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31.发明授权Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a CLLD8 protein 有权鉴定使用CLLD8蛋白调节IL-4受体介导的IgE合成的化合物的方法公开(公告)号：US06979549B2
公开(公告)日：2005-12-27
申请号：US10197368
申请日：2002-07-16
Applicant: Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
Inventor： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
CPC classification number: C07K7/08 , A61K38/1709 , C07K14/5406 , G01N33/6869 , G01N2333/5406 , G01N2500/00 , Y10S435/975
Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Abstract translation: 本发明提供能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用CLLD8蛋白作为替代分析物的化合物的方法和试剂盒以及使用该化合物的方法 各种体外，体外和体外上下文。
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公开(公告)号：US09096542B2
公开(公告)日：2015-08-04
申请号：US13242994
申请日：2011-09-23
Applicant: Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
Inventor： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
IPC: C07D495/04 , C07D495/12 , A61K31/519 , C07D239/94 , C07D239/95 , C07D473/16 , C07D487/04 , A61P19/02 , A61P35/00
CPC classification number: C07D519/00 , A61K31/517 , C07D239/94 , C07D239/95 , C07D471/04 , C07D473/16 , C07D487/04 , C07D495/04 , C07D495/12
Abstract: The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity.
Abstract translation: 本公开提供了抑制蛋白激酶（例如JAK，Ax1或Syk激酶）的化合物，包含该化合物的组合物和使用该化合物抑制蛋白激酶并治疗和/或预防与不适当激酶活性相关疾病的方法。
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公开(公告)号：US08962643B2
公开(公告)日：2015-02-24
申请号：US11678488
申请日：2007-02-23
Applicant: Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
Inventor： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
IPC: C07D403/12 , A61K31/505 , C07D239/48 , C07D401/12 , C07D409/12 , C07D417/12
CPC classification number: C07D239/50 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
Abstract translation: 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US08710223B2
公开(公告)日：2014-04-29
申请号：US13188222
申请日：2011-07-21
Applicant: Sacha Holland , Rao Kolluri , Salvador Alvarez , Matthew Duncton , Rajinder Singh , Jing Zhang , Esteban Masuda
Inventor： Sacha Holland , Rao Kolluri , Salvador Alvarez , Matthew Duncton , Rajinder Singh , Jing Zhang , Esteban Masuda
IPC: C07D401/14
CPC classification number: C07D401/14 , A61K31/506 , C12N9/12 , C12Y207/11013
Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
Abstract translation: 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08481521B2
公开(公告)日：2013-07-09
申请号：US13487979
申请日：2012-06-04
Applicant: Esteban Masuda , Donald G. Payan , Elliot B. Grossbard , Somasekhar Bhamidipati , Rajinder Singh
Inventor： Esteban Masuda , Donald G. Payan , Elliot B. Grossbard , Somasekhar Bhamidipati , Rajinder Singh
IPC: A61K31/33
CPC classification number: A61K31/505 , A61K31/5383 , A61K31/542
Abstract: The present disclosure provides methods for the treatment of cell proliferative disorders by administration of a Syk kinase or Syk/Flt-3 kinase inhibitor. Cell proliferative disorders treatable by the methods include, hematopoietic neoplasms and virally associated tumors. The compounds are also directed to therapeutic or prophylactic inhibition of tumor metastasis.
Abstract translation: 本公开提供了通过施用Syk激酶或Syk / Flt-3激酶抑制剂治疗细胞增殖性疾病的方法。 可通过该方法治疗的细胞增殖性疾病包括造血赘生物和病毒相关的肿瘤。 该化合物还涉及肿瘤转移的治疗或预防性抑制。
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Patent Agency Ranking
36.发明授权公开(公告)号：US08334297B2
公开(公告)日：2012-12-18
申请号：US12687053
申请日：2010-01-13
Applicant: Hui Li , Esteban Masuda , Stephanie Yung , Taisei Kinoshita , Rongxian Ding , Rajinder Singh , Tarikere Gururaja , Donald G. Payan , Kin Tso
Inventor： Hui Li , Esteban Masuda , Stephanie Yung , Taisei Kinoshita , Rongxian Ding , Rajinder Singh , Tarikere Gururaja , Donald G. Payan , Kin Tso
IPC: A01N43/54 , A61K31/505
CPC classification number: C07D451/04
Abstract: 2,4-Pyrimidinediamine compounds represented by formula (I), methods for preparing the same and methods for treating an inflammatory disorder and for inhibiting the production of IL-23 and/or stimulating the production of IL-10 using the same:
Abstract translation: 由式（I）表示的2,4-嘧啶二胺化合物，其制备方法及其用于治疗炎性病症和抑制IL-23产生和/或刺激IL-10产生的方法：
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公开(公告)号：US07915273B2
公开(公告)日：2011-03-29
申请号：US12711534
申请日：2010-02-24
Applicant: Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
Inventor： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC: C07D239/48 , A61K31/506
CPC classification number: C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
Abstract translation: 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US07576053B2
公开(公告)日：2009-08-18
申请号：US11452767
申请日：2006-06-13
Applicant: Esteban Masuda , Polly Pine
Inventor： Esteban Masuda , Polly Pine
CPC classification number: A61K31/202 , A61K31/506 , A61K31/5383 , A61K31/56 , A61K31/66 , A61K38/27 , A61K38/29 , A61K45/06 , A61K2300/00
Abstract: The present disclosure provides methods and compositions using Syk inhibitory compounds for treating degenerative bone disorders and as prophylactic treatment to prevent bone loss. These treatments may reduce the fracture risk associated with bone loss and compromised bone strength.
Abstract translation: 本公开提供使用Syk抑制化合物治疗退行性骨病的方法和组合物，以及作为预防骨质流失的预防性治疗。 这些治疗可以降低与骨丢失和骨折强度相关的骨折风险。
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公开(公告)号：US20090124580A1
公开(公告)日：2009-05-14
申请号：US12268218
申请日：2008-11-10
Applicant: Rajinder Singh , Somasekhar Bhamidipati , Esteban Masuda
Inventor： Rajinder Singh , Somasekhar Bhamidipati , Esteban Masuda
IPC: A61K31/675 , C07D498/04 , A61P19/02 , C07D413/14
CPC classification number: C07D498/04 , A61K31/5383 , A61K31/675 , C07F9/65583 , C07F9/6561 , C07F9/65742
Abstract: The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.
Abstract translation: 本公开提供了生物活性2,4-嘧啶二胺化合物的前药，包含前体药物的组合物，用于合成前药的中间体和方法以及在各种应用中使用前药的方法。
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公开(公告)号：US07425418B2
公开(公告)日：2008-09-16
申请号：US10098243
申请日：2002-03-15
Applicant: Todd M. Kinsella , Esteban Masuda , Mark K. Bennett , Justin E. Warner , David C. Anderson
Inventor： Todd M. Kinsella , Esteban Masuda , Mark K. Bennett , Justin E. Warner , David C. Anderson
IPC: G01N33/53
CPC classification number: C40B30/04 , G01N33/566 , G01N33/6845 , G01N33/6875 , G01N2333/70567 , G06F19/18
Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Abstract translation: 本发明提供了能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用类视黄醇X受体作为替代分析物的化合物的方法和试剂盒以及使用该化合物的方法 在各种体外，体外和体外上下文中。
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