公开(公告)号：US09643142B2

公开(公告)日：2017-05-09

申请号：US14321120

申请日：2014-07-01

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf Pavlik

IPC: B01F13/02 ,  B01F11/00 ,  B01F15/00 ,  B01F3/04 ,  C12M1/00

CPC classification number: B01F13/0238 ,  B01F3/04248 ,  B01F11/0082 ,  B01F15/0085 ,  C12M23/14 ,  C12M29/06

Abstract: A plunge-mixing bag arrangement includes a flexible mixing bag defining a mixing region, and a shaft extending from outside of the flexible mixing bag into the mixing region, the shaft comprising a sparger within the mixing region. The sparger comprises an interior channel and ports extending from the interior channel. The shaft is capable of axial movement within the bag to fracture gas bubbles being released from the interior channel through the ports. A plunge-mixing system includes a mechanism for raising and lowering the shaft.

公开(公告)号：US20160022538A1

公开(公告)日：2016-01-28

申请号：US14875442

申请日：2015-10-05

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf Pavlik

IPC: A61J1/20

CPC classification number: A61J1/2051 ,  A61J1/201 ,  A61J1/2048 ,  A61M39/10 ,  A61M39/1055 ,  A61M39/12 ,  A61M39/16 ,  A61M39/18 ,  A61M2039/1072 ,  A61M2039/2433 ,  A61M2039/2473 ,  B65B3/003

Abstract: A method for forming an aseptic connection includes inserting an end of a sealed fill connector into a receptacle of an aseptic connector assembly; moving a pivot portion of the aseptic connector assembly relative to a body portion of the aseptic connector assembly so as to sever a portion of the fill connector, the pivot portion being at least partially disposed within the body portion; and advancing a conduit portion of the aseptic connector assembly into the fill connector so as to form an aseptic connection therebetween, the conduit portion being at least partially disposed within the pivot portion or the body portion of the aseptic connector assembly after advancing.

Abstract translation: 用于形成无菌连接的方法包括将密封填充连接器的一端插入到无菌连接器组件的容器中; 使所述无菌连接器组件的枢转部分相对于所述无菌连接器组件的主体部分移动，从而切断所述填充连接器的一部分，所述枢转部分至少部分地设置在所述主体部分内; 以及将所述无菌连接器组件的导管部分推进到所述填充连接器中，以在其间形成无菌连接，所述导管部分在推进之后至少部分地设置在所述无菌连接器组件的枢轴部分或主体部分内。

公开(公告)号：US20150374583A1

公开(公告)日：2015-12-31

申请号：US14738442

申请日：2015-06-12

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf Pavlik

IPC: A61J1/16 ,  A61J1/14 ,  A61J1/10

CPC classification number: A61J1/16 ,  A01N1/0263 ,  A01N1/0268 ,  A61J1/10 ,  A61J1/1475 ,  B65D31/06 ,  F25D31/00

Abstract: A freezer bag, a storage system, and a method of freezing are provided. The freezer bag includes a pliable housing having opposing sides and bounding a cavity at least partially disposed between the opposing sides, each opposing side having an interior surface communicating with the cavity and an opposing exterior surface that is openly exposed, the pliable housing including a first panel and a seam. A first tufting couples together the opposing sides of the pliable housing at a distance spaced apart from the seam so that the cavity encircles the first tufting. A first port is connected to the pliable housing and communicates with the cavity.

Abstract translation: 提供冷冻袋，储存系统和冷冻方法。 冷冻袋包括具有相对侧面并且限定至少部分地设置在相对侧之间的空腔的柔性外壳，每个相对侧具有与空腔连通的内表面和露出的相对的外表面，所述柔性外壳包括第一 面板和接缝。 第一簇绒在与缝合间隔开的距离处将柔性外壳的相对侧联合在一起，使得腔围绕第一簇绒。 第一端口连接到柔性外壳并与空腔连通。

公开(公告)号：US09186493B2

公开(公告)日：2015-11-17

申请号：US14476900

申请日：2014-09-04

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf Pavlik

IPC: A61M39/00 ,  A61M39/10 ,  A61M39/18 ,  A61M39/16

CPC classification number: A61J1/2051 ,  A61J1/201 ,  A61J1/2048 ,  A61M39/10 ,  A61M39/1055 ,  A61M39/12 ,  A61M39/16 ,  A61M39/18 ,  A61M2039/1072 ,  A61M2039/2433 ,  A61M2039/2473 ,  B65B3/003

Abstract: An aseptic connector assembly and a method of aseptically transferring fluid are provided. The aseptic connector assembly includes a body portion, the body portion having a receptacle configured to receive a corresponding fill connector; a pivot portion adjustably disposed within and extending partially from the body portion, the pivot portion having a channel formed therein; and a conduit portion axially slidably disposed within the channel formed in the pivot portion. The pivot portion comprises a ready position and an operative position, the pivot portion being adjustable from the ready position to the operative position via relative movement with respect to the body portion. The method includes providing an aseptic connector in a ready position, coupling a flexible tubing and a fill connector to the aseptic connector, moving a pivot portion to an operative position, axially sliding the conduit portion into the fill connector, and transferring a fluid through the connector.

Abstract translation: 提供无菌连接器组件和无菌转移流体的方法。 所述无菌连接器组件包括主体部分，所述主体部分具有被配置为容纳相应的填充连接器的插座; 枢转部分可调节地设置在主体部分内并部分地从主体部分延伸，枢转部分具有形成在其中的通道; 以及导管部分，其轴向可滑动地设置在形成在枢转部分中的通道内。 枢转部分包括准备位置和操作位置，枢转部分可以通过相对于主体部分的相对运动从就绪位置调整到操作位置。 该方法包括将无菌连接器提供在就绪位置，将柔性管和填充连接器连接到无菌连接器，将枢轴部分移动到操作位置，将导管部分轴向滑动到填充连接器中，以及将流体通过 连接器。

公开(公告)号：US20150306554A1

公开(公告)日：2015-10-29

申请号：US14794641

申请日：2015-07-08

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf Pavlik

IPC: B01F15/00 ,  C12M1/00

CPC classification number: B01F15/0085 ,  B01F3/1221 ,  B01F11/0048 ,  B01F11/0082 ,  B01F15/00129 ,  B01F15/00155 ,  B01F15/00207 ,  B01F15/00253 ,  B01F15/00259 ,  B01F15/00402 ,  B01F15/00467 ,  B01F15/00538 ,  B01F2215/0073 ,  C12M23/14

Abstract: A mixing system and mixing method are provided. The mixing system includes a tank assembly, a container positioned within the tank assembly, a mixer disposed within a compartment of the container, a linear motor, and a shaft having a first end secured to the mixer and an opposing second end secured to the linear motor. The linear motor provides a variable stroke length for the shaft. The mixing method includes providing a tank assembly having a linear motor, positioning a mixing assembly including a mixing bag in the tank assembly, combining two or more components in a compartment of the mixing bag, attaching a mixing shaft extending from a mixer disposed within the mixing bag to the linear motor, and raising and lowering the mixing shaft to mix the two or more components. A stroke length of the mixing shaft during the raising and lowering is varied.

Abstract translation: 提供了一种混合系统和混合方法。 混合系统包括罐组件，位于罐组件内的容器，设置在容器的隔室内的混合器，线性马达和具有固定到混合器的第一端的轴，以及固定到线性的相对的第二端 发动机。 线性电机为轴提供了可变行程长度。 该混合方法包括提供具有线性马达的罐组件，将包括混合袋的混合组件定位在罐组件中，将混合袋的隔室中的两个或更多个部件组合在一起，将从设置在该混合袋内的混合器延伸的混合轴 混合袋到线性马达，以及升降混合轴以混合两个或更多个部件。 混合轴在升降过程中的行程长度变化。

公开(公告)号：US20150290448A1

公开(公告)日：2015-10-15

申请号：US14476900

申请日：2014-09-04

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: A61M39/10 ,  A61M39/16 ,  A61M39/18

CPC classification number: A61J1/2051 ,  A61J1/201 ,  A61J1/2048 ,  A61M39/10 ,  A61M39/1055 ,  A61M39/12 ,  A61M39/16 ,  A61M39/18 ,  A61M2039/1072 ,  A61M2039/2433 ,  A61M2039/2473 ,  B65B3/003

Abstract: An aseptic connector assembly and a method of aseptically transferring fluid are provided. The aseptic connector assembly includes a body portion, the body portion having a receptacle configured to receive a corresponding fill connector; a pivot portion adjustably disposed within and extending partially from the body portion, the pivot portion having a channel formed therein; and a conduit portion axially slidably disposed within the channel formed in the pivot portion. The pivot portion comprises a ready position and an operative position, the pivot portion being adjustable from the ready position to the operative position via relative movement with respect to the body portion. The method includes providing an aseptic connector in a ready position, coupling a flexible tubing and a fill connector to the aseptic connector, moving a pivot portion to an operative position, axially sliding the conduit portion into the fill connector, and transferring a fluid through the connector.

Abstract translation: 提供无菌连接器组件和无菌转移流体的方法。 所述无菌连接器组件包括主体部分，所述主体部分具有被配置为容纳相应的填充连接器的插座; 枢转部分可调节地设置在主体部分内并部分地从主体部分延伸，枢转部分具有形成在其中的通道; 以及导管部分，其轴向可滑动地设置在形成在枢转部分中的通道内。 枢转部分包括就绪位置和操作位置，枢转部分可以通过相对于主体部分的相对运动从就绪位置调整到操作位置。 该方法包括将无菌连接器提供在就绪位置，将柔性管和填充连接器连接到无菌连接器，将枢轴部分移动到操作位置，将导管部分轴向滑动到填充连接器中，以及将流体通过 连接器。