公开(公告)号：US20180247158A1

公开(公告)日：2018-08-30

申请号：US15757261

申请日：2016-09-02

Applicant: STC.UNM

Inventor： Yin Yang

IPC: G06K9/62 ,  G06T13/20 ,  G06T17/20 ,  G06F17/16

CPC classification number: G06K9/6247 ,  G06F17/16 ,  G06K9/6214 ,  G06T13/20 ,  G06T17/20

Abstract: Technologies are disclosed for precomputation of reduced deformable models. In such precomputation, a Krylov subspace iteration may be used to construct a series of inertia modes for an input mesh. The inertia modes may be condensed into a mode matrix. A set of cubature points may be sampled from the input mesh, and cubature weights of the set of cubature points may be calculated for each of the inertia modes in the mode matrix. A training dataset may be generated by iteratively adding training samples to the training dataset until a training error metric converges, wherein each training sample is generated from an inertia mode in the mode matrix and corresponding cubature weights. The reduced deformable model may be generated, including inertia modes in the training dataset and corresponding cubature weights.

公开(公告)号：US20180220133A1

公开(公告)日：2018-08-02

申请号：US15747982

申请日：2016-07-31

Applicant: STC.UNM

Inventor： Marios Stephanou PATTICHIS ,  Yuebing JIANG ,  Cong ZONG ,  Gangadharan ESAKKI ,  Venkatesh JATLA ,  Andreas PANAYIDES

IPC: H04N19/127 ,  H04N19/126 ,  H04N19/147

CPC classification number: H04N19/127 ,  H04N19/119 ,  H04N19/126 ,  H04N19/147 ,  H04N19/149 ,  H04N19/172

Abstract: System and methods for the joint control of reconstructed video quality, computational complexity and compression rate for intra-mode and inter-mode video encoding in HEVC. The invention provides effective methods for (i) generating a Pareto front for intra-coding by varying CTU parameters and the QP, (ii) generating a Pareto front for inter-coding by varying GOP configurations and the QP, (iii) real-time and offline Pareto model front estimation using regression methods, (iv) determining the optimal encoding configurations based on the Pareto model by root finding and local search, and (v) robust adaptation of the constraints and model updates at both the CTU and GOP levels.

公开(公告)号：US20180209910A1

公开(公告)日：2018-07-26

申请号：US15743204

申请日：2016-07-11

Applicant: STC.UNM

Inventor： Mani Hossein-Zadeh

IPC: G01N21/77 ,  G02B6/122 ,  G01J3/453 ,  G01J3/02 ,  G01N33/543

CPC classification number: G01N21/7703 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/42 ,  G01J3/453 ,  G01N33/54373 ,  G01N2201/0638 ,  G02B6/1223 ,  G02B6/1225 ,  G02B6/125

Abstract: The present invention provides a sensor having, one or more optical slab waveguides having one or more target regions. The target regions may interact with gas molecules or trap, entrain or capture one or more targets of interest. The optical slab waveguides are adapted to receive one or more input optical beams from one or more light sources to create a plurality of propagating optical waves in optical slab waveguide. The propagating optical waves interact with said one or more target regions to create an optical output wavefront that may be in the form of a diffraction pattern. The target regions may be functionalized with an antibody, polymer, cell, tissue, or biological material.

公开(公告)号：USRE46953E1

公开(公告)日：2018-07-17

申请号：US14020500

申请日：2013-09-06

Applicant: University of Maryland, Baltimore ,  STC.UNM ,  University of Notre Dame du Lac

Inventor： Cedric X. Yu ,  Shuang Luan ,  Danny Z. Chen ,  Matthew A. Earl ,  Chao Wang

IPC: A61N5/10 ,  G21K1/02 ,  H05G1/42

CPC classification number: A61N5/10 ,  G21K1/02 ,  H05G1/42

Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.

公开(公告)号：US10022327B2

公开(公告)日：2018-07-17

申请号：US14970998

申请日：2015-12-16

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K39/05 ,  C12N15/113 ,  C07K14/47 ,  C12N15/88 ,  A61K45/06 ,  A61K47/62 ,  A61K47/69 ,  A61K38/00 ,  A61K48/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：US10010558B2

公开(公告)日：2018-07-03

申请号：US15552541

申请日：2016-02-23

Applicant: STC.UNM ,  Charles Melancon ,  Pamela Hall ,  Jacob Greenberg ,  Yasushi Ogasawara ,  Snezna Rogelj

Inventor： Charles Melancon ,  Pamela Hall ,  Jacob Greenberg ,  Yasushi Ogasawara ,  Snezna Rogelj

IPC: A61K31/65

CPC classification number: A61K31/65 ,  A61K31/122 ,  A61K31/192

Abstract: In one aspect, this disclosure describes a pharmaceutical composition that generally includes frankiamicin A and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating a subject having, or at risk of having, a condition caused by a microbial infection treatable with frankiamicin A. Generally, the method includes administering to the subject an amount of frankiamicin A effective to ameliorate at least one symptom or clinical sign of the condition.

公开(公告)号：US20180177722A1

公开(公告)日：2018-06-28

申请号：US15738512

申请日：2016-06-24

Applicant: STC.UNM ,  RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jason Thomas McConville ,  Thiago Carvalho ,  Kristina Schonhoff

IPC: A61K9/00 ,  A61K31/122 ,  A61K47/14 ,  A61K47/26

CPC classification number: A61K9/0078 ,  A61K31/122 ,  A61K47/14 ,  A61K47/26

Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nano dispersion that can be readily aerosolized for inhalation.

公开(公告)号：US20180175218A1

公开(公告)日：2018-06-21

申请号：US15737250

申请日：2016-06-17

Applicant: STC.UNM

Inventor： Sang M. Han ,  Omar Abudayyeh ,  David Wilt ,  Nathan Gapp

IPC: H01L31/02

CPC classification number: H01L31/02008 ,  B82Y30/00 ,  B82Y40/00 ,  H01L31/05 ,  H02S40/44 ,  Y10S977/75 ,  Y10S977/752 ,  Y10S977/842 ,  Y10S977/89 ,  Y10S977/891 ,  Y10S977/901 ,  Y10S977/948

Abstract: A method for forming electrical contacts for a solar cell and a solar cell formed using the method is provided. The method includes forming a first metal layer over predefined portions of a surface of the solar cell; depositing a carbon nanotube layer over the first metal layer; and forming a second metal layer over the carbon nanotube layer, wherein the first metal layer, the carbon nanotube layer, and the second metal layer form a first metal matrix composite layer that provides electrical conductivity and mechanical support for the metal contacts.

公开(公告)号：US20180170897A1

公开(公告)日：2018-06-21

申请号：US15735840

申请日：2016-06-10

Applicant: STC.UNM ,  ROSALIND FRANKLIN UNIVERSITY

Inventor： Tudor I. Oprea ,  Cristian George Bologa ,  Oleg Ursu ,  Jun-Yong Choe ,  Cristina Iancu

IPC: C07D317/66 ,  A61K31/36 ,  A61K45/06 ,  C40B30/02 ,  A23L33/125

Abstract: The present invention relates to compounds which have been discovered to be potent ligands (inhibitors) of human GLUT5 (glucose transporter type 5), a facilitative glucose transporter that transports fructose, and their use as ligands assays which can uncover additional ligands of GLUT5, having the potential for being used as drugs. In addition, the present invention is directed to compounds, chemical compositions and methods for treating disease states and conditions which are mediated through GLUT5, including such disease states and conditions as GLUT5 deficiency syndrome, diabetes (type I and II), cancer, metabolic diseases including metabolic syndrome and fatty liver disease, among others.

公开(公告)号：US20180156783A1

公开(公告)日：2018-06-07

申请号：US15577809

申请日：2016-06-02

Applicant: STC.UNM

Inventor： Charles MELANCON ,  Shijie HUANG

IPC: G01N33/50 ,  C12Q1/6897 ,  G01N33/533

CPC classification number: G01N33/5076 ,  C12Q1/6897 ,  G01N33/533

Abstract: This disclosure describes a cell genetically modified to detect ribosome inhibition in the cell and methods involving such a cell. Generally, the genetically-modified cell includes an aminoglycoside-sensitive orthogonal 16S rRNA (O-16S) coding region bearing a mutated anti-Shine-Dalgarno (O-ASD) sequence, a repressor/operator system, and a polynucleotide encoding a detectable reporter under transcriptional control of the repressor/operator system. The repressor/operator system includes a coding region that encodes a transcriptional regulator and having an orthogonal SD (O-SD) sequence complementary to the 16S rRNA O-ASD sequence. The operator sequence, which is repressable by the transcriptional regulator, is operably linked to the polynucleotide encoding a detectable reporter.