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公开(公告)号：US11517636B2
公开(公告)日：2022-12-06
申请号：US16640971
申请日：2018-09-10
Inventor： Hisashi Yabutani , Takeshi Ishida , Yoshihiro Yamashita , Taku Sakazume , Michaela Windfuhr , Bernhard Hauptmann , Andreas Finke
Abstract: An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container. The third electric power switch is opened when an amount of the reagent within the shared reagent storage container is equal to or smaller than a constant value. When one of the first electric power switch, the second electric power switch, and the third electric power switch is opened, supply of the electric power to the ultraviolet LED is intercepted.
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公开(公告)号：US11511279B2
公开(公告)日：2022-11-29
申请号：US16672869
申请日：2019-11-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Enck
Abstract: A method to handle tubes in a diagnostic laboratory automation system comprising a control device and a tube-analyzing device is presented. The tube-analyzing device comprises a tube identification reader, a tube type recognition unit, a sample color determination unit, and a tube consistence unit. The tube identification reader reads tube identification device. The tube type recognition unit identifies tube type. The sample color determination unit determines sample color. The tube consistence unit determines sample consistency. The sample tube type, the tube type, the sample color, the sample consistency are send to the control device. The control device determines a construed tube type from one or more of the information of the tube type, the sample color, and the sample consistency. The control device checks whether the tube type matches the construed tube type and changes a used tube type from the tube type to the construed tube type.
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公开(公告)号：US20220365099A1
公开(公告)日：2022-11-17
申请号：US17745429
申请日：2022-05-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Gaston Hubertus Maria Vondenhoff
IPC: G01N33/68 , G01N33/543 , B01L3/00
Abstract: The present invention relates to derivatization of antibiotic analytes as well as methods of determining the amount or concentration of derivatized antibiotic analytes in an obtained sample.
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公开(公告)号：US20220328295A1
公开(公告)日：2022-10-13
申请号：US17809760
申请日：2022-06-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Nadja Arens , Daniel Intelmann
Abstract: Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.
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公开(公告)号：US11454615B2
公开(公告)日：2022-09-27
申请号：US15931152
申请日：2020-05-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Adrian Sievers-Engler
Abstract: A liquid chromatographic (LC) system and a method of exchanging a liquid in an LC system are disclosed. The LC system includes an LC pump with at least one pump head having a primary and a secondary pump head, each with a syringe-like cylinder body having an inner wall surface and a plunger translatable through the cylinder body leaving an interspace between the inner wall surface and the plunger when the plunger is translated through the cylinder body, an upstream inlet valve configured to allow liquid into the cylinder body and a downstream outlet valve configured to allow liquid out of the cylinder body. The LC system further includes at least one liquid-exchange pump connected either to the upstream inlet valve of the primary pump head or to the downstream outlet valve of the secondary pump head.
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Patent Agency Ranking
公开(公告)号：US11428701B2
公开(公告)日：2022-08-30
申请号：US17025495
申请日：2020-09-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thomas Martin
Abstract: An in-vitro diagnostics system arranged is presented. The system comprises a track, carriers to carry samples with data carriers, and a control station comprising a camera to detect sample images, a data carrier reader, a relocation device to relocate the sample, and a controller. The data carrier reader reads the data carrier through a read-out window. Measurement data indicates data carrier characteristics on a sample in a starting position determined from the camera images. Obscuring data indicates obscuring of part of the data carrier when the images are detected in the starting position. The controller determines, from the measurement data and the obscuring data, characteristics of the data carrier comprising location and size of the data carrier. Based on the data carrier characteristics, the sample is relocated relative to the read-out window from the starting position into a read-out position optimizing visibility of the data carrier through the read-out window.
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公开(公告)号：US11408902B2
公开(公告)日：2022-08-09
申请号：US16156348
申请日：2018-10-10
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Waldburger
Abstract: A method to store sample tubes in a laboratory storage and retrieval system is presented. The laboratory storage and retrieval system comprises a storage section, a database comprising a sample tube inventory of the storage section, a control device, and at least one sample tube transport system. The storage section comprises at least two storage subsections. In a first step of the method, the control device identifies at least two sample tubes with at least one substantially identical sample tube attribute and distributed over the at least two storage subsections. In a second step of the method, the at least one sample tube transport system consolidates the at least two sample tubes in at least one storage subsection, wherein the control device further determines in which of the at least two storage subsections the identified sample tubes are consolidated.
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公开(公告)号：US20220243250A1
公开(公告)日：2022-08-04
申请号：US17720577
申请日：2022-04-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andrea Lichte , Michael-Harold Town
Abstract: A method for determining a non-anticoagulant interferent in a blood-derived sample of a subject, the method comprising a) determining a value of a coagulation time-related parameter in the sample; b) comparing the value of the coagulation time-related parameter determined in a) to a value of the coagulation time-related parameter determined in at least one reference sample; and c) based on the result of comparison step b), determining the non-anticoagulant interferent in a blood-derived sample of a subject. A method for identifying a blood-derived sample having insufficient quality is further disclosed, the method comprising determining non-anticoagulant interferent(s) according to the aforesaid method.
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公开(公告)号：US20220203350A1
公开(公告)日：2022-06-30
申请号：US17699872
申请日：2022-03-21
Inventor： Ertan Ergezen , Stephen Conroy , Rijk Oosterbroek , Claudio Cherubini
Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.
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公开(公告)号：US20220196052A1
公开(公告)日：2022-06-23
申请号：US17453977
申请日：2021-11-08
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Eugen Lusser , Thomas Meyer , Leon Felipe Apodaca Lujan , Timo Gutmann , Avinash Addihalli Narayana
Abstract: A connecting joint for adjustably connecting at least two components of a laboratory automation system is disclosed. The connecting joint comprises a horizontal bearing unit connectable to a first component of the at least two components of the laboratory automation system; a vertical bearing unit connectable to a second component of the at least two components of the laboratory automation system; and a slider bar connecting the horizontal bearing unit with the vertical bearing unit, wherein the slider bar is movably mounted along a vertical axis within the vertical bearing unit; and wherein the slider bar is adjustably mounted in the horizontal bearing unit, wherein the slider bar is adjustable in at least one dimension essentially perpendicular to the vertical axis by the horizontal bearing unit.
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