公开(公告)号：US11815527B2

公开(公告)日：2023-11-14

申请号：US17520318

申请日：2021-11-05

申请人： New York University in Abu Dhabi Corporation

发明人： Mohammad A. Qasaimeh ,  Ayoub Glia

IPC分类号： G01Q60/38 ,  G01Q20/02

CPC分类号： G01Q60/38 ,  G01Q20/02

摘要： Disclosed is a multipurpose scanning microscopy probe comprising a probe holder, a cantilever connected to the probe holder, and a probe tip connected to the cantilever, wherein the probe tip is a three-dimensional geometry, and wherein the probe tip is a 3D printed part. In some embodiments the probe is made from SU8 epoxy-based resin. In some embodiments the probe is made from a combination of SU8 and nanomaterial such as carbon nanotubes. In some embodiments the probe includes cavities and voids. In some embodies the probe includes fluidic features and elements. Scanning microscopy probe methods are also disclosed.

公开(公告)号：US11795511B2

公开(公告)日：2023-10-24

申请号：US16934850

申请日：2020-07-21

申请人： NEW YORK UNIVERSITY

发明人： William L. Carroll ,  Julia A. Meyer

IPC分类号： C12Q1/6886 ,  A61K31/52 ,  A61K31/573 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06

CPC分类号： C12Q1/6886 ,  A61K31/52 ,  A61K31/573 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06 ,  C12Q2600/118 ,  C12Q2600/156

摘要： The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject.

公开(公告)号：US20230332136A1

公开(公告)日：2023-10-19

申请号：US18303421

申请日：2023-04-19

申请人： New York University

发明人： Yuelin Song ,  Dan R. Littman

IPC分类号： C12N15/10

CPC分类号： C12N15/1055

摘要： Provided are compositions and methods for identifying agents that can modulate IL-17 receptors. The compositions and methods use modified cells that produce a detectable signal that indicates whether or not a test agent is an agonist or antagonist of and IL-17 receptor.

公开(公告)号：US20230295668A1

公开(公告)日：2023-09-21

申请号：US18185601

申请日：2023-03-17

申请人： Opentrons Labworks Inc. ,  New York University

发明人： David Minh TRUONG

IPC分类号： C12N15/90 ,  C12N15/11 ,  C12N9/22

CPC分类号： C12N15/907 ,  C12N15/111 ,  C12N9/22 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided herein are methods and compositions for integrating a large DNA construct into a genome in a cell. Also provided herein are methods and compositions for producing a synthetic genome.

公开(公告)号：US20230295300A1

公开(公告)日：2023-09-21

申请号：US18309132

申请日：2023-04-28

申请人： New York University

发明人： Shohei Koide ,  George Miller ,  Akiko Koide ,  Tatyana Panchenko

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

CPC分类号： C07K16/2809 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/55 ,  C07K2317/76

摘要： Disclosed herein are antibodies specific to a delta1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti-Delta1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.

公开(公告)号：US20230280343A1

公开(公告)日：2023-09-07

申请号：US18058703

申请日：2022-11-23

申请人： New York University

发明人： Jin Kim Montclare ,  Farbod Mahmoudinobar ,  Kamia Punia ,  Dustin Robert Britton

IPC分类号： G01N33/569 ,  G01N33/543 ,  C07K14/78 ,  A61P31/14

CPC分类号： G01N33/56983 ,  G01N33/54388 ,  C07K14/78 ,  A61P31/14 ,  C12Y304/17023 ,  G01N2469/10 ,  G01N2469/20 ,  C07K2319/50

摘要： Provided is a multivalent protein that targets interaction of SARS-CoV-2 spike receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) receptor protein. The multivalent proteins may also be used to treat subjects having cancer and/or a disease and/or viral infection. Also presented is a multiplex lateral flow test strips for simultaneous detection of the virus and viral antibodies.

公开(公告)号：US20230237200A1

公开(公告)日：2023-07-27

申请号：US18101105

申请日：2023-01-24

申请人： New York University

发明人： Abhijit CHITNIS ,  William DOCKERY ,  NFN JIGYASA

IPC分类号： G06F21/64 ,  G06F21/16 ,  G06F21/44 ,  G06F21/62 ,  H04L9/32 ,  H04L9/00

CPC分类号： G06F21/64 ,  G06F21/16 ,  G06F21/44 ,  G06F21/6209 ,  H04L9/3239 ,  H04L9/3247 ,  H04L9/50 ,  G06F2221/0733

摘要： Digital Witness is a solution based on advanced cryptographic techniques to ensure data integrity, authenticity, irrefutability and confidentiality at the point of data creation. The DigiWit process guarantee is based on using strong cryptographic techniques in conjunction with PKI and public/private block-chains. DigiWit process establishes a ‘root of trust’ for a digital artifact in conjunction with notarization provided by a trusted third-party. The result is a mathematical non-repudiable guarantee that the file under audit is exactly as recorded by the author. The authenticity of the author and the root of trust are provided by the notarizing trusted third-party. Integrity of the captured data is based on the time to insert its unique signature to the block-chain public ledger. This root of trust is intended to be permissible to prove authenticity of evidence in the legal arena (e.g., images of crime scenes, contracts, etc.) based on mathematical veracity.

公开(公告)号：US20230218463A1

公开(公告)日：2023-07-13

申请号：US18002125

申请日：2021-06-17

申请人： NEW YORK UNIVERSITY ,  AERAGEN, INC.

发明人： Vikram Kapila ,  Valentin SIDERSKIY ,  Armando GRANADO ,  Sahil KUMAR ,  Tom Sowers ,  Hassam Khan WAZIR ,  Miles Quinn KILCOURSE ,  Sai Prasanth KRISHNAMOOTHY ,  Ryan GONZALEZ

IPC分类号： A61G10/00 ,  B01D46/44 ,  B08B15/02 ,  B01D46/54 ,  B01D39/20

CPC分类号： A61G10/005 ,  B01D46/44 ,  B08B15/02 ,  B01D46/543 ,  B01D46/546 ,  B01D39/2062 ,  A61L2209/14 ,  B01D2239/0618

摘要： The present invention provides devices and methods to capture airborne agents, microbes, including viruses, and microbial antigens, toxins and allergens and prevent the spread of infection from direct contact with contaminated surfaces (contact contamination), from large droplets of infectious material that fall out of the air, or from small droplets that can be carried by the air stream throughout the environment (airborne contamination).

公开(公告)号：US20230195421A1

公开(公告)日：2023-06-22

申请号：US18110671

申请日：2023-02-16

申请人： New York University

发明人： David J. Heeger ,  Wayne E. Mackey

IPC分类号： G06F7/544 ,  G06N3/08 ,  G06N20/00 ,  G06N3/065

CPC分类号： G06F7/5443 ,  G06N3/08 ,  G06N20/00 ,  G06N3/065

摘要： A method for computation with recurrent neural networks includes receiving an input drive and a recurrent drive, producing at least one modulatory response; computing at least one output response, each output response including a sum of: (1) the input drive multiplied by a function of at least one of the at least one modulatory response, each input drive including a function of at least one input, and (2) the recurrent drive multiplied by a function of at least one of the at least one modulatory response, each recurrent drive including a function of the at least one output response, each modulatory response including a function of at least one of (i) the at least one input, (ii) the at least one output response, or (iii) at least one first offset, and computing a readout of the at least one output response.

公开(公告)号：US20230180718A1

公开(公告)日：2023-06-15

申请号：US17906572

申请日：2021-03-19

申请人： New York University

发明人： Dmitry RINBERG ,  Hirofumi NAKAYAMA

IPC分类号： A01K15/02

CPC分类号： A01K15/02 ,  A01K2227/105 ,  A01K2267/0356

摘要： A method of training a rodent to identify pairs of same or different odors, whereby the rodent learns the rule irrespective of the particular odors. Once trained, the rodent can be used to measure perceptual odor similarities between members of pairs of odors, which odors may be unrelated to the odors the rodent was trained on.