公开(公告)号：US07776922B2

公开(公告)日：2010-08-17

申请号：US11791144

申请日：2005-11-17

申请人： Ulf Brüggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Süβmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Köbberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

发明人： Ulf Brüggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Süβmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Köbberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

IPC分类号： A61K31/165 ,  A61K31/381 ,  A61K31/357 ,  A61K31/36 ,  A61K31/47 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07C237/28

CPC分类号： C07D307/81 ,  C07D215/12 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07D409/12 ,  C07D417/12

摘要： The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.

摘要翻译： 本发明涉及取代的[（苯基乙酰基）氨基]苯甲酰胺及其制备方法及其用于制备用于治疗和/或预防疾病，特别是炎症性疾病例如皮肤，呼吸道疾病 道和心血管疾病，例如动脉硬化和冠心病。

公开(公告)号：US20080171786A1

公开(公告)日：2008-07-17

申请号：US11791144

申请日：2005-11-17

申请人： Ulf Bruggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Sussmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Kobberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

发明人： Ulf Bruggemeier ,  Petros Gatsios ,  Mark Meininghaus ,  Leila Telan ,  Elisabeth Woltering ,  Martina Wuttke ,  Hartmut Beck ,  Nils Griebenow ,  Frank Sussmeier ,  Niels Svenstrup ,  Axel Kretschmer ,  Marcus Bauser ,  Johannes Kobberling ,  Wahed Moradi ,  Siegfried Zaiss ,  Claudia Hirth-Dietrich ,  Barbara Albrecht

IPC分类号： A61K31/381 ,  C07C233/76 ,  A61K31/166 ,  A61P9/10 ,  A61P29/00 ,  C07D333/60

CPC分类号： C07D307/81 ,  C07D215/12 ,  C07D317/60 ,  C07D333/24 ,  C07D333/60 ,  C07D409/12 ,  C07D417/12

摘要： The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.

摘要翻译： 本发明涉及取代的[（苯基乙酰基）氨基]苯甲酰胺及其制备方法及其用于制备用于治疗和/或预防疾病，特别是炎症性疾病例如皮肤，呼吸道疾病 道和心血管疾病，例如动脉硬化和冠心病。

公开(公告)号：US20060247303A1

公开(公告)日：2006-11-02

申请号：US10531881

申请日：2003-10-21

申请人： Hilmar Bischoff ,  Frank-Thorsten Hafner ,  Carsten Schmeck ,  Joachim Telser ,  Alexandros Vakalopoulos ,  Gabriele Wirtz ,  Marcus Bauser ,  David Bruckner ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Frank-Thorsten Hafner ,  Carsten Schmeck ,  Joachim Telser ,  Alexandros Vakalopoulos ,  Gabriele Wirtz ,  Marcus Bauser ,  David Bruckner ,  Martina Wuttke

IPC分类号： A61K31/365 ,  C07D321/02

CPC分类号： A61K31/365 ,  C07D321/12

摘要： The present invention relates to substituted 7H-dibenzo[b,g][1,5]dioxocin-5-one-derivatives, to processes for their preparation and to their use in medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemia, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias and arteriosclerosis.

摘要翻译： 本发明涉及取代的7H-二苯并[b，g] [1,5]二氧环辛-5-酮衍生物，其制备方法及其在药物中的用途，特别是胆固醇酯转移蛋白的抑制剂 CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症和动脉硬化。

公开(公告)号：US20100048641A1

公开(公告)日：2010-02-25

申请号：US12224417

申请日：2007-02-16

申请人： Peter Nell ,  Barbara Albrecht-Küpper ,  Walter Hübsch ,  Martina Wuttke ,  Thomas Krahn ,  Nicole Diedrichs ,  Hilmar Bischoff

发明人： Peter Nell ,  Barbara Albrecht-Küpper ,  Walter Hübsch ,  Martina Wuttke ,  Thomas Krahn ,  Nicole Diedrichs ,  Hilmar Bischoff

IPC分类号： A61K31/4439 ,  C07D417/12 ,  A61P3/00 ,  A61P3/10

CPC分类号： C07D417/12

摘要： The present invention relates to the use of A1 and/or dual A1/A2b agonists of the formulae (IA) and (IB) for preparing a medicament for treating dyslipidemia, metabolic syndrome and diabetes and dyslipidemia, metabolic syndrome and diabetes in association with hypertension and cardiovascular disorders.

摘要翻译： 本发明涉及式（IA）和（IB）的A1和/或双重A1 / A2b激动剂在制备用于治疗血脂异常，代谢综合征和糖尿病和血脂异常，代谢综合征和与高血压相关的糖尿病的药物中的用途 和心血管疾病。

公开(公告)号：US20080255068A1

公开(公告)日：2008-10-16

申请号：US11793482

申请日：2005-12-15

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

IPC分类号： A61K31/695 ,  A61K31/47 ,  A61P3/04 ,  A61P25/28 ,  C07D215/20

CPC分类号： C07D215/20

摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

摘要翻译： 本申请涉及一种新的四氢喹啉衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯的抑制剂 转运蛋白（CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。

公开(公告)号：US08039629B2

公开(公告)日：2011-10-18

申请号：US11793482

申请日：2005-12-15

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

IPC分类号： C07D215/38

摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

公开(公告)号：US08124775B2

公开(公告)日：2012-02-28

申请号：US11793482

申请日：2005-12-15

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Alexandros Vakalopoulos ,  Olaf Weber ,  Martina Wuttke

IPC分类号： C07D215/38

CPC分类号： C07D215/20

摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

摘要翻译： 本申请涉及一种新的四氢喹啉衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯的抑制剂 转运蛋白（CETP）用于治疗和/或预防心血管疾病，特别是下皮脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。

公开(公告)号：US20080194609A1

公开(公告)日：2008-08-14

申请号：US11793483

申请日：2005-12-10

申请人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Martina Wuttke ,  Alexandros Vakalopoulos ,  Olaf Weber

发明人： Hilmar Bischoff ,  Heike Gielen-Haertwig ,  Volkhart Li ,  Carsten Schmeck ,  Michael Thutewohl ,  Martina Wuttke ,  Alexandros Vakalopoulos ,  Olaf Weber

IPC分类号： A61K31/47 ,  C07D215/20 ,  A61P1/00 ,  A61P3/00

CPC分类号： C07D215/20

摘要： The present application relates to novel tetrahydroquinoline derivatives, to a process for their preparation, to their use on their own or in combination for treating and/or preventing diseases and to their use for preparing medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinemias, dyslipidemias, hypertriglyceridemias, hyperlipidemias, hypercholesterolemias and arteriosclerosis.

摘要翻译： 本申请涉及新四氢喹啉衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯转移蛋白的抑制剂 （CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。

公开(公告)号：US20060100230A1

公开(公告)日：2006-05-11

申请号：US10519125

申请日：2003-06-30

申请人： Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Martina Wuttke ,  Heike Heckroth ,  Wolfgang Thielemann ,  Michael Woltering ,  Michael Otteneder

发明人： Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Martina Wuttke ,  Heike Heckroth ,  Wolfgang Thielemann ,  Michael Woltering ,  Michael Otteneder

IPC分类号： A61K31/4745 ,  A61K31/404 ,  C07D471/02 ,  C07D405/02

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D209/96

摘要： The invention relates to novel substituted indolin phenylsulfonamide derivatives, to a method for the production thereof and to the use thereof in medicaments, especially as potent PPAR-delta activating compounds for the prophylaxis and/or treatment of cardiovascular diseases, especially dyslipidaemia and coronary heart diseases.

摘要翻译： 本发明涉及新的取代的二氢吲哚苯磺酰胺衍生物，其制备方法及其在药物中的用途，特别是用于预防和/或治疗心血管疾病，特别是血脂障碍和冠心病的有效PPAR-δ活化化合物 。