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    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT
    31.
    发明申请
    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
    APO A-I MIME技术和治疗方法

    公开(公告)号：US20110263497A1

    公开(公告)日：2011-10-27

    申请号：US13177473

    申请日：2011-07-06

    Applicant: Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    Inventor： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    IPC: A61K38/10 ,  A61P9/10

    CPC classification number: A61K38/17 ,  A61K31/661 ,  A61K38/10 ,  A61K38/1709

    Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.

    Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

    Packet coalescing
    33.
    发明授权
    Packet coalescing 有权
    分组聚合

    公开(公告)号：US08036246B2

    公开(公告)日：2011-10-11

    申请号：US12586964

    申请日：2009-09-30

    Applicant: Srihari Makineni ,  Ravi Iyer ,  Dave Minturn ,  Sujoy Sen ,  Donald Newell ,  Li Zhao

    Inventor： Srihari Makineni ,  Ravi Iyer ,  Dave Minturn ,  Sujoy Sen ,  Donald Newell ,  Li Zhao

    IPC: H04J3/24

    CPC classification number: H04L45/74 ,  H04L49/20 ,  H04L69/16 ,  H04L69/161 ,  H04L69/166

    Abstract: In general, in one aspect, the disclosures describes a method that includes receiving multiple ingress Internet Protocol packets, each of the multiple ingress Internet Protocol packets having an Internet Protocol header and a Transmission Control Protocol segment having a Transmission Control Protocol header and a Transmission Control Protocol payload, where the multiple packets belonging to a same Transmission Control Protocol/Internet Protocol flow. The method also includes preparing an Internet Protocol packet having a single Internet Protocol header and a single Transmission Control Protocol segment having a single Transmission Control Protocol header and a single payload formed by a combination of the Transmission Control Protocol segment payloads of the multiple Internet Protocol packets. The method further includes generating a signal that causes receive processing of the Internet Protocol packet.

    Abstract translation: 一般来说，一方面，本公开内容描述了一种方法，其包括接收多个入口因特网协议分组，所述多个入口因特网协议分组中的每一个具有因特网协议报头和具有传输控制协议报头和传输控制的传输控制协议段 协议有效载荷，其中属于相同传输控制协议/因特网协议的多个分组流。 该方法还包括准备具有单个因特网协议报头的互联网协议分组和具有单个传输控制协议报头的单个传输控制协议段和由多个因特网协议分组的传输控制协议段有效载荷的组合形成的单个有效载荷 。 该方法还包括产生导致因特网协议分组的接收处理的信号。

    HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
    34.
    发明申请
    HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 审中-公开
    杂环化合物和作为反应剂的用途

    公开(公告)号：US20110207751A1

    公开(公告)日：2011-08-25

    申请号：US13031134

    申请日：2011-02-18

    Applicant: Long Mao ,  Xiaobo Wang ,  Xiao Xu ,  Li Zhao ,  Jia Liu

    Inventor： Long Mao ,  Xiaobo Wang ,  Xiao Xu ,  Li Zhao ,  Jia Liu

    IPC: A61K31/519 ,  C07D487/04 ,  A61P35/00 ,  A61P35/02 ,  A61K31/429 ,  C07D513/04 ,  A61K31/4439

    CPC classification number: C07D471/04 ,  C07D513/04

    Abstract: Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

    Abstract translation: 公开了具有被噻唑环取代的稠合双环杂芳环体系的新型化合物。 这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。 通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。 此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。 公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

    Controlling Access To A Cache Memory Using Privilege Level Information
    35.
    发明申请
    Controlling Access To A Cache Memory Using Privilege Level Information 有权
    控制使用特权级别信息访问缓存内存

    公开(公告)号：US20110153926A1

    公开(公告)日：2011-06-23

    申请号：US12645788

    申请日：2009-12-23

    Applicant: Zhen Fang ,  Li Zhao ,  Ravishankar Iyer ,  Tong Li ,  Donald K. Newell

    Inventor： Zhen Fang ,  Li Zhao ,  Ravishankar Iyer ,  Tong Li ,  Donald K. Newell

    IPC: G06F12/00 ,  G06F12/08

    CPC classification number: G06F12/0895 ,  G06F12/1491 ,  Y02D10/13

    Abstract: In one embodiment, a cache memory includes entries each to store a ring level identifier, which may indicate a privilege level of information stored in the entry. This identifier may be used in performing read accesses to the cache memory. As an example, a logic coupled to the cache memory may filter an access to one or more ways of a selected set of the cache memory based at least in part on a current privilege level of a processor and the ring level identifier of the one or more ways. Other embodiments are described and claimed.

    Abstract translation: 在一个实施例中，高速缓冲存储器包括各自存储环电平标识符的条目，其可以指示存储在条目中的信息的权限级别。 该标识符可用于执行对高速缓冲存储器的读取访问。 作为示例，耦合到高速缓存存储器的逻辑可以至少部分地基于处理器的当前特权级别和一个或多个高速缓冲存储器的环电平标识符来过滤对所选择的高速缓冲存储器组的一种或多种方式的访问， 更多的方式 描述和要求保护其他实施例。

    AUTOMATICALLY USING SUPERPAGES FOR STACK MEMORY ALLOCATION
    38.
    发明申请
    AUTOMATICALLY USING SUPERPAGES FOR STACK MEMORY ALLOCATION 审中-公开
    自动使用SUPERPAGES进行堆叠内存分配

    公开(公告)号：US20100332788A1

    公开(公告)日：2010-12-30

    申请号：US12495509

    申请日：2009-06-30

    Applicant: LI ZHAO ,  Zhen Fang ,  Ravishankar Iyer ,  Donald Newell

    Inventor： LI ZHAO ,  Zhen Fang ,  Ravishankar Iyer ,  Donald Newell

    IPC: G06F12/10 ,  G06F12/00

    CPC classification number: G06F12/1027 ,  G06F2212/652

    Abstract: In one embodiment, the present invention includes a page fault handler to create page table entries and TLB entries in response to a page fault, the page fault handler to determine if a page fault resulted from a stack access, to create a superpage table entry if the page fault did result from a stack access, and to create a TLB entry for the superpage. Other embodiments are described and claimed.

    Abstract translation: 在一个实施例中，本发明包括页面错误处理程序，以响应于页面错误来创建页面表项和TLB条目，页面错误处理程序来确定页面错误是否由堆栈访问导致，以创建超级页面表项 页面错误确实来自堆栈访问，并为超级页面创建一个TLB条目。 描述和要求保护其他实施例。

    Selective storage of data in levels of a cache memory
    39.
    发明授权
    Selective storage of data in levels of a cache memory 失效
    在高速缓冲存储器的级别中选择性地存储数据

    公开(公告)号：US07596662B2

    公开(公告)日：2009-09-29

    申请号：US11513554

    申请日：2006-08-31

    Applicant: Srihari Makineni ,  Jaideep Moses ,  Ravishankar Iyer ,  Ramesh Illikkal ,  Don Newell ,  Li Zhao

    Inventor： Srihari Makineni ,  Jaideep Moses ,  Ravishankar Iyer ,  Ramesh Illikkal ,  Don Newell ,  Li Zhao

    IPC: G06F12/00

    CPC classification number: G06F12/0897 ,  G06F12/128

    Abstract: In one embodiment, the present invention includes a method for incrementing a counter value associated with a cache line if the cache line is inserted into a first level cache, and storing the cache line into a second level cache coupled to the first level cache or a third level cache coupled to the second level cache based on the counter value, after eviction from the first level cache. Other embodiments are described and claimed.

    Abstract translation: 在一个实施例中，本发明包括一种用于在高速缓存行插入到第一级高速缓存中时递增与高速缓存线相关联的计数器值的方法，并且将高速缓存行存储到耦合到第一级高速缓存的第二级高速缓存或 在从第一级高速缓存驱逐之后，基于计数器值耦合到第二级高速缓存的第三级缓存。 描述和要求保护其他实施例。

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