公开(公告)号：US07186241B2

公开(公告)日：2007-03-06

申请号：US10265075

申请日：2002-10-03

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M5/24

CPC classification number: A61M5/3129 ,  A61J1/2041 ,  A61J1/2044 ,  A61J1/2055 ,  A61J1/2093 ,  A61M5/1782 ,  A61M5/284 ,  A61M2005/3123

Abstract: A syringe and a reconstitution syringe are provided for the delivery of controlled doses of any of numerous different sterile substances, such as vaccines, medicaments, pharmaceutical preparations, cosmetics, and food products. A plunger of the syringe defines a resealable stopper frictionally and slidably received within a hollow syringe body for dispensing the medicament or other substance through a dispensing tip of the syringe upon movement of the plunger. The resealable stopper defines a heat-sealable portion to allow the stopper to be penetrated by a needle or other filling device to fill the syringe with a medicament or other substance, and in turn allow the hole remaining upon withdrawal of the needle to be heat sealed by transmission of laser energy thereon. The plunger assembly further defines a plurality of cam-like members that each engage and cooperate with a respective helical path of steps formed on the inner wall of the syringe body to provide stepwise movement of the plunger and, in turn, precise metering of the substance dispensed therefrom. A reconstitution syringe defines within a syringe body plural compartments, wherein each compartment stores a respective component of a multi-component medicament or other preparation. An elastomeric plug is coupled to the plunger and connected between the two compartments to prevent intermixing of the components. Upon moving the plunger, the plug is released to thereby place the compartments in fluid communication with each other, and to facilitate intermixing of the components upon shaking the syringe.

Abstract translation: 提供注射器和重组注射器用于递送受控剂量的许多不同的无菌物质，例如疫苗，药物，药物制剂，化妆品和食品中的任何一种。 注射器的柱塞限定了摩擦并可滑动地容纳在中空注射器主体内的可再密封塞子，用于在柱塞移动时通过注射器的分配尖端分配药物或其它物质。 可重新密封的止动件限定了可热封部分，以允许止动器被针或其他填充装置穿透，以用药物或其它物质填充注射器，并且进而允许在针头被热封时提供剩余的孔 通过在其上传输激光能量。 柱塞组件还限定多个凸轮状构件，每个凸轮状构件与形成在注射器主体的内壁上的步骤的相应螺旋路径接合并配合，以提供柱塞的逐步运动，并且进而精确地计量物质 从中分配。 重建注射器在注射器主体内限定多个隔室，其中每个隔室存储多组分药物或其它制剂的相应组分。 弹性塞连接到柱塞并连接在两个隔室之间以防止部件的混合。 在移动柱塞时，塞子被释放，从而将隔间彼此流体连通，并且有助于在振动注射器时组件的混合。

公开(公告)号：USD536138S1

公开(公告)日：2007-01-30

申请号：US29259756

申请日：2006-05-15

Applicant: Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

公开(公告)号：USD532700S1

公开(公告)日：2006-11-28

申请号：US29245669

申请日：2005-12-28

Applicant: Daniel Py ,  Julian V. Chan

Designer： Daniel Py ,  Julian V. Chan

公开(公告)号：US20060124197A1

公开(公告)日：2006-06-15

申请号：US11349873

申请日：2006-02-08

Applicant: Daniel Py ,  Julian Chan

Inventor： Daniel Py ,  Julian Chan

IPC: B65B1/04

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：USD503345S1

公开(公告)日：2005-03-29

申请号：US29205954

申请日：2004-05-21

Applicant: Daniel Py ,  Julian V. Chan ,  Catalina M. Aranyi

Designer： Daniel Py ,  Julian V. Chan ,  Catalina M. Aranyi

公开(公告)号：US20050000591A1

公开(公告)日：2005-01-06

申请号：US10843902

申请日：2004-05-12

Applicant: Daniel Py ,  Julian Chan

Inventor： Daniel Py ,  Julian Chan

IPC: A61M20060101 ,  B65B1/04 ,  B65B3/30

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：US06604561B2

公开(公告)日：2003-08-12

申请号：US09781846

申请日：2001-02-12

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B104

CPC classification number: A61L2/081 ,  A61J1/1468 ,  A61J1/18 ,  A61L2202/121 ,  A61M2207/00 ,  B65B3/003 ,  B65D39/007 ,  B65D51/002

Abstract: A resealable cap for a medicament vial has a base portion formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion overlying the base portion. The resealable portion is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member for dispensing medicament into the vial. Prior to filling, the cap is assembled to the vial and the cap/vial assembly is sterilized. Then, a needle is inserted through the cap and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle, the penetrated region of the cap is fused by laser or direct heat sealing to hermetically seal the needle hole in the cap.

公开(公告)号：USRE37047E1

公开(公告)日：2001-02-06

申请号：US08567510

申请日：1995-12-05

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M3500

CPC classification number: A61F9/0026 ,  A61F9/0008 ,  A61F2250/0067

Abstract: A cartridge for actuating a piston-like or accordion-like dispenser-vial for applying medicament to an eye. The cartridge includes a housing for holding the dispenser-vial and a telescoping cylinder for compressing the dispenser-vial in the longitudinal direction to actuate the vial. The cartridge includes a locking mechanism for locking the telescoping cylinder to restrict its movement and a trigger mechanism for releasing the cylinder from the locked position so that a drop is released from the dispenser. The housing includes a finger for engaging the lower eyelid and exposing the conjunctival cul de sac.

Abstract translation: 用于致动用于将药物施用于眼睛的活塞式或类风琴式分配器 - 小瓶的药筒。 该盒包括用于保持分配器 - 小瓶的壳体和用于在纵向方向上压缩分配器 - 小瓶以致动小瓶的伸缩圆柱体。 该卡盘包括用于锁定伸缩缸以限制其运动的锁定机构和用于将汽缸从锁定位置释放的触发机构，使得液滴从分配器释放。 外壳包括用于接合下眼睑并暴露结膜cul囊的手指。

公开(公告)号：US5875931A

公开(公告)日：1999-03-02

申请号：US661246

申请日：1996-06-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/05 ,  A61F9/00 ,  A61J3/00 ,  A61M11/00 ,  B05B11/00 ,  A61M35/00

CPC classification number: B05B11/3084 ,  A61F9/0008

Abstract: A double-dispenser system for dispensing medicinal liquids has two jet-trigger pumps housed in an outer casing having at least one front opening and one rear opening. Each jet-trigger pump is provided with a dosing mechanism for dispensing a predetermined dose of medicinal liquid. Dispensation from the two pumps may be triggered simultaneously by a trigger device common to the two pumps and accessible from the outside of the casing. The pumps incorporated in the double-dispenser system may be of the type having a pump body and a piston housed in an elastic bottle. For each pump, relative movements between the piston and the pump body causes changes in the relative-displacement between the piston and the pump body such that medicinal liquid is initially loaded into a medicine-holding cavity within the pump and subsequently dispensed.

Abstract translation: 用于分配医用液体的双分配器系统具有容纳在具有至少一个前开口和一个后开口的外壳中的两个喷射触发泵。 每个喷射触发泵设置有用于分配预定剂量的药液的计量机构。 来自两个泵的分配可以由两个泵共用的触发装置同时触发并且可从壳体的外部进入。 结合在双分配器系统中的泵可以是具有容纳在弹性瓶中的泵体和活塞的类型。 对于每个泵，活塞和泵体之间的相对运动导致活塞和泵体之间的相对位移的变化，使得药用液体最初被装载到泵内的药物保持腔中并随后被分配。

公开(公告)号：US5685869A

公开(公告)日：1997-11-11

申请号：US433856

申请日：1995-05-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M11/00 ,  A61F9/00 ,  A61J1/05 ,  A61M35/00 ,  B05B11/00 ,  B67D5/64

CPC classification number: B05B11/307 ,  A61F9/0008 ,  A61M35/003 ,  B05B11/0072 ,  B05B11/3001 ,  B05B11/3074 ,  B05B11/3095

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A seam is formed by the interface of the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The seam opens in response to the flow of medicament of sufficient pressure into the seam to permit the passage of medicament through the nozzle for release into the eye.

Abstract translation: 使用一种装置将药物施用于眼睛并将药物储存在药物室中。 喷嘴与药物室流体连通地连接并由外部喷嘴部分和容纳在外部喷嘴部分内部的内部喷嘴部分形成。 接缝由内部喷嘴部分和外部喷嘴部分的界面形成，并且通常处于关闭位置以防止药物通过喷嘴。 响应于足够压力的药物流进入接缝以使药物通过喷嘴以释放到眼睛中，接缝开口。