公开(公告)号：US09907983B2

公开(公告)日：2018-03-06

申请号：US13630727

申请日：2012-09-28

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61N7/02 ,  A61B8/00 ,  A61B90/98 ,  A61B5/00 ,  A61B8/08 ,  A61B17/00 ,  A61B18/00 ,  A61N7/00

CPC classification number: A61N7/022 ,  A61B5/0008 ,  A61B5/4893 ,  A61B8/08 ,  A61B90/98 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2018/00005 ,  A61N2007/0026 ,  A61N2007/0078

Abstract: A tissue ablation method for treating atrial fibrillation in a patient comprises locating an ostium of a pulmonary vein and positioning an interventional catheter adjacent the ostium. The interventional catheter has an energy source. Collateral tissue adjacent the ostium is located and tissue around the ostium is ablated with energy from the energy source so as to form a contiguous lesion circumscribing the ostium. The lesion blocks aberrant electrical pathways in the tissue so as to reduce or eliminate the atrial fibrillation. The ablating is modified so as to avoid ablating or otherwise damaging the collateral tissue.

公开(公告)号：US20130267875A1

公开(公告)日：2013-10-10

申请号：US13630750

申请日：2012-09-28

Applicant: Hira V. THAPLIYAL ,  David A. GALLUP ,  James W. ARENSON ,  Robert BROMMER

Inventor： Hira V. THAPLIYAL ,  David A. GALLUP ,  James W. ARENSON ,  Robert BROMMER

IPC: A61B17/32

CPC classification number: A61N7/022 ,  A61B2017/00053 ,  A61B2017/00092 ,  A61B2017/00106 ,  A61B2017/320069 ,  A61B2018/00029 ,  A61M25/0147 ,  A61M25/0152 ,  A61N2007/0091

Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

Abstract translation: 用于治疗患者原纤维化的组织消融系统包括具有能量源的可引导介入​​导管，所述能量源发射能量束以消融组织，从而为异常电通路形成传导阻滞。 该系统还包括设置在介入导管的近端附近的手柄，并具有用于转导介入导管的致动机构。 控制台允许系统被控制并为系统提供电力，并且显示盒与控制台电耦合。 显示盒具有显示面板，用于向用户显示系统信息，并允许用户控制系统。 导管盒与手柄电气和机械可释放地联接，并且还与显示盒电耦合。

公开(公告)号：US20130103064A1

公开(公告)日：2013-04-25

申请号：US13446552

申请日：2012-04-13

Applicant: James W. Arenson ,  Thilaka Sumanaweera ,  John P. Madden

Inventor： James W. Arenson ,  Thilaka Sumanaweera ,  John P. Madden

IPC: A61N7/02

CPC classification number: A61N7/022 ,  A61B5/0422 ,  A61B5/061 ,  A61B5/1076 ,  A61B34/20 ,  A61B34/25 ,  A61B2017/00044 ,  A61B2018/00577 ,  A61B2018/00839

Abstract: A system for ablating and mapping tissue comprises a stand alone tissue ablation system adapted to ablate the tissue, and a stand alone cardiac mapping system adapted to map the tissue. The ablation system is operably coupled with the cardiac mapping system such that mapping data from the cardiac mapping system is provided to the ablation system to create a graphical display of the tissue and the ablation system position relative to the tissue. Motion of the ablation system may be monitored and adjusted based on feedback provided by ablation system actuators as well as position sensors.

Abstract translation: 用于消融和映射组织的系统包括适于消融组织的独立组织消融系统和适于映射组织的独立心脏图谱系统。 消融系统与心脏测绘系统可操作地耦合，使得将来自心脏测绘系统的映射数据提供给消融系统以创建组织的图形显示和相对于组织的消融系统位置。 可以基于由消融系统致动器以及位置传感器提供的反馈来监测和调整消融系统的运动。

公开(公告)号：US20130096594A1

公开(公告)日：2013-04-18

申请号：US13630727

申请日：2012-09-28

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61N7/02

CPC classification number: A61N7/022 ,  A61B5/0008 ,  A61B5/4893 ,  A61B8/08 ,  A61B90/98 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2018/00005 ,  A61N2007/0026 ,  A61N2007/0078

Abstract: A tissue ablation method for treating atrial fibrillation in a patient comprises locating an ostium of a pulmonary vein and positioning an interventional catheter adjacent the ostium. The interventional catheter has an energy source. Collateral tissue adjacent the ostium is located and tissue around the ostium is ablated with energy from the energy source so as to form a contiguous lesion circumscribing the ostium. The lesion blocks aberrant electrical pathways in the tissue so as to reduce or eliminate the atrial fibrillation. The ablating is modified so as to avoid ablating or otherwise damaging the collateral tissue.

Abstract translation: 用于治疗患者心房颤动的组织消融方法包括定位肺静脉的口，并将介入导管定位在邻近口处。 介入导管具有能量源。 定位邻近口的附近组织，并且能量来自能量的能量消除口周围的组织，以形成围绕口的连续病变。 病变阻止组织中的异常电通路，以减少或消除心房颤动。 烧蚀被修改以避免消融或以其他方式损伤侧支组织。

公开(公告)号：US20130096593A1

公开(公告)日：2013-04-18

申请号：US13630697

申请日：2012-09-28

Applicant: Hira V. THAPLIYAL ,  David A. GALLUP ,  James W. ARENSON

Inventor： Hira V. THAPLIYAL ,  David A. GALLUP ,  James W. ARENSON

IPC: A61N7/02

CPC classification number: A61N7/00 ,  A61B8/12 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/00106 ,  A61B2018/00029 ,  A61B2018/00642 ,  A61B2090/061 ,  A61N7/022 ,  A61N2007/0052 ,  A61N2007/0073 ,  A61N2007/0078

Abstract: Systems and methods for ablating tissue include an ablation device having an energy source and a sensor. The energy source provides a beam of energy directable to target tissue, and the sensor senses energy reflected back from the target tissue. The sensor collects various information from the target tissue in order to facilitate adjustment of ablation operating parameters, such as changing power or position of the energy beam. Gap distance between the energy source and target tissue, energy beam incident angle, tissue motion, tissue type, lesion depth, etc. are examples of some of the information that may be collected during the ablation process and used to help control ablation of the tissue.

Abstract translation: 用于烧蚀组织的系统和方法包括具有能量源和传感器的消融装置。 能量源提供可瞄准组织的能量束，并且传感器感测从目标组织反射的能量。 传感器从目标组织收集各种信息，以便于调整消融操作参数，例如改变能量束的功率或位置。 能量源和目标组织之间的间隙距离，能量束入射角，组织运动，组织类型，损伤深度等是可以在消融过程期间收集的并且用于帮助控制组织消融的一些信息的示例 。

公开(公告)号：US20120157984A1

公开(公告)日：2012-06-21

申请号：US13405712

申请日：2012-02-27

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B17/2202 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2018/00029 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

Abstract translation: 用于治疗患者原纤维化的组织消融系统包括具有能量源的可引导介入​​导管，所述能量源发射能量束以消融组织，从而为异常电通路形成传导阻滞。 该系统还包括设置在介入导管的近端附近的手柄，并具有用于转导介入导管的致动机构。 控制台允许系统被控制并为系统提供电力，并且显示盒与控制台电耦合。 显示盒具有显示面板，用于向用户显示系统信息，并允许用户控制系统。 导管盒与手柄电气和机械可释放地联接，并且还与显示盒电耦合。

公开(公告)号：US07950397B2

公开(公告)日：2011-05-31

申请号：US11747862

申请日：2007-05-11

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61B19/00

CPC classification number: A61B17/320068 ,  A61B17/2202 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2018/00029 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A cardiac ablation method including the following steps: inserting a treatment catheter into an atrium of a heart, the treatment catheter including an ultrasound emitter; positioning the ultrasound emitter to face heart tissue within the left atrium outside of a pulmonary vein; emitting ultrasound energy from the ultrasound emitter while rotating the ultrasound emitter about a rotation axis; and ablating heart tissue with the ultrasound energy to form a lesion outside of a pulmonary vein.

Abstract translation: 一种心脏消融方法，包括以下步骤：将治疗导管插入心脏的心房，所述治疗导管包括超声发射器; 定位超声波发射器以面对肺静脉外的左心房内的心脏组织; 在围绕旋转轴线旋转超声发射器的同时从超声发射器发射超声能量; 并用超声能量消融心脏组织以在肺静脉外部形成病变。

公开(公告)号：US5997478A

公开(公告)日：1999-12-07

申请号：US17756

申请日：1998-02-03

Applicant: John I. Jackson ,  James W. Arenson

Inventor： John I. Jackson ,  James W. Arenson

IPC: A61B8/00 ,  A61B8/08 ,  A61B8/14

CPC classification number: A61B8/00 ,  A61B8/08 ,  A61B8/14 ,  A61B8/488

Abstract: An ultrasound system and method are presented for facilitating a reproducible ultrasound imaging environment by reducing the variability in ultrasound parameters as a source of discrepancy when performing serial studies. In this way, an operator can rigorously compare ultrasound images from a single patient and can ensure that a plurality of patients are imaged in the same way. Additionally, an imaging environment can be duplicated on a plurality of ultrasound systems. This is especially helpful in ensuring that several machines are configured in the same way and in tracking down unexpected behavior (e.g., hardware or software bugs or anomalies).

Abstract translation: 提出了一种超声系统和方法，用于通过在执行连续研究时减小超声参数的变异性作为差异来促进可重现的超声成像环境。 以这种方式，操作者可以严格地比较来自单个患者的超声图像，并且可以确保以相同的方式对多个患者进行成像。 另外，成像环境可以复制在多个超声系统上。 这尤其有助于确保以相同的方式配置多台计算机，并跟踪意外行为（例如，硬件或软件错误或异常情况）。

公开(公告)号：US5899864A

公开(公告)日：1999-05-04

申请号：US827863

申请日：1997-04-09

Applicant: James W. Arenson ,  Stanley S. C. Chim ,  Ismayil M. Guracar ,  Samuel H. Maslak

Inventor： James W. Arenson ,  Stanley S. C. Chim ,  Ismayil M. Guracar ,  Samuel H. Maslak

IPC: A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  G01S7/52 ,  G01S15/89 ,  G06T1/00 ,  G06T5/20

CPC classification number: G01S15/8979 ,  G01S7/52071 ,  G01S7/52073 ,  A61B8/06 ,  A61B8/08 ,  A61B8/13 ,  A61B8/488 ,  G01S7/52046 ,  G01S7/52063

Abstract: The energy, power or amplitude of Doppler or time shift information signals is compared to a threshold in order to select a large or small weighting factor for temporal persistence. In the event of a "flash" signal or strong arterial flow signal, a small weighting factor is chosen to reduce the extent of temporal persistence via feedback of the averaged value for the prior frames so that the effect of the "flash" or strong flow signal would quickly dissipate in the imaging of subsequent frames and good temporal resolution preserved for the current frames, while low energy flow signals would cause a large weighting factor to be selected to improve the signal-to-noise ratio of low energy signals. Similar effects can be achieved by clipping the signals to not exceed a certain threshold.

Abstract translation: 将多普勒或时移信息信号的能量，功率或振幅与阈值进行比较，以便为时间持续性选择大或小的加权因子。 在“闪光”信号或强动脉信号的情况下，选择小的加权因子以通过对现有帧的平均值的反馈来减小时间持续的程度，使得“闪光”或强流的效果 信号将在后续帧的成像中快速消散，并为当前帧保留良好的时间分辨率，而低能量流信号将导致选择较大的加权因子以改善低能量信号的信噪比。 可以通过将信号削波到不超过某个阈值来实现类似的效果。

公开(公告)号：USRE35720E

公开(公告)日：1998-02-03

申请号：US601262

申请日：1996-02-14

Applicant: James W. Arenson ,  Ismavil M. Guracar ,  Janna G. Clark ,  Marc D. Weinshenker

Inventor： James W. Arenson ,  Ismavil M. Guracar ,  Janna G. Clark ,  Marc D. Weinshenker

IPC: A61B8/06 ,  A61B8/14 ,  G01N29/06 ,  G01N29/44 ,  G01P5/00 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00

CPC classification number: G01S15/8979 ,  A61B8/06 ,  A61B8/13 ,  G01N29/0609 ,  G01S7/5206 ,  G01S7/52071 ,  G01S7/52074 ,  A61B8/0883

Abstract: An ultrasound tissue imaging system having an acoustic transducer, B-mode imaging means to produce with said transducer an electronically scanned B-mode image of tissue under examination. Doppler imaging means that accepts and processes large amplitude, low frequency signals to produce with said transducer an electronically scanned acoustic image of moving tissue, and color display means for displaying the B-mode image as a two-dimensional image with echo intensities encoded using a first mapping function and for simultaneously displaying Doppler information from moving tissue as a two-dimensional image using a second and distinct mapping function that is spatially coordinated with and superimposed upon said B-mode image to augment the B-mode image.

Abstract translation: 一种具有声换能器的超声组织成像系统，B模式成像装置，用所述换能器产生检查中的组织的电子扫描B模式图像。 多普勒成像装置接受和处理大幅度的低频信号以与所述换能器一起产生移动组织的电子扫描声像，以及彩色显示装置，用于将B模式图像显示为二维图像，其中回波强度使用 第一映射功能，并且使用与所述B模式图像空间协调并叠加在所述B模式图像上的第二和不同映射函数同时将来自移动组织的多普勒信息显示为二维图像以增大B模式图像。