公开(公告)号：US10697955B2

公开(公告)日：2020-06-30

申请号：US16208441

申请日：2018-12-03

Applicant: MONASH UNIVERSITY

Inventor： Bayden R. Wood ,  Philip Heraud ,  David Perez-Guaita

IPC: G01J5/00 ,  G01N33/49 ,  G01N21/552 ,  G01N21/3577 ,  C12Q1/70 ,  C12Q1/689 ,  G01N21/35 ,  G01N33/487

Abstract: The invention principally relates to a method of detecting a disease agent in blood, comprising: (i) creating a sample infra-red spectrum representative of the blood, with one or more spectral components, each having a wavenumber and absorbance value; (ii) providing a reference database of spectral models, each model having one or more database spectral components of a wavenumber and an absorbance value, wherein the database spectral components identify disease agents; (iii) determining whether one or more database spectral components corresponds to one or more sample spectral components, and (iv) compiling a list of corresponding database components identified.

公开(公告)号：US20190316116A1

公开(公告)日：2019-10-17

申请号：US15535899

申请日：2015-12-15

Applicant: MONASH UNIVERSITY

Inventor： Benjamin POREBSKI ,  Ashley BUCKLE

IPC: C12N15/10 ,  C07K14/78

Abstract: The invention relates to a highly stable polypeptide scaffold comprising an amino acid sequence based on a fibronectin type III (Fn3) domain and a polypeptide comprising the scaffold with grafted loops. The invention also relates to a nucleic acid molecule encoding the polypeptide scaffold, a method of making the polypeptide scaffold, and a composition comprising the polypeptide scaffold.

公开(公告)号：US20190307937A1

公开(公告)日：2019-10-10

申请号：US16462910

申请日：2017-11-22

Applicant: Alfred Health ,  Monash University

Inventor： Mark FITZGERALD ,  Peter FINNEGAN ,  Wing CHIU ,  Nayeem CHOWDHURY ,  Nabil CHOWDHURY

IPC: A61M1/04 ,  A61B17/34

Abstract: A surgical system for use in establishing and maintaining an opening to an anatomical space of a body, the system comprising an obturator assembly having a cutting portion at a distal end and a cannula, the cannula being detachably coupled to the cutting portion and deployable into the anatomical space of a patient, the cannula comprises a locking portion, and a lengthwise extendable body; a valve assembly comprising a passage for receiving the cannula, a first end for coupling to a fluid extraction device and a second end for placement external and adjacent the anatomical space; a base comprising a plate for placement on a patient external and adjacent the anatomical space, the plate has an aperture configured for receiving the obturator assembly and coupling means located about the aperture for coupling with the valve assembly; and wherein, in use, the locking portion of the cannula is configured to be retained in the valve assembly with the extendable body extended into the anatomical space to facilitate a path for fluid extraction, and wherein the cannula comprises means for retaining the cannula in its extended state.

公开(公告)号：US20190298743A1

公开(公告)日：2019-10-03

申请号：US16303023

申请日：2017-05-19

Applicant: Takeda Pharmaceutical Company Limited ,  MONASH UNIVERSITY ,  QUEENS UNIVERSITY

Inventor： Nigel Bunnett

IPC: A61K31/58 ,  A61P23/00

Abstract: The present invention relates to compounds and their uses. In particular, to compounds that inhibit endosomal protease-activated receptor-2 (PAR2) signaling and their use in the treatment of pain.

公开(公告)号：US10426598B2

公开(公告)日：2019-10-01

申请号：US15124402

申请日：2015-03-23

Applicant: Monash University

Inventor： Wai Ho Li

IPC: A61N1/36 ,  A61F2/14 ,  G06K9/00 ,  G06T11/00 ,  G06T11/60

Abstract: A visual image processing method is based on received spatial field information (302) from a spatial field sensor (116). A data store (804) is accessed, which contains a sensor map data structure (206) comprising a set of predefined regions (208) within a spatial field corresponding with the information received via the sensor input. Each predefined region is associated in the data structure with one or more of a set of stimuli (204) applicable to a biological visual system, and each stimulus corresponds with a visual percept (210). The spatial field information associated with each region is processed to generate stimulus control information which is applied to select, from within the sensor map data structure, stimuli from the set of stimuli for application to the biological visual system. Output stimulus signals (310) are generated, which are suitable for application to the biological visual system based upon the selected stimuli. Flexible mappings are thus provided between visual percepts, stimuli which may be applied (e.g. via a prosthetic implant) in order to generate the percepts, and associations between those stimuli and regions of the spatial field corresponding with the visual percepts.

公开(公告)号：US20190167615A1

公开(公告)日：2019-06-06

申请号：US16323726

申请日：2017-08-10

Applicant: MONASH UNIVERSITY ,  COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR

Inventor： Charles REAY MACKAY ,  Eliana Marino MORENO ,  Trevor LOCKETT ,  Julie CLARKE ,  David TOPPING

IPC: A61K31/19 ,  A61P37/06 ,  A23L33/12 ,  A61K9/16 ,  A61K9/00 ,  A61K9/02

Abstract: The present invention relates to methods for treating or preventing or delaying the progression or onset of autoimmune disease, providing dietary metabolites comprising a combination of two or more short chain fatty acids, esters or salts thereof. The present invention also provides compositions for treating, preventing or delaying the progression of, or onset of autoimmune disease.

公开(公告)号：US20190139760A1

公开(公告)日：2019-05-09

申请号：US16177286

申请日：2018-10-31

Applicant: MONASH UNIVERSITY

Inventor： Michael Sears Fuhrer ,  John Thery Hellerstedt ,  Mark Thomas Edmonds ,  James Lee Richard Jessee Collins ,  Chang Liu

IPC: H01L21/02 ,  H01L29/66 ,  H01L43/06 ,  H01L51/05 ,  H01L29/16

Abstract: Dirac semimetals, methods for modulating charge carrying density and/or band gap in a Dirac semimetal, devices including a Dirac semimetal layer, and methods for forming a Dirac semimetal layer on a substrate are described.

公开(公告)号：US10246496B2

公开(公告)日：2019-04-02

申请号：US15503841

申请日：2015-08-14

Applicant: MONASH UNIVERSITY ,  LA TROBE UNIVERSITY ,  PEPTIDES INTERNATIONAL, INC. ,  BAYLOR COLLEGE OF MEDICINE

Inventor： Raymond S. Norton ,  Shih Chieh Chang ,  Michael W. Pennington ,  Christine Beeton ,  Brian J. Smith

IPC: A61K38/00 ,  A61K38/17 ,  C07K14/435 ,  C12N15/63 ,  C07K4/00 ,  C07K19/00

Abstract: Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X−4 is D, E or other negatively-charged amino acid or derivative thereof, X−3 is E, I, L, S, V, W or a tryptophan derivative, X−2 is any amino acid, X−1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety. a-X−4X−3X−2X−1-b(SEQ ID NO: 3)  (I)

公开(公告)号：US20190093239A1

公开(公告)日：2019-03-28

申请号：US16087615

申请日：2016-10-24

Applicant: MONASH UNIVERSITY

Inventor： Dhanraj SHINDE ,  Jason BRENKER ,  Rico TABOR ,  Adrian NEILD ,  Mainak MAJUMDER

IPC: C25B1/00 ,  C01B32/19 ,  C01G39/06 ,  C25B15/08

Abstract: A method for shear-assisted electrochemical exfoliation of a layered van der Waals solid (such as graphite, MoS2, BN, or WS2) into a two dimensional material (such as graphene where the original layered van der Waals solid is graphite) can at least partly overcome certain limitations of electrochemical exfoliation techniques with shear-induced effects.

公开(公告)号：US20180222857A1

公开(公告)日：2018-08-09

申请号：US15579964

申请日：2016-06-09

Applicant: MONASH UNIVERSITY ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Anne Kathrin VOSS ,  Jonathan BAELL ,  Huu Nghi NGUYEN ,  David J. LEAVER ,  Benjamin L. CLEARY ,  H. Rachel LAGIAKOS ,  Bilal Nadeem SHEIKH ,  Timothy John THOMAS

IPC: C07C311/49 ,  A61P35/00

Abstract: Compound of formula I: wherein: A is selected from: (i) where RF1 is H or F; (ii) (iii) a N-containing C6 heteroaryl group; and B is where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.