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公开(公告)号:US08710223B2
公开(公告)日:2014-04-29
申请号:US13188222
申请日:2011-07-21
申请人: Sacha Holland , Rao Kolluri , Salvador Alvarez , Matthew Duncton , Rajinder Singh , Jing Zhang , Esteban Masuda
发明人: Sacha Holland , Rao Kolluri , Salvador Alvarez , Matthew Duncton , Rajinder Singh , Jing Zhang , Esteban Masuda
IPC分类号: C07D401/14
CPC分类号: C07D401/14 , A61K31/506 , C12N9/12 , C12Y207/11013
摘要: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本公开涉及可用作蛋白激酶C(PKC)的抑制剂的化合物,因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US20120022092A1
公开(公告)日:2012-01-26
申请号:US13188222
申请日:2011-07-21
申请人: Sacha Holland , Rao Kolluri , Salvador Alvarez , Matthew Duncton , Rajinder Singh , Jing Zhang , Esteban Masuda
发明人: Sacha Holland , Rao Kolluri , Salvador Alvarez , Matthew Duncton , Rajinder Singh , Jing Zhang , Esteban Masuda
IPC分类号: A61K31/506 , A61P29/00 , A61P37/00 , A61P27/02 , A61P9/10 , A61P7/00 , A61P3/04 , A61P3/00 , A61P3/08 , A61P15/00 , A61P9/12 , A61P9/04 , A61P11/00 , A61P25/00 , A61P25/28 , A61P25/18 , A61P35/00 , A61P31/00 , A61P31/18 , A61P13/12 , A61P19/02 , A61P19/04 , A61P5/16 , A61P21/04 , A61P3/10 , A61P37/06 , A61P11/06 , A61P17/06 , A61P17/00 , A61P17/08 , A61P1/00 , A61P1/04 , A61P37/08 , C12N9/99 , C07D401/14
CPC分类号: C07D401/14 , A61K31/506 , C12N9/12 , C12Y207/11013
摘要: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本公开涉及可用作蛋白激酶C(PKC)的抑制剂的化合物,因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US20110130415A1
公开(公告)日:2011-06-02
申请号:US12958284
申请日:2010-12-01
申请人: Rajinder Singh , Kin Tso , Jing Zhang , Matthew Duncton , Salvador Alvarez , Rao Kolluri , John Ramphal , Sacha Holland
发明人: Rajinder Singh , Kin Tso , Jing Zhang , Matthew Duncton , Salvador Alvarez , Rao Kolluri , John Ramphal , Sacha Holland
IPC分类号: A61K31/506 , C07D401/14 , C07D405/14 , A61P29/00 , A61P17/00 , A61P17/06 , A61P37/08 , A61P1/16 , A61P11/00 , A61P9/10 , A61P25/00 , A61P31/18 , A61P9/12 , A61P3/04 , A61P37/06 , C12N9/99 , C12Q1/48
CPC分类号: C07D405/14 , A61K31/41 , A61K31/506 , C07D401/14
摘要: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本公开涉及可用作蛋白激酶C(PKC)的抑制剂的化合物,因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08377924B2
公开(公告)日:2013-02-19
申请号:US12691607
申请日:2010-01-21
申请人: Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人: Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号: A61K31/55 , A61K31/497 , A61K31/535 , A61K31/505 , C07D403/10 , C07D413/12 , C07D401/12
CPC分类号: A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号:US20100204208A1
公开(公告)日:2010-08-12
申请号:US12691607
申请日:2010-01-21
申请人: Rajinder Singh , Hui Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人: Rajinder Singh , Hui Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号: A61K31/55 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D403/14 , A61P1/00 , A61P27/02 , A61P37/00 , A61P29/00 , A61P17/06 , A61P25/28 , C12Q1/48
CPC分类号: A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号:US09609939B2
公开(公告)日:2017-04-04
申请号:US14918498
申请日:2015-10-20
申请人: Salvador Alvarez
发明人: Salvador Alvarez
CPC分类号: A46B7/06 , A46B5/0012 , A46B7/02 , A46B9/02 , A46B2200/302 , A46D3/04 , A46D3/08 , B25G3/30
摘要: The double action push broom of the present invention includes a dynamic double action dual brush head and a broom handle. The dynamic double action dual brush head includes two brush heads rotatably attached to a brush head base, allowing the brush heads to independently rotate about the axis in which it is rotatably attached to the brush head base. A mechanical device capable of storing and releasing energy is connected between the two brush heads, which is rigidly attached to the brush head base. The double action push broom stores kinetic energy in the form of potential energy in the mechanical energy storage device of the dynamic double action dual brush head during the sweeping stroke of the double action push broom. At the end of the sweeping stroke, the stored potential energy is converted into kinetic energy and rotates the dual brush, thereby providing an additional sweeping motion.
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公开(公告)号:US20060082085A1
公开(公告)日:2006-04-20
申请号:US10711973
申请日:2004-10-16
申请人: Salvador Alvarez
发明人: Salvador Alvarez
IPC分类号: B62D39/00
CPC分类号: B62B5/06 , B62B5/069 , Y10S280/04
摘要: A disposable sanitary sheath for a shopping cart handle featuring a sheet wrappable about said handle, said sheet having a length and width so as to cover at least the portion of said handle coming into contact with a user's hands, an adhesive strip positioned about one side of a surface of said sheet for securing said sheet about said handle, a perforated pull-away strip disposed along the length of said sheet, and a pull tab accommodated on said pull-away strip. Other embodiments include disposable sanitary sheaths for shopping cart handles with a sheet wrappable about said handle wherein said sheet is made of one of the following materials: paper, polyethylene, rubber, polypropylene, vinyl, mylar, Teflon, polycarbonate, Kynar, Uvex, butyrate, F.E.P. (tetraflourethyleneperflourpropylene,) and polyester. The sheath may also be made up of two or more sheaths that are used in conjunction to cover one or more portions of a handle. Additionally, a sanitizing compound such as an antibacterial agent can be applied to the sheath.
摘要翻译: 一种用于购物车手柄的一次性卫生护套,其特征在于可围绕所述手柄包装的片材,所述片材具有长度和宽度,以便至少覆盖所述手柄的与使用者的手接触的部分,位于一侧的粘合带 所述片材的表面用于将所述片材固定在所述手柄周围,沿着所述片材的长度设置的穿孔的拉出条以及容纳在所述拉出条带上的拉片。 其他实施方案包括用于购物车手柄的一次性卫生护套,其中所述片可围绕所述柄处理,其中所述片由以下材料之一制成:纸,聚乙烯,橡胶,聚丙烯,乙烯基,聚酯薄膜,特氟隆,聚碳酸酯,Kynar,Uvex,丁酸酯 ,FEP (四氟乙烯基丙烯)和聚酯。 护套还可以由两个或更多个护套组成,其用于结合以覆盖手柄的一个或多个部分。 另外,也可以在护套上涂敷抗菌剂等消毒剂。
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公开(公告)号:US20200338689A1
公开(公告)日:2020-10-29
申请号:US16393486
申请日:2019-04-24
申请人: Salvador Alvarez
发明人: Salvador Alvarez
摘要: A guard attachment for a grinding tool has a metal body with an upper surface, a side wall along part of a perimeter of the upper surface, and a connector with which it can be attached to a grinding tool. Additional features include a bottom plate opposite the upper surface and a debris outlet attached at one end to the surface and side wall of the guard, and having a magnet removably attached to the other end. The bottom plate swivels outward from the body of the guard to facilitate changing the wheel or disk of the grinding tool. The magnet has an aperture allowing for the passage of air, but prevents sparks from escaping the guard attachment.
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公开(公告)号:US20170202347A1
公开(公告)日:2017-07-20
申请号:US15477105
申请日:2017-04-02
申请人: Salvador Alvarez
发明人: Salvador Alvarez
CPC分类号: A46B7/06 , A46B5/0012 , A46B7/02 , A46B9/02 , A46B2200/302 , A46D3/04 , A46D3/08 , B25G3/30
摘要: The double action push broom of the present invention includes a dynamic double action dual brush head and a broom handle. The dynamic double action dual brush head includes two brush heads rotatably attached to a brush head base, allowing the brush heads to independently rotate about the axis in which it is rotatably attached to the brush head base. A mechanical device capable of storing and releasing energy is connected between the two brush heads, which is rigidly attached to the brush head base. The double action push broom stores kinetic energy in the form of potential energy in the mechanical energy storage device of the dynamic double action dual brush head during the sweeping stroke of the double action push broom. At the end of the sweeping stroke, the stored potential energy is converted into kinetic energy and rotates the dual brush, thereby providing an additional sweeping motion.
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公开(公告)号:US07163211B2
公开(公告)日:2007-01-16
申请号:US10711973
申请日:2004-10-16
申请人: Salvador Alvarez
发明人: Salvador Alvarez
IPC分类号: B62D39/00
CPC分类号: B62B5/06 , B62B5/069 , Y10S280/04
摘要: A disposable sanitary sheath for a shopping cart handle featuring a sheet wrappable about the handle having a length and width so as to cover at least the portion of the handle coming into contact with a user's hands, an adhesive strip positioned about one side of a surface of the sheet for securing the sheet about the handle, a perforated pull-away strip disposed along the length of the sheet, and a pull tab accommodated on the pull-away strip. Other embodiments include disposable sanitary sheaths for shopping cart handles with a sheet wrappable about the handle wherein the sheet is made of one of the following materials: paper, polyethylene, rubber, polypropylene, vinyl, mylar, Teflon, polycarbonate, Kynar, Uvex, butyrate, F.E.P. (tetraflourethyleneperflourpropylene,) and polyester. The sheath may also be made up of two or more sheaths that are used in conjunction to cover one or more portions of a handle. Additionally, a sanitizing compound such as an antibacterial agent can be applied to the sheath.
摘要翻译: 一种用于购物车手柄的一次性卫生护套,其特征在于,围绕所述手柄可包装的片材具有长度和宽度,以便至少覆盖所述手柄与使用者的手接触的部分;位于表面的一侧的粘合带 用于将片材固定在手柄周围的片材,沿着片材的长度设置的穿孔的拉出条以及容纳在拉出条带上的拉片。 其他实施例包括用于购物车手柄的一次性卫生护套,其具有可围绕手柄的片材,其中片材由以下材料之一制成:纸,聚乙烯,橡胶,聚丙烯,乙烯基,聚酯薄膜,特氟隆,聚碳酸酯,Kynar,Uvex,丁酸酯 ,FEP (四氟乙烯基丙烯)和聚酯。 护套还可以由两个或更多个护套组成,其用于结合以覆盖手柄的一个或多个部分。 另外,也可以在护套上涂敷抗菌剂等消毒剂。
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