to realize suppression by selecting wavelets for feature compression in distributed speech recognition. The system comprises a first device and a second device. The first device comprising: a first network module for connecting to a network; an acoustic transducer module for recording speech and outputting frames of recorded signal; and a first processor configured for the following: extracting multiple-dimensional speech features from the frames of the recorded signal to generate multiple feature sequences; applying discrete wavelet transform (DWT) to the feature sequences to obtain a plurality of component data; and transmitting at least one of the plurality of component data via the network, wherein another one of the plurality of component data is not transmitted. The second device comprising: a second network module for connecting to the network and receiving the at least one of the plurality of component data from the first device; and a second processor configured for the following: updating the received data to generate an updated data; and applying inverse discrete wavelet transform (IDWT) to the updated data to obtain reconstructed speech data.