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公开(公告)号：US5054045A
公开(公告)日：1991-10-01
申请号：US614790
申请日：1990-11-14
申请人： James S. Whiting , Neal Eigler
发明人： James S. Whiting , Neal Eigler
CPC分类号： A61B6/481 , A61B6/504 , G06T7/2033 , H04N5/3205 , H04N5/325 , H05G1/60
摘要： A method of displaying details of a coronary artery lesion in a cineangiogram, by digitally adjusting each frame of the cineangiogram so that the lesion is continually displayed at a fixed location on a display screen. The remaining cardiac anatomy appears to move, in background, past a stationary arterial segment, thus making the displayed arterial segment easier to identify and to examine by medical personnel. Cineangiographic image frames are digitized and processed by an image processor and the image frames are digitally shifted to place the arterial segment in substantially the same viewing location in each frame. Sequential image frames may be presented to the viewer as a stereoscopic pair, to produce pseudostereopsis. The arterial segment appears to the viewer in foreground, as if it was floating in front of the remaining cardiac anatomy. Image frames may be further processed to aid examination by medical personnel. Frames may be averaged to reduce quantum noise and to blur any structure noise. Frame averaging may be used to make numerical measurements of arterial cross-section.
摘要翻译： 通过数字调整电影照相的每一帧以使病变在显示屏上的固定位置不断显示的方法来显示电影照相中的冠状动脉病变的细节。 剩余的心脏解剖似乎在背景中移动通过静止的动脉段，从而使得显示的动脉段更容易识别和由医务人员进行检查。 血管造影图像帧由图像处理器数字化和处理，并且图像帧被数字移位以将动脉段在每个帧中基本上相同的观察位置。 顺序图像帧可以作为立体对呈现给观看者，以产生伪造图。 动脉段在前景中出现在观察者身上，好像它悬浮在剩下的心脏解剖结构的前面。 可以进一步处理图像帧以帮助医务人员进行检查。 可以对帧进行平均以减少量子噪声并模糊任何结构噪声。 可以使用帧平均来进行动脉横截面的数值测量。
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公开(公告)号：US07678081B2
公开(公告)日：2010-03-16
申请号：US10889319
申请日：2004-07-12
申请人： James S. Whiting , Neal Eigler , John L. Wardle
发明人： James S. Whiting , Neal Eigler , John L. Wardle
IPC分类号： A61M5/178
CPC分类号： A61M25/0084
摘要： Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a guiding catheter, an access catheter and a guidewire. The access catheter may include a tissue penetration member disposed within a housing wherein the tissue penetration member is substantially contained within the housing when in a retracted configuration. When the distal end of the access catheter is disposed adjacent the septal wall, the user can initiate an actuator switch, which may be in a proximal portion of the system, to cause the tissue penetration member to extend through the septal wall. Alternatively, the tissue penetration member can be actuated automatically by a contact trigger mechanism, without initiation by the user, upon contact with the septal wall by a distal contact member which is coupled to the contact trigger mechanism. Such a system may also include an interlock mechanism to prevent triggering of the tissue penetration member at undesirable times during a procedure.
摘要翻译： 公开了渗透组织膜以获得进入目标部位的系统和方法。 在一些实例中，通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。 一个实施例提供了一种用于经心脏进入的系统，其包括引导导管，进入导管和导丝。 进入导管可以包括设置在壳体内的组织穿透构件，其中当处于缩回构型时，组织穿透构件基本上容纳在壳体内。 当进入导管的远端邻近隔膜设置时，使用者可以启动可在系统的近端部分中的致动器开关，以使组织穿透构件延伸通过隔壁。 或者，组织穿透构件可以由接触触发机构自动致动，而不会由使用者触发时通过与接触触发机构联接的远端接触构件与间隔壁接触。 这种系统还可以包括互锁机构，以防止组织穿透部件在手术期间的不期望的时间触发。
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公开(公告)号：US20110054405A1
公开(公告)日：2011-03-03
申请号：US12552199
申请日：2009-09-01
IPC分类号： A61B17/34
CPC分类号： A61B17/3462 , A61B17/3439 , A61M39/0613
摘要： A hemostasis valve is disclosed herein. The hemostasis valve may include an inner bushing, a rotation sleeve, an elastomeric sleeve, and a biasing element. The rotation sleeve may extend about the inner bushing and be rotationally displaceable relative to the inner bushing. The elastomeric sleeve may include a first end operably coupled to the inner bushing, a second end operably coupled to the rotation sleeve, and an iris valve portion. Rotation of the rotation sleeve relative to the inner bushing may cause the iris valve to transition from an open state to a closed state. The biasing element may act between the rotation sleeve and inner bushing to bias the iris valve towards at least one of a closed state or an open state.
摘要翻译： 本文公开了一种止血阀。 止血阀可以包括内衬套，旋转套筒，弹性体套筒和偏置元件。 旋转套筒可以围绕内衬套延伸并且可相对于内衬套旋转移位。 弹性体套筒可以包括可操作地联接到内衬套的第一端，可操作地联接到旋转套筒的第二端和可变光阀部分。 旋转套筒相对于内衬套的旋转可能导致虹膜阀从打开状态转换到关闭状态。 偏置元件可以在旋转套筒和内衬套之间作用，以将虹膜阀朝向关闭状态或打开状态中的至少一个偏压。
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公开(公告)号：US07717854B2
公开(公告)日：2010-05-18
申请号：US11746593
申请日：2007-05-09
申请人： Brian Mann , James S. Whiting , Neal L. Eigler
发明人： Brian Mann , James S. Whiting , Neal L. Eigler
IPC分类号： A61B5/0215
CPC分类号： A61N1/36564 , A61B5/021 , A61B5/02108 , A61B5/0215 , A61B5/4839 , A61B5/6882 , A61B2560/0209 , A61N1/3627 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： A method of treating cardiovascular disease in a medical patient is provided. The method includes the steps of generating a sensor signal indicative of a fluid pressure within the left atrium of the patient's heart, and delivering an electrical stimulus to a location in the heart. The electrical stimulus is delivered based at least in part on the sensor signal. The method also includes the steps of generating a processor output indicative of a treatment to a signaling device. The processor output is based at least in part on the sensor signal. At least two treatment signals are provided to the medical patient. The treatment signals are distinguishable from one another by the patient, and are indicative of a therapeutic treatment. The treatment signals are based at least in part on the processor output.
摘要翻译： 提供了一种在医疗患者中治疗心血管疾病的方法。 该方法包括以下步骤：产生指示患者心脏的左心房内的流体压力的传感器信号，以及将电刺激递送到心脏中的位置。 至少部分地基于传感器信号传送电刺激。 该方法还包括以下步骤：产生指示对信号装置的处理的处理器输出。 处理器输出至少部分地基于传感器信号。 向医疗病人提供至少两个治疗信号。 治疗信号可由患者彼此区分，并且指示治疗性治疗。 治疗信号至少部分地基于处理器输出。
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公开(公告)号：US07402899B1
公开(公告)日：2008-07-22
申请号：US11622647
申请日：2007-01-12
IPC分类号： H01L21/30
CPC分类号： H01L23/10 , B81B7/0077 , H01L2924/0002 , H01L2924/01079 , H01L2924/09701 , H01L2924/00
摘要： A device and method for hermetically sealing a medical device is provided. In one aspect, a silicon device is coupled to a sensor, such as a pressure transducer, which benefits from having direct contact with its environment, which in many cases, is the human body. Thus, a method to hermetically seal the non-sensing portion of a silicon device while allowing the sensing portion (e.g. the pressure transducer) to have direct contact with the body is provided. In one aspect, a silicon chip, a gold preform and a metallic housing are each primed for sealing and are assembled. The assembly is then heated to react the gold preform to the silicon chip and to form a molten gold-silicon alloy in-situ to bind the metallic housing to the non-sensing portion of the silicon chip. In this way, the non-sensing portion of the silicon chip is hermetically sealed and protected from exposure, while still permitting exposure of the sensing portion to the environment.
摘要翻译： 提供一种用于密封医疗装置的装置和方法。 在一个方面，硅器件耦合到诸如压力传感器的传感器，其受益于与其环境的直接接触，其在许多情况下是人体。 因此，提供了一种使允许感测部分（例如压力传感器）与身体直接接触的硅器件的非感测部分密封的方法。 在一个方面，硅芯片，金预成型件和金属外壳各自用于密封并组装。 然后将组件加热以使金预成型件与硅芯片反应，并原位形成熔融的金 - 硅合金，以将金属外壳固定到硅芯片的非感测部分。 以这种方式，硅芯片的非感测部分被气密地密封并防止暴露，同时仍然允许感测部分暴露于环境中。
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6.发明授权Implantable pressure transducer system optimized to correct environmental factors 有权植入式压力传感器系统优化，以纠正环境因素公开(公告)号：US09060696B2
公开(公告)日：2015-06-23
申请号：US11116138
申请日：2005-04-27
IPC分类号： A61B5/0215 , A61M25/04 , A61M25/02
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures is also provided.
摘要翻译： 本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。 还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。
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7.发明授权Implantable pressure transducer system optimized for reduced thrombosis effect 有权植入式压力传感器系统优化减少血栓形成的作用公开(公告)号：US08303511B2
公开(公告)日：2012-11-06
申请号：US11111691
申请日：2005-04-21
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures are also provided.
摘要翻译： 本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。 还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。
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8.发明申请SYSTEM AND METHOD FOR MANIPULATING INSERTION PATHWAYS FOR ACCESSING TARGET SITES 有权用于操纵目标站点的插入路径的系统和方法公开(公告)号：US20120035590A1
公开(公告)日：2012-02-09
申请号：US13248922
申请日：2011-09-29
IPC分类号： A61M25/09
CPC分类号： A61B17/3468 , A61B2017/00243 , A61M25/01 , A61M25/09 , A61M2025/0681 , A61N1/056
摘要： A method for accessing a target site in the body by transferring a guidewire from an initial insertion site on the body to a different insertion site on the body is provided. In one aspect, a method for transferring a medical device or component, such as a sensor lead, from an initial insertion site to another insertion site is also provided. A guidewire of sufficient length, pliancy and deformability to perform a transfer from one insertion site to another insertion site is provided. In one aspect, the guidewire comprises a removable core mandrel to increase rigidity, facilitate insertion and/or improve steerability. A kit or system, comprising introducers, guidewires and catheters for performing a guidewire or device transfer is also provided.
摘要翻译： 提供了一种通过将导丝从身体上的初始插入位置传递到身体上的不同插入位置来访问身体中的目标部位的方法。 一方面，还提供了用于将诸如传感器引线的医疗装置或部件从初始插入位置转移到另一插入位置的方法。 提供了足够的长度，柔软度和变形性的导线，以执行从一个插入位点到另一个插入位点的转移。 在一个方面，导丝包括可移除的芯心，以增加刚性，便于插入和/或提高可操纵性。 还提供了一种套件或系统，其包括用于执行导丝或设备转移的导引器，导线和导管。
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公开(公告)号：US08029470B2
公开(公告)日：2011-10-04
申请号：US10956899
申请日：2004-09-30
IPC分类号： A61M5/178
CPC分类号： A61M25/0662 , A61M25/0041 , A61M2025/0681
摘要： Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a stabilizer sheath having a side port, a shaped guiding catheter configured to exit the side port and a tissue penetration member disposed within and extendable from the distal end of the guide catheter. The tissue penetration member may be configured to penetrate tissue upon rotation and may be coupled to a distal portion of a torqueable shaft. In some embodiments, the stabilizer sheath and shaped guiding catheter may be moved relative to the patient's body structure and relative to each other so that a desired approach angle may be obtained for the tissue penetration member with respect to the target tissue.
摘要翻译： 公开了渗透组织膜以获得进入目标部位的系统和方法。 在一些实例中，通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。 一个实施例提供了一种用于经心脏进入的系统，其包括具有侧端口的稳定器护套，被配置为离开侧端口的成形引导导管和设置在引导导管的远端内并且可从引导导管的远端延伸的组织穿透构件。 组织穿透构件可以构造成在旋转时穿透组织并且可以联接到可扭转轴的远侧部分。 在一些实施例中，稳定器护套和成形引导导管可以相对于患者的身体结构相对于彼此移动，使得组织穿透构件相对于目标组织可以获得期望的接近角。
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公开(公告)号：US5822391A
公开(公告)日：1998-10-13
申请号：US555673
申请日：1996-03-25
申请人： James S. Whiting , Neal L. Eigler
发明人： James S. Whiting , Neal L. Eigler
CPC分类号： A61B6/481 , A61B6/504 , G06T7/004 , G06T7/20 , G06T7/2033 , H04N5/3205 , H04N5/325 , H05G1/60 , G06T2207/30101
摘要： A method of displaying details of a coronary artery lesion in a cineangiogram, by adjusting each frame of the cineangiogram so that the lesion is continually displayed at a fixed location on a display. The remaining cardiac anatomy appears to move, in background, past a stationary arterial segment, thus making the displayed arterial segment easier to identify and to examine by medical personnel. Cineangiographic image frames are digitized and processed by a processor and the image frames are digitally shifted to place the arterial segment in substantially the same viewing location in each frame. Sequential image frames may be presented to the viewer as a stereoscopic pair, to produce pseudostereopsis. The arterial segment appears to the viewer in foreground, as if it was floating in front of the remaining cardiac anatomy. Image frames may be further processed to aid examination by medical personnel. The processor may make quantitative measurements of the cineangiogram and may display results of those measurements to aid review of the cineangiogram. Frames may be averaged to reduce quantum noise and to blur any structure noise; frames may be compared with prior cineangiograms to increase clarity or contrast. Coordinate adjustments for a cineangiogram may help guide therapeutic procedures, or may help enhance other imaging procedures such as fluoroscopy.
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