公开(公告)号：US07488794B2

公开(公告)日：2009-02-10

申请号：US10881713

申请日：2004-06-30

申请人： Robert A. Herrmann ,  David Knapp

发明人： Robert A. Herrmann ,  David Knapp

IPC分类号： C07K1/113 ,  C08B37/16

CPC分类号： C07C381/00 ,  C08B37/00 ,  C08B37/0012

摘要： A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation. The S-nitrosylated species can be isolated, for example, by a process in which the precipitate is removed from the solution (e.g., by centrifugation) and the aqueous solvent remaining in the precipitate is sublimated (e.g., by freezing the precipitate and subjecting it to a vacuum). The isolated S-nitrosylated product is preferably protected from heat, light, moisture and oxygen.

公开(公告)号：US20080095191A1

公开(公告)日：2008-04-24

申请号：US11961086

申请日：2007-12-20

申请人： David Knapp ,  Patrick Heck

发明人： David Knapp ,  Patrick Heck

IPC分类号： H04J3/22

CPC分类号： H04J3/1682 ,  H04J3/0638 ,  H04J3/12

摘要： A communication system, network interface, and communication port is provided for interconnecting a network of multimedia devices. The multimedia devices can send streaming and/or non-streaming data across the network. The network accommodates all such types of data and assigns data types to time slots or frame segments within each frame to ensure streaming data maintains its temporal relationship at the receiver consistent with the transmitter. A signaling byte is preferably used to keep track of an amount by which isochronous streaming data occupies a frame segment.

公开(公告)号：US20070075237A1

公开(公告)日：2007-04-05

申请号：US11243562

申请日：2005-10-05

申请人： James Mills ,  David Garrett ,  Wayne Sunne ,  David Knapp ,  Daniel Brunton ,  David Anthony ,  Emmet Anderson ,  Daniel Harrison ,  Frank Smith ,  Jim Hicks

发明人： James Mills ,  David Garrett ,  Wayne Sunne ,  David Knapp ,  Daniel Brunton ,  David Anthony ,  Emmet Anderson ,  Daniel Harrison ,  Frank Smith ,  Jim Hicks

IPC分类号： H01J5/02 ,  H01J40/14

CPC分类号： F41G7/224 ,  F41H13/0056 ,  G01S7/4818 ,  G01S7/495

摘要： A control mechanism pins an optical fiber assembly on and off gimbal and between gimbals to route the assembly from an off-gimbal optical source across the gimbal axis/axes to an on-gimbal optical element so that the fiber assembly moves with the rotation of the gimbals. To accommodate a relatively large range of motion, the control mechanism is suitably configured to route the fiber assembly in a “U-shaped” loop with one end pinned off-gimbal in a stationary guide track and the other end pinned on-gimbal point in a rotating guide track so that the loose fiber assembly is constrained in the concentric tracks on and off gimbal. As the gimbal rotates, the loop seats onto one guiding track and peels off of the other guiding track while always maintaining its U shape. To accommodate a relatively small range of motion in other gimbal configurations, the control mechanism is suitably configured to pin one end of the fiber assembly off-gimbal and pass the fiber assembly directly over the gimbal where it is pinned on the other side of the gimbal. In a multi-gimbal pointer, the fiber assembly preferably exhibits different mechanical stresses as it crosses the different gimbals.

摘要翻译： 控制机构将光纤组件插入和关闭万向节和万向节之间，以将组件从万向节光源穿过万向节轴/轴线到达万向节光学元件，使得光纤组件随着 万向节 为了适应相对较大的运动范围，控制机构被适当地构造成将光纤组件以“U形”形环路路线固定在固定导轨中，另一端固定在万向节上 旋转的导轨，使得松散的纤维集合体被限制在同步轨道上和/或从万向节关闭。 当万向架旋转时，环路将位于一个引导轨道上并从另一个引导轨道剥离，同时始终保持其U形。 为了适应其他万向架构中的相对较小的运动范围，控制机构适当地构造成将纤维组件的一端分离成万向节，并将纤维组件直接通过万向节，将其固定在万向节的另一侧 。 在多万向节指针中，纤维组件优选地在穿过不同的万向节时表现出不同的机械应力。

公开(公告)号：US06904310B2

公开(公告)日：2005-06-07

申请号：US10140738

申请日：2002-05-07

申请人： David Knapp ,  Brian T. Berg

发明人： David Knapp ,  Brian T. Berg

IPC分类号： A61B6/00 ,  A61B6/03 ,  A61B6/12 ,  A61F2/86 ,  A61L31/18 ,  H05G1/70

CPC分类号： A61F2/86 ,  A61B6/482 ,  A61F2/91 ,  A61L31/18

摘要： A method for obtaining diagnostic information about a region of a living being, the region having a medical device with a radiopaque portion disposed therein. An X-ray beam having a first energy level in excess of the K-absorption edge of the radiopaque portion of the medical device is directed at the region to obtain a first image information and radiographically locate the medical device within the living being and an X-ray beam having second energy level at or below the K-absorption edge is applied to the region to obtain a second image information.

公开(公告)号：US20050053179A1

公开(公告)日：2005-03-10

申请号：US10655265

申请日：2003-09-04

申请人： David Knapp ,  Jason Lewis

发明人： David Knapp ,  Jason Lewis

IPC分类号： H04L7/00

CPC分类号： H04L7/0004

摘要： A communication system, clock recovery circuit, and method are provided for allowing data to be transmitted across a communication system and between clock recovery circuits absent a clock master specifically designed for one node of the communication system. Absent a clock master, the communication system is permitted to enter into an all slave mode, with periodic unlock conditions possibly rotating about the communication system ring topology. However, the unlock condition can be readily detected and if the received data bitstream formed into a recovered clock exceeds a threshold above or is less than a threshold below a reference clock generated during instances of unlock, then the clock recovery circuit will fix the synchronizing clock to the reference clock, and cause the bitstream to resynchronize to the reference clock before the reference clock is again disabled to allow the communication system to re-enter the all slave and rotating unlock condition. Periodic application of a reference clock interspersed with periodic application of a clock having transitions equal to the incoming bitstream proves advantageous in avoiding a design where a dedicated master must be used within a specified communication system node.

摘要翻译： 提供一种通信系统，时钟恢复电路和方法，用于允许数据通过通信系统传输，并且在时钟恢复电路之间，而不存在专门为通信系统的一个节点设计的时钟主机。 没有时钟主机，通信系统被允许进入全从机模式，周期性解锁条件可能围绕通信系统环形拓扑旋转。 然而，可以容易地检测到解锁状态，并且如果形成为恢复时钟的接收数据比特流超过了在解锁实例期间产生的参考时钟以下或低于阈值以下的阈值，则时钟恢复电路将固定同步时钟 并且在再次禁用参考时钟之前使比特流重新同步到参考时钟，以允许通信系统重新进入所有从动和旋转解锁状态。 周期性地施加散布有周期性应用具有等于进入比特流的转换的时钟的参考时钟证明有利于避免必须在指定的通信系统节点内使用专用主机的设计。

公开(公告)号：US20050030644A1

公开(公告)日：2005-02-10

申请号：US10633811

申请日：2003-08-04

申请人： David Knapp

发明人： David Knapp

IPC分类号： G02B13/06 ,  G02B27/00 ,  G02B17/00

CPC分类号： G02B27/4216 ,  G02B13/06 ,  G02B27/0037 ,  G02B27/0068

摘要： An optical system includes a window having a nonspherically curved outer surface and a curved inner surface, and a transmission optical corrector adjacent to the curved inner surface of the window. The transmission optical corrector has a selectively nonuniform passive transmission optical property, such as a spatially varying index of refraction of the transmission optical corrector or a spatially varying diffractive property of the transmission optical corrector. The optical system further has an optical train positioned such that the transmission optical corrector lies between the curved window and the optical train. A sensor is disposed to receive the optical ray passing sequentially through the window, the transmission optical corrector, and the optical train.

摘要翻译： 光学系统包括具有非曲面外表面和弯曲内表面的窗口，以及与窗口的弯曲内表面相邻的透射光学校正器。 透射光学校正器具有选择性地不均匀的无源透射光学特性，例如透射光学校正器的空间变化的折射率或透射光学校正器的空间变化的衍射特性。 该光学系统还具有光学系列，该光学系列定位成使得透射光学校正器位于弯曲窗口和光学系列之间。 传感器设置成接收依次通过窗口，透射光学校正器和光学列车的光线。

公开(公告)号：US06782511B1

公开(公告)日：2004-08-24

申请号：US09579825

申请日：2000-05-25

申请人： Elof Frank ,  Bernd Braune ,  David Knapp ,  Pradeep Fernandes ,  Hans-Joachim Schmidt

发明人： Elof Frank ,  Bernd Braune ,  David Knapp ,  Pradeep Fernandes ,  Hans-Joachim Schmidt

IPC分类号： G06F1750

CPC分类号： G06F17/5045 ,  G06F17/505

摘要： A business-to-business application service provider includes an Internet website and webserver with EDA-on-demand solutions for system-on-a-chip designers. Such website allows electronic designs in hardware description language to be uploaded into a front-end EDA design environment. A behavioral model simulation tool hosted privately on the webserver tests and validates the design. Such tool executes only in the secure environment of the business-to-business application service provider. The validated solution is then downloaded back over the Internet for a pay-per-use fee to the customer, and in a form ready to be placed and routed by a back-end EDA tool. Such validated design solutions are also downloadable to others in exchange for other designs, or available in technology libraries. The intellectual property created can be re-used, sold, shared, exchanged, and otherwise distributed efficiently and easily from a central for-profit clearinghouse.

摘要翻译： 企业对企业应用服务提供商包括一个互联网网站和具有EDA按需解决方案的网络服务器，用于系统级芯片设计者。 这样的网站允许以硬件描述语言的电子设计上传到前端EDA设计环境中。 网络服务器上私有的行为模型仿真工具进行测试并验证设计。 此类工具仅在企业对企业应用服务提供商的安全环境中执行。 经验证的解决方案然后通过互联网向客户下载一次付费的费用，并以后台EDA工具准备放置和路由的形式。 这些经过验证的设计解决方案也可以下载到其他设计中，以换取其他设计，或者可用于技术库。 创造的知识产权可以从中央营利交换所高效地轻易地重新使用，出售，共享，交换和分发。

公开(公告)号：US06310730B1

公开(公告)日：2001-10-30

申请号：US09495610

申请日：2000-02-01

申请人： David Knapp ,  Scott W. Sparrold

发明人： David Knapp ,  Scott W. Sparrold

IPC分类号： G02B2722

CPC分类号： F41G7/2213 ,  F41G7/2253 ,  F41G7/2293 ,  G02B26/101 ,  G02B27/0025

摘要： An optical system includes a curved window, an asymmetric, scoop-shaped optical corrector adjacent to a curved inner surface of the window, an optical train positioned such that the optical corrector lies between the curved window and the optical train, a movable optical train support upon which the optical train is mounted, and a sensor disposed to receive an optical ray passing sequentially through the window, the optical corrector, and the optical train. The optical corrector has an inner surface and an outer surface, at least one of which has a shape defined by an asymmetric polynomial.

摘要翻译： 光学系统包括与窗口的弯曲内表面相邻的弯曲窗口，不对称的勺状光学校正器，光学校准器定位成使得光学校正器位于弯曲窗口和光学列车之间，可移动的光学列车支架 安装有光学系列的传感器，以及设置成接收依次通过窗口，光学校正器和光学系列的光线的传感器。 光学校正器具有内表面和外表面，其至少一个具有由非对称多项式定义的形状。

公开(公告)号：US09194040B2

公开(公告)日：2015-11-24

申请号：US13557348

申请日：2012-07-25

申请人： David Knapp

发明人： David Knapp

IPC分类号： C23C16/00 ,  C07F15/00 ,  C23C16/18 ,  C07F15/04

CPC分类号： C23C16/18 ,  C07F15/04

摘要： Provided are precursors and methods of using same to deposit film consisting essentially of nickel. Certain methods comprise providing a substrate surface; exposing the substrate surface to a vapor comprising a precursor having a structure represented, without limitation to specific orientation, by: wherein R1 and R2 are each independently H or any C1-C3 alkyl group, R4 is trimethylsilyl or C1-C3 alkyl, and L is any ligand that does not contain oxygen; and exposing the substrate to a reducing gas to provide a film consisting essentially of nickel on the substrate surface.

摘要翻译： 提供的是使用其沉积基本上由镍组成的膜的前体和方法。 某些方法包括提供基底表面; 将基板表面暴露于包含前体的蒸汽，所述前体具有但不限于特定取向的结构，其中R1和R2各自独立地为H或任何C1-C3烷基，R4为三甲基甲硅烷基或C1-C3烷基，L为 是不含氧的任何配体; 并将衬底暴露于还原气体，以在衬底表面上提供基本上由镍组成的膜。

公开(公告)号：US08859045B2

公开(公告)日：2014-10-14

申请号：US13555832

申请日：2012-07-23

申请人： David Knapp ,  David Thompson

发明人： David Knapp ,  David Thompson

IPC分类号： C07F17/00 ,  C23C16/18 ,  C07F15/04

CPC分类号： C23C16/18 ,  C07F17/00

摘要： Provided are precursors and methods of using same to deposit film consisting essentially of nickel. Certain methods comprise providing a substrate surface; exposing the substrate surface to a vapor comprising a precursor having a structure represented by formula (I): wherein R1 is t-butyl and each R2 is each independently any C1-C3 alkyl group; and exposing the substrate to a reducing gas to provide a film consisting essentially of nickel on the substrate surface.

摘要翻译： 提供的是使用其沉积基本上由镍组成的膜的前体和方法。 某些方法包括提供基底表面; 将基材表面暴露于包含具有由式（I）表示的结构的前体的蒸气：其中R 1是叔丁基，每个R 2各自独立地是任何C 1 -C 3烷基; 并将衬底暴露于还原气体，以在衬底表面上提供基本上由镍组成的膜。