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公开(公告)号：US20200308118A1
公开(公告)日：2020-10-01
申请号：US16784016
申请日：2020-02-06
IPC分类号： C07D231/14 , A61K9/00
摘要： Disclosed are crystalline salts of Compound I, methods of preparing them, and related pharmaceutical preparations thereof. Also disclosed are methods of treatment using the crystalline salts of the invention.
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公开(公告)号：US10662160B1
公开(公告)日：2020-05-26
申请号：US16671649
申请日：2019-11-01
IPC分类号： C07D231/14 , A61K9/00 , A23L33/10
摘要： Disclosed are crystalline salts of Compound I, methods of preparing them, and related pharmaceutical preparations thereof. Also disclosed are methods of treatment using the crystalline salts of the invention.
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公开(公告)号：US10562850B2
公开(公告)日：2020-02-18
申请号：US15764071
申请日：2016-09-30
IPC分类号： C07D401/14 , C07D207/12 , A61K31/444 , A61K31/40 , C07D207/16 , C07D401/12 , C07D409/14 , C07D207/24 , A61P17/00
摘要： Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.
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公开(公告)号：US20190142802A1
公开(公告)日：2019-05-16
申请号：US16073934
申请日：2017-02-01
发明人： Pravin L. Kotian , Yarlagadda S. Babu , Weihe Zhang , Lakshminarayana Vogeti , Minwan Wu , Venkat R. Chintareddy , Krishhan Raman
摘要： Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising a compound of formula I, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by aberrant complement system activity.
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公开(公告)号：US10125102B2
公开(公告)日：2018-11-13
申请号：US15123059
申请日：2015-03-09
发明人： Pravin L. Kotian , Yarlagadda S. Babu , Minwan Wu , Venkat R. Chintareddy , V. Satish Kumar , Weihe Zhang
IPC分类号： C07D231/14 , C07D403/04 , C07D417/12 , C07D413/04 , C07D403/12 , C07D401/04 , C07D401/14 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also disclosed are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.
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公开(公告)号：US08440813B2
公开(公告)日：2013-05-14
申请号：US12522892
申请日：2008-01-11
IPC分类号： C07H5/04 , C07D253/10 , A61K31/7052
CPC分类号： C07H19/23
摘要： The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译： 本发明提供如本文所述的式（I）化合物以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。 式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。
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![Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer](/abs-image/US/2012/08/14/US08242085B2/abs.jpg.150x150.jpg)
37.发明授权Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer 有权用于治疗病毒感染和癌症的四氢呋喃并[3,4-D]二氧戊环化合物公开(公告)号：US08242085B2
公开(公告)日：2012-08-14
申请号：US12599656
申请日：2008-05-08
申请人： Yarlagadda S. Babu , Pooran Chand
发明人： Yarlagadda S. Babu , Pooran Chand
CPC分类号： C07D519/00
摘要： The invention provides compounds of formula (I), as described herein, or pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译： 本发明提供如本文所述的式（I）化合物或其药学上可接受的盐，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。 式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。
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公开(公告)号：US20110165183A1
公开(公告)日：2011-07-07
申请号：US13057100
申请日：2009-07-31
IPC分类号： A61K39/00 , C07D491/048 , A61K31/519 , C07D487/04 , A61K31/53 , C07D513/04
CPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04
摘要： The invention provides a compound of formula (I): wherein W is a bicyclic heteroaromatic group; or a salt thereof. The compounds and salts thereof have beneficial therapeutic properties (e.g. immunosuppressant properties).
摘要翻译： 本发明提供式（I）化合物：其中W是双环杂芳基; 或其盐。 其化合物及其盐具有有益的治疗特性（例如免疫抑制剂特性）。
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公开(公告)号：US20110015264A1
公开(公告)日：2011-01-20
申请号：US12749030
申请日：2010-03-29
IPC分类号： A61K31/215 , A61K31/195 , C07C61/06 , A61P31/16
CPC分类号： A61K31/195
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
摘要翻译： 本发明提供了用于治疗病毒感染的单位剂量形式，试剂盒和方法。
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公开(公告)号：US20090227524A1
公开(公告)日：2009-09-10
申请号：US12398866
申请日：2009-03-05
申请人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
发明人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
IPC分类号： A61K31/7052 , C07H7/00 , C12N9/99 , A61P35/00 , A61P31/12
CPC分类号： C12N9/99 , C07D487/06 , C07D491/06 , C07D498/06 , C12N9/1241
摘要： The invention provides compounds of Formula I: as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译： 本发明提供式I化合物：如本文所述，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。 式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。
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