公开(公告)号：US4248884A

公开(公告)日：1981-02-03

申请号：US74470

申请日：1979-09-11

Applicant: Jean-Jacques Legrand ,  Christain L. A. Renault

Inventor： Jean-Jacques Legrand ,  Christain L. A. Renault

IPC: C07D207/08 ,  C07D207/26 ,  A61K31/40

CPC classification number: C07D207/08 ,  C07D207/26

Abstract: The compounds of the formula: ##STR1## in which X is a hydrogen or halogen atom or an alkoxy group having 1 to 4 carbon atoms, an alkyl or cycloalkyl group having 1 to 8 carbon atoms, and R represents a hydrogen atom, alkyl group having 1 to 4 carbon atoms, or an aralkyl or hydroxyalkyl group in which the alkyl chain has 1 to 4 carbon atoms are disclosed together with processes for their preparation and medicaments containing the compounds. These compounds are hypolipemiants. In addition, some of them are psychostimulants.

Abstract translation: 下式的化合物：其中X是氢或卤素原子或具有1至4个碳原子的烷氧基，具有1至8个碳原子的烷基或环烷基，R表示氢原子 ，具有1至4个碳原子的烷基或其中烷基链具有1至4个碳原子的芳烷基或羟烷基以及其制备方法和含有该化合物的药物。 这些化合物是降血糖。 此外，其中一些是精神兴奋剂。

公开(公告)号：US20130035383A1

公开(公告)日：2013-02-07

申请号：US13575402

申请日：2011-01-31

Applicant: Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

Inventor： Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

IPC: A61K31/341 ,  A61P1/02 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61K8/49 ,  A61Q19/08

CPC classification number: B01D11/0492 ,  A23L33/10 ,  A23L33/105 ,  A23L33/115 ,  C11B1/10 ,  C11C1/025 ,  C11C3/003

Abstract: The invention relates to a method for the extraction of all unsaponifiable fraction contained in a vegetable oil, an oil originating from a micro-organism or a vegetable butter or in a co-product from the vegetable oil refining industry, such as deodorisation discharge. The method includes at least: A) a step comprising the transformation of the aforementioned oils, butter or co-product from the vegetable oil refining industry or oils originating from micro-organisms into a hydro-alcoholic solution by means of, in particular, a step selected from saponification and esterification steps; B) a step comprising the extraction of the hydro-alcoholic solution in which the fatty fraction is separated from the unsaponitiable fraction by means of liquid/liquid extraction; and C) an optional step comprising the purification of the unsaponiable fraction, selected from the group containing crystallisation and liquid/liquid extraction steps. According to the invention, at least one step from the liquid/liquid extraction steps in step B, the crystallisation steps in step C and the liquid/liquid extraction steps in step C is performed using a first solvent system containing a concentration of solvent selected from among: fluorinated aromatic solvents, particularly trifluorotoluene (BTF) and hexalluorobenzene (BHF); tert-butyl ethers, particularly 2-ethoxy-2-methylpropane, also known as ethyl-tert-butyl-ether (ETU); solvents comprising at least one silicon atom, particularly hexamethyldisiloxane (HMDS) and tertramethylsilane (TMS); methyl-tetrahydrofuran (MeTHF); and mixtures thereof, representing at least 50 vol.-% in relation to the total volume of the solvent system. The invention also relates to the fractions obtained using this method and to compositions containing said fractions.

Abstract translation: 本发明涉及一种用于提取植物油，来自微生物或植物黄油的油或来自植物油精炼工业的共同产品（例如除臭排放物）中所含的所有不皂化成分的方法。 该方法至少包括：A）包括将来自植物油精炼工业的前述油，黄油或副产物或由微生物产生的油转化成水醇溶液的步骤，特别是通过 从皂化和酯化步骤中选择的步骤; B）包括通过液/液萃取提取其中脂肪部分与不可撒色部分分离的水醇溶液的步骤; 和C）任选的步骤，其包括纯化不可溶性馏分，其选自包含结晶和液/液萃取步骤的组。 根据本发明，从步骤B中的液/液萃取步骤至少一步，步骤C中的结晶步骤和步骤C中的液/液萃取步骤是使用含有浓度为 其中：氟化芳族溶剂，特别是三氟甲苯（BTF）和六氟苯（BHF）; 叔丁基醚，特别是2-乙氧基-2-甲基丙烷，也称为乙基叔丁基醚（ETU）; 包含至少一个硅原子，特别是六甲基二硅氧烷（HMDS）和三甲基硅烷（TMS）的溶剂; 甲基 - 四氢呋喃（MeTHF）; 和其混合物，相对于溶剂系统的总体积代表至少50vol。％。 本发明还涉及使用该方法获得的级分和含有所述级分的组合物。

公开(公告)号：US5484921A

公开(公告)日：1996-01-16

申请号：US211443

申请日：1994-04-08

Applicant: Christophe Daubie ,  Jean-Jacques Legrand ,  Clive Pemberton

Inventor： Christophe Daubie ,  Jean-Jacques Legrand ,  Clive Pemberton

IPC: A61K31/445 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/5375 ,  A61P31/04 ,  C07D221/00 ,  C07D471/04 ,  C07D401/12 ,  C07D417/12

CPC classification number: C07D471/04

Abstract: This invention relates to a method for the preparation of benzo[b]naphthyridines having the general formula (I) ##STR1## comprising: 1) condensation of an amine having the formula R'--NH--CH.sub.2 --CH.sub.2 --R" with a chlorofluoroquinoline of formula (II) ##STR2## 2) cyclization of the obtained fluoroquinoline of formula (IV) ##STR3## and; 3) oxidation of tetrahydro-1,2,3,4benzo[b]naphthyridine-1,8 of formula (V) ##STR4## is effected, and then, optionally, the ester obtained is transformed into an acid and optionally into a salt.

Abstract translation: PCT No.PCT / FR92 / 00937 Sec。 371日期1994年4月8日 102（e）日期1994年4月8日PCT 1991年10月8日PCT PCT。 公开号WO93 / 07145 本发明涉及一种制备具有通式（I）的苯并[b]萘啶的方法，其包括：1）具有式R'-NH的胺的缩合 （II）的氯氟喹啉与式（II）的氯氟喹啉的反应2）所得的式（IV）的氟喹啉的环化，（IV）和 3）实现式（V）的四氢-1,2,3,4并[b]萘啶-1,8（Ⅴ）的氧化，然后任选地，将所得酯转化成酸，任选地 变成盐

公开(公告)号：US5395508A

公开(公告)日：1995-03-07

申请号：US130549

申请日：1993-10-01

Applicant: Renaud Jolly ,  Jacques Legrand ,  Cornelia Petrescu

Inventor： Renaud Jolly ,  Jacques Legrand ,  Cornelia Petrescu

IPC: C25D5/02 ,  C25D5/54 ,  H05K3/24 ,  C25D3/00 ,  C25D17/00

CPC classification number: C25D5/022 ,  H05K3/241

Abstract: Apparatus and method for the electrolytic deposition of a metal on a weakly conductive, flexible substrate such as a textile or a paper sheet for the manufacture of flexible heating elements such as heated gloves, heated car seats, panels used in construction for the heating of rooms, etc. Metallic circuits of varying shapes can be formed on the weakly conductive, flexible substrate.

Abstract translation: 在诸如纺织品或纸张的弱导电柔性基材上电解沉积金属的装置和方法，用于制造柔性加热元件，例如加热手套，加热的汽车座椅，用于房间加热的结构中使用的面板 可以在弱导电柔性基板上形成各种形状的金属电路。