公开(公告)号：US06970742B2

公开(公告)日：2005-11-29

申请号：US10697960

申请日：2003-10-29

申请人： Brian Mann ,  James S. Whiting ,  Neal L. Eigler

发明人： Brian Mann ,  James S. Whiting ,  Neal L. Eigler

IPC分类号： A61B5/0215 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/36564 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/0215 ,  A61B5/4839 ,  A61B5/6882 ,  A61B2560/0209 ,  A61N1/3627 ,  A61N1/37247 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06F19/3481 ,  G16H40/63

摘要： A method of treating cardiovascular disease in a medical patient is provided. The method includes the steps of generating a sensor signal indicative of a fluid pressure within the left atrium of the patient's heart, and delivering an electrical stimulus to a location in the heart. The electrical stimulus is delivered based at least in part on the sensor signal. The method also includes the steps of generating a proccessor output indicative of a treatment to a signaling device. The processor output is based at least in part on the sensor signal. At least two treatment signals are provided to the medical patient. The treatment signals are distinguishable from one another by the patient, and are indicative of a therapeutic treatment. The treatment signals are based at least in part on the processor output.

摘要翻译： 提供了一种在医疗患者中治疗心血管疾病的方法。 该方法包括以下步骤：产生指示患者心脏的左心房内的流体压力的传感器信号，以及将电刺激递送到心脏中的位置。 至少部分地基于传感器信号传送电刺激。 该方法还包括以下步骤：产生指示对信号装置的处理的处理器输出。 处理器输出至少部分地基于传感器信号。 向医疗病人提供至少两个治疗信号。 治疗信号可由患者彼此区分，并且指示治疗性治疗。 治疗信号至少部分地基于处理器输出。

公开(公告)号：US06328699B1

公开(公告)日：2001-12-11

申请号：US09481084

申请日：2000-01-11

申请人： Neal L. Eigler ,  James S. Whiting

发明人： Neal L. Eigler ,  James S. Whiting

IPC分类号： A61B502

CPC分类号： A61B5/0215 ,  A61B5/4839 ,  A61B5/6882 ,  A61B2560/0209 ,  A61N1/3627 ,  A61N1/36564 ,  G06F19/00

摘要： The invention provides improved apparatus and methods for treating congestive heart failure in a medical patient. The apparatus includes a pressure transducer permanently implantable within the left atrium of the patient's heart and operable to generate electrical signals indicative of fluid pressures within the patient's left atrium. The pressure transducer is connected to a flexible electrical lead, which is connected in turn to electrical circuitry, which in the preferred embodiment includes digital circuitry for processing electrical signals. The electrical circuitry processes the electrical signals from the pressure transducer and, based at least in part on those signals, generates a signal that indicates a desired therapeutic treatment for treating the patient's condition. That signal is then communicated to the patient via a patient signaling device, following which the patient administers to him or herself the prescribed therapeutic treatment indicated by the signal.

摘要翻译： 本发明提供用于治疗医疗患者的充血性心力衰竭的改进的装置和方法。 该装置包括可永久植入患者心脏的左心房内的压力换能器，并可操作以产生指示患者左心房内的流体压力的电信号。 压力传感器连接到柔性电引线，其依次连接到电路，其在优选实施例中包括用于处理电信号的数字电路。 电路处理来自压力传感器的电信号，并且至少部分地基于那些信号产生指示治疗患者状况的期望治疗治疗的信号。 然后，该信号经由患者信号装置传送给患者，随后患者向他或她自己施加由信号指示的规定的治疗治疗。

公开(公告)号：US09060696B2

公开(公告)日：2015-06-23

申请号：US11116138

申请日：2005-04-27

申请人： Neal L. Eigler ,  Brian M. Mann ,  James S. Whiting ,  Werner Hafelfinger

发明人： Neal L. Eigler ,  Brian M. Mann ,  James S. Whiting ,  Werner Hafelfinger

IPC分类号： A61B5/0215 ,  A61M25/04 ,  A61M25/02

CPC分类号： A61B5/6882 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/6869 ,  A61B8/12 ,  A61B17/3468 ,  A61M25/0108 ,  A61M25/04 ,  A61M31/002 ,  A61M2025/0233 ,  A61N1/362 ,  A61N2001/0578

摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures is also provided.

摘要翻译： 本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。 还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

公开(公告)号：US08303511B2

公开(公告)日：2012-11-06

申请号：US11111691

申请日：2005-04-21

申请人： Neal L. Eigler ,  Brian M. Mann ,  James S. Whiting ,  Werner Hafelfinger

发明人： Neal L. Eigler ,  Brian M. Mann ,  James S. Whiting ,  Werner Hafelfinger

IPC分类号： A61B5/02 ,  A61B5/00 ,  A61M31/00

CPC分类号： A61B5/6882 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/6869 ,  A61B8/12 ,  A61B17/3468 ,  A61M25/0108 ,  A61M25/04 ,  A61M31/002 ,  A61M2025/0233 ,  A61N1/362 ,  A61N2001/0578

摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures are also provided.

摘要翻译： 本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。 还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

公开(公告)号：US20120035590A1

公开(公告)日：2012-02-09

申请号：US13248922

申请日：2011-09-29

申请人： James S. Whiting ,  Neal L. Eigler ,  Brian M. Mann ,  Werner Hafelfinger

发明人： James S. Whiting ,  Neal L. Eigler ,  Brian M. Mann ,  Werner Hafelfinger

IPC分类号： A61M25/09

CPC分类号： A61B17/3468 ,  A61B2017/00243 ,  A61M25/01 ,  A61M25/09 ,  A61M2025/0681 ,  A61N1/056

摘要： A method for accessing a target site in the body by transferring a guidewire from an initial insertion site on the body to a different insertion site on the body is provided. In one aspect, a method for transferring a medical device or component, such as a sensor lead, from an initial insertion site to another insertion site is also provided. A guidewire of sufficient length, pliancy and deformability to perform a transfer from one insertion site to another insertion site is provided. In one aspect, the guidewire comprises a removable core mandrel to increase rigidity, facilitate insertion and/or improve steerability. A kit or system, comprising introducers, guidewires and catheters for performing a guidewire or device transfer is also provided.

摘要翻译： 提供了一种通过将导丝从身体上的初始插入位置传递到身体上的不同插入位置来访问身体中的目标部位的方法。 一方面，还提供了用于将诸如传感器引线的医疗装置或部件从初始插入位置转移到另一插入位置的方法。 提供了足够的长度，柔软度和变形性的导线，以执行从一个插入位点到另一个插入位点的转移。 在一个方面，导丝包括可移除的芯心，以增加刚性，便于插入和/或提高可操纵性。 还提供了一种套件或系统，其包括用于执行导丝或设备转移的导引器，导线和导管。

公开(公告)号：US08029470B2

公开(公告)日：2011-10-04

申请号：US10956899

申请日：2004-09-30

申请人： James S. Whiting ,  Neal L. Eigler ,  John L. Wardle ,  Werner Hafelfinger ,  Brian Mann

发明人： James S. Whiting ,  Neal L. Eigler ,  John L. Wardle ,  Werner Hafelfinger ,  Brian Mann

IPC分类号： A61M5/178

CPC分类号： A61M25/0662 ,  A61M25/0041 ,  A61M2025/0681

摘要： Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a stabilizer sheath having a side port, a shaped guiding catheter configured to exit the side port and a tissue penetration member disposed within and extendable from the distal end of the guide catheter. The tissue penetration member may be configured to penetrate tissue upon rotation and may be coupled to a distal portion of a torqueable shaft. In some embodiments, the stabilizer sheath and shaped guiding catheter may be moved relative to the patient's body structure and relative to each other so that a desired approach angle may be obtained for the tissue penetration member with respect to the target tissue.

摘要翻译： 公开了渗透组织膜以获得进入目标部位的系统和方法。 在一些实例中，通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。 一个实施例提供了一种用于经心脏进入的系统，其包括具有侧端口的稳定器护套，被配置为离开侧端口的成形引导导管和设置在引导导管的远端内并且可从引导导管的远端延伸的组织穿透构件。 组织穿透构件可以构造成在旋转时穿透组织并且可以联接到可扭转轴的远侧部分。 在一些实施例中，稳定器护套和成形引导导管可以相对于患者的身体结构相对于彼此移动，使得组织穿透构件相对于目标组织可以获得期望的接近角。

公开(公告)号：US5822391A

公开(公告)日：1998-10-13

申请号：US555673

申请日：1996-03-25

申请人： James S. Whiting ,  Neal L. Eigler

发明人： James S. Whiting ,  Neal L. Eigler

IPC分类号： A61B6/00 ,  A61M25/01 ,  G06T7/00 ,  G06T7/20 ,  H04N5/32 ,  H04N5/325 ,  H05G1/60 ,  H05G1/64

CPC分类号： A61B6/481 ,  A61B6/504 ,  G06T7/004 ,  G06T7/20 ,  G06T7/2033 ,  H04N5/3205 ,  H04N5/325 ,  H05G1/60 ,  G06T2207/30101

摘要： A method of displaying details of a coronary artery lesion in a cineangiogram, by adjusting each frame of the cineangiogram so that the lesion is continually displayed at a fixed location on a display. The remaining cardiac anatomy appears to move, in background, past a stationary arterial segment, thus making the displayed arterial segment easier to identify and to examine by medical personnel. Cineangiographic image frames are digitized and processed by a processor and the image frames are digitally shifted to place the arterial segment in substantially the same viewing location in each frame. Sequential image frames may be presented to the viewer as a stereoscopic pair, to produce pseudostereopsis. The arterial segment appears to the viewer in foreground, as if it was floating in front of the remaining cardiac anatomy. Image frames may be further processed to aid examination by medical personnel. The processor may make quantitative measurements of the cineangiogram and may display results of those measurements to aid review of the cineangiogram. Frames may be averaged to reduce quantum noise and to blur any structure noise; frames may be compared with prior cineangiograms to increase clarity or contrast. Coordinate adjustments for a cineangiogram may help guide therapeutic procedures, or may help enhance other imaging procedures such as fluoroscopy.

公开(公告)号：US5054045A

公开(公告)日：1991-10-01

申请号：US614790

申请日：1990-11-14

申请人： James S. Whiting ,  Neal Eigler

发明人： James S. Whiting ,  Neal Eigler

IPC分类号： A61B6/00 ,  G06T7/20 ,  H04N5/32 ,  H04N5/325 ,  H05G1/60

CPC分类号： A61B6/481 ,  A61B6/504 ,  G06T7/2033 ,  H04N5/3205 ,  H04N5/325 ,  H05G1/60

摘要： A method of displaying details of a coronary artery lesion in a cineangiogram, by digitally adjusting each frame of the cineangiogram so that the lesion is continually displayed at a fixed location on a display screen. The remaining cardiac anatomy appears to move, in background, past a stationary arterial segment, thus making the displayed arterial segment easier to identify and to examine by medical personnel. Cineangiographic image frames are digitized and processed by an image processor and the image frames are digitally shifted to place the arterial segment in substantially the same viewing location in each frame. Sequential image frames may be presented to the viewer as a stereoscopic pair, to produce pseudostereopsis. The arterial segment appears to the viewer in foreground, as if it was floating in front of the remaining cardiac anatomy. Image frames may be further processed to aid examination by medical personnel. Frames may be averaged to reduce quantum noise and to blur any structure noise. Frame averaging may be used to make numerical measurements of arterial cross-section.

摘要翻译： 通过数字调整电影照相的每一帧以使病变在显示屏上的固定位置不断显示的方法来显示电影照相中的冠状动脉病变的细节。 剩余的心脏解剖似乎在背景中移动通过静止的动脉段，从而使得显示的动脉段更容易识别和由医务人员进行检查。 血管造影图像帧由图像处理器数字化和处理，并且图像帧被数字移位以将动脉段在每个帧中基本上相同的观察位置。 顺序图像帧可以作为立体对呈现给观看者，以产生伪造图。 动脉段在前景中出现在观察者身上，好像它悬浮在剩下的心脏解剖结构的前面。 可以进一步处理图像帧以帮助医务人员进行检查。 可以对帧进行平均以减少量子噪声并模糊任何结构噪声。 可以使用帧平均来进行动脉横截面的数值测量。