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公开(公告)号：US20210171648A1
公开(公告)日：2021-06-10
申请号：US17077456
申请日：2020-10-22
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Nicholas S. WILSON , Jeremy D. WAIGHT , Gerd RITTER , David SCHAER , Daniel HIRSCHHORN-CYMERMAN , Taha MERGHOUB , Ekaterina V. BREOUS-NYSTROM , Volker SEIBERT , Takemasa TSUJI , Olivier LÉGER , Dennis J. UNDERWOOD , Marc VAN DIJK
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions comprising such antibodies. In a specific aspect, the multispecific antibodies specifically bind to human GITR and OX40 and modulate GITR and/or OX40 activity, e.g., enhance, activate, or induce GITR and/or OX40 activity, or reduce, deactivate, or inhibit GITR and/or OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., enhances, activates, or induces GITR and/or OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., reduces, deactivates, or inhibits GITR and/or OX40 activity.
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公开(公告)号：US20210070872A1
公开(公告)日：2021-03-11
申请号：US16999374
申请日：2020-08-21
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker SEIBERT , Olivier LÉGER , Marc VAN DIJK , Taha MERGHOUB , David SCHAER , Gerd RITTER , Takemasa TSUJI
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US20210047693A1
公开(公告)日：2021-02-18
申请号：US16764569
申请日：2018-11-15
发明人： Paul MISCHEL , Vineet BAFNA , Junho KO , Wenjing ZHANG , Utkrisht RAJKUMAR
IPC分类号： C12Q1/6886 , A61K31/55 , A61K31/502 , A61P35/00
摘要： Provided herein are, inter alia, methods of treating cancer in a subject having or being at risk of developing cancer, wherein the subject has an amplified extrachromosomal oncogene. The treatment methods provided herein target cancer cells that include extrachromosomal DNA by administering a therapeutically effective amount of a DNA repair pathway inhibitor (e.g., a PARP inhibitor). The methods provided herein are furthermore useful to indicate the progressiveness of cancer, and/or to facilitate evaluation of responsiveness to therapy.
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公开(公告)号：US10912831B1
公开(公告)日：2021-02-09
申请号：US17030650
申请日：2020-09-24
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , C07K16/28 , A61P11/00 , A61P35/04 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20200370114A1
公开(公告)日：2020-11-26
申请号：US16960510
申请日：2019-01-08
发明人： Chunxiao Song , Yibin Liu
IPC分类号： C12Q1/6869 , C12P17/16
摘要： This disclosure provides methods for bisulfite-free identification in a nucleic acid sequence of the locations of 5-methyl-cytosine, 5-hydroxymethylcytosine, 5-carboxylcytosine and 5-formylcytosine.
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公开(公告)号：US10800849B2
公开(公告)日：2020-10-13
申请号：US15962752
申请日：2018-04-25
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Ana M. Gonzalez , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US20200002766A1
公开(公告)日：2020-01-02
申请号：US16481936
申请日：2018-01-30
发明人： Raphael Genolet
IPC分类号： C12Q1/6881 , C12Q1/6874
摘要： Disclosed are methods for sequencing immune cell receptor repertoires from immune cell populations, and kits containing primer mixtures for the sequencing of immune cell receptor repertoires.
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公开(公告)号：US10450373B2
公开(公告)日：2019-10-22
申请号：US16399262
申请日：2019-04-30
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Baek Holmgaard , David Schaer , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20190256601A1
公开(公告)日：2019-08-22
申请号：US16399262
申请日：2019-04-30
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： MARC VAN DIJK , CORNELIA ANNE MUNDT , GERD RITTER , JEDD DAVID WOLCHOK , TAHA MERGHOUB , ROBERTA ZAPPASODI , RIKKE BAEK HOLMGAARD , DAVID SCHAER , DAVID ADAM SAVITSKY , NICHOLAS STUART WILSON
IPC分类号： C07K16/28
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US10323091B2
公开(公告)日：2019-06-18
申请号：US15254315
申请日：2016-09-01
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Nicholas Stuart Wilson , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Bæk Holmgaard , David Schaer , David Adam Savitsky
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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