公开(公告)号：US07776922B2

公开(公告)日：2010-08-17

申请号：US11791144

申请日：2005-11-17

Applicant: Ulf Brüggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Süβmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Köbberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

Inventor： Ulf Brüggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Süβmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Köbberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

IPC: A61K31/165 ,  A61K31/381 ,  A61K31/357 ,  A61K31/36 ,  A61K31/47 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07C237/28

CPC classification number: C07D307/81 ,  C07D215/12 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07D409/12 ,  C07D417/12

Abstract: The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.

Abstract translation: 本发明涉及取代的[（苯基乙酰基）氨基]苯甲酰胺及其制备方法及其用于制备用于治疗和/或预防疾病，特别是炎症性疾病例如皮肤，呼吸道疾病 道和心血管疾病，例如动脉硬化和冠心病。

公开(公告)号：US20090318475A1

公开(公告)日：2009-12-24

申请号：US12086783

申请日：2006-12-08

Applicant: Thomas Lampe ,  Eva-Maria Becker ,  Raimund Kast ,  Hartmut Beck ,  Mario Jeske ,  Joachim Schuhmacher ,  Friederike Stoll ,  Martina Klein ,  Metin Akbaba ,  Andreas Knorr ,  Johannes-Peter Stasch ,  Lars Bärfacker ,  Alexander Hillisch ,  Gunter Karig ,  Mark Meininghaus ,  Karl-Heinz Schlemmer ,  Rudolf Schohe-Loop

Inventor： Thomas Lampe ,  Eva-Maria Becker ,  Raimund Kast ,  Hartmut Beck ,  Mario Jeske ,  Joachim Schuhmacher ,  Friederike Stoll ,  Martina Klein ,  Metin Akbaba ,  Andreas Knorr ,  Johannes-Peter Stasch ,  Lars Bärfacker ,  Alexander Hillisch ,  Gunter Karig ,  Mark Meininghaus ,  Karl-Heinz Schlemmer ,  Rudolf Schohe-Loop

IPC: A61K31/519 ,  C07D491/048

CPC classification number: C07D491/04

Abstract: The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Abstract translation: 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。

公开(公告)号：US20080214654A1

公开(公告)日：2008-09-04

申请号：US11665316

申请日：2005-10-12

Applicant: Thomas Lampe ,  Cristina Alonso-Alija ,  Beatrix Stelte-Ludwig ,  Peter Sandner ,  Marcus Bauser ,  Hartmut Beck ,  Klemens Lustig ,  Ulrich Rosentreter ,  Elke Stahl ,  Hiroko Takagi

Inventor： Thomas Lampe ,  Cristina Alonso-Alija ,  Beatrix Stelte-Ludwig ,  Peter Sandner ,  Marcus Bauser ,  Hartmut Beck ,  Klemens Lustig ,  Ulrich Rosentreter ,  Elke Stahl ,  Hiroko Takagi

IPC: A61K31/381 ,  C07C271/06 ,  A61K31/27 ,  A61K31/164 ,  A61P13/02 ,  C07C237/00 ,  C07D333/02

CPC classification number: C07C233/40 ,  C07C233/36 ,  C07C233/37 ,  C07C233/38 ,  C07C233/62 ,  C07C233/73 ,  C07C233/78 ,  C07C271/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D231/14 ,  C07D333/38

Abstract: The present invention relates to novel substituted benzyloxy-phenylmethylamide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR-1) activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

Abstract translation: 本发明涉及新的取代的苄氧基 - 苯基甲基甲酰胺衍生物，其制备方法及其在药物中的用途，特别是用于预防和治疗与冷薄荷醇受体1（CMR-1）活性有关的疾病，特别是用于治疗 泌尿系统疾病或障碍，如逼尿肌过度活动症（膀胱过度活动症），尿失禁，神经源性逼尿肌过敏反应（逼尿肌过敏症），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

公开(公告)号：US20080171786A1

公开(公告)日：2008-07-17

申请号：US11791144

申请日：2005-11-17

Applicant: Ulf Bruggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Sussmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Kobberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

Inventor： Ulf Bruggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Sussmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Kobberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

IPC: A61K31/381 ,  C07C233/76 ,  A61K31/166 ,  A61P9/10 ,  A61P29/00 ,  C07D333/60

CPC classification number: C07D307/81 ,  C07D215/12 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07D409/12 ,  C07D417/12

Abstract: The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.

Abstract translation: 本发明涉及取代的[（苯基乙酰基）氨基]苯甲酰胺及其制备方法及其用于制备用于治疗和/或预防疾病，特别是炎症性疾病例如皮肤，呼吸道疾病 道和心血管疾病，例如动脉硬化和冠心病。