公开(公告)号：US20170032529A1

公开(公告)日：2017-02-02

申请号：US15142334

申请日：2016-04-29

Applicant: CSIR

Inventor： Jason Peter DE VILLIERS ,  Jaco CRONJE

IPC: G06T7/00 ,  B25J9/16 ,  G01B11/00

CPC classification number: B25J9/1697 ,  G01B11/002 ,  G06T7/73 ,  G06T2207/30204 ,  G06T2207/30212 ,  G06T2207/30244

Abstract: A system and method for calibrating a helmet with a plurality of optical markers thereon is provided. The system includes a memory, a camera and a mechanical actuator to which the helmet is connected during the calibration process so that it is movable relative to the camera. A processor is connected to the camera and the mechanical actuator and is programmed to control the mechanical actuator to move the helmet relative to the camera through a plurality of discrete points on a calibration target pattern and at each of the discrete points, control the camera to take a digital image. For each of the images, the processor determines the position of at least one of the plurality of markers in the image and uses the position of the at least one marker in the image together with the position of the mechanical actuator to calibrate the helmet.

Abstract translation: 提供了一种用于在其上校准具有多个光学标记的头盔的系统和方法。 该系统包括存储器，照相机和机械致动器，头盔在校准过程期间连接到头部，使得其相对于照相机是可移动的。 处理器连接到相机和机械致动器，并且被编程为控制机械致动器以通过校准目标图案上的多个离散点和在每个离散点处相对于相机移动头盔，将相机控制到 拿一个数字图像。 对于每个图像，处理器确定图像中的多个标记中的至少一个的位置，并且使用图像中的至少一个标记的位置以及机械致动器的位置来校准头盔。

公开(公告)号：US20160215280A1

公开(公告)日：2016-07-28

申请号：US14916338

申请日：2014-09-04

Applicant: CSIR

Inventor： Stephanie FANUCCHI ,  Youtaro SHIBAYAMA ,  Shaun BURD ,  Musa M. MHLANGA

IPC: C12N15/01 ,  C12Q1/68

CPC classification number: C12N15/01 ,  C12N9/22 ,  C12N15/63 ,  C12Q1/6841 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell and to methods of silencing gene expression in a cell by way of perturbing gene regulatory elements which are engaged in chromosomal contact.

Abstract translation: 本发明涉及用于确定染色体接触对细胞中感兴趣的基因的转录活性的影响的单细胞测定法，以及通过干扰参与染色体接触的基因调控元件沉默细胞中基因表达的方法。

公开(公告)号：US09330463B2

公开(公告)日：2016-05-03

申请号：US14002195

申请日：2012-11-29

Applicant: CSIR

Inventor： Jason Peter De Villiers ,  Jaco Cronje

IPC: G06K9/00 ,  G06T7/00 ,  H04N5/232 ,  H04N17/00

CPC classification number: G06T7/0018 ,  G06T5/006 ,  G06T7/80 ,  G06T2207/10016 ,  G06T2207/30208 ,  H04N5/23241 ,  H04N17/002

Abstract: A system and method for calibrating a camera includes an energy source and a camera to be calibrated, with at least one of the energy source and the camera being mounted on a mechanical actuator so that it is movable relative to the other. A processor is connected to the energy source, the mechanical actuator and the camera and is programmed to control the mechanical actuator to move at least one of the energy source and the camera relative to the other through a plurality of discrete points on a calibration target pattern. The processor further, at each of the discrete points, controls the camera to take a digital image and perform a lens distortion characterization on each image. A focal length of the camera is determined including any lens connected to the camera and an extrinsic camera position for each image is then determined.

Abstract translation: 用于校准相机的系统和方法包括能量源和待校准的照相机，其中能量源和照相机中的至少一个安装在机械致动器上，使得其相对于另一个可移动。 处理器连接到能量源，机械致动器和照相机，并且被编程为控制机械致动器通过校准目标图案上的多个离散点相对于另一个移动能量源和照相机中的至少一个 。 另外处理器在每个离散点处控制相机拍摄数字图像，并在每个图像上执行镜头失真表征。 确定相机的焦距，包括连接到相机的任何透镜，然后确定每个图像的外在相机位置。

公开(公告)号：US20160025799A1

公开(公告)日：2016-01-28

申请号：US14775479

申请日：2014-03-13

Applicant: CSIR

Inventor： Geert Roelf Stolper ,  Robert Anderson Schutz

IPC: G01R31/12

CPC classification number: G01R31/1218

Abstract: The invention relates to an apparatus, method and system for measuring and optionally detecting an electrical discharge having a discharge magnitude, wherein the electrical discharge causes a corresponding emission of optical radiation. The apparatus embodies the system and method in accordance with the invention, wherein the method comprises measuring electrical discharge by firstly storing pre-determined calibration data comprising calibrated quantitative measurement values associated with magnitudes of electrical discharge and detector parameters corresponding thereto, the detector parameters being operating parameters associated with the optical detector, receiving and processing a particular detector parameter with the stored calibration data to detect an electrical discharge, and determine a quantitative measurement associated with the magnitude of the detected electrical discharge.

Abstract translation: 本发明涉及一种用于测量和可选地检测具有放电大小的放电的装置，方法和系统，其中放电导致相应的光辐射发射。 该装置体现了根据本发明的系统和方法，其中该方法包括通过首先存储预定的校准数据来测量放电，该校准数据包括与放电量和与之对应的检测器参数相关联的校准的定量测量值，检测器参数正在运行 与光学检测器相关联的参数，用存储的校准数据接收和处理特定检测器参数以检测放电，以及确定与检测到的放电量的大小相关联的定量测量。

公开(公告)号：US20150287196A1

公开(公告)日：2015-10-08

申请号：US14002195

申请日：2012-11-29

Applicant: CSIR

Inventor： Jason Peter De Villiers ,  Jaco Cronje

IPC: G06T7/00 ,  H04N5/232 ,  H04N17/00

CPC classification number: G06T7/0018 ,  G06T5/006 ,  G06T7/80 ,  G06T2207/10016 ,  G06T2207/30208 ,  H04N5/23241 ,  H04N17/002

Abstract: A system and method for calibrating a camera includes an energy source and a camera to be calibrated, with at least one of the energy source and the camera being mounted on a mechanical actuator so that it is movable relative to the other. A processor is connected to the energy source, the mechanical actuator and the camera and is programmed to control the mechanical actuator to move at least one of the energy source and the camera relative to the other through a plurality of discrete points on a calibration target pattern. The processor further, at each of the discrete points, controls the camera to take a digital image and perform a lens distortion characterisation on each image. A focal length of the camera is determined including any lens connected to the camera and an extrinsic camera position for each image is then determined.

Abstract translation: 用于校准相机的系统和方法包括能量源和待校准的照相机，其中能量源和照相机中的至少一个安装在机械致动器上，使得其相对于另一个可移动。 处理器连接到能量源，机械致动器和照相机，并且被编程为控制机械致动器通过校准目标图案上的多个离散点相对于另一个移动能量源和照相机中的至少一个 。 另外处理器在每个离散点处控制相机拍摄数字图像，并在每个图像上执行镜头失真表征。 确定相机的焦距，包括连接到相机的任何透镜，然后确定每个图像的外在相机位置。

公开(公告)号：US20140087008A1

公开(公告)日：2014-03-27

申请号：US14038378

申请日：2013-09-26

Applicant: COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Sung-Kwon CHUNG ,  Hak Cheol KWON ,  Jin Wook CHA ,  Vinesh Jaichand MAHARAJ ,  Rudzani NTHAMBELENI ,  Dashnie NAIDOO ,  Young-Joo KIM ,  Jungyeob HAM ,  Jeremiah SENABE ,  Gerda FOUCHE ,  Eric KHOROMBI ,  Joon Ki KIM

IPC: A61K36/185 ,  A23L2/52 ,  A23L1/30

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating dementia comprising extracts of Monsonia sp.; a food composition for preventing and/or improving dementia comprising extracts of Monsonia sp.; and a method of preparing an extract of Monsonia sp. with excellent inhibitory effect on the formation of β-amyloid. The plant extract can inhibit the formation of β-amyloid which has been known as a factor causing the dementia, especially Alzheimer's disease, thereby being used for preventing, improving and/or treating the dementia.

Abstract translation: 本发明涉及一种用于预防和/或治疗痴呆症的药物组合物，其包含麻黄属植物提取物。 一种用于预防和/或改善痴呆症的食物组合物，其包含孟山药的提取物。 和一种制备麻黄提取物的方法 对淀粉样蛋白的形成具有优异的抑制作用。 植物提取物可以抑制已知作为引起痴呆的因素，特别是阿尔茨海默氏病的β-淀粉样蛋白的形成，从而用于预防，改善和/或治疗痴呆。

公开(公告)号：US20040083826A1

公开(公告)日：2004-05-06

申请号：US10639685

申请日：2003-08-13

Applicant: CSIR

Inventor： Coenraad Frederik Botha ,  Pieter Francois Smith ,  Philip Keith Roach ,  Dennis Kappetijn ,  Marthinus Christoffel Barnard ,  Paul Fritz Fuls

IPC: G01N001/22

CPC classification number: G01N1/2202 ,  G01N1/405 ,  G01N2001/2223

Abstract: A gas borne substance sampling device (10) includes a housing (12) through which gas can be passed, and a holder (14) for gas borne substance capturing material. The holder (14) is located or locatable inside the housing (12) to contact the capturing material with gas passing through the housing (12). The device (10) has a sampling condition in which at least a major portion of the holder (14) is protected inside or covered by the housing (12) and an analysis condition in which at least a portion of the holder (14) is exposed or outside the housing (12).

Abstract translation: 气体物质取样装置（10）包括可以通过气体的壳体（12）和用于气体传播物质捕获材料的保持器（14）。 保持器（14）位于或定位在壳体（12）内部，以使捕获材料与穿过壳体（12）的气体接触。 装置（10）具有采样状态，其中保持器（14）的至少大部分被保护在壳体内部或被壳体（12）覆盖，并且分析条件中，保持器（14）的至少一部分是 露出或外壳外（12）。

公开(公告)号：US20030138929A1

公开(公告)日：2003-07-24

申请号：US10356575

申请日：2003-02-03

Applicant: Council for Scientific and Industrial Research (CSIR)

Inventor： Jui Venkatesh Vernekar ,  Mohini Sadanand Ghatge ,  Mala Balchandra Rao ,  Vasanti Vishnu Deshpande

IPC: C12N009/99 ,  A01N063/00

CPC classification number: C12R1/465 ,  C12N1/20

Abstract: The present invention provides a novel strain of Streptomyces sp. having Accession Number PTA 973 and a process for the preparation of an alkaline protease inhibitor employing the said strain.

Abstract translation: 本发明提供了一种新型的链霉菌菌株 具有登录号PTA 973和使用所述菌株制备碱性蛋白酶抑制剂的方法。

公开(公告)号：US20030086984A1

公开(公告)日：2003-05-08

申请号：US10170750

申请日：2002-06-14

Applicant: CSIR

Inventor： Fanie Retief Van Heerden ,  Robert Vleggaar ,  Roelof Marthinus Horak ,  Robin Alec Learmonth ,  Vinesh Maharaj ,  Rory Desmond Whittal

IPC: A61K035/78

CPC classification number: A61K31/57 ,  A23L33/105 ,  A61K31/58 ,  A61K31/704 ,  A61K31/78 ,  A61K36/27 ,  C07H3/04 ,  C07H3/06 ,  C07H5/10 ,  C07H13/08 ,  C07J7/002 ,  C07J7/0025 ,  C07J7/0035 ,  C07J7/007 ,  C07J15/00 ,  C07J17/00 ,  C07J17/005 ,  C07J41/00 ,  Y02P20/582 ,  A61K2300/00

Abstract: 1 A pharmaceutical composition which contains an extract obtainable from a plant of the genus Trichocualon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1).

Abstract translation: 一种药物组合物，其含有可从含有具有式（1）的食欲抑制剂的Trichocualon属或Hoodia植物获得的提取物。 还提供了获得提取物的方法和化合物（1）及其类似物和衍生物的合成方法。 本发明还涉及这种提取物和化合物（1）及其类似物用于制造具有食欲抑制活性的药物的用途。 本发明还提供了用于合成化合物（1）的新型中间体，

公开(公告)号：US20240116863A1

公开(公告)日：2024-04-11

申请号：US17932386

申请日：2022-09-15

Applicant: Indian Institute of Science Education and Research, Mohali (IISER Mohali) ,  Indian Institute of Technology Ropar (IIT Ropar) ,  Council of Scientific and Industrial Research (CSIR)

Inventor： NIRMAL KUMAR ,  INDRANIL BANERJEE ,  IRSHAD MAAJID TAILY ,  PRABAL BANERJEE ,  CHARANDEEP SINGH ,  ANSHUL SHARMA ,  RAJESH P. RINGE ,  KRISHAN GOPAL THAKUR ,  PRIYANKA SINGH

IPC: C07C335/12 ,  C07C275/30

CPC classification number: C07C335/12 ,  C07C275/30

Abstract: The present invention relates to method of inhibition of cellular endocytosis by treating the cells with compound of formula-1 Diphenylthio urea and Diphenylurea derivatives. Said invention also discloses method of treatment of infectious diseases, neurological disease, cancer, kidney disease in a subject in need thereof by administering therapeutically effective concentration of compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives which are effective inhibitors of cellular endocytosis. Said invention also discloses compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives and pharmaceutical composition comprising compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives along with suitable excipients.